Affiliation: Institute of Biomedical Technologies
- The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviourL Zecca
Institute of Advanced Biomedical Technologies CNR, Segrate, Milano, Italy
J Neural Transm Suppl . 2003..However, its putative neuroprotective effects could be quenched in conditions of toxin overload...
- New melanic pigments in the human brain that accumulate in aging and block environmental toxic metalsLuigi Zecca
Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Milan, Italy
Proc Natl Acad Sci U S A 105:17567-72. 2008..Furthermore, the resulting melanic component serves an additional protective role through its ability to chelate and accumulate metals, including environmentally toxic metals such as mercury and lead...
- Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's diseaseLuigi Zecca
Institute of Biomedical Technologies Italian National Research Council, Milano, Italy
J Neurochem 106:1866-75. 2008..This occurs in PD when extraneuronal iron-neuromelanin is phagocytosed by microglia and iron-neuromelanin degradation releases reactive/toxic iron...
- A proposed dual role of neuromelanin in the pathogenesis of Parkinson's diseaseL Zecca
Institute of Biomedical Technologies Italian Research Council, Segrate, Milano, Italy
Neurology 67:S8-11. 2006..Neuromelanin appears to be a suitable target for devising chemical agents that might modify the course of these diseases...
- Iron, brain ageing and neurodegenerative disordersLuigi Zecca
Institute of Biomedical Technologies Italian National Research Council, 20090 Segrate, Milano, Italy
Nat Rev Neurosci 5:863-73. 2004..By studying the accumulation and cellular distribution of iron during ageing, we should be able to increase our understanding of these neurodegenerative disorders and develop new therapeutic strategies...
- The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during agingLuigi Zecca
Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Italy
Proc Natl Acad Sci U S A 101:9843-8. 2004..Manganese-SOD and copper/zinc-SOD had similar age trend in LC and SN. These results may explain at least one of the reasons underlying lower vulnerability of LC compared to SN in Parkinsonian syndromes...
- Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristicsLuigi Zecca
Institute of Biomedical Technologies National Council of Research, Segrate, Italy
Trends Neurosci 26:578-80. 2003..However, dying neurons in Parkinson's disease that release neuromelanin might induce a vicious cycle of chronic neuroinflammation and neuronal loss...
- Substantia nigra neuromelanin: structure, synthesis, and molecular behaviourL Zecca
Institute of Advanced Biomedical Technologies CNR, via Cervi 93, 20090 Segrate Mi, Italy
Mol Pathol 54:414-8. 2001..However, its putative neuroprotective effects could be quenched in conditions of toxin overload...
- Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processesL Zecca
Institute of Advanced Biomedical Technologies CNR, Segrate, Italy
J Neurochem 76:1766-73. 2001..Based on this data and on the low H- and L-ferritin content in neurones it is concluded that neuromelanin is the major iron storage in substantia nigra neurones in normal individuals...
- The neuromelanin of human substantia nigra and its interaction with metalsL Zecca
Institute of Biomedical Technologies CNR, Segrate, Milano, Italy
J Neural Transm (Vienna) 109:663-72. 2002..The overloading of NM with iron and other metals in neurons may trigger inflammatory and degenerative processes aggravating the underlying pathological condition...
- Interaction of human substantia nigra neuromelanin with lipids and peptidesL Zecca
Institute of Advanced Biomedical Technologies CNR, University of Milan, Italy
J Neurochem 74:1758-65. 2000..The presence of a peptide component in the neuromelanin structure and the selective affinity for lipid molecules suggest new aspects of the functional role and metabolic pathway of neuromelanin...
- A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compoundsM G Sacco
Institute of Advanced Biomedical Technologies, National Research Council, Milan, Italy
Nat Biotechnol 15:1392-7. 1997..Transgenic mice injected intraperitoneally with sodium arsenite, cadmium chloride, copper sulphate, or methylmercurium chloride showed significant hGH levels in plasma...
- Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and diseaseDavid Sulzer
Department of Neurology, Columbia University, New York, NY 10036, USA
J Neurochem 106:24-36. 2008....
- Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's diseaseLuigi Zecca
Institute of Biomedical Technologies, Via Fratelli Cervi 93, 20090, Segrate Milan, Italy
Acta Neuropathol 116:47-55. 2008..This may be highly relevant to the elucidation of therapeutic strategies in PD...
- In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damageLuigi Zecca
Institute of Biomedical Technologies CNR, Segrate Milano, Italy
Mov Disord 20:1278-85. 2005....
- The neuromelanin of human substantia nigra: physiological and pathogenic aspectsFabio A Zucca
Institute of Biomedical Technologies CNR 20090 Segrate Milano, Italy
Pigment Cell Res 17:610-7. 2004..On the other hand, experiments in cell culture indicate that NM can activate microglia, eliciting the release of cytotoxic factors that can induce neurodegeneration...
- The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's diseaseLuigi Zecca
Institute of Biomedical Technologies CNR, Segrate, Italy
FEBS Lett 510:216-20. 2002..These data demonstrate a continuous NM accumulation in SNPC neurons during aging, the presence of large amounts of NM in SNPC and severe depletion of NM in Parkinson's disease...
- Iron-binding characteristics of neuromelanin of the human substantia nigraKay L Double
Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
Biochem Pharmacol 66:489-94. 2003..The interaction between NM and iron has implications for disorders such as Parkinson's disease where an increase in iron in the SN is associated with increased indices of oxidative stress...
- The structure of neuromelanin as studied by chemical degradative methodsKazumasa Wakamatsu
Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
J Neurochem 86:1015-23. 2003..The involvement of DA and CysDA as building blocks of NM demonstrates the detoxifying role of NM synthesis, since it prevents the intraneuronal accumulation of DA and CysDA, which would cause toxic effects...
- Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's diseaseManfred Gerlach
Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, D 97080 Wurzburg, Germany
Neurotox Res 5:35-44. 2003..The resultant radical-mediated cytotoxicity may contribute to cellular damage observed in PD...
- The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surfaceWilliam D Bush
Department of Chemistry, Duke University, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 103:14785-9. 2006..Such a kinetic model would predict a structural motif with pheomelanin at the core and eumelanin at the surface, which is consistent with the measured surface oxidation potential of the approximately 30-nm constituents of NM granules...
- Microglia-mediated neurotoxicity: uncovering the molecular mechanismsMichelle L Block
Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Nat Rev Neurosci 8:57-69. 2007....
- Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brainWeslyn C Ward
Department of Chemistry, Duke University, Durham, NC, USA
J Lipid Res 48:1457-62. 2007..The distribution of dol-CA chains lengths in NM also differed from that of dol, suggesting that the enzyme(s) responsible for the conversion of dol to dol-CA prefer a dolichol substrate containing 19 isoprene units...
- Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's diseaseHenrik Wilms
Klinik fur Neurologie, Christian Albrechts Universitat zu Kiel, 24105 Kiel, Germany
FASEB J 17:500-2. 2003..The antagonization of microglial activation by a pharmacological intervention targeting microglial NF-kappaB or p38 MAPK could point to additional venues in the treatment of PD...