Gaetano Lombardi

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint The roles of parathyroid hormone in bone remodeling: prospects for novel therapeutics
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology University Federico II, Naples, Italy
    J Endocrinol Invest 34:18-22. 2011
  2. doi request reprint The cardiovascular system in growth hormone excess and growth hormone deficiency
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 35:1021-9. 2012
  3. ncbi request reprint Estrogens and health in males
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Faculty of Medicine, University of Naples Federico II, Naples, Italy
    Mol Cell Endocrinol 178:51-5. 2001
  4. ncbi request reprint Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 25:971-6. 2002
  5. ncbi request reprint Associated hormonal decline in aging: is there a role for GH therapy in aging men?
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini, 5 80131, Napoli, Italy
    J Endocrinol Invest 28:99-108. 2005
  6. ncbi request reprint Somatopause: dismetabolic and bone effects
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 28:36-42. 2005
  7. ncbi request reprint Acromegaly and the cardiovascular system
    Gaetano Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Neuroendocrinology 83:211-7. 2006
  8. ncbi request reprint The role of growth hormone in glucocorticoid-induced osteoporosis
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy
    J Endocrinol Invest 31:38-42. 2008
  9. ncbi request reprint Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in somatostatin analogue-naive patients with acromegaly
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
    J Endocrinol Invest 32:202-9. 2009
  10. ncbi request reprint Role of IGF-I on PTH effects on bone
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Endocrinol Invest 33:22-6. 2010

Detail Information

Publications166 found, 100 shown here

  1. ncbi request reprint The roles of parathyroid hormone in bone remodeling: prospects for novel therapeutics
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology University Federico II, Naples, Italy
    J Endocrinol Invest 34:18-22. 2011
    ..In conclusion, the intermittent administration of PTH has a pleiotropic anabolic effect on bone; further studies about mechanisms of action of PTH could be a starting point to new osteoporosis treatments...
  2. doi request reprint The cardiovascular system in growth hormone excess and growth hormone deficiency
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 35:1021-9. 2012
    ..In conclusion, acromegaly and GHD are associated with an increased risk for cardiovascular morbidity and mortality, but the control of GH/IGF-I secretion reverses cardiovascular abnormalities and restores the normal life expectancy...
  3. ncbi request reprint Estrogens and health in males
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Faculty of Medicine, University of Naples Federico II, Naples, Italy
    Mol Cell Endocrinol 178:51-5. 2001
    ....
  4. ncbi request reprint Improvement of left ventricular hypertrophy and arrhythmias after lanreotide-induced GH and IGF-I decrease in acromegaly. A prospective multi-center study
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 25:971-6. 2002
    ..3% of patients before treatment vs 16.5%, after treatment. In conclusion, lanreotide reduced the left ventricular mass, and improved ventricular filling and ventricular arrhythmic profile...
  5. ncbi request reprint Associated hormonal decline in aging: is there a role for GH therapy in aging men?
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini, 5 80131, Napoli, Italy
    J Endocrinol Invest 28:99-108. 2005
    ..In conclusion, there is not sufficient evidence for a clear therapeutic role of rhGH, IGF-I, and secretagogues in aging. Further studies are needed to evaluate the real benefit of somatotropic treatment in aging men...
  6. ncbi request reprint Somatopause: dismetabolic and bone effects
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 28:36-42. 2005
    ..Thus, more data are needed to define the effects of somatopause to identify who could potentially benefit from the effects of somatotropic treatment...
  7. ncbi request reprint Acromegaly and the cardiovascular system
    Gaetano Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Neuroendocrinology 83:211-7. 2006
    ..In conclusion, an early diagnosis and a careful evaluation of cardiac function, morphology and activity seem to be mandatory in acromegaly...
  8. ncbi request reprint The role of growth hormone in glucocorticoid-induced osteoporosis
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Via Pansini 5, 80131 Naples, Italy
    J Endocrinol Invest 31:38-42. 2008
    ....
  9. ncbi request reprint Efficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in somatostatin analogue-naive patients with acromegaly
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
    J Endocrinol Invest 32:202-9. 2009
    ..To evaluate efficacy and safety of lanreotide autogel (ATG) 120 mg injections every 4-8 weeks in somatostatin analogue-naïve patients with acromegaly...
  10. ncbi request reprint Role of IGF-I on PTH effects on bone
    G Lombardi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Endocrinol Invest 33:22-6. 2010
    ..GH administration resulted in increased IGF-I concentration, decreased PTH concentration, and increased nephrogenous cAMP. In conclusion, the anabolic action of PTH requires paracrine and autocrine effects of IGF-I...
  11. ncbi request reprint Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome
    Teresa Cascella
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples 80131, Italy
    Hum Reprod 23:153-9. 2008
    ..The aim of this study was to evaluate the relationship between visceral fat (VF) and early markers of CVD in PCOS women...
  12. ncbi request reprint The treatment with cabergoline for 24 month normalizes the quality of seminal fluid in hyperprolactinaemic males
    Michele De Rosa
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 64:307-13. 2006
    ..Cabergoline treatment reverses alterations in semen. No information is currently available on the quality of seminal tests in hyperprolactinemia in response to cabergoline treatment...
  13. ncbi request reprint Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Eur J Endocrinol 157:359-66. 2007
    ..This study is aimed at investigating the role of sex steroids and severity of hypercortisolism on bone mineral density (BMD) and prevalence of vertebral fractures in female patients...
  14. ncbi request reprint Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH defici
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:5146-55. 2005
    ..GH secretion and response to GH replacement are gender-related...
  15. ncbi request reprint Growth hormone excess with onset in adolescence: clinical appearance and long-term treatment outcome
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 66:714-22. 2007
    ..Limited data are available on clinical presentation and treatment strategy in patients with GH-secreting adenomas with onset in adolescence...
  16. ncbi request reprint Predictors of remission of hyperprolactinaemia after long-term withdrawal of cabergoline therapy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 67:426-33. 2007
    ..Remission rates of 76, 69.5 and 64.3% have been reported in patients with nontumoural hyperprolactinaemia (NTH), microprolactinoma and macroprolactinoma, respectively, 2-5 years after cabergoline (CAB) withdrawal...
  17. doi request reprint Impact of somatostatin analogs versus surgery on glucose metabolism in acromegaly: results of a 5-year observational, open, prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:528-37. 2009
    ..The aim of the study was to investigate the 5-yr impact of surgery and somatostatin analogs (SSA) on glucose metabolism in acromegaly...
  18. ncbi request reprint Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Napoli, Italy
    Clin Endocrinol (Oxf) 58:169-76. 2003
    ..Cardiovascular disease is the most frequent cause of death of patients with acromegaly...
  19. ncbi request reprint Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 61:360-6. 2004
    ..To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography...
  20. ncbi request reprint Lack of an association between peroxisome proliferator-activated receptor-gamma gene Pro12Ala polymorphism and adiponectin levels in the polycystic ovary syndrome
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    J Clin Endocrinol Metab 89:5110-5. 2004
    ..In conclusion, our results confirm that adiponectin concentrations are similar in PCOS and controls and demonstrate no effect of the PPAR-gamma gene Pro12Ala polymorphism on serum adiponectin levels...
  21. ncbi request reprint The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5998-6004. 2004
    ..5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHD hypopituitary patients...
  22. ncbi request reprint Effect of gender and gonadal status on the long-term response to somatostatin analogue treatment in acromegaly
    Annamaria Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 63:342-9. 2005
    ..GH and IGF-I secretion is related to gender and age...
  23. ncbi request reprint PRL secreting adenomas in male patients
    Antonio Ciccarelli
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131, Naples, Italy
    Pituitary 8:39-42. 2005
    ....
  24. ncbi request reprint Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status
    Libuse Tauchmanova
    Department of Molecular, Clinical Endocrinology, and Oncology, Federico II University of Naples, via Sergia Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:1779-84. 2006
    ..e. Cushing's disease and adrenal and ectopic Cushing's syndrome...
  25. ncbi request reprint Cardiopulmonary impairment in young women with polycystic ovary syndrome
    Francesco Orio
    Department of Molecular, Clinical Endocrinology, and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2967-71. 2006
    ..At the moment, no evaluation of cardiopulmonary functional capacity in young patients with PCOS has been performed...
  26. ncbi request reprint Metabolic and cardiopulmonary effects of detraining after a structured exercise training programme in young PCOS women
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:976-81. 2008
    ..The aim of the present study was to determine if the favourable cardiopulmonary and metabolic benefits induced by exercise training (ET) programme are maintained after its cessation...
  27. ncbi request reprint Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: a prospective study
    Carolina Di Somma
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University Naples, Italy
    Clin Endocrinol (Oxf) 58:302-8. 2003
    ..Osteoporosis is a frequent, severe and often underestimated consequence of long-term hypercortisolism, often presenting as bone fracture...
  28. doi request reprint Impact of treating acromegaly first with surgery or somatostatin analogs on cardiomyopathy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 93:2639-46. 2008
    ..The objective of the study was to investigate whether first-line surgery or somatostatin analogs (SSA) have a different outcome on cardiomyopathy after 12 months...
  29. ncbi request reprint Beneficial effects of a three-month structured exercise training program on cardiopulmonary functional capacity in young women with polycystic ovary syndrome
    Carlo Vigorito
    Department of Clinical Medicine, University Federico II of Naples, Italy
    J Clin Endocrinol Metab 92:1379-84. 2007
    ..An impaired cardiopulmonary functional capacity was previously demonstrated in PCOS women. No data regarding the effects of a structured exercise training (ET) program on cardiopulmonary functional capacity in PCOS women are available...
  30. doi request reprint Relationship between growth hormone/insulin-like growth factor-1 axis integrity and voluntary weight loss after gastric banding surgery for severe obesity
    Silvia Savastano
    Division of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Obes Surg 20:211-20. 2010
    ....
  31. doi request reprint Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study
    Maurizio Galderisi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    J Am Soc Echocardiogr 23:1190-8. 2010
    ....
  32. ncbi request reprint Imbalance of the osteoprotegerin/RANKL ratio in bone marrow microenvironment after allogeneic hemopoietic stem cell transplantation
    Patrizia Ricci
    Department of Biochemistry and Medical Biotechnology, Hematology Branch, Federico II University of Naples, Naples, Italy
    Transplantation 82:1449-56. 2006
    ..We investigated OPG and RANKL in serum and marrow plasma in transplanted patients...
  33. ncbi request reprint Cardiovascular consequences of early-onset growth hormone excess
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3097-104. 2002
    ..These deleterious effects of early-onset acromegaly are ameliorated by suppressing GH/IGF-I levels for 6 months...
  34. ncbi request reprint The cardiovascular risk of young women with polycystic ovary syndrome: an observational, analytical, prospective case-control study
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    J Clin Endocrinol Metab 89:3696-701. 2004
    ..In conclusion, our data show the detrimental effect of PCOS on the cardiovascular system even in young women asymptomatic for cardiac disease...
  35. ncbi request reprint Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Italy
    Eur J Endocrinol 154:467-77. 2006
    ..We aimed to investigate the efficacy of pegvisomant in patients with acromegaly resistant to long-term (> or = 24-month), high-dose treatment with octreotide-LAR (40 mg/month) or lanreotide (120 mg/month)...
  36. ncbi request reprint Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 65:250-6. 2006
    ....
  37. ncbi request reprint [Polycystic ovary syndrome: an example of obesity-related cardiovascular complication affecting young women]
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Monaldi Arch Chest Dis 66:48-53. 2006
    ..All these features, probably linked to insulin-resistance, are often present in obese PCOS patients. Cardiovascular abnormalities represent important long-term sequelae of PCOS that need further investigations...
  38. ncbi request reprint Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a 6-month prospective study
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 157:69-73. 2007
    ..Low-grade chronic inflammation is a related complication recently observed in PCOS. Increased white blood cell (WBC) count was previously reported in PCOS women...
  39. doi request reprint Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS)
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:792-8. 2008
    ..Exercise training (ET) favourably modulates cardiopulmonary function and insulin-sensitivity markers in PCOS women. The present study investigated the effects of ET on autonomic function and inflammatory pattern in PCOS women...
  40. doi request reprint Growth hormone treatment on atherosclerosis: results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 93:3416-24. 2008
    ..Severe GH deficiency (GHD) is associated with, increased cardiovascular risk and intima-media thickness (IMT) at major arteries...
  41. doi request reprint Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 159:389-97. 2008
    ..In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality...
  42. doi request reprint Endothelial-mediated coronary flow reserve in patients with mild thyroid hormone deficiency
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 161:323-9. 2009
    ..Although coronary flow reserve (CFR) is reduced in patients with subclinical hypothyroidism (SHypo), the endothelial response of coronary vasomotion has never been explored in this clinical setting...
  43. ncbi request reprint Outcome of cabergoline treatment in men with prolactinoma: effects of a 24-month treatment on prolactin levels, tumor mass, recovery of pituitary function, and semen analysis
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:1704-11. 2004
    ..These data demonstrate that cabergoline treatment is as effective and safe in men as in women with prolactinoma and can be successfully used as primary therapy even in men bearing large macroprolactinomas...
  44. ncbi request reprint Left ventricular mass and function in children with GH deficiency before and during 12 months GH replacement therapy
    Mariacarolina Salerno
    Department of Pediatrics, University Frederico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 60:630-6. 2004
    ..This open, prospective study was designed to evaluate the effect of GH deficiency (GHD) on left ventricular (LV) mass (LVM) and performance, by echocardiography, and on lipid profile during childhood...
  45. ncbi request reprint Prolactin and prostate hypertrophy: a pilot observational, prospective, case-control study in men with prolactinoma
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:2770-5. 2004
    ..In conclusion, in young men with prolactinoma PRL excess is unlikely to have effects on the prostate per se, because it is accompanied by low testosterone and DHT levels that produce the major effects...
  46. ncbi request reprint Is plasminogen activator inhibitor-1 a cardiovascular risk factor in young women with polycystic ovary syndrome?
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Reprod Biomed Online 9:505-10. 2004
    ..In conclusion, women with PCOS have significantly elevated PAI-1 activity independent of obesity, and it is speculated that elevated PAI-1 activity may be a factor in the increased cardiovascular morbidity seen in PCOS...
  47. ncbi request reprint Endocrine disorders during the first year after autologous stem-cell transplant
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Am J Med 118:664-70. 2005
    ..Frequent endocrine disorders have been reported after allogeneic stem-cell transplant, but data on adult survivors of autologous transplants are still scarce...
  48. ncbi request reprint Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study
    Francesco Orio
    Department of Molecular, Clinical Endocrinology and Oncology, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:6072-6. 2005
    ..Recent data indicate that women affected by the polycystic ovary syndrome (PCOS) are at greater risk for cardiovascular disease and that metformin may improve the metabolic alterations in these patients...
  49. ncbi request reprint Sulfur amino acids in Cushing's disease: insight in homocysteine and taurine levels in patients with active and cured disease
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:6616-22. 2005
    ..Although a series of cardiovascular risk factors have been identified, sulfur amino acids (SAAs), recently indicated as independent cardiovascular risk factors, have been poorly investigated in patients with Cushing's syndrome...
  50. ncbi request reprint Predictors of tumor shrinkage after primary therapy with somatostatin analogs in acromegaly: a prospective study in 99 patients
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2112-8. 2006
    ..Primary treatment with depot octreotide and lanreotide induces tumor shrinkage in newly diagnosed patients with acromegaly...
  51. ncbi request reprint Treatment with growth hormone receptor antagonist in acromegaly: effect on cardiac structure and performance
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 92:476-82. 2007
    ..The aim of the current study was to evaluate the effect of short-term (6 months) and long-term (18 months) treatment with pegvisomant on cardiac structure and performance in patients with acromegaly...
  52. ncbi request reprint Overexpression of the phosphoprotein enriched in diabetes gene product (Ped/pea-15) in women with polycystic ovary syndrome
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Clin Endocrinol (Oxf) 67:557-62. 2007
    ..To evaluate Ped/pea-15 (phosphoprotein enriched in diabetes) expression in polycystic ovary syndrome (PCOS) women...
  53. doi request reprint Inflammatory markers and visceral fat are inversely associated with maximal oxygen consumption in women with polycystic ovary syndrome (PCOS)
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 70:394-400. 2009
    ....
  54. doi request reprint Cardiovascular risk in women with polycystic ovary syndrome
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Naples, Italy
    J Cardiovasc Med (Hagerstown) 9:987-92. 2008
    ....
  55. doi request reprint Significant tumour shrinkage after 12 months of lanreotide Autogel-120 mg treatment given first-line in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 71:237-45. 2009
    ..To evaluate GH and IGF-I control and tumour shrinkage in newly diagnosed patients with acromegaly treated first-line with lanreotide-Autogel (ATG) 120 mg. Design Open, prospective...
  56. doi request reprint GH and IGF-I deficiency are associated with reduced loss of fat mass after laparoscopic-adjustable silicone gastric banding
    Carolina Di Somma
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:393-9. 2008
    ..It is still unclear if changes in the GH/IGF-I axis after laparoscopic-adjustable silicone gastric banding (LASGB) are associated with changes of body composition...
  57. ncbi request reprint Hypertension in acromegaly and in the normal population: prevalence and determinants
    Giovanni Vitale
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 63:470-6. 2005
    ..The GH/IGF-I axis has a relevant role to play in the cardiovascular system but its implication in the pathogenesis of hypertension in the normal population and in acromegaly is not yet clear...
  58. ncbi request reprint The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 91:2191-200. 2006
    ..Partial GH deficiency (GHD) in adults is poorly studied...
  59. ncbi request reprint Increased prevalence of thyroid autoimmunity and hypothyroidism in patients with glycogen storage disease type I
    Daniela Melis
    Department of Pediatrics, Federico II University, Naples, Italy
    J Pediatr 150:300-5, 305.e1. 2007
    ..To investigate the hypothalamus-pituitary-thyroid axis in patients with glycogen storage disease type 1(GSD1)...
  60. ncbi request reprint Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:88-93. 2008
    ..Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS)...
  61. ncbi request reprint Cushing's syndrome: aftermath of the cure
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Arq Bras Endocrinol Metabol 51:1381-91. 2007
    ..The totality of these complications persisting or occurring after successful treatment contribute to the impairment of quality of life registered in patients with CS after disease cure...
  62. doi request reprint Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-I levels, tumor shrinkage, and cardiovascular disease: a prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:3746-56. 2009
    ..The objective of the study was to evaluate the efficacy of 5 yr of depot somatostatin analogs (SSAs) as first-line therapy in acromegaly...
  63. ncbi request reprint Six months of treatment with cabergoline restores sexual potency in hyperprolactinemic males: an open longitudinal study monitoring nocturnal penile tumescence
    Michele De Rosa
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:621-5. 2004
    ..7% of controls. Six months of treatment with cabergoline normalized testosterone levels in most cases, thus restoring and maintaining during treatment the capability of normal sexual activity in hyperprolactinemic males...
  64. ncbi request reprint Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Maturitas 48:299-306. 2004
    ..Although overt hyperthyroidism is a well known cause of bone loss, systemic effects of subclinical hyperthyroidism (SH) are still a matter of debate...
  65. ncbi request reprint Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:4588-93. 2004
    ..0.5 +/- 0.2 pmol/liter for PCOS patients and controls, respectively).In conclusion, our data show that young, normal-weight, nondyslipidemic, nonhypertensive women with PCOS have an early impairment of endothelial structure and function...
  66. ncbi request reprint Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:85-92. 2006
    ..Surgery is a cornerstone in the treatment of acromegaly, but its efficacy in large, invasive tumors is scant...
  67. ncbi request reprint Lack of electrocardiographic changes in women with polycystic ovary syndrome
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 67:46-50. 2007
    ..The aim of the present study was to investigate the potential alterations in electrocardiographic (ECG) pattern in patients with polycystic ovary syndrome (PCOS)...
  68. doi request reprint The medical treatment of Cushing's disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery
    Rosario Pivonello
    Department of Molecular and Clinical, Endocrinology, Federico II University, Via Sergio Pansini, 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:223-30. 2009
    ..The role of dopamine agonists in the treatment of Cushing's disease (CD) has been previously debated...
  69. doi request reprint Growth hormone treatment prevents loss of lean mass after bariatric surgery in morbidly obese patients: results of a pilot, open, prospective, randomized, controlled study
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 94:817-26. 2009
    ..The loss of lean body mass (LBM) negatively influences the outcome in bariatric surgery. Impaired GH secretion is frequent in obese patients...
  70. doi request reprint Complete disappearance of a GH-secreting pituitary macroadenoma in a patient with acromegaly: effect of treatment with lanreotide Autogel and consequence of treatment withdrawal
    Renata S Auriemma
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Eur J Endocrinol 162:993-9. 2010
    ..SA withdrawal has been demonstrated to keep safe levels of GH and IGF1 at least in a small subset of patients well responsive to SA, although it is generally followed by disease recurrence after several months...
  71. ncbi request reprint Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Endocrine 20:279-83. 2003
    ..No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned...
  72. doi request reprint Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 93:3777-84. 2008
    ..Cabergoline, a dopamine receptor-2 agonist used to treat prolactinomas, was associated with increased risk of cardiac valve disease in Parkinson's disease...
  73. ncbi request reprint GH release after GHRH plus arginine administration in obese and overweight women with polycystic ovary syndrome
    F Orio
    Department of Molecular and Clinical Endocrinology, University of Naples Federico II, Naples, Italy
    J Endocrinol Invest 26:117-22. 2003
    ..In conclusion, in PCOS women there is a BMI-independent alteration of the GH levels. Further investigations will be necessary to establish the real cause of these data...
  74. doi request reprint Prevalence of the metabolic syndrome in moderately-severely obese subjects with and without growth hormone deficiency
    C Di Somma
    IRCCS SDN Foundation, Naples, Italy
    J Endocrinol Invest 33:171-7. 2010
    ....
  75. ncbi request reprint Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up
    A Colao
    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita Federico II di Napoli, Naples, Italy
    J Clin Endocrinol Metab 83:2777-80. 1998
    ..In conclusion, the medical treatment with dopaminergic compounds is effective and safe in patients with prolactinoma with onset in childhood, allowing preservation of the anterior pituitary function...
  76. ncbi request reprint Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy
    A Di Sarno
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, 80131 Naples, Italy
    J Clin Endocrinol Metab 86:5256-61. 2001
    ..Therefore, an absence of tumor shrinkage cannot be considered as end point to indicate resistance to CAB, and increasing the dose of CAB higher than 3 mg/wk does not seem to be helpful in controlling PRL hypersecretion...
  77. ncbi request reprint Subclinical hypothyroidism and cardiac function
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II School of Medicine, Naples, Italy
    Thyroid 12:505-10. 2002
    ..Therefore, it would seem appropriate to initiate timely treatment of patients with mild thyroid failure to prevent cardiac involvement...
  78. ncbi request reprint Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs
    C Matrone
    Division of Pharmacology, Department of Neuroscience, Federico II University, Naples, Italy
    Neuroendocrinology 79:142-8. 2004
    ....
  79. ncbi request reprint Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess. A case report in a young girl with recurrent, functioning paraga
    M Pulcrano
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University School of Medicine, Naples, Italy
    J Endocrinol Invest 27:774-7. 2004
    ....
  80. ncbi request reprint Bone density and turnover in young adult patients with growth hormone deficiency after 2-year growth hormone replacement according with gender
    F Rota
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, 80131 Naples, Italy
    J Endocrinol Invest 31:94-102. 2008
    ..In particular, GH replacement dose, to be successful on bone mass and turnover, depends on gender in hypopituitary patients aged below 50 yr...
  81. ncbi request reprint Severe impairment of bone mass and turnover in Cushing's disease: comparison between childhood-onset and adulthood-onset disease
    Carolina Di Somma
    Department of Molecular and Clinical Endocrinology and Oncology, CNR Biomorphological and Functional Sciences, Federico II University of Naples and Servizio di Endocrinologia Pediatrica, Ospedale Regionale per le Microcitemie, Cagliari, Italy
    Clin Endocrinol (Oxf) 56:153-8. 2002
    ..Osteoporosis is an important, frequently unrecognized consequence of hypercortisolism...
  82. ncbi request reprint Beneficial treatment with risedronate in long-term survivors after allogeneic stem cell transplantation for hematological malignancies
    L Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131, Naples, Italy
    Osteoporos Int 14:1013-9. 2003
    ..In conclusion, treatment with risedronate for 12 months increased BMD significantly at the lumbar spine and prevented further bone loss at the femoral neck in long-term survivors after allo-SCT...
  83. ncbi request reprint Adrenal adenoma and normal androgen levels in a young woman with polycystic ovaries: a case of idiopathic hirsutism?
    F Orio
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 27:61-6. 2004
    ..This case report underlines the need of cautious interpretation of imaging results and clinical signs of severe hirsutism, reminding one that the true cause of a medical problem may not be the most evident...
  84. ncbi request reprint Impairment of bone status in patients with central diabetes insipidus
    R Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 83:2275-80. 1998
    ..These findings suggest that, in patients with central diabetes insipidus, bone status analysis is mandatory; and a bone-loss preventing treatment might be beneficial...
  85. ncbi request reprint Growth-hormone and prolactin excess
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Lancet 352:1455-61. 1998
    ..Moreover, the improvement in the management of acromegaly has enabled the reversal, at least partly, of cardiomyopathy and sleep apnoea, two important risk factors for morbidity and mortality in these patients...
  86. ncbi request reprint Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease
    A Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:142-51. 2002
    ..Normalization of cortisol levels restored the amino acid profile...
  87. ncbi request reprint Increased intima-media thickness of the carotid artery wall, normal blood pressure profile and normal left ventricular mass in subjects with primary hyperparathyroidism
    V Nuzzo
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Eur J Endocrinol 147:453-9. 2002
    ..Given the multiple influence of PHPT on the cardiovascular system, this study aimed to assess the effects of PHPT on blood pressure profile, and on features of the heart and arterial vessels in normotensive symptomless patients...
  88. ncbi request reprint Hypothalamus-pituitary-adrenal axis in central diabetes insipidus: ACTH and cortisol responsiveness to CRH administration
    R Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 25:932-7. 2002
    ..In addition, replacement treatment with DDAVP normalized CRH-induced but not baseline ACTH and F secretion...
  89. ncbi request reprint Nephrolithiasis in Cushing's disease: prevalence, etiopathogenesis, and modification after disease cure
    Antongiulio Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 88:2076-80. 2003
    ....
  90. ncbi request reprint Avascular necrosis in long-term survivors after allogeneic or autologous stem cell transplantation: a single center experience and a review
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Cancer 97:2453-61. 2003
    ..The most debilitating skeletal complication of stem cell transplantation (SCT) is avascular necrosis (AVN)...
  91. ncbi request reprint Dopamine receptor expression and function in clinically nonfunctioning pituitary tumors: comparison with the effectiveness of cabergoline treatment
    Rosario Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini, 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:1674-83. 2004
    ..In conclusion, this study demonstrates D(2) receptor expression and function in nearly 70% of cases, suggesting a role of this drug in the treatment schedule of clinically nonfunctioning pituitary tumors...
  92. doi request reprint Androgens in polycystic ovary syndrome: the role of exercise and diet
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Semin Reprod Med 27:306-15. 2009
    ....
  93. doi request reprint Therapy of aggressive pituitary tumors
    Annamaria Colao
    Federico II University, Department of Molecular and Clinical Endocrinology and Oncology, Via S Pansini 5, 80131 Napoli, Italy
    Expert Opin Pharmacother 12:1561-70. 2011
    ..They are notoriously difficult to manage and are associated with poor prognosis because the therapeutic options are limited and the tumors are generally unresponsive to therapy...
  94. ncbi request reprint Acute and chronic effects of human recombinant GH (hrGH) on adrenal steroidogenesis in children affected with isolated GH deficiency (IGHD)
    E Rossi
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 80:2251-4. 1995
    ....
  95. ncbi request reprint Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:17-23. 1999
    ..These data suggest that prolonged suppression of circulating GH and IGF-I levels could normalize cardiac performance and probably reverse the poor prognosis for cardiovascular disease in acromegaly...
  96. ncbi request reprint Role of somatostatin analogue-based therapy in unresponsive malignant thymomas
    G Palmieri
    Department of Molecular and Clinical Oncology and Endocrinology, University Federico II, Naples, Italy
    Ann Med 31:80-5. 1999
    ....
  97. ncbi request reprint Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients
    B Biondi
    Departments of Endocrinology and Internal Medicine, University of Naples Federico II Medical School, 80131 Naples, Italy
    J Clin Endocrinol Metab 85:4701-5. 2000
    ....
  98. ncbi request reprint Myocardial contractility and total arterial stiffness in patients with overt hyperthyroidism: acute effects of beta1-adrenergic blockade
    E A Palmieri
    Department of Clinical Medicine and Cardiovascular Sciences, University Federico II School of Medicine, Napoli, Italy
    Eur J Endocrinol 150:757-62. 2004
    ..To ascertain whether myocardial contractility and total arterial stiffness are significantly altered in human thyrotoxicosis, and to what extent they are affected by acute beta(1)-adrenergic blockade...
  99. ncbi request reprint Role of somatostatin analogs in the management of non-functioning neuroendocrine tumors
    R Pivonello
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 26:82-8. 2003
  100. ncbi request reprint Cardiovascular complications in acromegaly
    G Vitale
    Department of Molecular and Clinical Endocrinology, School of Medicine, Federico II University of Naples, Naples, Italy
    Minerva Endocrinol 29:77-88. 2004
    ..In conclusion, a careful evaluation of cardiac function, morphology and activity seems to be mandatory in acromegaly...
  101. ncbi request reprint Octreotide-LAR vs lanreotide-SR as first-line therapy for acromegaly: a retrospective, comparative, head-to-head study
    R S Auriemma
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, 80131 Naples, Italy
    J Endocrinol Invest 31:956-65. 2008
    ..Therefore, both drugs can be safely employed as first-line therapy of acromegaly...