Elvira Grandone

Summary

Country: Italy

Publications

  1. ncbi request reprint Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations
    Elvira Grandone
    Unità di Aterosclerosi e Trombosi and Obstetrics, Gynecology Department, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
    Haematologica 87:177-81. 2002
  2. ncbi request reprint Homocysteine levels in amniotic fluid. Relationship with birth-weight
    Elvira Grandone
    Unita di Aterosclerosi e Trombosi, Poliambulatorio Giovanni Paolo II, IRCCS Casa Sollievo della Sofferenza S Giovanni R FG, 71013 Italy
    Thromb Haemost 95:625-8. 2006
  3. ncbi request reprint Protein Z levels and unexplained fetal losses
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo Foggia and Medical Genetics, University of Foggia, Foggia, Italy
    Fertil Steril 82:982-3. 2004
  4. ncbi request reprint Homocysteine and antiphospholipid antibodies in a woman undergoing ovarian follicular stimulation: prospective clinical and laboratory evaluation
    Elvira Grandone
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S Giovanni R, Foggia, Italy
    Am J Obstet Gynecol 191:370-1. 2004
  5. ncbi request reprint Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation
    E Grandone
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Viale Padre Pio, 71013, Italy
    Hum Reprod 19:1796-9. 2004
  6. ncbi request reprint Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Italy
    Prenat Diagn 26:1-5. 2006
  7. ncbi request reprint Inherited thrombophilia and gestational vascular complications
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Department of Obstetrics and Gynaecology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, S Giovanni Rotondo, Foggia 71013, Italy
    Best Pract Res Clin Haematol 16:321-32. 2003
  8. ncbi request reprint Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Division of Obstetrics and Gynaecology, I R C C S, Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Hypertens Pregnancy 22:149-55. 2003
  9. doi request reprint Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Research Department, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Am J Obstet Gynecol 203:461.e1-5. 2010
  10. doi request reprint Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis
    Donatella Colaizzo
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Res 128:233-6. 2011

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Lower birth-weight in neonates of mothers carrying factor V G1691A and factor II A(20210) mutations
    Elvira Grandone
    Unità di Aterosclerosi e Trombosi and Obstetrics, Gynecology Department, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
    Haematologica 87:177-81. 2002
    ..Inherited thrombophilia has been associated with fetal and maternal complications of pregnancy. It is reasonable to suppose that an imbalance of maternal hemostasis could lead to decreased fetal growth...
  2. ncbi request reprint Homocysteine levels in amniotic fluid. Relationship with birth-weight
    Elvira Grandone
    Unita di Aterosclerosi e Trombosi, Poliambulatorio Giovanni Paolo II, IRCCS Casa Sollievo della Sofferenza S Giovanni R FG, 71013 Italy
    Thromb Haemost 95:625-8. 2006
    ..05-1.51; p = 0.03). In a large setting, these data provide reference values for homocysteine in amniotic fluids. Moreover, they suggest that homocysteine levels in amniotic fluids may be higher in pregnancies with a SGA newborn...
  3. ncbi request reprint Protein Z levels and unexplained fetal losses
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo Foggia and Medical Genetics, University of Foggia, Foggia, Italy
    Fertil Steril 82:982-3. 2004
    ..We found that protein Z deficiency is not associated with otherwise unexplained fetal losses...
  4. ncbi request reprint Homocysteine and antiphospholipid antibodies in a woman undergoing ovarian follicular stimulation: prospective clinical and laboratory evaluation
    Elvira Grandone
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S Giovanni R, Foggia, Italy
    Am J Obstet Gynecol 191:370-1. 2004
    ..The potential thrombotic risks associated with in vitro fertilization will be discussed...
  5. ncbi request reprint Age and homocysteine plasma levels are risk factors for thrombotic complications after ovarian stimulation
    E Grandone
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Viale Padre Pio, 71013, Italy
    Hum Reprod 19:1796-9. 2004
    ..We calculated the magnitude of thrombotic risk in a cohort of women starting a new cycle of ovarian stimulation and investigated the role of inherited and acquired thrombophilia for these events...
  6. ncbi request reprint Homocysteine metabolism in families from southern Italy with neural tube defects: role of genetic and nutritional determinants
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Italy
    Prenat Diagn 26:1-5. 2006
    ..To evaluate the role of different polymorphic gene variants involved in homocysteine metabolism and plasma levels of homocysteine, folate and vitamin B12 in families from southern Italy with neural tube defects (NTDs)...
  7. ncbi request reprint Inherited thrombophilia and gestational vascular complications
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Department of Obstetrics and Gynaecology, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, S Giovanni Rotondo, Foggia 71013, Italy
    Best Pract Res Clin Haematol 16:321-32. 2003
    ..Although these are not randomized controlled trials, all have found significantly better outcomes in treated pregnancies compared to those of untreated pregnancies in the same women...
  8. ncbi request reprint Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Division of Obstetrics and Gynaecology, I R C C S, Casa Sollievo della Sofferenza, S Giovanni Rotondo FG, Italy
    Hypertens Pregnancy 22:149-55. 2003
    ..Nitric oxide is suggested to play a role in the development of preeclampsia...
  9. doi request reprint Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Research Department, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Am J Obstet Gynecol 203:461.e1-5. 2010
    ..Knowledge about risk factors for venous thromboembolism (VTE) is still limited. A recently found haplotype within the natural anticoagulant protein annexin A5 (ANXA5) exerts an important modulating effect on gene expression...
  10. doi request reprint Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis
    Donatella Colaizzo
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Res 128:233-6. 2011
    ..We wondered whether gender would modulate the role of the JAK2 V617F mutation as susceptibility risk factor for SVT...
  11. doi request reprint Markers of haemostasis and angiogenesis in placentae from gestational vascular complications: impairment of mechanisms involved in maintaining intervillous blood flow
    Elena Chinni
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Thromb Res 125:267-71. 2010
    ..A significant relationship between haemostasis and angiogenesis in placentae from uneventful pregnancies was previously shown...
  12. ncbi request reprint Adverse outcome in women with thrombophilia and bilateral uterine artery notches
    Elvira Grandone
    IRCCS Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Foggia, Italy
    Fertil Steril 86:726-7. 2006
    ..We prospectively evaluated a cohort of pregnant women (n = 41) with bilateral uterine artery notches and found that women with inherited thrombophilia showed a sixfold higher risk to have an adverse outcome than women without...
  13. doi request reprint Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2
    Elena Chinni
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S Giovanni R, Foggia, Italy
    Fertil Steril 91:940-2. 2009
    ..This is the first "ex vivo" demonstration that annexin V gene expression in placentas is dependent on the M2 haplotype...
  14. doi request reprint Outcome of patients with splanchnic venous thrombosis presenting without overt MPN: a role for the JAK2 V617F mutation re-evaluation
    Donatella Colaizzo
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Res 132:e99-e104. 2013
    ..In MPN-free SVT patients, to investigate the clinical outcome, the clinical impact of re-evaluation for the JAK2 V617F mutation, and relationships with the occurrence and time to diagnosis of MPN...
  15. doi request reprint Haplotype M2 in the annexin A5 (ANXA5) gene and the occurrence of obstetric complications
    Giovanni Tiscia
    Casa Sollievo della Sofferenza, Poliambulatorio Giovanni Paolo II, S Giovanni Rotondo, Italy
    Thromb Haemost 102:309-13. 2009
    ..1; 95%CI: 1.1-9.5; p = 0.047) and pregnancy-related hypertensive disorders (2.1; 95%CI: 1.2-3.5; p = 0.008). The M2 haplotype might be a new and relevant risk factor for obstetric complications...
  16. doi request reprint Antithrombotic prophylaxis during pregnancy in women with deficiency of natural anticoagulants
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, IRCCS, Casa Sollievo della Sofferenza, Poliambulatorio Giovanni Paolo II, Viale Padre Pio, S Giovanni Rotondo, Foggia, Italy
    Blood Coagul Fibrinolysis 19:226-30. 2008
    ..1 times (95% CI 1.7-3.5) higher than in treated ones. In this setting of patients with rare causes of thrombophilia, antithrombotic prophylaxis during pregnancy improves foeto-maternal outcome...
  17. ncbi request reprint Preventing adverse obstetric outcomes in women with genetic thrombophilia
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Italy
    Fertil Steril 78:371-5. 2002
    ..To improve fetomaternal outcomes in women with obstetric complications and inherited causes of thrombophilia...
  18. ncbi request reprint Modulation of factors involved in placental haemostasis and angiogenesis by low-molecular-weight-heparins
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, Poliambulatorio Giovanni Paolo II, Viale Padre Pio, S Giovanni Rotondo, Foggia, Italy
    Arch Gynecol Obstet 294:1323-1329. 2016
    ....
  19. ncbi request reprint A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin
    Giovanna D'Andrea
    Unita di Aterosclerosi e Trombosi, Istituto di Ricovero e Cura a Carattere Scientifico, S Giovanni Rotondo, Foggia, Italy
    Blood 105:645-9. 2005
    ..353) of the interindividual variability. Genetic variants of the VKORC1 gene locus modulate the mean daily dose of drug prescribed to acquire the target anticoagulation intensity...
  20. doi request reprint Fetal sex identification in maternal plasma by means of short tandem repeats on chromosome x
    Gennaro Vecchione
    Unita di Aterosclerosi e Trombosi, S Giovanni Rotondo, Foggia, Italy
    Ann N Y Acad Sci 1137:148-56. 2008
    ..This study showed that this noninvasive technique is a reliable and accurate tool to investigate free fetal DNA in pregnancies within the first trimester and could be widely used in clinical research and diagnosis...
  21. doi request reprint Role of thrombophilia in adverse obstetric outcomes and their prevention using antithrombotic therapy
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo dela Sofferenza, S Giovanni R FG, Italy
    Semin Thromb Hemost 35:630-43. 2009
    ..Although in most cases these are not randomized controlled trials, all studies found significantly better outcomes in treated pregnancies compared with those of untreated pregnancies...
  22. ncbi request reprint The factor V (FV) gene ASP79HIS polymorphism modulates FV plasma levels and affects the activated protein C resistance phenotype in presence of the FV Leiden mutation
    Anna Bossone
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, San Giovanni Rotondo, 71013 Foggia, Italy
    Haematologica 88:286-9. 2003
    ..Among a series of FV gene variants characterized, the Asp79His polymorphism appeared to be a good candidate for the modulation of FV activity...
  23. pmc Pregnancy-related venous thrombosis: comparison between spontaneous and ART conception in an Italian cohort
    Michela Villani
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, Foggia, Italy
    BMJ Open 5:e008213. 2015
    ..To evaluate in an Italian cohort the incidence of venous thromboembolic events (VTE) in pregnancies after assisted reproductive technologies (ART)...
  24. doi request reprint Stable-isotope dilution LC-ESI-MS/MS techniques for the quantification of total homocysteine in human plasma
    Michela Tomaiuolo
    Atherosclerosis and Thrombosis Unit, I R C S S Casa Sollievo della Sofferenza, Poliambulatorio Giovanni Paolo II, Foggia, FG, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3292-9. 2009
    ..Taking advantage of the high sensitivity and specificity, approaches involving LC-ESI-MS/MS require less laborious sample preparation, no derivatization and produce reliable results...
  25. doi request reprint An unreported mutation within protein Z gene is associated with very low protein levels in women with fetal loss
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Fertil Steril 90:864-5. 2008
    ..Gene variant intron C G-42A of protein Z is significantly associated with the occurrence of fetal loss. A previously unreported sporadic missense mutation within exon 8 is described in a patient with very low protein Z levels...
  26. ncbi request reprint Glanzmann's thrombasthenia: identification of 19 new mutations in 30 patients
    Giovanna D'Andrea
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Haemost 87:1034-42. 2002
    ..In conclusion, we have identified a spectrum of unreported mutations that may be of value to unravel the role of specific regions of alphaIIb and beta3 genes...
  27. doi request reprint A beta3 Asp217-->Val substitution in a patient with variant Glanzmann Thrombasthenia severely affects integrin alphaIIBbeta3 functions
    Giovanna D'Andrea
    Medical Genetics, Department of Biomedical Science, University of Foggia, Viale Luigi Pinto 7, Foggia, Italy
    Blood Coagul Fibrinolysis 19:657-62. 2008
    ..Our results confirm ex-vivo data and suggest that the D217 amino acid is required for alphaIIBbeta3 receptor interactions with fibrinogen...
  28. doi request reprint Pharmacogenetics of dabigatran etexilate interindividual variability
    Claudia Dimatteo
    Medical Genetics, Dept of Clinical and Experimental Medicine, University of Foggia, Italy
    Thromb Res 144:1-5. 2016
    ..To investigate whether screening for polymorphisms within the ABCB1 and the CES1 genes would explain a portion of the inter-individual variability in blood concentrations of the active metabolite of dabigatran...
  29. doi request reprint Postpartum haemorrhage in a woman with essential thrombocythemia carrying calreticulin mutation: a case report
    Michela Villani
    aAtherosclerosis and Thrombosis Unit bHematology Department, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo Foggia, Italy
    Blood Coagul Fibrinolysis 27:727-8. 2016
    ..Although the postpartum is a high-risk period for thrombotic events, we have to carefully evaluate in women with essential thrombocythemia the likelihood of developing a hemorrhagic complication. ..
  30. doi request reprint A novel congenital dysprothrombinemia leading to defective prothrombin maturation
    Valeria Bafunno
    Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
    Thromb Res 134:1135-41. 2014
    ....
  31. doi request reprint A reliable and rapid tool for plasma quantification of 18 psychotropic drugs by ESI tandem mass spectrometry
    Gennaro Vecchione
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    J Pharm Biomed Anal 67:104-13. 2012
    ..Precision and accuracy data have been satisfactory for a therapeutic drug monitoring (TDM) service as for managing plasma samples from patients receiving psycho-pharmacological treatment...
  32. doi request reprint Fatal pulmonary thromboembolism. A retrospective autopsy study: searching for genetic thrombophilias (Factor V Leiden (G1691A) and FII (G20210A) gene variants) and dating the thrombus
    Vittorio Fineschi
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, Foggia, Italy
    Forensic Sci Int 214:152-8. 2012
    ..We strongly underline the relevance of a complete methodological approach, integrating clinical data by means of autopsy findings and histological study. On the contrary, investigating common inherited thrombophilia is not warranted...
  33. ncbi request reprint A rapid method for the quantification of the enantiomers of Warfarin, Phenprocoumon and Acenocoumarol by two-dimensional-enantioselective liquid chromatography/electrospray tandem mass spectrometry
    Gennaro Vecchione
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 850:507-14. 2007
    ..99. The recoveries ranged from 98% to 118%. Determinations in 10 normal healthy individuals revealed a high reproducibility of RTs. These findings confer to the method suitability for large population studies...
  34. ncbi request reprint Molecular characterization of a factor VII deficient patient supports the importance of the second epidermal growth factor-like domain
    Giovanna D'Andrea
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Haematologica 89:979-84. 2004
    ..We investigated a 6-year old Italian girl who had low functional and antigenic FVII plasma levels...
  35. ncbi request reprint FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile
    Maurizio Margaglione
    Unita di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Thromb Haemost 87:32-6. 2002
    ..8 (95% CI: 1.1-2.8). Present data indicate that the HR2 haplotype is independently associated with vein thrombosis among individuals with a high-risk profile...
  36. pmc Clinical utility of antithrombotic prophylaxis in ART procedures: an Italian experience
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy
    PLoS ONE 9:e97604. 2014
    ..The usefulness of antithrombotic prophylaxis in management of Assisted Reproductive Technologies (ART) is questionable...
  37. ncbi request reprint Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection
    Paola Parrella
    Laboratory of Oncology, Department of Research, IRCCS Casa Sollievo della Sofferenza, Viale Padre Pio, San Giovanni Rotondo, FG, I 71013, Italy
    Eur J Epidemiol 22:159-62. 2007
    ..No differences between cases (HPV(+)) and controls (HPV(-)) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV(-) groups...
  38. doi request reprint Occurrence of the JAK2 V617F mutation in the Budd-Chiari syndrome
    Donatella Colaizzo
    aAtherosclerosis and Thrombosis, Casa Sollievo della Sofferenza, S Giovanni Rotondo, Italy
    Blood Coagul Fibrinolysis 19:459-62. 2008
    ..Determination of the JAK2 V617F mutation may be useful to recognize patients with Budd-Chiari syndrome with or at risk for the subsequent development of overt myeloproliferative diseases...
  39. ncbi request reprint A new method for determination of plasma homocystine by isotope dilution and electrospray tandem mass spectrometry
    Michela Tomaiuolo
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S Giovanni R FG, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 842:64-9. 2006
    ..4%, respectively. The accuracy for the added homocystine ranged from 85% to 110%. High specificity of tandem mass spectrometry coupled with a fast chromatographic process is suitable for a rapid and reliable assay of homocystine...
  40. doi request reprint Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Pharmacogenet Genomics 21:225-30. 2011
    ..The aim of this study was to evaluate the effect of 16 functional polymorphisms in the CYP2D6 gene on the clinical response to donepezil treatment in patients with mild-to-moderate AD...
  41. doi request reprint Liquid chromatography-tandem mass spectrometry method as the golden standard for therapeutic drug monitoring in renal transplant
    Filippo Aucella
    Nephrology and Dialysis Department, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo Foggia, Italy
    J Pharm Biomed Anal 86:123-6. 2013
    ..The main important features of LC-MS/MS methodology for immunosuppressive drugs are the shortened analysis time, an increased throughput, higher selectivity, specificity, and sensitivity, and low cost of analysis. ..
  42. doi request reprint Correlation between factors involved in the local haemostasis and angiogenesis in full term human placenta
    Elena Chinni
    Atherosclerosis and Thrombosis Unit, I R C C S Casa Sollievo della Sofferenza, S Giovanni R FOGGIA, Italy
    Thromb Res 122:376-82. 2008
    ..A possible relationship between the expression of genes involved in the haemostasis and angiogenesis of human placenta has not been investigated...
  43. ncbi request reprint Symptomatic venous thromboembolism and thrombophilic status in adult acute leukemia: a single-center experience of 114 patients at diagnosis
    Lorella Melillo
    Hematology and Stem Cell Unit, IRCCS, S Giovanni Rotondo, Italy
    Acta Haematol 117:215-20. 2007
    ..026). The results of this study indicate that measurements of homocysteinemia could be useful in determining the risk of early TE in adult acute leukemia patients, while systematic thrombophilia screening should not be justified...
  44. doi request reprint Aspirin and heparin in pregnancy
    Elvira Grandone
    Unita di Aterosclerosi e Trombosi, I R C C S Casa Sollievo della Sofferenza, S Giovanni Rotondo Foggia, Italy 39 0 882 416 286 39 0 882 416 273
    Expert Opin Pharmacother 16:1793-803. 2015
    ..A pro-coagulant state during pregnancy can be involved in the occurrence of gestational vascular complications (GVCs) and venous thromboembolism (VTE)...
  45. doi request reprint Functional characterization of annexin A5 gene promoter allelic variants
    Giovanni Luca Tiscia
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy
    Thromb Res 144:93-9. 2016
    ..467G>A, c.-448A>C, c.-422T>C, c.-373G>A). We also characterized two other allelic variants located in the same regulatory region (c.-628C>T, c.-302T>G)...
  46. doi request reprint Assisted reproductive technologies and thrombosis
    Elvira Grandone
    Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S Giovanni Rotondo, Foggia, Italy Electronic address
    Thromb Res 135:S44-5. 2015
    ..The role of known or possible risk factors and the efficacy of antithrombotic prophylaxis will be discussed. ..
  47. ncbi request reprint The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study
    Filippo Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    Nephrol Dial Transplant 20:382-6. 2005
    ....
  48. ncbi request reprint Expression and hormonal modulation of the thromboxane A2 receptor gene in mammalian testicular arteries
    Maria Matteo
    Department of Surgical Sciences, University of Foggia, Foggia, Italy
    Fertil Steril 85:1276-80. 2006
    ..This study aimed to evaluate the presence of TXA2 receptors in mammalian testicular arteries and the influence of exogenous gonadotropin administration on their expression...
  49. ncbi request reprint Impact of prothrombotic mutations and family history on the occurrence of intra-uterine fetal deaths
    Elvira Grandone
    Haematologica 87:1118-9. 2002
  50. ncbi request reprint Thrombophilia polymorphisms and intrauterine growth restriction
    Elvira Grandone
    N Engl J Med 347:1530-1; author reply 1530-1. 2002
  51. doi request reprint Venous thrombosis in oral contraceptive users and the presence of the JAK2 V617F mutation
    Elvira Grandone
    Thromb Haemost 99:640-2. 2008
  52. ncbi request reprint Polymorphisms in factor II and factor VII genes modulate oral anticoagulation with warfarin
    Rosa Lucia D'Ambrosio
    Istituto di Genetica Medica, Dipartimento di Scienze Biomediche, Universita di Foggia, Italy
    Haematologica 89:1510-6. 2004
    ..Polymorphisms within the genes coding for vitamin K-dependent proteins have been suggested to predict sensitivity to warfarin therapy...
  53. ncbi request reprint Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors
    Andrea L Tranquilli
    Department of Obstetrics and Gynecology, Polytechnic University of Marche, Salesi Hospital via Corridoni 11, 60123 Ancona, Italy
    Eur J Obstet Gynecol Reprod Biol 117:144-7. 2004
    ..To determine to what extent adverse pregnancy outcomes are associated with thrombophilia...
  54. pmc Gain-of-function gene mutations and venous thromboembolism: distinct roles in different clinical settings
    Donatella Colaizzo
    J Med Genet 44:412-6. 2007
    ..To calculate the prevalence of common gain of function gene mutations in patients with different clinical manifestations of venous thromboembolism...
  55. ncbi request reprint Risk factors and clinical presentation of portal vein thrombosis in patients with liver cirrhosis
    Lucio Amitrano
    Gastroenterology Unit, A Cardarelli Hospital, Naples, Italy
    J Hepatol 40:736-41. 2004
    ..Clinical presentation of non-neoplastic portal vein thrombosis (PVT) in cirrhotic patients has not been specifically studied and risk factors of PVT in this group of patients are still poorly understood...
  56. ncbi request reprint Clinical relevance of inherited thrombophilia in implantation failure: who needs to be screened?
    Elvira Grandone
    Haematologica 88:ELT35. 2003
  57. ncbi request reprint Thrombophilic mutations are a main risk factor for placental abruption
    Fabio Facchinetti
    Mother Infant Dept, Univ of Modena and Reggio Emilia, Italy
    Haematologica 88:785-8. 2003
    ..The aim of the present study was to evaluate inherited thrombophilic factor V Leiden and factor II A20210 mutations in women presenting with abruption of a normally implanted placenta...
  58. ncbi request reprint Inherited abnormalities of fibrinogen: 10-year clinical experience of an Italian group
    Rosa Santacroce
    Genetica Medica, Dipartimento di Scienze Biomediche, Universita di Foggia, Italy
    Blood Coagul Fibrinolysis 17:235-40. 2006
    ....
  59. ncbi request reprint Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics
    Paolo Ventura
    Dipt di Medicine e Specialità Mediche, Cattedra di Medicina Interna II, University of Modena and Reggio Emilia, Policlinico di Modena, Italy
    Liver Int 25:49-56. 2005
    ....
  60. ncbi request reprint Pregnancy in a woman with a history of Budd-Chiari syndrome treated by porto-systemic shunt, protein C deficiency and bicornuate uterus
    Pasquale Martinelli
    Department of Gynaecology, Obstetrics and Reproductive Physiopathology, Obstetric and Gynaecological Emergency Unit, Frederico II University, Naples, Italy
    Thromb Haemost 95:1033-4. 2006
  61. ncbi request reprint Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms
    Alberto Pilotto
    Geriatric Unit, Department of Medical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Gastroenterology 133:465-71. 2007
    ..The aim of this study was to evaluate the impact of CYP2C9 polymorphisms on the risk of gastroduodenal bleeding in acute NSAID users...
  62. doi request reprint The Italian AICE-Genetics hemophilia A database: results and correlation with clinical phenotype
    Maurizio Margaglione
    Cattedra di Genetica Medica, Dipartimento di Scienze Biomediche, Universita degli Studi di Foggia, Viale Pinto, 71100 Foggia, Italy
    Haematologica 93:722-8. 2008
    ..We plan to identify the mutation in patients with hemophilia A in order to create a confidential national database of mutations for the optimization of genetic services in Italy...
  63. ncbi request reprint Maternal and fetal inherited thrombophilias
    Elvira Grandone
    Am J Obstet Gynecol 186:1376; author reply 1376-7. 2002
  64. ncbi request reprint PAI-1 4G/5G and ACE I/D gene polymorphisms and the occurrence of myocardial infarction in patients on intermittent dialysis
    Filippo Aucella
    Department of Nephrology and Dialysis, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Nephrol Dial Transplant 18:1142-6. 2003
    ..We have prospectively evaluated the effect of plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphisms on the occurrence of MI in uraemics...
  65. ncbi request reprint Deep venous thrombosis in elderly hospitalized patients: prevalence and clinical features
    Maria Grazia Longo
    Geriatric Unit, Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo FG, Italy
    Aging Clin Exp Res 17:42-5. 2005
    ..This study aimed at evaluating the effect of age on the prevalence and clinical features of DVT in patients admitted to acute medical wards in a general hospital...