Valentina Franco

Summary

Country: Italy

Publications

  1. doi request reprint Novel treatment options for epilepsy: focus on perampanel
    V Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Pharmacol Res 70:35-40. 2013
  2. doi request reprint Changes in lamotrigine pharmacokinetics during pregnancy and the puerperium
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 30:544-7. 2008
  3. ncbi request reprint A novel enantioselective microassay for the high-performance liquid chromatography determination of oxcarbazepine and its active metabolite monohydroxycarbazepine in human plasma
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 29:319-24. 2007
  4. doi request reprint Off-label prescribing of antiepileptic drugs in pharmacoresistant epilepsy: a cross-sectional drug utilization study of tertiary care centers in Italy
    Valentina Franco
    Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata, 9, 27100, Pavia, Italy
    CNS Drugs 28:939-49. 2014
  5. doi request reprint Development and validation of an HPLC-UV detection assay for the determination of rufinamide in human plasma and saliva
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Anal Bioanal Chem 401:1013-21. 2011
  6. ncbi request reprint Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma
    Valentina Franco
    Genomic and post Genomic Center, C Mondino National Neurological Institute Division of Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy and Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy
    Ther Drug Monit 38:744-750. 2016
  7. doi request reprint Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy
    Veriano Alexandre
    Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsia 51:921-5. 2010
  8. ncbi request reprint Stereoselective determination of vigabatrin enantiomers in human plasma by high performance liquid chromatography using UV detection
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 854:63-7. 2007
  9. doi request reprint CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects
    Valentina Franco
    C Mondino National Neurological Institute, Pavia, Italy
    Expert Opin Drug Metab Toxicol 11:1269-79. 2015
  10. doi request reprint The pharmacogenomics of epilepsy
    Valentina Franco
    a 1 C Mondino National Neurological Institute, Pavia, Italy
    Expert Rev Neurother 15:1161-70. 2015

Collaborators

Detail Information

Publications10

  1. doi request reprint Novel treatment options for epilepsy: focus on perampanel
    V Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Pharmacol Res 70:35-40. 2013
    ..Based on these data, perampanel offers a valuable option in the add-on treatment of partial-onset and secondarily generalized seizures...
  2. doi request reprint Changes in lamotrigine pharmacokinetics during pregnancy and the puerperium
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 30:544-7. 2008
    ....
  3. ncbi request reprint A novel enantioselective microassay for the high-performance liquid chromatography determination of oxcarbazepine and its active metabolite monohydroxycarbazepine in human plasma
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 29:319-24. 2007
    ..However, because the two enantiomers of monohydroxycarbazepine exhibit similar pharmacologic activity, nonenantioselective assays are likely to be more cost-effective for therapeutic drug monitoring purposes...
  4. doi request reprint Off-label prescribing of antiepileptic drugs in pharmacoresistant epilepsy: a cross-sectional drug utilization study of tertiary care centers in Italy
    Valentina Franco
    Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata, 9, 27100, Pavia, Italy
    CNS Drugs 28:939-49. 2014
    ..To assess the extent of off-label prescribing of antiepileptic drugs (AEDs) and associated variables in a large population of patients with pharmacoresistant epilepsy...
  5. doi request reprint Development and validation of an HPLC-UV detection assay for the determination of rufinamide in human plasma and saliva
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy
    Anal Bioanal Chem 401:1013-21. 2011
    ..25-20.0 μg ml(-1), with a limit of quantification at 0.25 μg ml(-1). Precision and accuracy are within current acceptability standards. The assay is suitable for pharmacokinetic studies in humans and for therapeutic drug monitoring...
  6. ncbi request reprint Development and Validation of an HPLC-UV Assay for the Therapeutic Monitoring of the New Antiepileptic Drug Perampanel in Human Plasma
    Valentina Franco
    Genomic and post Genomic Center, C Mondino National Neurological Institute Division of Clinical and Experimental Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy and Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy
    Ther Drug Monit 38:744-750. 2016
    ..The development of a simple and broadly applicable method for measuring plasma perampanel concentrations is desirable to permit the use of TDM for this drug in clinical practice...
  7. doi request reprint Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy
    Veriano Alexandre
    Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsia 51:921-5. 2010
    ..2%) in adults, and disorders of cortical development (14.7%) and nonprogressive encephalopathies (6.8%) in children. More than three-fourths of subjects in both age groups were on antiepileptic drug (AED) polytherapy...
  8. ncbi request reprint Stereoselective determination of vigabatrin enantiomers in human plasma by high performance liquid chromatography using UV detection
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 854:63-7. 2007
    ..999) over the range of 0.5-40 microg/mL for each enantiomer, with a limit of quantification of 0.5 microg/mL for both analytes. The assay is suitable for therapeutic drug monitoring and for single-dose pharmacokinetic studies in man...
  9. doi request reprint CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects
    Valentina Franco
    C Mondino National Neurological Institute, Pavia, Italy
    Expert Opin Drug Metab Toxicol 11:1269-79. 2015
    ..This article reviews the contribution of genetic polymorphisms affecting the activity of CYP2C9, the main enzyme responsible for phenytoin metabolism, to the variation in phenytoin clearance and susceptibility to adverse effects...
  10. doi request reprint The pharmacogenomics of epilepsy
    Valentina Franco
    a 1 C Mondino National Neurological Institute, Pavia, Italy
    Expert Rev Neurother 15:1161-70. 2015
    ....