Aldo Clerico

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. doi request reprint State of the art of BNP and NT-proBNP immunoassays: the CardioOrmoCheck study
    Aldo Clerico
    Fondazione Toscana G Monasterio, Pisa, Italy
    Clin Chim Acta 414:112-9. 2012
  2. doi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences
    Aldo Clerico
    Fondazione G Monasterio CNR Regione Toscana and Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chem Lab Med 50:1505-17. 2012
  3. doi request reprint Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance
    Aldo Clerico
    Scuola Superiore Sant Anna, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Clin Chem Lab Med 49:1949-54. 2011
  4. ncbi request reprint Analytical performance and diagnostic accuracy of immunometric assays for the measurement of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 51:445-7. 2005
  5. doi request reprint Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana G Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 301:H12-20. 2011
  6. ncbi request reprint Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-proBNP assay
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 44:366-78. 2006
  7. doi request reprint The paradox of low BNP levels in obesity
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana Gabriele Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Heart Fail Rev 17:81-96. 2012
  8. ncbi request reprint Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 290:H17-29. 2006
  9. doi request reprint The search for a pathophysiological link between gender, cardiac endocrine function, body mass regulation and cardiac mortality: proposal for a working hypothesis
    Aldo Clerico
    Fondazione Gabriele Monasterio CNR Regione Toscana, Pisa, Italy
    Clin Chim Acta 405:1-7. 2009
  10. doi request reprint Will high-sensitive troponin immunoassays lead to more clarity or confusion in clinical practice?
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Scuola Superiore Sant Anna and Fondazione CNR, Regione Toscana Gabriele Monasterio, 56126 Pisa, Italy
    Clin Sci (Lond) 119:203-5. 2010

Detail Information

Publications96

  1. doi request reprint State of the art of BNP and NT-proBNP immunoassays: the CardioOrmoCheck study
    Aldo Clerico
    Fondazione Toscana G Monasterio, Pisa, Italy
    Clin Chim Acta 414:112-9. 2012
    ..These findings suggest that it may be not reasonable to recommend identical cut-off or decision values for all BNP immunoassays...
  2. doi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker of acute kidney injury: a review of the laboratory characteristics and clinical evidences
    Aldo Clerico
    Fondazione G Monasterio CNR Regione Toscana and Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chem Lab Med 50:1505-17. 2012
    ..These results also suggest that the concept and definition of AKI might need to be reassessed...
  3. doi request reprint Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance
    Aldo Clerico
    Scuola Superiore Sant Anna, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Clin Chem Lab Med 49:1949-54. 2011
    ....
  4. ncbi request reprint Analytical performance and diagnostic accuracy of immunometric assays for the measurement of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 51:445-7. 2005
  5. doi request reprint Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana G Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 301:H12-20. 2011
    ..Finally, we will review the pathophysiological role and the clinical relevance of both peripheral maturation of the precursor of B-type natriuretic peptides and hormone signal transduction...
  6. ncbi request reprint Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-proBNP assay
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 44:366-78. 2006
    ..While awaiting more accurate studies, we suggest that variations of plasma BNP three-fold greater than the analytical imprecision should be considered as potentially relevant from a physiological and clinical point of view...
  7. doi request reprint The paradox of low BNP levels in obesity
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana Gabriele Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Heart Fail Rev 17:81-96. 2012
    ..We are still not able to well integrate these multiple information together; therefore, we should learn to do it...
  8. ncbi request reprint Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 290:H17-29. 2006
    ....
  9. doi request reprint The search for a pathophysiological link between gender, cardiac endocrine function, body mass regulation and cardiac mortality: proposal for a working hypothesis
    Aldo Clerico
    Fondazione Gabriele Monasterio CNR Regione Toscana, Pisa, Italy
    Clin Chim Acta 405:1-7. 2009
    ..As a matter of fact the heart plays a key role in the regulation of circulation, salt-water homeostasis, and can exchange physiologically relevant information with other organs and systems...
  10. doi request reprint Will high-sensitive troponin immunoassays lead to more clarity or confusion in clinical practice?
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Scuola Superiore Sant Anna and Fondazione CNR, Regione Toscana Gabriele Monasterio, 56126 Pisa, Italy
    Clin Sci (Lond) 119:203-5. 2010
    ....
  11. ncbi request reprint Clinical relevance of BNP measurement in the follow-up of patients with chronic heart failure
    Aldo Clerico
    Gabriele Monasterio Foundation CNR Regione Toscana, 56126 Pisa, Italy
    Adv Clin Chem 48:163-79. 2009
    ..Further prospective and randomized clinical studies are necessary to definitively demonstrate whether BNP/ NT-proBNP-guided therapy is able to significantly improve the outcome of patients with HF...
  12. ncbi request reprint Diagnostic accuracy and prognostic relevance of the measurement of cardiac natriuretic peptides: a review
    Aldo Clerico
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Endocrinology, Pisa, Italy
    Clin Chem 50:33-50. 2004
    ..Authors have sought to evaluate the diagnostic accuracy and prognostic relevance of the measurement of CNHs according to evidence-based laboratory medicine principles...
  13. doi request reprint New and emerging biomarkers of heart failure
    Aldo Clerico
    G Monasterio Foundation, Institute of Clinical Physiology National Research Council and Scuola Superiore di Studi Universitari e Perfezionamento Sant Anna, Pisa 56126, Italy
    Crit Rev Clin Lab Sci 46:107-28. 2009
    ..Finally, we present a scheme to search for more efficient diagnostic and prognostic biomarkers for HF...
  14. ncbi request reprint The increasing impact of laboratory medicine on clinical cardiology
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, C N R Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Clin Chem Lab Med 41:871-83. 2003
    ..In the present article, after a brief description of the analytical tests included in these four groups, each group's impact on clinical cardiology is discussed in detail...
  15. ncbi request reprint High-sensitivity troponin: a new tool for pathophysiological investigation and clinical practice
    Aldo Clerico
    G Monasterio Foundation, CNR Regione Toscana, 56126 Pisa, Italy
    Adv Clin Chem 49:1-30. 2009
    ..The aim of this review is to update the present knowledge in the field of cTnI and cTnT with particular attention on the impact of immunoassays with increased analytical sensitivity on both laboratory and clinical practice...
  16. ncbi request reprint Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: a systematic review
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, Department of Cardiovascular Medicine, Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 53:813-22. 2007
    ..We used evidence-based laboratory medicine principles to compare the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) assays for the diagnosis of heart failure...
  17. doi request reprint Distribution of plasma cardiac troponin I values in healthy subjects: pathophysiological considerations
    Aldo Clerico
    Fondazione Gabriele Monasterio and CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:804-8. 2008
    ....
  18. doi request reprint Low triiodothyronine and exercise capacity in heart failure
    Marianna Fontana
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:153-7. 2012
    ....
  19. ncbi request reprint C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    Eur J Cardiovasc Prev Rehabil 15:168-72. 2008
    ..Endothelial dysfunction, commonly observed in chronic heart failure (HF) patients is positively affected by physical training...
  20. doi request reprint Response of cardiac endocrine function to surgery stress is age dependent in neonates and children with congenital heart defects: consequences in diagnostic and prognostic accuracy of brain natriuretic peptide measurement
    Massimiliano Cantinotti
    Fondazione Regione Toscana G Monasterio, Pisa, Italy
    Pediatr Crit Care Med 14:508-17. 2013
    ..The aim of this study was to evaluate the diagnostic and prognostic accuracy of brain natriuretic peptide assay in neonates and children undergoing surgery for congenital heart disease...
  21. ncbi request reprint Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP for early diagnosis of heart failure
    Michele Emdin
    CNR Institute of Clinical Physiology, Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Pisa, Italy
    Clin Chem 53:1289-97. 2007
    ..We compared the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) for diagnosis of preclinical and mild heart failure (HF)...
  22. doi request reprint Prognostic value of combined measurement of brain natriuretic peptide and triiodothyronine in heart failure
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    J Card Fail 15:35-40. 2009
    ..Both low free triiodothyronine (fT3) and high brain natriuretic peptide (BNP) have been separately described as prognostic predictors for mortality in heart failure (HF). We investigated whether their prognostic value is independent...
  23. doi request reprint Proficiency testing project for brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) immunoassays: the CardioOrmocheck study
    Concetta Prontera
    Fondazione Toscana Gabriele Monasterio and CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 47:762-8. 2009
    ..We organized and conducted a proficiency testing study (CardioOrmocheck) to evaluate the differences in analytical performance of brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) immunoassays...
  24. doi request reprint Natriuretic peptide testing in primary care patients
    Michele Emdin
    Cardiovascular Medicine Department, G Monasterio Foundation, CNR Regione Toscana, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:1533-42. 2008
    ..Its implementation in this setting in screening programs and diagnostic algorithms might contribute to decrease the apparent disparity between the general practitioner and the specialist approach to disease management...
  25. doi request reprint Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study
    Stefania Giovannini
    QualiMedLab Srl, Scuola Superiore Sant Anna, Fondazione CNR Regione Toscana G Monasterio, Istituto di Fisiologia Clinica del CNR, Pisa, Italy
    Clin Chem Lab Med 49:1669-76. 2011
    ....
  26. ncbi request reprint Neuro-hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure
    Claudio Passino
    CNR Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy
    Eur J Heart Fail 8:46-53. 2006
    ..Heart failure (HF) is characterised by reduced tolerance to effort, associated with progressive fatigue and dyspnoea. Neuro-hormonal activation is a hallmark of HF and influences its clinical evolution...
  27. ncbi request reprint Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    J Am Coll Cardiol 47:1835-9. 2006
    ..We sought to evaluate the effect of physical training on neurohormonal activation in patients with heart failure (HF)...
  28. ncbi request reprint Analytical performance and diagnostic accuracy of a fully-automated electrochemiluminescent assay for the N-terminal fragment of the pro-peptide of brain natriuretic peptide in patients with cardiomyopathy: comparison with immunoradiometric assay methods
    Concetta Prontera
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Clin Chem Lab Med 42:37-44. 2004
    ....
  29. ncbi request reprint Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure
    Michele Emdin
    Laboratory of Cardiovascular Endocrinology and Cell Biology, C N R Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:627-36. 2004
    ....
  30. doi request reprint The combined use of neutrophil gelatinase-associated lipocalin and brain natriuretic peptide improves risk stratification in pediatric cardiac surgery
    Massimiliano Cantinotti
    Fondazione Toscana G Monasterio, Massa, Italy
    Clin Chem Lab Med 50:2009-17. 2012
    ....
  31. ncbi request reprint Post-reperfusion changes of monocyte function in coronary blood after extracorporeal circulation
    Silverio Sbrana
    Laboratory of Hematology and Flow Cytometry, CNR Institute of Clinical Physiology, Massa, Italy
    Cytometry B Clin Cytom 65:14-21. 2005
    ..Knowledge of mechanisms underlying monocyte functional modulation in coronary blood may be useful to develop protective interventions that can limit ischemia/reperfusion injury...
  32. doi request reprint Pilot study on harmonization of cardiac troponin I immunoassays using patients and quality control plasma samples. On behalf of the Italian Section of the European Ligand Assay Society (ELAS) and of the Study Group on Cardiovascular Biomarkers of the Soci
    Aldo Clerico
    Fondazione CNR Regione Toscana G Monasterio, Pisa, Italy Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chim Acta 456:42-8. 2016
    ....
  33. doi request reprint Systematic differences between BNP immunoassays: comparison of methods using standard protocols and quality control materials
    Maria Franzini
    Scuola Superiore Sant Anna, Pisa, Italy Department of Laboratory Medicine, Fondazione Toscana G Monasterio, Pisa, Italy Electronic address
    Clin Chim Acta 424:287-91. 2013
    ..In this study we compared the BNP data and clinical results obtained with different immunoassays, including a new method (ST-AIA-PACK, TOSOH Corporation)...
  34. doi request reprint Diagnostic accuracy of B-type natriuretic hormone for congenital heart disease in the first month of life
    Massimiliano Cantinotti
    Fondazione Toscana G Monasterio, G Pasquinucci Hospital, Pisa, Italy
    Clin Chem Lab Med 48:1333-8. 2010
    ..The goal of the present study was to evaluate the diagnostic accuracy of B-type natriuretic hormone (BNP) assay in children with congenital heart disease (CHD) in the first month of life...
  35. ncbi request reprint Analytical performance and clinical results of a fully automated MEIA system for brain natriuretic peptide assay: comparison with a point of care testing method
    Simona Storti
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:1178-85. 2004
    ..Then, different reference values, as well as cut-off values, should be taken into account for the clinical use of these two immunoassays...
  36. doi request reprint Comparison between analytical performances of polyclonal and monoclonal electrochemiluminescence immunoassays for NT-proBNP
    Concetta Prontera
    Fondazione Toscana Gabriele Monasterio and CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chim Acta 400:70-3. 2009
    ..We evaluated the analytical characteristics of electrochemiluminescence (ECLIA) immunoassay for NT-proBNP (proBNP II, Roche Diagnostics, Germany) and compared its analytical performance to that of the previous polyclonal method...
  37. ncbi request reprint Comparison of a fully automated immunoassay with a point-of-care testing method for B-type natriuretic peptide
    Concetta Prontera
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 51:1274-6. 2005
  38. doi request reprint Clinical relevance of non-cardiac determinants of natriuretic peptide levels
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:1515-23. 2008
    ..Because several of these diseases may be present in patients with left ventricular dysfunction, the possible influence on diagnostic and prognostic accuracy of natriuretic peptides in heart failure will be discussed...
  39. ncbi request reprint Granulocyte- and monocyte-platelet adhesion index in coronary and peripheral blood after extracorporeal circulation and reperfusion
    Silverio Sbrana
    Laboratory of Hematology and Flow Cytometry, CNR Institute of Clinical Physiology, Massa, Italy
    Cytometry B Clin Cytom 72:215-22. 2007
    ..In particular, leukocyte-platelet interaction, leading to generation of heterotypic coaggregates, represents an amplification mechanism of the local inflammatory response and tissue damage...
  40. ncbi request reprint Evaluation of the analytical performance of the advanced method for cardiac troponin I for the AxSYM platform: comparison with the old method and the Access system
    Simona Storti
    CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Clin Chem Lab Med 44:1022-9. 2006
    ....
  41. ncbi request reprint Platelet activation predicts recurrent ischemic events after percutaneous coronary angioplasty: a 6 months prospective study
    Jacopo Gianetti
    Laboratory of Atherosclerosis and Thrombosis, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Thromb Res 118:487-93. 2006
    ....
  42. ncbi request reprint Recommendations for the clinical use of cardiac natriuretic peptides
    Michele Emdin
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Ital Heart J 6:430-46. 2005
  43. doi request reprint Reference intervals for brain natriuretic peptide in healthy newborns and infants measured with an automated immunoassay platform
    Massimiliano Cantinotti
    Fondazione G Monasterio CNR Regione Toscana, Pisa and Massa, Italy
    Clin Chem Lab Med 48:697-700. 2010
    ..In order to assess the reference intervals for B-type natriuretic hormone (BNP) in the first days of life, we measured peptide concentrations using the fully automated Access platform...
  44. doi request reprint Risk factors and prognostic value of daytime Cheyne-Stokes respiration in chronic heart failure patients
    Roberta Poletti
    Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Foundation G Monasterio, CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 137:47-53. 2009
    ..We aimed to study the prevalence, clinical correlates, risk factors and prognostic relevance of daytime CS, as well as its relation with neurohormonal derangement...
  45. ncbi request reprint Relationships between optical aggregometry (type born) and flow cytometry in evaluating ADP-induced platelet activation
    Silverio Sbrana
    Laboratory of Hematology and Flow Cytometry, CNR Institute of Clinical Physiology, Massa, Italy
    Cytometry B Clin Cytom 74:30-9. 2008
    ..The aim of our study has been to demonstrate the existence of relationships between early events of ADP-induced platelet activation, measured by flow cytometry and platelet-rich plasma aggregation, quantified by optical aggregometry...
  46. doi request reprint Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnI+3 for the measurement of cardiac troponin I using both patients and quality control plasma samples
    Simona Storti
    Fondazione CNR Regione Toscana G Monasterio, Pisa, Italy
    Clin Chim Acta 451:129-34. 2015
    ..Our results confirm that the AccuTnI+3 method for the Access2 and DxI 800 platforms is a clinically usable method for cTnI measurement...
  47. doi request reprint Biomarkers of activation of renin-angiotensin-aldosterone system in heart failure: how useful, how feasible?
    Michele Emdin
    Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana G Monasterio, Pisa, Italy Scuola Superiore Sant Anna, Pisa, Italy Electronic address
    Clin Chim Acta 443:85-93. 2015
    ....
  48. ncbi request reprint Thyroid and brain natriuretic Peptide response in children undergoing cardiac surgery for congenital heart disease- age-related variations and prognostic value
    Massimiliano Cantinotti
    Fondazione Toscana G Monasterio, Pisa, Italy
    Circ J 77:188-97. 2013
    ..The aim of this study was to test age-related variations and prognostic values of thyroid hormones, and brain natriuretic peptide (BNP) levels before and after surgery...
  49. ncbi request reprint Influence of gender on circulating cardiac natriuretic hormones in patients with heart failure
    Michele Emdin
    Department of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Clin Chem Lab Med 41:686-92. 2003
    ....
  50. doi request reprint Distribution of circulating cardiac biomarkers in healthy children: from birth through adulthood
    Chiara Caselli
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Biomark Med 10:357-65. 2016
    ..While circulating biomarkers are critical tools for cardiovascular adult care, their relevance in childhood is unknown...
  51. doi request reprint Usefulness of High-Sensitive Troponin Elevation After Effort Stress to Unveil Vulnerable Myocardium in Patients With Heart Failure
    Luigi Emilio Pastormerlo
    Division of Cardiology and Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy Institute of Life Sciences, Scuola Superiore Sant Anna, Pisa, Italy Electronic address
    Am J Cardiol 116:567-72. 2015
    ....
  52. doi request reprint Clinical relevance of measurement of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in pediatric cardiology
    Massimiliano Cantinotti
    Foundation G Monasterio and CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chim Acta 390:12-22. 2008
    ..The aim of this review is to understand the clinical usefulness of Brain Natriuretic Peptide (BNP) and N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) in pediatric cardiology...
  53. doi request reprint When the heart is burning: amino-terminal pro-brain natriuretic peptide as an early marker of cardiac involvement in active autoimmune rheumatic disease
    Alberto Giannoni
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Regione Toscana, Pisa, Italy Scuola Superiore S Anna, Pisa, Italy
    Int J Cardiol 148:161-7. 2011
    ..We evaluated the influence of inflammation on cardiac endocrine function in autoimmune rheumatic disease (RD) patients with preserved left ventricular systolic function...
  54. ncbi request reprint The circulating levels of cardiac natriuretic hormones in healthy adults: effects of age and sex
    Aldo Clerico
    Institute of Clinical Physiology, University of Pisa, Italy
    Clin Chem Lab Med 40:371-7. 2002
    ..These effects should be taken into account in the calculation of appropriate reference values for cardiac natriuretic hormones...
  55. doi request reprint Diagnostic, prognostic and therapeutic relevance of B-type natriuretic hormone and related peptides in children with congenital heart diseases
    Massimiliano Cantinotti
    G Pasquinucci Hospital, Fondazione CNR Regione Toscana G Monasterio, Massa and Pisa, Italy
    Clin Chem Lab Med 49:567-80. 2011
    ....
  56. doi request reprint B-type natriuretic peptide secretion following scuba diving
    Claudio Passino
    Department of Cardiovascular Medicine, Fondazione G Monasterio, Pisa, Italy
    Biomark Med 5:205-9. 2011
    ..To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor...
  57. doi request reprint Old and new biomarkers of heart failure
    Michele Emdin
    Cardiovascular Medicine Department, G Monasterio Foundation, CNR Regione Toscana, 56124 Pisa, Italy
    Eur J Heart Fail 11:331-5. 2009
    ....
  58. doi request reprint Analysis of the 2010-2012 results of the multicenter external proficiency study for 25-hydroxyvitamin D
    Sara Bianchi
    Fondazione G Monasterio CNR Regione Toscana, Via Moruzzi 1, I 56124, Pisa, Italy
    Biomark Med 7:691-9. 2013
    ....
  59. doi request reprint Adiponectin plasma levels decrease after surgery in pediatric patients with congenital heart disease
    Chiara Caselli
    Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Clin Biochem 45:1510-2. 2012
    ..The aim of this study was to examine the response of plasma adiponectin to cardiac surgery in children with congenital defects to determine whether its measurement is associated to the response to injury...
  60. doi request reprint Platelet proteome and clopidogrel response in patients with stable angina undergoing percutaneous coronary intervention
    Elisabetta Volpi
    Scuola Superiore Sant Anna, Pisa, Italy
    Clin Biochem 45:758-65. 2012
    ....
  61. doi request reprint Clinical relevance of time course of BNP levels in neonates with congenital heart diseases
    Massimiliano Cantinotti
    Fondazione CNR Regione Toscana G Monasterio and Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chim Acta 412:2300-4. 2011
    ....
  62. doi request reprint Harmonization of free thyroid hormone tests: a mission impossible?
    Giorgio Iervasi
    CNR Institute of Clinical Physiology, Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chem Lab Med 49:43-8. 2011
    ..In conclusion, further studies are necessary to answer the question of whether standardization and harmonization of the FT3 and FT4 test is an impossible mission (or not)...
  63. doi request reprint State of the art of immunoassay methods for B-type natriuretic peptides: An update
    Aldo Clerico
    Scuola Superiore Sant Anna and Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Crit Rev Clin Lab Sci 52:56-69. 2015
    ..Finally, the authors believe that the development of more specific methods for the active peptide, BNP1-32, should reduce the systematic differences between methods and result in better harmonization of results. ..
  64. doi request reprint Markers of fibrosis, inflammation, and remodeling pathways in heart failure
    Claudio Passino
    Division of Cardiology and Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Italy Scuola Superiore Sant Anna, Pisa, Italy Electronic address
    Clin Chim Acta 443:29-38. 2015
    ..For this reason, there is an increasing interest in the development of new biomarkers and a great number of laboratory tests have been recently proposed, whose clinical usefulness, however, is not fully established yet. ..
  65. doi request reprint The potential and limitations of plasma BNP measurement in the diagnosis, prognosis, and management of children with heart failure due to congenital cardiac disease: an update
    Massimiliano Cantinotti
    Fondazione Toscana G Monasterio, Ospedale del Cuore, Via Aurelia Sud, 54100, Massa, Pisa, Italy
    Heart Fail Rev 19:727-42. 2014
    ..BNP/NT-proBNP can be used as adjunctive markers in the integrated screening, diagnosis, management, and follow-up of children with heart failure caused by various acquired and congenital heart disease...
  66. doi request reprint Recent advances on natriuretic peptide system: new promising therapeutic targets for the treatment of heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy Electronic address
    Pharmacol Res 76:190-8. 2013
    ..This would open new perspectives also in the treatment of heart failure, and identify novel pharmacological targets for drugs inducing and/or modulating the maturation of the pro-hormone into active hormone. ..
  67. ncbi request reprint Circulating forms of the b-type natriuretic peptide prohormone: pathophysiologic and clinical considerations
    Aldo Clerico
    Fondazione G Monasterio, CNR Regione Toscana, Pisa, Italy
    Adv Clin Chem 58:31-44. 2012
    ....
  68. doi request reprint Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?
    Alberto Giannoni
    G Monasterio Foundation, CNR Regione Toscana, and Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chem Lab Med 47:1167-77. 2009
    ..Only specific and well-designed clinical trials will answer this important question...
  69. doi request reprint Cardiovascular biomarkers: increasing impact of laboratory medicine in cardiology practice
    Simona Vittorini
    Institute of Clinical Physiology National Research Council, Pisa, Italy
    Clin Chem Lab Med 46:748-63. 2008
    ..In this review, we first present the general characteristics of a biomarker followed by the analytical and clinical performance of assay methods...
  70. ncbi request reprint Imaging and laboratory biomarkers in cardiovascular disease
    Maria Grazia Andreassi
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Curr Pharm Des 15:1131-41. 2009
    ..In general, a targeted approach tailored on the individual patient should be preferred to a carpet diagnostic bombing, which will lead to an exorbitant multiplier of costs, risks and inappropriate testing...
  71. ncbi request reprint Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease
    Nicoletta Botto
    CNR, Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 570:81-8. 2005
    ..The obtained results may suggest that the increase of oxidative stress in cardiovascular disease may be responsible for the accumulation of mtDNA damage in coronary artery disease patients...
  72. ncbi request reprint Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty
    Maria Grazia Andreassi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    J Am Coll Cardiol 40:862-8. 2002
    ..BACKGROUND; Although it has recognized that ischemia-reperfusion can induce oxidative DNA damage, its occurrence in patients undergoing PTCA has not yet been demonstrated...
  73. pmc SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects
    Simona Vittorini
    Molecular Cardiology and Genetics Laboratory, Institute of Clinical Physiology, National Research Council, G Pasquinucci Hospital, Massa, Italy
    Mol Med 13:105-11. 2007
    ..These data suggest a complex mechanism aimed to enhance the intracellular Ca(2+) reserve in children affected by tetralogy of Fallot...
  74. doi request reprint Diagnostic accuracy and clinical relevance of brain natriuretic peptide assay in pediatric patients with congenital heart diseases
    Massimiliano Cantinotti
    Pediatric Cardiology and Pediatric Cardiac Surgery Unit, Molecular Cardiology and Genetics Laboratory, G Monasterio Foundation and Institute of Clinical Physiology National Research Council, Heart Hospital, Massa, Italy
    J Cardiovasc Med (Hagerstown) 10:706-13. 2009
    ..We evaluated the diagnostic accuracy and clinical relevance of this assay in different cardiovascular hemodynamic conditions in pediatric patients with congenital heart diseases...
  75. ncbi request reprint The neuroendocrinal system of the heart after construction of a Glenn anastomosis or the Fontan circulation
    Simona Vittorini
    Laboratory of Molecular Cardiology and Genetics, Clinical Physiology Institute, National Research Council, Massa, Italy
    Cardiol Young 15:21-5. 2005
  76. ncbi request reprint Free triiodothyronine: a novel predictor of postoperative atrial fibrillation
    Alfredo Giuseppe Cerillo
    U O Cardiochirurgia Adulti, Institute of Clinical Physiology, The National Research Council, CREAS, Massa, Italy
    Eur J Cardiothorac Surg 24:487-92. 2003
    ..A reduced incidence of postoperative AF has been described in CABG patients receiving IV tri-iodothyronine (T3). This study was designed to define the role of thyroid metabolism on the genesis of postoperative AF...
  77. ncbi request reprint [Recommendations for the clinical use of cardiac natriuretic peptides]
    Michele Emdin
    Istituto di Fisiologia Clinica del CNR, Pisa
    Ital Heart J Suppl 6:308-25. 2005
  78. ncbi request reprint The non-thyroidal illness syndrome after coronary artery bypass grafting: a 6-month follow-up study
    Alfredo Giuseppe Cerillo
    Operative Unit of Adult Cardiac Surgery, Ospedale G Pasquinucci, Institute of Clinical Physiology, The National Research Council, Massa, Italy
    Clin Chem Lab Med 43:289-93. 2005
    ..However, we observed significant alterations of the thyroid profile in 5 out of 40 patients. Further studies are needed to define the long-term consequences of postoperative NTIS...
  79. ncbi request reprint Pathophysiological and clinical relevance of circulating levels of cardiac natriuretic hormones: are they merely markers of cardiac disease?
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, C N R Institute of Clinical Physiology, University of Pisa, Italy
    Clin Chem Lab Med 40:752-60. 2002
    ....
  80. ncbi request reprint Monitoring of monocyte functional state after extracorporeal circulation: a flow cytometry study
    Silverio Sbrana
    Laboratory of Hematology and Flow Cytometry, CNR Institute of Clinical Physiology, Massa, Italy
    Cytometry B Clin Cytom 58:17-24. 2004
    ..Activated polymorphonuclear cells and monocytes may be responsible for morbidity associated with CPB. Knowledge of the monocyte functional state in particular may help to develop protective interventions...
  81. ncbi request reprint Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk
    Serena Masetti
    Sant Anna School, Pisa, Italy
    J Mol Med (Berl) 81:488-94. 2003
    ..These observations suggest that GST-null genotypes strengthen the effect of smoking on CAD risk by modulating the detoxification of genotoxic atherogens...
  82. ncbi request reprint Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease
    Maria Grazia Andreassi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Hum Genet 112:171-7. 2003
    ..429, P=0.005). These data indicate that the MN index is associated with the severity of CAD and is related to the MTHFR polymorphism, suggesting an interesting link between coronary atherosclerosis and genetic instability in humans...
  83. ncbi request reprint Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298-->Asp and T-786-->C polymorphisms
    Umberto Paradossi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Stroke 35:1305-9. 2004
    ....
  84. ncbi request reprint Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation
    Jacopo Gianetti
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    J Thorac Cardiovasc Surg 127:44-50. 2004
    ..We examined the effects of 20 ppm of inhaled nitric oxide administered for 8 hours during and after cardiopulmonary bypass...
  85. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease
    Maria Giovanna Colombo
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Clin Chem 49:389-95. 2003
    ..This study investigated the relationship of the eNOS Glu(298)-->Asp and T(786)-->C polymorphisms with the presence and severity of CAD in the Italian population...
  86. ncbi request reprint Determination of nitrite plus nitrate and malondialdehyde in human plasma: analytical performance and the effect of smoking and exercise
    Cristina Vassalle
    CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 40:802-9. 2002
    ..The assays evaluated in this study proved to be sensitive, specific and practicable, and therefore suitable for routine application in clinical chemistry laboratories and/or physiopathological studies involving human blood samples...
  87. ncbi request reprint Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT) data
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Clin Chem 52:1528-38. 2006
    ..This work aimed to provide a direct comparison of the prognostic value of BNP and NT-proBNP in patients with chronic and stable HF...
  88. ncbi request reprint Clinical relevance of biological variation of B-type natriuretic peptide
    Aldo Clerico
    Clin Chem 51:925-6. 2005
  89. ncbi request reprint Coronary artery bypass grafting surgery is associated with a marked reduction in serum homocysteine and folate levels in the early postoperative period
    Simona Storti
    Clinical Chemistry Laboratory Unit, Ospedale G Pasquinucci, Institute of Clinical Physiology, The National Research Council, Via Aurelia Sud 54100 Massa, Italy
    Eur J Cardiothorac Surg 26:682-6. 2004
    ..This study was designed to evaluate the Hcy metabolism in CABG patients during the early postoperative period...
  90. ncbi request reprint Understanding the clinical biochemistry of N-terminal pro-B-type natriuretic peptide: the prerequisite for its optimal clinical use
    Mauro Panteghini
    Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, Brescia, Italy
    Clin Lab 50:325-31. 2004
    ..Some confounding factors may, however, affect the interpretation of the Nt-proBNP test and its clinical value. The objective of this review is to highlight and discuss these potentially confounding variables...
  91. ncbi request reprint Natriuretic peptides (NPs): Automated electrochemiluminescent immunoassay for N-terminal pro-BNP compared with IRMAs for ANP and BNP in heart failure patients and healthy individuals
    Concetta Prontera
    Clin Chem 49:1552-4. 2003
  92. ncbi request reprint Endocrine paradox in heart failure: resistance to biological effects of cardiac natriuretic hormones
    Aldo Clerico
    Clin Chem 50:2465-7; author reply 2467-8. 2004
  93. pmc Analysis of the variation in the hsp70-1 and hsp90alpha mRNA expression in human myocardial tissue that has undergone surgical stress
    Simona Storti
    Clinical Physiology Institute, G Pasquinucci Hospital, National Research Council, Massa, Italy
    Cell Stress Chaperones 8:18-25. 2003
    ..The lack of any observed increase in the hsp70-1 expression level may be due to the high basal level of the Hsp70 protein in the tissues examined...
  94. ncbi request reprint Association between 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and conotruncal heart defects
    Simona Storti
    Molecular Cardiology Laboratory, IFC CNR G Pasquinucci Hospital, Massa, Italy
    Clin Chem Lab Med 41:276-80. 2003
    ..However, none of the odds ratios was statistically significant. We observed a higher frequency of the 677T allele in Italy than in other European countries. No association has been demonstrated between the 677TT MTHFR genotype and CD...
  95. ncbi request reprint Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia
    Simona Vittorini
    Molecular Cardiology and Genetics Laboratory, National Research Council, Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Clin Chem Lab Med 45:244-8. 2007
    ..We assessed hsp70-1 gene expression during blood cardioplegic arrest in children undergoing surgical correction of congenital heart defects...
  96. ncbi request reprint Evaluation of analytical performance of the Siemens ADVIA TnI ultra immunoassay
    Concetta Prontera
    Clin Chem 53:1722-3. 2007