Daniela Di Paolo

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    J Natl Cancer Inst 98:1142-57. 2006
  2. ncbi request reprint Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy
    Fabio Pastorino
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 66:10073-82. 2006
  3. ncbi request reprint Drug delivery systems: application of liposomal anti-tumor agents to neuroectodermal cancer treatment
    Daniela Di Paolo
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Tumori 94:246-53. 2008
  4. doi request reprint Anti-IL-10R antibody improves the therapeutic efficacy of targeted liposomal oligonucleotides
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, 16147 Genoa, Italy
    J Control Release 138:122-7. 2009
  5. ncbi request reprint Ligand-targeted liposomal therapies of neuroblastoma
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Curr Med Chem 14:3070-8. 2007
  6. doi request reprint Liposome-mediated therapy of neuroblastoma
    Daniela Di Paolo
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Methods Enzymol 465:225-49. 2009
  7. doi request reprint Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma
    Monica Loi
    G Gaslini Children s Hospital, Genoa, Italy
    J Control Release 145:66-73. 2010
  8. doi request reprint The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response
    Gabriella Pagnan
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 15:1199-209. 2009
  9. pmc Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings
    Monica Loi
    Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
    J Control Release 170:233-41. 2013
  10. doi request reprint Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin
    Fabio Pastorino
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 14:7320-9. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    J Natl Cancer Inst 98:1142-57. 2006
    ..No data are available on bortezomib activity against human pediatric neuroblastoma...
  2. ncbi request reprint Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy
    Fabio Pastorino
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 66:10073-82. 2006
    ..Long-term survivors were obtained only in animals treated with the combined tumor- and vascular-targeted formulations, confirming the pivotal role of combination therapies in treating aggressive metastatic neuroblastoma...
  3. ncbi request reprint Drug delivery systems: application of liposomal anti-tumor agents to neuroectodermal cancer treatment
    Daniela Di Paolo
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Tumori 94:246-53. 2008
    ..The most multifunctional targeted liposomes are herein described, with primary attention on testing their efficacy in clinically relevant animal models for the treatment of neuroblastoma and melanoma...
  4. doi request reprint Anti-IL-10R antibody improves the therapeutic efficacy of targeted liposomal oligonucleotides
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, 16147 Genoa, Italy
    J Control Release 138:122-7. 2009
    ..These results support the feasibility of a clinical trial with TL-asCpG and aIL-10R in advanced NB patients...
  5. ncbi request reprint Ligand-targeted liposomal therapies of neuroblastoma
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Curr Med Chem 14:3070-8. 2007
    ..This review will focus on the description of the most clinically relevant animal models established to test the efficacy of targeted liposomal anti-tumour formulations for the treatment of Neuroblastoma...
  6. doi request reprint Liposome-mediated therapy of neuroblastoma
    Daniela Di Paolo
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Methods Enzymol 465:225-49. 2009
    ..Here, we describe the methodology used in these studies, as well as the antitumor results obtained by the use of several "anticancer drugs," encapsulated into antibody- and peptide-targeted liposomal formulations, against NB...
  7. doi request reprint Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma
    Monica Loi
    G Gaslini Children s Hospital, Genoa, Italy
    J Control Release 145:66-73. 2010
    ..The availability of novel ligands binding to additional tumor vasculature-associated antigens will allow the design of sophisticated combinations of ligand-targeted liposomal anti-cancer drugs...
  8. doi request reprint The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response
    Gabriella Pagnan
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 15:1199-209. 2009
    ..Here we have investigated the antitumor activity of bortezomib in combination with fenretinide, a synthetic retinoid, against neuroblastoma cells...
  9. pmc Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings
    Monica Loi
    Experimental Therapy Unit, Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
    J Control Release 170:233-41. 2013
    ..Coupling of the corresponding targeting peptides with doxorubicin-loaded liposomes led to a significant inhibition in tumor volume and enhanced survival in preclinical NB models, thereby paving the way to their clinical development. ..
  10. doi request reprint Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin
    Fabio Pastorino
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 14:7320-9. 2008
    ....
  11. pmc Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma
    Daniela Di Paolo
    Experimental Therapy Unit, Laboratory of Oncology, Department of Experimental Medicine, IRCCS Istituto G Gaslini, Genoa, Italy
    Mol Ther 19:2201-12. 2011
    ....
  12. doi request reprint The use of the orthotopic model to validate antivascular therapies for cancer
    Monica Loi
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Int J Dev Biol 55:547-55. 2011
    ..This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies...
  13. doi request reprint Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma
    Daniela Di Paolo
    Experimental Therapies Unit, Laboratory of Oncology, Istituto Giannina Gaslini, 16148 Genoa, Italy
    J Control Release 170:445-51. 2013
    ..In conclusion, the use of this novel targeted delivery system for the apoptotic and antiangiogenic drug, fenretinide, could be considered as an adjuvant tool in the future treatment of neuroblastoma patients. ..
  14. ncbi request reprint Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
    Danilo Marimpietri
    Laboratory of Oncology, G Gaslini Children s Hospital, Italian Neuroblastoma Foundation c o National Institute for Cancer Research, Genoa, Italy
    Clin Cancer Res 13:3977-88. 2007
    ..Vinblastine and rapamycin displayed synergistic inhibition of human neuroblastoma-related angiogenesis. Here, we studied the antitumor activity of vinblastine and rapamycin against human neuroblastoma...
  15. doi request reprint Therapeutic targeting of TLR9 inhibits cell growth and induces apoptosis in neuroblastoma
    Chiara Brignole
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 70:9816-26. 2010
    ..TLR9 expression in primary human NB specimens was found to correlate inversely with disease stage. Our findings establish functional expression of TLR9 in NB and suggest that TLR9 may represent a novel theranostic target in this disease...
  16. pmc Neuroblastoma-targeted nanoparticles entrapping siRNA specifically knockdown ALK
    Daniela Di Paolo
    Department of Experimental Medicine, Experimental Therapy Unit, Laboratory of Oncology, Istituto G Gaslini, Genoa, Italy
    Mol Ther 19:1131-40. 2011
    ..v.) injection of the targeted ALK-siRNA liposomes showed gene-specific antitumor activity with no side effects. ALK-selective siRNA entrapped in anti-GDâ‚‚-targeted nanoparticles is a promising new modality for NB treatment...
  17. ncbi request reprint Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD2 immunoliposome: immune cell-mediated anti-tumor activities
    Chiara Brignole
    Laboratory of Oncology, Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini, 5, 16148 Genova, Italy
    Cancer Lett 228:181-6. 2005
    ..Here, we will describe a novel experimental therapeutic approach for neuroblastoma based on anti-GD2 liposomal c-myb-selective antisense oligonucleotides...
  18. ncbi request reprint Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148, Genoa, Italy
    Ann N Y Acad Sci 1028:90-103. 2004
    ..These results suggest that inhibition of c-myc or c-myb proto-oncogenes by GD2-targeted antisense therapy could provide an effective approach for the treatment of neuroectodermal tumors in an adjuvant setting...
  19. pmc New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK
    Daniela Di Paolo
    Laboratorio di Oncologia, Istituto G Gaslini, Genoa, Italy
    Oncotarget 6:28774-89. 2015
    ..Our findings provide a rational basis to design innovative molecular-based treatment combinations for clinical application in ALK-driven NB tumors...
  20. doi request reprint Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion
    Irene Cossu
    Laboratorio di Oncologia, Istituto G Gaslini, Genoa, Italy
    Biomaterials 68:89-99. 2015
    ..Our findings are functional to the design of targeted nanocarriers with potentiated therapeutic efficacy towards the clinical translation. ..
  21. pmc PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma
    Tiziana Bachetti
    Laboratory of Molecular Genetics, G Gaslini Children s Hospital, Genoa, Italy
    PLoS ONE 5:. 2010
    ..These observations led us to test the hypothesis of a regulatory or functional relationship between ALK and PHOX2B underlying NB pathogenesis...