Daniela Giannessi

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk
    D Giannessi
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Pharmacol Res 56:459-67. 2007
  2. pmc Circulating heat shock proteins and inflammatory markers in patients with idiopathic left ventricular dysfunction: their relationships with myocardial and microvascular impairment
    Daniela Giannessi
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa 56100, Italy
    Cell Stress Chaperones 12:265-74. 2007
  3. ncbi request reprint [Role of biomarkers in the detection of sub-clinical myocardial injury: H-FABP and radiofrequency ablation of ventricular arrhythmias]
    Daniela Giannessi
    Istituto di Fisiologia Clinica CNR e Fondazione Toscana Gabriele Monasterio, Pisa
    Recenti Prog Med 101:364-8. 2010
  4. doi request reprint Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation
    Daniela Giannessi
    CNR Institute of Clinical Physiology and Fondazione Toscana G Monasterio, Pisa, Italy
    Clin Biochem 43:1241-5. 2010
  5. pmc Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure
    Daniela Giannessi
    Research National Council CNR Institute of Clinical Physiology Laboratory of Cardiovascular Biochemistry, Pisa 56124, Italy
    Metabolism 60:227-33. 2011
  6. doi request reprint Multimarker approach for heart failure management: perspectives and limitations
    Daniela Giannessi
    Laboratory of Cardiovascular Biochemistry CNR Institute of Clinical Physiology and Fondazione CNR Regione Toscana G Monasterio, Via G Moruzzi 1, 56125 Pisa, Italy
    Pharmacol Res 64:11-24. 2011
  7. doi request reprint Apoptotic transcriptional profile remains activated in late remodeled left ventricle after myocardial infarction in swine infarcted hearts with preserved ejection fraction
    Tommaso Prescimone
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
    Pharmacol Res 70:41-9. 2013
  8. pmc Impact of obesity on the expression profile of natriuretic peptide system in a rat experimental model
    Manuela Cabiati
    CNR Institute of Clinical Physiology, Pisa, Italy
    PLoS ONE 8:e72959. 2013
  9. doi request reprint Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
  10. doi request reprint Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Pisa, Italy
    Cytokine 49:325-30. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk
    D Giannessi
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Pharmacol Res 56:459-67. 2007
    ..Particular attention is paid to practical considerations relative to the analytical determination of this protein in humans...
  2. pmc Circulating heat shock proteins and inflammatory markers in patients with idiopathic left ventricular dysfunction: their relationships with myocardial and microvascular impairment
    Daniela Giannessi
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa 56100, Italy
    Cell Stress Chaperones 12:265-74. 2007
    ..These results suggest a pathogenic role of infective-metabolic insult and inflammatory reaction in the development of vascular and myocardial damage in patients with heart failure even in the absence of overt coronary artery disease...
  3. ncbi request reprint [Role of biomarkers in the detection of sub-clinical myocardial injury: H-FABP and radiofrequency ablation of ventricular arrhythmias]
    Daniela Giannessi
    Istituto di Fisiologia Clinica CNR e Fondazione Toscana Gabriele Monasterio, Pisa
    Recenti Prog Med 101:364-8. 2010
    ..We report a case of a patient complaining of life-threatening arrhythmias treated by RF in whom temporal changes of cardiac biomarkers was determined after the procedure...
  4. doi request reprint Heart-type fatty acid binding protein is an early marker of myocardial damage after radiofrequency catheter ablation
    Daniela Giannessi
    CNR Institute of Clinical Physiology and Fondazione Toscana G Monasterio, Pisa, Italy
    Clin Biochem 43:1241-5. 2010
    ....
  5. pmc Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure
    Daniela Giannessi
    Research National Council CNR Institute of Clinical Physiology Laboratory of Cardiovascular Biochemistry, Pisa 56124, Italy
    Metabolism 60:227-33. 2011
    ..76 ± 0.16 vs 2.43 ± 0.19, P = .01). These results could suggest that down-regulation of the adiponectin levels and reduced HDL cholesterol have a key role in causing impaired coronary function and myocardial perfusion in DCM...
  6. doi request reprint Multimarker approach for heart failure management: perspectives and limitations
    Daniela Giannessi
    Laboratory of Cardiovascular Biochemistry CNR Institute of Clinical Physiology and Fondazione CNR Regione Toscana G Monasterio, Via G Moruzzi 1, 56125 Pisa, Italy
    Pharmacol Res 64:11-24. 2011
    ..A reliable selection of biomarkers for the careful management of HF patients is of pivotal importance in reducing healthcare costs without reducing patient care...
  7. doi request reprint Apoptotic transcriptional profile remains activated in late remodeled left ventricle after myocardial infarction in swine infarcted hearts with preserved ejection fraction
    Tommaso Prescimone
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
    Pharmacol Res 70:41-9. 2013
    ....
  8. pmc Impact of obesity on the expression profile of natriuretic peptide system in a rat experimental model
    Manuela Cabiati
    CNR Institute of Clinical Physiology, Pisa, Italy
    PLoS ONE 8:e72959. 2013
    ..The understanding of mechanisms involved in the modulation of the NP system in obesity could be a useful starting point for future clinical study devoted to identifying new obesity treatment strategies. ..
  9. doi request reprint Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
    ..Higher BNP mRNA expression in the PS is consistent with a reduction in contractile function in this region, while higher CNP mRNA expression in the OS suggests the presence of concomitant endothelial dysfunction in the remote region...
  10. doi request reprint Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Pisa, Italy
    Cytokine 49:325-30. 2010
    ..26, p=0.04). Both in patients with milder or more severe LV dysfunction lower MBF values were associated with higher OPN levels and PRA. These results suggest a interdependent role of RAS and vascular inflammation in cardiomyopathy...
  11. ncbi request reprint Increased levels of C-type natriuretic peptide in patients with idiopathic left ventricular dysfunction
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Peptides 28:1068-73. 2007
    ..In these patients CNP is also related with both systemic and coronary indicators of endothelial/microvascular damage...
  12. ncbi request reprint Plasma adrenomedullin relation with Doppler-derived dP/dt in patients with congestive heart failure
    Maria Aurora Morales
    Cardiology and Cardiovascular Biochemistry Laboratory, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Cardiol 29:126-30. 2006
    ..Increased circulating adrenomedullin (AM) concentration has been reported in congestive heart failure (HF) and considered as a possible marker of cardiac dysfunction...
  13. doi request reprint Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 29:2208-15. 2008
    ..The co-localization of the CNP system and NPR-B suggests a possible role of CNP in HF and may prompt novel therapeutical strategies...
  14. pmc Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model
    Chiara Caselli
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cardiovasc Diabetol 11:143. 2012
    ..We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein kinase (AMPK) activity in a swine model of non-ischemic dilated cardiomyopathy...
  15. doi request reprint Abnormal glucose and lipid control in non-ischemic left ventricular dysfunction
    Danilo Neglia
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Cardiol 19:1182-9. 2012
    ..We sought to investigate whether risk factors are also associated with left ventricular (LV) dilatation, contractile impairment and reduced myocardial blood flow (MBF) in patients with non-ischemic LV dysfunction...
  16. ncbi request reprint Early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction
    Alessandro Pingitore
    Institute of Clinical Physiology, CNR, Pisa, Italy
    J Card Fail 12:520-6. 2006
    ..We wanted to assess the thyroid state in patients with ILVD...
  17. doi request reprint Impact of normalization strategy on cardiac expression of pro-inflammatory cytokines: evaluation of reference genes in different human myocardial regions after Left Ventricular Assist Device support
    Chiara Caselli
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cytokine 63:113-22. 2013
    ....
  18. doi request reprint Caspase-1 transcripts in failing human heart after mechanical unloading
    Tommaso Prescimone
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cardiovasc Pathol 24:11-8. 2015
    ..The aim of this study was to assess whether Left Ventricular Assist Device (LVAD) implantation modifies the inflammatory and apoptotic profile in the heart through the modulation of Casp-1 expression level...
  19. ncbi request reprint C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    Eur J Cardiovasc Prev Rehabil 15:168-72. 2008
    ..Endothelial dysfunction, commonly observed in chronic heart failure (HF) patients is positively affected by physical training...
  20. doi request reprint Comparison of NT-proCNP and CNP plasma levels in heart failure, diabetes and cirrhosis patients
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Regul Pept 166:15-20. 2011
    ..Due to its higher analytical feasibility, this determination could become widespread in clinical biochemistry laboratories and serve as a complementary marker of disease conditions...
  21. ncbi request reprint Sequencing and cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 28:1390-6. 2007
    ..Therefore, NPR-B sequencing provides a new tool to investigate the role of CNP under physiological and pathological conditions in the experimental and clinical setting...
  22. doi request reprint Adrenomedullin plasma levels predict left ventricular reverse remodeling after cardiac resynchronization therapy
    Maria Aurora Morales
    CNR Institute of Clinical Physiology and G Monasterio Foundation, Pisa, Italy
    Pacing Clin Electrophysiol 33:865-72. 2010
    ..Aim of this study was to assess the role of plasma ADM levels in HF patients treated by cardiac resynchronization therapy (CRT)...
  23. doi request reprint Nitric oxide treatment reduces neo-intimal formation and modulates osteopontin expression in an ex-vivo human model of intimal hyperplasia
    Chiara Colotti
    Scuola Superiore S Anna, Pisa, Italy
    Cytokine 46:228-35. 2009
    ..NO could modulates the initial inflammatory signals that induces the OPN over-production with the related cascade of events leading to IH...
  24. doi request reprint Exploring PTX3 expression in Sus scrofa cardiac tissue using RNA sequencing
    Manuela Cabiati
    CNR Institute of Clinical Physiology and G Monasterio Foundation, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Regul Pept 174:1-5. 2012
    ..N; p=0.022, HF left ventricle vs. N). Knowledge of the PTX3 sequence could be a useful starting point for future studies devoted to better understanding the specific role of this molecule in the pathogenesis of cardiovascular diseases...
  25. ncbi request reprint Cardiac production of C-type natriuretic peptide in heart failure
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 7:397-9. 2006
    ..In light of the difficulty in recruiting patients with these characteristics, this kind of study can be performed with a small number of subjects...
  26. doi request reprint Cardiac molecular markers of programmed cell death are activated in end-stage heart failure patients supported by left ventricular assist device
    Tommaso Prescimone
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cardiovasc Pathol 23:272-82. 2014
    ..Literature data regarding the modulation of the apoptotic process during LVAD support are still controversial...
  27. pmc Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation
    Andrea D'Amico
    Scuola Superiore Sant Anna, Institute of Life Sciences, 56100, Pisa, Italy
    J Transl Med 12:350. 2014
    ..The aim of this study was to evaluate the role of cathepsin system in HF patients supported by LVAD, in order to determine their involvement in cardiac remodeling...
  28. doi request reprint A methodological reappraisal of total and high molecular weight adiponectin determination in human peripheral circulation: comparison of four immunometric assays
    Chiara Caselli
    Laboratory of Cardiovascular Biochemistry, Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Clin Chem Lab Med 48:561-8. 2010
    ..The comparative performance of these assays is thus an issue of major relevance...
  29. ncbi request reprint Radioimmunoassay for plasma C-type natriuretic peptide determination: a methodological evaluation
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 43:641-5. 2005
    ..0001 and p = 0.001, respectively). The sensitivity, accuracy and variability levels of the method proposed for CNP assay was suitable for reliable detection of changes in CNP plasma levels in the clinical setting...
  30. doi request reprint Adrenomedullin and intermedin gene transcription is increased in leukocytes of patients with chronic heart failure at different stages of the disease
    Manuela Cabiati
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 55:13-6. 2014
    ....
  31. doi request reprint High peripheral levels of h-FABP are associated with poor prognosis in end-stage heart failure patients with mechanical circulatory support
    Manuela Cabiati
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Via G Moruzzi 1, 56121 Pisa, Italy
    Biomark Med 7:481-92. 2013
    ..To associate the time-course of h-FABP and N-terminal pro B-type natriuretic peptide (NT-proBNP)after left ventricular assist device (LVAD) implantation to outcome in end-stage heart failure patients...
  32. doi request reprint Adiponectin plasma levels decrease after surgery in pediatric patients with congenital heart disease
    Chiara Caselli
    Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Clin Biochem 45:1510-2. 2012
    ..The aim of this study was to examine the response of plasma adiponectin to cardiac surgery in children with congenital defects to determine whether its measurement is associated to the response to injury...
  33. doi request reprint Tissue-specific selection of stable reference genes for real-time PCR normalization in an obese rat model
    Manuela Cabiati
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    J Mol Endocrinol 48:251-60. 2012
    ..The findings obtained in this study underline the importance of having three stably expressed reference gene sets for use in the cardiac, renal, and pulmonary tissues of an experimental model of obese and hyperglycemic Zucker rats...
  34. doi request reprint Reappraisal of quantitative gel zymography for matrix metalloproteinases
    Tommaso Prescimone
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    J Clin Lab Anal 28:374-80. 2014
    ....
  35. doi request reprint Sequencing and cardiac expression of Apelin in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, 56124 Pisa, Italy
    Pharmacol Res 60:314-9. 2009
    ..The knowledge of Apelin sequence can be an useful starting point for future studies devoted to better understand the possible alterations of Apelin mRNA expression in different cardiac diseases...
  36. ncbi request reprint C-type natriuretic peptide plasma levels increase in patients with chronic heart failure as a function of clinical severity
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Eur J Heart Fail 7:1145-8. 2005
    ..corrected] C-type natriuretic peptide (CNP), secreted by the endothelium and the heart, is structurally related to atrial and brain natriuretic peptides, but its clinical significance in chronic heart failure (CHF) is controversial...
  37. ncbi request reprint C-type natriuretic peptide and heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology, National Research Council Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Pharmacol Res 54:326-33. 2006
    ..In fact, CNP may represent an important new local autocrine and endocrine mediator in CHF although further evaluations are required to define its full pathophysiological role in this disease...
  38. doi request reprint Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina
    Chiara Caselli
    From the CNR, Institute of Clinical Physiology, Pisa, Italy C C, M M, S D R, D R, D G, R S, D N Fondazione Toscana G Monasterio, Pisa, Italy C P, A C, M L, A C, D N Cardio Thoracic and Vascular Department, University Hospital of Pisa, Italy R L Leiden University Medical Center, Leiden, The Netherlands M A D G, J J B, A J S University Hospital Zurich, Zurich, Switzerland O G, P A K Scuola Superiore Sant Anna, Pisa, Italy V L, R R, A C Hospital Universitario Vall d Hebron, Barcelona, Spain S A B University Alcala, Hospital Ramon y Cajal, Madrid, Spain J Z University of Turku and Turku University Hospital, Turku, Finland J K and Imperial College London, Department of Physiology
    Arterioscler Thromb Vasc Biol 36:757-64. 2016
    ..We aimed at evaluating the effect of coronary atherosclerosis and myocardial ischemia on cardiac release of hs-cTnT and NT-proBNP in patients with suspected CAD...
  39. ncbi request reprint The circulating levels of cardiac natriuretic hormones in healthy adults: effects of age and sex
    Aldo Clerico
    Institute of Clinical Physiology, University of Pisa, Italy
    Clin Chem Lab Med 40:371-7. 2002
    ..These effects should be taken into account in the calculation of appropriate reference values for cardiac natriuretic hormones...
  40. ncbi request reprint [Adrenomedullin plasma levels as indicators of prognosis after cardiac resynchronization therapy]
    Silvia Del Ry
    Istituto di Fisiologia Clinica, Fondazione Toscana G Monasterio, Pisa
    Recenti Prog Med 101:475-9. 2010
    ..The case described illustrates the importance of basal ADM plasma levels in predicting the clinical and functional improvement after treatment with CRT...
  41. doi request reprint Osteopontin plasma levels and accelerated atherosclerosis in patients with CAD undergoing PCI: a prospective clinical study
    Annamaria Mazzone
    Department of Cardiology, Heart Hospital, Fondazione Toscana G Monasterio CNR, Massa, Italy
    Coron Artery Dis 22:179-87. 2011
    ....
  42. doi request reprint Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities
    Marco Bucci
    Turku PET Centre, University of Turku, Turku, Finland
    Am J Physiol Endocrinol Metab 301:E105-12. 2011
    ....
  43. pmc Transcriptional alterations of ET-1 axis and DNA damage in lung tissue of a rat obesity model
    Silvia Del Ry
    1 Cardiovascular Biochemistry Laboratories, CNR Institute of Clinical Physiology, Pisa, Italy
    DNA Cell Biol 34:170-7. 2015
    ..038). The study shows an inappropriate secretion of ET-1 in O animals with a parallel DNA damage in their lungs, providing novel mechanisms by which ET receptor antagonist may exert organ protection...
  44. doi request reprint Age-related changes in endothelin-1 receptor subtypes in rat heart
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Exp Aging Res 34:251-66. 2008
    ..These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution...
  45. ncbi request reprint A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients
    Daniela Giannessi
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Via Moruzzi, 156100 Pisa and G Pasquinucci Hospital, Massa, Italy
    Pharmacol Res 48:519-29. 2003
    ..Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the heart and if this alteration is associated to cardiac preservation...
  46. ncbi request reprint Matrix metalloprotease-2 and -9 concentration and activity in serum and culture medium samples: a methodological reappraisal
    Chiara Colotti
    Scuola Superiore S Anna, Pisa, Italy
    Clin Chem Lab Med 45:1292-8. 2007
    ..The aim of this study was to compare two different methods for MMP-2 and MMP-9 concentration and activity determination...
  47. doi request reprint Novel biodegradable, biomimetic and functionalised polymer scaffolds to prevent expansion of post-infarct left ventricular remodelling
    Caterina Cristallini
    Institute for Composite and Biomedical Materials, CNR, UOS of Pisa, Pisa, Italy
    J Mater Sci Mater Med 23:205-16. 2012
    ..Nanoparticles showed the capability to rebind MMP-9 (specific rebinding 18.67) and to be permanently immobilised on the scaffold surface...