R Meli

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. pmc Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet
    Giuseppina Mattace Raso
    Department of Pharmacy, University of Naples Federico II, Naples, Italy
    PLoS ONE 8:e68626. 2013
  2. ncbi request reprint Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats
    Rosaria Meli
    Department of Experimental Pharmacology, University of Naples, Italy
    Endocrinology 145:3115-21. 2004
  3. ncbi request reprint Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells
    R Meli
    Department of Experimental Pharmacology, University of Naples, Federico II, Naples, Italy
    J Neurochem 79:556-63. 2001
  4. ncbi request reprint Effect of fumonisin B1 on inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated J774A.1 cells
    R Meli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Life Sci 67:2845-53. 2000
  5. ncbi request reprint Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
    G M Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Life Sci 68:921-31. 2001
  6. doi request reprint Differential modification of inflammatory enzymes in J774A.1 macrophages by ochratoxin A alone or in combination with lipopolysaccharide
    M C Ferrante
    Department of Pathology and Animal Health, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy
    Toxicol Lett 181:40-6. 2008
  7. doi request reprint Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway
    M C Ferrante
    Department of Pathology and Animal Health, University of Naples Federico II, 80131 Naples, Italy
    Toxicol Lett 202:61-8. 2011
  8. ncbi request reprint Evidence against a dependence of the senna effect on prostaglandin formation
    N Mascolo
    Department of Experimental Pharmacology, University of Naples, Italy
    Pharmacology 36:92-7. 1988
  9. doi request reprint Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems
    R Russo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Peptides 38:81-8. 2012
  10. doi request reprint Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α
    G Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neuroendocrinol 23:591-600. 2011

Collaborators

Detail Information

Publications38

  1. pmc Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet
    Giuseppina Mattace Raso
    Department of Pharmacy, University of Naples Federico II, Naples, Italy
    PLoS ONE 8:e68626. 2013
    ..We evaluated the effects of sodium butyrate (butyrate) and its synthetic derivative N-(1-carbamoyl-2-phenyl-ethyl) butyramide (FBA) in a rat model of insulin resistance and steatosis induced by high-fat diet (HFD)...
  2. ncbi request reprint Estrogen and raloxifene modulate leptin and its receptor in hypothalamus and adipose tissue from ovariectomized rats
    Rosaria Meli
    Department of Experimental Pharmacology, University of Naples, Italy
    Endocrinology 145:3115-21. 2004
    ..We provide evidence that central and peripheral Ob-Rb expression is related to modification of estrogen levels...
  3. ncbi request reprint Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells
    R Meli
    Department of Experimental Pharmacology, University of Naples, Federico II, Naples, Italy
    J Neurochem 79:556-63. 2001
    ....
  4. ncbi request reprint Effect of fumonisin B1 on inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated J774A.1 cells
    R Meli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Life Sci 67:2845-53. 2000
    ..1-10 microM) and was found to be concentration dependent. By western blot analysis we demonstrated that the observed increase of NO and PGE2 production by FB1 was related to an enhancement of iNOS and COX-2 expression...
  5. ncbi request reprint Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
    G M Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Life Sci 68:921-31. 2001
    ..This study suggests that inhibition of iNOS and COX-2 expression by flavonoids may be one of the mechanisms responsible for their anti-inflammatory effects...
  6. doi request reprint Differential modification of inflammatory enzymes in J774A.1 macrophages by ochratoxin A alone or in combination with lipopolysaccharide
    M C Ferrante
    Department of Pathology and Animal Health, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy
    Toxicol Lett 181:40-6. 2008
    ....
  7. doi request reprint Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway
    M C Ferrante
    Department of Pathology and Animal Health, University of Naples Federico II, 80131 Naples, Italy
    Toxicol Lett 202:61-8. 2011
    ....
  8. ncbi request reprint Evidence against a dependence of the senna effect on prostaglandin formation
    N Mascolo
    Department of Experimental Pharmacology, University of Naples, Italy
    Pharmacology 36:92-7. 1988
    ..In light of our findings it appears conceivable that non-PG-mediated mechanism(s) play a relevant role in laxation induced by senna...
  9. doi request reprint Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems
    R Russo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Peptides 38:81-8. 2012
    ..In conclusion, our experiments suggest that central administration of OXT reduces hyperalgesia induced by intraplantar injection of carrageenan, and this effect may work via cannabinoid and opioid systems...
  10. doi request reprint Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α
    G Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neuroendocrinol 23:591-600. 2011
    ....
  11. ncbi request reprint Elevated bioactive prolactin levels in systemic lupus erythematosus--association with disease activity
    M Pacilio
    Department of Experimental Pharmacology, University of Naples, Federico II, Italy
    J Rheumatol 28:2216-21. 2001
    ..01, respectively). CONCLUSION: Hyperprolactinemia was frequently detected in patients with SLE by IRMA and by BA and was associated with disease activity. Our findings suggest that PRL may play a role in the pathogenesis of SLE...
  12. doi request reprint Polychlorinated biphenyls and organochlorine pesticides in European eel (Anguilla anguilla) from the Garigliano River (Campania region, Italy)
    Maria Carmela Ferrante
    University of Naples Federico II, Faculty of Veterinary Medicine, Department of Pathology and Animal Health, Toxicology Sector, Via Delpino 1, 80137 Naples, Italy
    Chemosphere 78:709-16. 2010
    ..Our results imply that OCPs and PCBs are still important persistent chemical contaminants in Campania freshwaters, although their manufacture and use are banned or highly restricted...
  13. doi request reprint Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue
    Giuseppina Mattace Raso
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano, 49 80131 Naples, Italy
    Biochem Pharmacol 78:1001-7. 2009
    ....
  14. ncbi request reprint Peroxisome proliferator-activated receptors and shock state
    Emanuela Esposito
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    ScientificWorldJournal 6:1770-82. 2006
    ....
  15. pmc Protective effect of a PAR2-activating peptide on histamine-induced bronchoconstriction in guinea-pig
    C Cicala
    Department of Experimental Pharmacology, University of Naples Federico II Via D Montesano 49, 80131 Naples, Italy
    Br J Pharmacol 132:1229-34. 2001
    ..6. Our results indicated that PAR2 might have a bronchoprotective role in the guinea-pig in vivo independent of prostaglandin or nitric oxide release...
  16. ncbi request reprint Raloxifene, a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats
    Emanuela Esposito
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Endocrinology 146:3301-8. 2005
    ..In addition, we confirm the antiinflammatory effect of RAL in male rats, using a single administration of RAL or E2...
  17. ncbi request reprint Maternal adaptations to pregnancy in spontaneously hypertensive rats: leptin and ghrelin evaluation
    Giuseppina Mattace Raso
    Department of Experimental Pharmacology, University of Naples, Federico II, via D Montesano, 49 80131 Naples, Italy
    J Endocrinol 194:611-9. 2007
    ..These data gain further insight into metabolic hormone modifications observed in a model of pre-existing hypertension associated with pregnancy...
  18. ncbi request reprint Analgesia and cyclo-oxygenase inhibitors
    R Meli
    Department of Experimental Pharmacology, Federico II University of Naples, Italy
    Dig Liver Dis 33:S8-11. 2001
    ..This short review addresses some recent preclinical data as well as some clinical evidence showing that cyclo-oxygenase-1 is an important component of inflammatory pain...
  19. pmc Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function
    M Bucci
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, Napoli, Italy
    Br J Pharmacol 168:411-20. 2013
    ..The aim of this study was to evaluate the possible cross-talk between PAR(2) and TLR4 in vessels in physiological condition and how it varies following stimulation of TLR4 by using in vivo and ex vivo models...
  20. doi request reprint Evaluation of placental protein modifications in normotensive and spontaneously hypertensive rats
    G Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Placenta 29:429-35. 2008
    ..Moreover, at the end of pregnancy, cyclooxygenase-2 expression decreased in SHR placentas. These data may provide new insights into the placental adaptive mechanisms that take place during pregnancy in SHR...
  21. ncbi request reprint Senna still causes laxation in rats maintained on a diet deficient in essential fatty acids
    N Mascolo
    Department of Experimental Pharmacology, University of Naples, Italy
    J Pharm Pharmacol 40:882-4. 1988
    ..Since PG mediation is not present in EFAD rats we conclude that the PG are not essential for laxation induced by senna and that water secretion and PG production in the rat intestinal lumen are unrelated...
  22. ncbi request reprint Bioactivity of prolactin in systemic sclerosis
    G La Montagna
    Dipartimento Scientifico di Internistica Clinica e Sperimentale F Magrassi and A Lanzara, Seconda Universita di Napoli, Naples, Italy
    Clin Exp Rheumatol 22:145-50. 2004
    ..To evaluate basal serum prolactin (PRL) levels in systemic sclerosis (SSc) patients with different degrees of skin involvement, and investigate its relationship with some of the clinical and serological parameters of the disease...
  23. ncbi request reprint AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors
    G La Rana
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Neuropharmacology 54:521-9. 2008
    ..Taken together, these data demonstrate the efficacy of cannabinoids in controlling pain behaviour through the modulation of several pain mediators and markers of vascular reactivity, such as SP, CGRP, PGs and NO...
  24. ncbi request reprint Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect
    Giuseppina Mattace Raso
    Department of Experimental Pharmacology, University of Naples, Federico II, via D Montesano, 49 80131 Naples, Italy
    Neurosci Lett 396:121-6. 2006
    ..These results confirm the pro-inflammatory role of leptin and identify it as a potential up-regulator of cytokine-induced inflammatory response in the CNS...
  25. ncbi request reprint Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice
    Giuseppe D'Agostino
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharmacol Exp Ther 322:1137-43. 2007
    ..In conclusion, our data show for the first time that PPAR-alpha activation in the CNS can control peripheral inflammation...
  26. pmc Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
    Giuseppina Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano, 49 80131 Naples, Italy
    Br J Pharmacol 137:799-804. 2002
    ..6. These data suggest that macrophages, among the peripheral immune cells, represent a target for leptin and confirm the relevance of this hormone in the pathophysiology of inflammation...
  27. doi request reprint Maternal adaptation in pregnant hypertensive rats: improvement of vascular and inflammatory variables and oxidative damage in the kidney
    Anna Iacono
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Am J Hypertens 22:777-83. 2009
    ..We hypothesized that at the end of pregnancy (20th day), the modified renal renin-angiotensin system (RAS) plays a pivotal role in this effect associated with reduced inflammation and oxidative damage...
  28. doi request reprint Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat
    Giuseppina Mattace Raso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Eur J Pharmacol 604:125-31. 2009
    ..Moreover a decrease of PPAR-gamma expression was also shown. These findings confirm the efficacy of both drugs as therapeutic tools in preventing the early onset of liver damage and non-alcoholic fatty liver disease progression...
  29. ncbi request reprint Green tea polyphenol extract attenuates zymosan-induced non-septic shock in mice
    Rosanna Di Paola
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Shock 26:402-9. 2006
    ..In conclusion this study provides evidence, for the first time, that GTE attenuates the degree of zymosan induced generalized inflammation in mice...
  30. ncbi request reprint Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy
    Concetta Crisafulli
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    J Pineal Res 41:228-37. 2006
    ....
  31. doi request reprint Effect of cyclopentanone prostaglandin 15-deoxy-delta12,14PGJ2 on early functional recovery from experimental spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Shock 30:142-52. 2008
    ..Taken together, our results clearly demonstrate that treatment with 15d-PGJ2 reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  32. ncbi request reprint Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting
    Anna Coppola
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St FMB 339, New Haven, CT 06520, USA
    FEBS Lett 579:4654-8. 2005
    ....
  33. ncbi request reprint Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats
    Anna Coppola
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB 339, New Haven, Connecticut 06510, USA
    Endocrinology 146:2827-33. 2005
    ..Thus, our observations suggest that appropriate induction of D2 activity during negative energy balance is dependent upon both leptin and glucocorticoid signaling...
  34. ncbi request reprint Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine, School of Medicine, University of Messina, Messina, Italy
    Mol Pharmacol 71:132-44. 2007
    ..In conclusion, these results suggest that the in vivo anti-inflammatory property of DEX is also related to the ER-alpha...
  35. ncbi request reprint Hypothalamic type II iodothyronine deiodinase: a light and electron microscopic study
    Sabrina Diano
    Department Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St FMB 338A New Haven, CT 06520, USA
    Brain Res 976:130-4. 2003
    ....
  36. doi request reprint Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury
    Tiziana Genovese
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario Via C Valeria Gazzi, 98100 Messina, Italy
    J Pharmacol Exp Ther 325:100-14. 2008
    ..Taken together, our results clearly demonstrate that PD98059 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  37. ncbi request reprint Absence of peroxisome proliferators-activated receptors (PPAR)alpha enhanced the multiple organ failure induced by zymosan
    Rosanna Di Paola
    Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Facolta di Medicina e Chirurgia, Universita di Messina, Via C Valeria, Gazzi, 98100 Messina, Italy
    Shock 26:477-84. 2006
    ..Taken together, the present study clearly demonstrates that PPAR-alpha pathway modulates the degree of MODS associated with zymosan-induced nonseptic shock...