G Mandolesi

Summary

Affiliation: Fondazione Santa Lucia
Country: Italy

Publications

  1. doi request reprint miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation
    Georgia Mandolesi
    Centro Europeo per la Ricerca sul Cervello, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    J Neurosci 37:546-561. 2017
  2. ncbi request reprint miR-142-3p is a key regulator of IL-1β-dependent synaptopathy in neuroinflammation
    Georgia Mandolesi
    Centro Europeo per la Ricerca sul Cervello CERC, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    J Neurosci . 2016
  3. doi request reprint IL-1β dependent cerebellar synaptopathy in a mouse mode of multiple sclerosis
    Georgia Mandolesi
    Fondazione Santa Lucia IRCSS, Via del Fosso di Fiorano 64, 00146, Rome, Italy
    Cerebellum 14:19-22. 2015
  4. ncbi request reprint A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity
    Georgia Mandolesi
    Scuola Normale Superiore and Via G Moruzzi 1, 56100 Pisa, Italy
    Curr Biol 15:2119-24. 2005
  5. pmc GluRdelta2 expression in the mature cerebellum of hotfoot mice promotes parallel fiber synaptogenesis and axonal competition
    Georgia Mandolesi
    EBRI Santa Lucia Foundation IRCCS, Rome, Italy
    PLoS ONE 4:e5243. 2009
  6. doi request reprint Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex
    G Mandolesi
    EBRI Santa Lucia Foundation IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Neuroscience 164:1084-96. 2009
  7. doi request reprint An orphan ionotropic glutamate receptor: the delta2 subunit
    G Mandolesi
    IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Neuroscience 158:67-77. 2009
  8. doi request reprint Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice
    G Martella
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy IRCCS Fondazione Santa Lucia, Laboratory of Neurophysiology and Plasticity, Rome, Italy
    Neurobiol Dis 91:21-36. 2016
  9. doi request reprint Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration
    G Mandolesi
    Centro Europeo per la Ricerca sul Cervello CERC Fondazione Santa Lucia, Rome, Italy
    Neurol Sci 31:S255-9. 2010
  10. pmc Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis
    G Grasselli
    Fondazione Santa Lucia Centro Europeo per la Ricerca sul Cervello CERC, Universita Tor Vergata, Rome, Italy
    Br J Pharmacol 168:502-17. 2013

Collaborators

  • D Centonze
  • A Pisani
  • P Strata
  • R Cesa
  • M Maccarrone
  • R Furlan
  • Elisabetta Menna
  • M Caleo
  • G Martella
  • G Grasselli
  • G Catanzaro
  • G Madeo
  • P Bonsi
  • M Maltese
  • T Schirinzi
  • V Vanni
  • M Bari
  • E M Valente
  • M T Viscomi
  • E Ferraro
  • M Lanuti
  • L Bonanni
  • M Pucci
  • S Angeletti
  • F Puglisi
  • M Feole
  • J Shen
  • C D'Addario
  • N B Mercuri
  • G Sciamanna
  • M Pignatelli
  • A Tassone
  • R Nistico
  • G Ponterio
  • A Usiello
  • V De Chiara
  • D Fresegna
  • G Martino
  • C Di Sanza
  • H Sepman
  • G Musumeci
  • F Errico
  • L Muzio
  • S Loizzo
  • S Rossi
  • N Haji
  • A Musella
  • A Gentile

Detail Information

Publications13

  1. doi request reprint miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation
    Georgia Mandolesi
    Centro Europeo per la Ricerca sul Cervello, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    J Neurosci 37:546-561. 2017
    ..Our findings highlight miR-142-3p as key molecular player in IL-1β-mediated synaptic dysfunction, possibly leading to excitotoxic damage in both EAE and MS diseases. Inhibition of miR-142-3p could be neuroprotective in MS...
  2. ncbi request reprint miR-142-3p is a key regulator of IL-1β-dependent synaptopathy in neuroinflammation
    Georgia Mandolesi
    Centro Europeo per la Ricerca sul Cervello CERC, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    J Neurosci . 2016
    ..Our findings highlight miR-142-3p as key molecular player in IL-1β-mediated synaptic dysfunction possibly leading to excitotoxic damage in both EAE and MS diseases. Inhibition of miR-142-3p could be neuroprotective in MS...
  3. doi request reprint IL-1β dependent cerebellar synaptopathy in a mouse mode of multiple sclerosis
    Georgia Mandolesi
    Fondazione Santa Lucia IRCSS, Via del Fosso di Fiorano 64, 00146, Rome, Italy
    Cerebellum 14:19-22. 2015
    ....
  4. ncbi request reprint A role for retinal brain-derived neurotrophic factor in ocular dominance plasticity
    Georgia Mandolesi
    Scuola Normale Superiore and Via G Moruzzi 1, 56100 Pisa, Italy
    Curr Biol 15:2119-24. 2005
    ..Retinal BDNF could also influence OD distribution in normal animals. These results show for the first time that OD plasticity is modulated by BDNF produced in the retina...
  5. pmc GluRdelta2 expression in the mature cerebellum of hotfoot mice promotes parallel fiber synaptogenesis and axonal competition
    Georgia Mandolesi
    EBRI Santa Lucia Foundation IRCCS, Rome, Italy
    PLoS ONE 4:e5243. 2009
    ..Collectively, our observations show that GluRdelta2 is an adhesion molecule that induces the formation of PF contacts independently of its cellular localization and promotes heterosynaptic competition in the PC proximal dendritic domain...
  6. doi request reprint Distribution of the SNAP25 and SNAP23 synaptosomal-associated protein isoforms in rat cerebellar cortex
    G Mandolesi
    EBRI Santa Lucia Foundation IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Neuroscience 164:1084-96. 2009
    ..In conclusion, the preferential localization of SNAP25 in specific synaptic boutons suggests a correlation between SNAP25 and the Pr. This evidence supports the hypothesis that SNAP25 has a modulatory role in shaping synaptic responses...
  7. doi request reprint An orphan ionotropic glutamate receptor: the delta2 subunit
    G Mandolesi
    IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Neuroscience 158:67-77. 2009
    ....
  8. doi request reprint Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice
    G Martella
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy IRCCS Fondazione Santa Lucia, Laboratory of Neurophysiology and Plasticity, Rome, Italy
    Neurobiol Dis 91:21-36. 2016
    ....
  9. doi request reprint Cognitive deficits in experimental autoimmune encephalomyelitis: neuroinflammation and synaptic degeneration
    G Mandolesi
    Centro Europeo per la Ricerca sul Cervello CERC Fondazione Santa Lucia, Rome, Italy
    Neurol Sci 31:S255-9. 2010
    ..Increased glutamate-mediated transmission and loss of GABAergic inputs were observed in EAE. They may thus underlie cognitive dysfunction in this model and in MS...
  10. pmc Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis
    G Grasselli
    Fondazione Santa Lucia Centro Europeo per la Ricerca sul Cervello CERC, Universita Tor Vergata, Rome, Italy
    Br J Pharmacol 168:502-17. 2013
    ..A characteristic of EAE is increased glutamate transmission associated with up-regulation of AMPA receptors. However, little is known about the role of NMDA receptors in the synaptic modifications induced by EAE...
  11. doi request reprint Epigenetic modifications of Dexras 1 along the nNOS pathway in an animal model of multiple sclerosis
    G Catanzaro
    Department of Medicine, Campus Bio Medico University of Rome, Rome, Italy European Center for Brain Research, IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroimmunol 294:32-40. 2016
    ..Taken together, these data demonstrate an unprecedented epigenetic modulation of nNOS-signaling in the pathogenesis of multiple sclerosis, and show that EE can specifically revert EAE effects on Dexras 1 along this pathway. ..
  12. doi request reprint Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia
    G Martella
    Department of System Medicine, University of Rome Tor Vergata, Italy Laboratory of Neurophysiology and Synaptic Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neurobiol Dis 65:124-32. 2014
    ..These results provide evidence for a regional specificity of the electrophysiological abnormalities observed and demonstrate the reproducibility of such alterations in distinct models of DYT1 dystonia. ..
  13. ncbi request reprint NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction
    Georgia Mandolesi
    Centro Acidi Nucleici CNR, Dipartimento Genetica e Biologia Molecolare, Universita La Sapienza, P le A Moro 5, 00185 Rome, Italy
    FEBS Lett 510:50-6. 2002
    ..The interaction, mediated by p300, of different transcription factors may add specificity to the neurotrophin response...