Annamaria Colao

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. doi Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 159:389-97. 2008
  2. ncbi Effect of growth hormone (GH) and insulin-like growth factor I on prostate diseases: an ultrasonographic and endocrine study in acromegaly, GH deficiency, and healthy subjects
    A Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1986-91. 1999
  3. pmc Interpreting biochemical control response rates with first-generation somatostatin analogues in acromegaly
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita Federico II di Napoli, Via S Pansini 5, 80131, Naples, Italy
    Pituitary 19:235-47. 2016
  4. pmc Environment and Health: Not Only Cancer
    Annamaria Colao
    Department of Clinical Medicine and Surgery, University Federico II School of Medicine, Via Pansini 5, Naples 80131, Italy
    Int J Environ Res Public Health 13:. 2016
  5. doi Adverse events associated with somatostatin analogs in acromegaly
    Ludovica F S Grasso
    University Federico II, Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Via S Pansini 5, 80131 Napoli, Italy 39 081 7462132 39 081 5465443
    Expert Opin Drug Saf 14:1213-26. 2015
  6. pmc The effects of somatostatin analogue therapy on pituitary tumor volume in patients with acromegaly
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Universita Federico II di Napoli, Via S Pansini 5, 80131, Naples, Italy
    Pituitary 19:210-21. 2016
  7. doi Hypovitaminosis D in adolescents living in the land of sun is correlated with incorrect life style: a survey study in Campania region
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita di Napoli Federico II, Via S Pansini 5, 80131, Naples, Italy
    Endocrine 49:521-7. 2015
  8. ncbi New medical approaches in pituitary adenomas
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Horm Res 53:76-87. 2000
  9. ncbi The cardiovascular risk of GH-deficient adolescents
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3650-5. 2002
  10. ncbi Cardiovascular effects of growth hormone treatment: potential risks and benefits
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Horm Res 62:42-50. 2004

Detail Information

Publications189 found, 100 shown here

  1. doi Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 159:389-97. 2008
    ..In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality...
  2. ncbi Effect of growth hormone (GH) and insulin-like growth factor I on prostate diseases: an ultrasonographic and endocrine study in acromegaly, GH deficiency, and healthy subjects
    A Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1986-91. 1999
    ..In conclusion, chronic excess of GH and IGF-I cause prostate overgrowth and further phenomena of rearrangement, but not prostate cancer...
  3. pmc Interpreting biochemical control response rates with first-generation somatostatin analogues in acromegaly
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita Federico II di Napoli, Via S Pansini 5, 80131, Naples, Italy
    Pituitary 19:235-47. 2016
    ..This review examines and attempts to account for these differences in response rates reported in the literature...
  4. pmc Environment and Health: Not Only Cancer
    Annamaria Colao
    Department of Clinical Medicine and Surgery, University Federico II School of Medicine, Via Pansini 5, Naples 80131, Italy
    Int J Environ Res Public Health 13:. 2016
    ..This special issue on "Environmental Diseases" is aimed at providing a global overview about different threats to human health possibily originating from environmental contamination. ..
  5. doi Adverse events associated with somatostatin analogs in acromegaly
    Ludovica F S Grasso
    University Federico II, Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Via S Pansini 5, 80131 Napoli, Italy 39 081 7462132 39 081 5465443
    Expert Opin Drug Saf 14:1213-26. 2015
    ....
  6. pmc The effects of somatostatin analogue therapy on pituitary tumor volume in patients with acromegaly
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Universita Federico II di Napoli, Via S Pansini 5, 80131, Naples, Italy
    Pituitary 19:210-21. 2016
    ..Somatostatin analogues are the medical treatment of choice in acromegaly, as first-line or post-surgical therapy, and have proven efficacy in pituitary tumor volume reduction (TVR)...
  7. doi Hypovitaminosis D in adolescents living in the land of sun is correlated with incorrect life style: a survey study in Campania region
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita di Napoli Federico II, Via S Pansini 5, 80131, Naples, Italy
    Endocrine 49:521-7. 2015
    ....
  8. ncbi New medical approaches in pituitary adenomas
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Horm Res 53:76-87. 2000
    ..However, some preliminary data suggest a potential use of cabergoline in combination with ketoconazole, or alone, in selected cases of Cushing's disease or Nelson's syndrome...
  9. ncbi The cardiovascular risk of GH-deficient adolescents
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3650-5. 2002
    ..Because the results on the cardiovascular system and on the lipid profile were suboptimal, it is likely that the GH dose in severe GHD adolescents should be higher...
  10. ncbi Cardiovascular effects of growth hormone treatment: potential risks and benefits
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Horm Res 62:42-50. 2004
    ..In recent years, GH therapy has been used to increase cardiac mass in ischaemic or dilated cardiomyopathy, but the results have produced contradictory data...
  11. doi Medical therapy for clinically non-functioning pituitary adenomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
    Endocr Relat Cancer 15:905-15. 2008
    ..Lack of randomized, placebo-controlled trials prevents any conclusion on the efficacy of these drugs. By contrast, use of gonatotrophin-releasing hormone analogues has been abandoned...
  12. ncbi Long-term effects of depot long-acting somatostatin analog octreotide on hormone levels and tumor mass in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 86:2779-86. 2001
    ..Tumor shrinkage was observed in de novo patients during OCT-LAR treatment, suggesting that it can be successfully applied as primary therapy in patients bearing invasive tumors, who are less likely to be cured after surgery...
  13. ncbi Gender differences in the prevalence, clinical features and response to cabergoline in hyperprolactinemia
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Via S Pansini 5, Italy
    Eur J Endocrinol 148:325-31. 2003
    ..Whether this reflects only a delay in diagnosis in men or a true gender difference in tumor pathogenesis is still unclear...
  14. ncbi Common carotid intima-media thickness in growth hormone (GH)-deficient adolescents: a prospective study after GH withdrawal and restarting GH replacement
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:2659-65. 2005
    ..In adolescents who were not confirmed to have GHD, IMT was increased while on GH therapy and normalized when they were taken off of GH...
  15. ncbi Age changes the diagnostic accuracy of mean profile and nadir growth hormone levels after oral glucose in postoperative patients with acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 65:250-6. 2006
    ....
  16. ncbi The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients
    Annamaria Colao
    Department of Molecular, Clinical Endocrinology and Oncology, Section of Endocrinilogy, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 92:3854-60. 2007
    ..Hyperinsulinemia is associated with colon carcinoma in the general population. PATIENTS with acromegaly are considered to be at risk for developing colonic lesions and typically have hyperinsulinemia...
  17. doi Managing Cushing's disease: the state of the art
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita Federico II di Napoli, Via S Pansini 5, 80131, Naples, Italy
    Endocrine 47:9-20. 2014
    ..Continuing research into improving the diagnosis and treatment of Cushing's disease will help to optimize patient management. ..
  18. pmc Hepatic arterial embolization in patients with neuroendocrine tumors
    Michela Del Prete
    Divisione di Endocrinologia, Dipartimento di Medicina Clinica e Chirurgia, Universita di Napoli Federico II, Naples, Italy
    J Exp Clin Cancer Res 33:43. 2014
    ..This review will focus on TAE performance and safety in NEN patients with liver metastases. ..
  19. pmc Preoperative workup in the assessment of adrenal incidentalomas: outcome from 282 consecutive laparoscopic adrenalectomies
    Mario Musella
    General and Emergency Surgery, Federico II University, Naples, Italy
    BMC Surg 13:57. 2013
    ..To confirm the efficacy of preoperative workup, the authors analyse the results of a multicentre study in a surgical series of patients diagnosed with an adrenal incidentaloma...
  20. ncbi Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency
    A Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Nuclear Medicine Center of the National Council of Research, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 86:1874-81. 2001
    ....
  21. ncbi Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly
    A Colao
    Department of Molecular, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:4193-7. 2002
    ..45; P = 0.006). In conclusion, short-term GH and IGF-I suppression after surgery or LAN significantly increased T and DHT levels and improved sperm number and motility in acromegalic men...
  22. ncbi The use of a GH receptor antagonist in patients with acromegaly resistant to somatostatin analogs
    A Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 26:53-6. 2003
    ..In conclusion, more than 80% of patients with acromegaly unsuccessfully treated by surgery or currently available somatostatin analogs can achieve normal IGF-I levels after short-term treatment with pegvisomant...
  23. ncbi Predictors of tumor shrinkage after primary therapy with somatostatin analogs in acromegaly: a prospective study in 99 patients
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:2112-8. 2006
    ..Primary treatment with depot octreotide and lanreotide induces tumor shrinkage in newly diagnosed patients with acromegaly...
  24. ncbi Medical consequences of acromegaly: what are the effects of biochemical control?
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131, Naples, Italy
    Rev Endocr Metab Disord 9:21-31. 2008
    ....
  25. doi The GH-IGF-I axis and the cardiovascular system: clinical implications
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Clin Endocrinol (Oxf) 69:347-58. 2008
    ..Both in GH deficiency (GHD) and excess life expectancy has been reported to be reduced because of cardiovascular disease...
  26. doi Resistance to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II, Naples, Italy
    Endocr Rev 32:247-71. 2011
    ..This latter evidence seems to occur in 25% of treated patients after 12 months of currently available long-acting SA...
  27. ncbi Increased prevalence of thyroid autoimmunity in patients successfully treated for Cushing's disease
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 53:13-9. 2000
    ..Cushing's disease is characterized by abnormalities of immune function...
  28. ncbi Predictors of remission of hyperprolactinaemia after long-term withdrawal of cabergoline therapy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 67:426-33. 2007
    ..Remission rates of 76, 69.5 and 64.3% have been reported in patients with nontumoural hyperprolactinaemia (NTH), microprolactinoma and macroprolactinoma, respectively, 2-5 years after cabergoline (CAB) withdrawal...
  29. ncbi The importance of presurgical somatostatin analogue therapy in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II
    Endokrynol Pol 58:356-60. 2007
    ..Somatostatin analogues also induce significant shrinkage of GH-secreting pituitary tumours, although this does not seem to be helpful in terms of improved surgical outcome...
  30. ncbi Impact of patient's age and disease duration on cardiac performance in acromegaly: a radionuclide angiography study
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Nuclear Medicine Center of the National Council of Research, Federico II University of Naples, Napoli, Italy
    J Clin Endocrinol Metab 84:1518-23. 1999
    ..abstract truncated)..
  31. ncbi Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:193-9. 2000
    ..6%), diastolic filling abnormalities (69.2%), and impaired systolic function at rest (53.9%). A careful cardiac investigation should thus be performed in all acromegalic patients showing these complications...
  32. ncbi Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University Naples, Italy
    Clin Endocrinol (Oxf) 52:319-27. 2000
    ..To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults...
  33. ncbi Effect of GH and/or testosterone deficiency on the prostate: an ultrasonographic and endocrine study in GH-deficient adult patients
    A Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Eur J Endocrinol 143:61-9. 2000
    ..The role of IGF-I in prostate development is currently under thorough investigation since it has been claimed that IGF-I is a positive predictor of prostate cancer...
  34. ncbi [New therapeutic strategies in gastroenteropancreatic neuroendocrine tumours]
    A Colao
    Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Universita Federico II, Naples, Italy
    Minerva Endocrinol 26:231-8. 2001
    ....
  35. ncbi Lymphocyte subset pattern in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:125-8. 2002
    ..These data further support the existence of abnormalities of the immune system in patients with chronic GH/IGF-1 excess...
  36. ncbi Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Napoli, Italy
    Clin Endocrinol (Oxf) 58:169-76. 2003
    ..Cardiovascular disease is the most frequent cause of death of patients with acromegaly...
  37. ncbi Withdrawal of long-term cabergoline therapy for tumoral and nontumoral hyperprolactinemia
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Naples, Italy
    N Engl J Med 349:2023-33. 2003
    ..We performed an observational, prospective study of cabergoline (a dopamine-receptor agonist) withdrawal in such patients...
  38. ncbi Outcome of cabergoline treatment in men with prolactinoma: effects of a 24-month treatment on prolactin levels, tumor mass, recovery of pituitary function, and semen analysis
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:1704-11. 2004
    ..These data demonstrate that cabergoline treatment is as effective and safe in men as in women with prolactinoma and can be successfully used as primary therapy even in men bearing large macroprolactinomas...
  39. ncbi Severe systemic complications of acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Napoli, Italy
    J Endocrinol Invest 28:65-77. 2005
    ..There is still no demonstration that improvement of different complications corresponds a reduction in mortality...
  40. ncbi First-line octreotide-LAR therapy induces tumour shrinkage and controls hormone excess in patients with acromegaly: results from an open, prospective, multicentre trial
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II, University of Naples, Italy
    Clin Endocrinol (Oxf) 64:342-51. 2006
    ..The majority of patients with acromegaly have large tumours and the outcome of conventional management remains poor...
  41. ncbi First-line therapy of acromegaly: a statement of the A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Education) Study Group
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Pansini 5, 80131 Napoli, Italy
    J Endocrinol Invest 29:1017-20. 2006
  42. ncbi Growth hormone excess with onset in adolescence: clinical appearance and long-term treatment outcome
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 66:714-22. 2007
    ..Limited data are available on clinical presentation and treatment strategy in patients with GH-secreting adenomas with onset in adolescence...
  43. ncbi A retrospective analysis on biochemical parameters, cardiovascular risk and cardiomyopathy in elderly acromegalic patients
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Endocrinol Invest 30:497-506. 2007
    ..We suggest that an accurate clinical check-up and, possibly, a more aggressive treatment of hypertension and diabetes are required in elderly acromegalics...
  44. ncbi Beneficial effect of dose escalation of octreotide-LAR as first-line therapy in patients with acromegaly
    Annamaria Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 157:579-87. 2007
    ..To evaluate the efficacy of dose escalation of Octreotide-long-acting repeatable (LAR) up to 40 mg/month we studied 56 newly diagnosed patients with acromegaly (24 women, 32 men; age 20-82 years)...
  45. doi Pituitary tumours: the prolactinoma
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 23:575-96. 2009
    ..The patients achieving disappearance of the tumours and suppression of PRL levels during treatment are those showing the highest likelihood to have persistent remission of hyperprolactinaemia after treatment withdrawal...
  46. doi Medical treatment of prolactinomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Italy, Via Sergio Pansini 5, I 80131 Naples, Italy
    Nat Rev Endocrinol 7:267-78. 2011
    ..This Review reports on efficacy and safety of pharmacotherapy in patients with prolactinomas...
  47. doi Improvement of cardiac parameters in patients with acromegaly treated with medical therapies
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Naples, Italy
    Pituitary 15:50-8. 2012
    ..Selected patients with acromegaly should consider first-line therapy or pre-treatment with somatostatin analogues prior to surgery to achieve biochemical control and improve cardiac dysfunction...
  48. doi Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy)
    Annamaria Colao
    Dipartimento di Medicina Clinica e ChirurgiaSezione di Endocrinologia, Universita Federico II di Napoli, Via S Pansini 5, 80131 Naples, ItalyClinical Center of Endocrinology and Gerontology Akad Ivan Pentchev Medical University Sofia2 Zdrave Street, 1431 Sofia, BulgariaNew Bulgarian University21 Montevideo Street, 1618 Sofia, Bulgaria
    Eur J Endocrinol 171:263-73. 2014
    ..This retrospective, comparative, cohort study investigated the impact of different treatment modalities on disease control (GH and IGF1) and mortality in acromegaly patients...
  49. pmc Managing hyperglycemia in patients with Cushing's disease treated with pasireotide: medical expert recommendations
    Annamaria Colao
    Dipartimento di Medicina Clinica e Chirurgia, Universita di Napoli Federico II, Naples, Italy
    Pituitary 17:180-6. 2014
    ..Further research into hyperglycemia following pasireotide treatment will help refine the optimal strategy in Cushing's disease. ..
  50. pmc Pasireotide versus octreotide in acromegaly: a head-to-head superiority study
    A Colao
    Dipartimento di Medicina Clinica e Chirurgia A C, Universita Federico II di Napoli, 80131 Naples, Italy Neuroendocrine Unit M D B, Division of Endocrinology and Metabolism, University of Sao Paulo Medical School, 3858 Jardim Paulista, Sao Paulo, Brazil Department of Medicine P F, Columbia University College of Physicians and Surgeons, New York, New York 10032 Department of Endocrinology F G, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Department of Neurosurgery C C S, Taichung Veterans General Hospital, Taichung 40705, Taiwan Department of Physical Therapy C C S, Hungkuang University, Taichung 43302, Taiwan Department of Medicine and Tri Service General Hospital C C S, National Defense Medical Center, Taipei 11490, Taiwan Endocrine Unit M G, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 22421020, Brazil Department of Medicine and Neurological Surgery M F, Northwest Pituitary Center, Oregon Health and Science University, Portland, Oregon 97239 Department of Medicine A J v d L, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands Brain Research Imaging Centre A J F, University of Edinburgh, Korea
    J Clin Endocrinol Metab 99:791-9. 2014
    ..With current medical therapies, including the gold standard octreotide long-acting-release (LAR), many patients do not achieve biochemical control...
  51. doi Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation
    Renata S Auriemma
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, I 80131 Napoli, Italy
    J Clin Endocrinol Metab 98:372-9. 2013
    ..The current survey study investigated the recurrence rate of hyperprolactinemia after cabergoline (CAB)-induced pregnancy and after lactation as well as safety of CAB exposure during early gestation...
  52. pmc Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS
    Silvia Savastano
    Department of Molecular and Clinical Endocrinology and Oncology, Division of Endocrinology, University Federico II of Naples, Via S, Pansini 5, Naples, 80131, Italy
    Nutr Metab (Lond) 8:84. 2011
    ..The aim of the study was to investigate the levels of 25-hydroxy vitamin D (25(OH)D), and L/A, in association with PED/PEA-15 protein abundance, in both lean and overweight/obese (o/o) women with PCOS...
  53. pmc The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
    ..Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons...
  54. pmc Relationship between heart rate recovery and inflammatory markers in patients with polycystic ovary syndrome: a cross-sectional study
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, University of Naples Federico II, Naples, Italy
    J Ovarian Res 2:3. 2009
    ..A subclinical increase of the inflammation markers has been also observed in the PCOS. This study was designed to study the relationships between HRR and inflammatory markers in PCOS women...
  55. pmc Prolactinomas, Cushing's disease and acromegaly: debating the role of medical therapy for secretory pituitary adenomas
    Beverly Mk Biller
    Neuroendocrine Clinical Center, Massachusetts General Hospital, Boston, USA
    BMC Endocr Disord 10:10. 2010
    ....
  56. ncbi The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1277-82. 1999
    ....
  57. ncbi Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:1919-24. 1999
    ..These abnormalities were consistently present in all patients with GHD regardless of the presence of additional hormone deficits, suggesting that GHD plays a central role in the development of osteopenia in hypopituitary patients...
  58. ncbi Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University, Naples, Italy
    J Clin Endocrinol Metab 84:2664-72. 1999
    ....
  59. ncbi Impaired cardiac performance in elderly patients with growth hormone deficiency
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 84:3950-5. 1999
    ..614; P < 0.05) and with systolic and diastolic blood pressures both at rest (r = 0.745; P < 0.01 and r = 0.650; P < 0.05) and at peak exercise (r = 0.684; P < 0.05 and r =..
  60. ncbi Ultrasonographic evidence of joint thickening reversibility in acromegalic patients treated with lanreotide for 12 months
    A Colao
    Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 51:611-8. 1999
    ..A major cause of morbidity and functional disability in acromegaly is represented by axial and peripheral arthropathy...
  61. ncbi Hormone levels and tumour size response to quinagolide and cabergoline in patients with prolactin-secreting and clinically non-functioning pituitary adenomas: predictive value of pituitary scintigraphy with 123I-methoxybenzamide
    A Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples Nuclear Medicine, National Cancer Institute, Fondazione G Pascale, Naples, Italy
    Clin Endocrinol (Oxf) 52:437-45. 2000
    ..Dopamine agonists are indicated as primary therapy for PRL-secreting pituitary adenomas, while controversial results have been reported in nonfunctioning adenomas (NFA)...
  62. ncbi Macroprolactinoma shrinkage during cabergoline treatment is greater in naive patients than in patients pretreated with other dopamine agonists: a prospective study in 110 patients
    A Colao
    Department of Molecular and Clinical Endocrinology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:2247-52. 2000
    ..In conclusion, the prevalence of macroprolactinoma shrinkage after CAB treatment at standard doses for 1-3 yr was higher in naive patients (92.3%) than in intolerant (42.1%), resistant (30.3%), and responsive patients (38.4%). Thus, C..
  63. ncbi Cardiovascular effects of depot long-acting somatostatin analog Sandostatin LAR in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:3132-40. 2000
    ..The sustained suppression of IGF-I levels was followed by a significant reduction of LVMi in all patients already after 3 months of treatment, with recovery of LV hypertrophy in 6 of 11 patients. (ABSTRACT TRUN..
  64. ncbi Effect of two years of growth hormone and insulin-like growth factor-I suppression on prostate diseases in acromegalic patients
    A Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 85:3754-61. 2000
    ..These data suggest that hyperplasia, but not cancer, is frequent in acromegalic men, and that the GH-IGF axis and age are independently associated with the development of this process...
  65. ncbi Growth hormone and the heart
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Clin Endocrinol (Oxf) 54:137-54. 2001
    ..Although these data need to be confirmed in more extensive studies, such promising results seem to open new perspectives for GH treatment in humans...
  66. ncbi Cabergoline
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Expert Opin Pharmacother 1:555-74. 2000
    ..CAB was also reported to have some efficacy in patients with Nelson's syndrome and Cushing's disease although these data are available only for limited case reports...
  67. ncbi Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 54:515-24. 2001
    ..Despite the increasing evidence for the existence of a specific cardiomyopathy in acromegaly, the presence of vascular abnormalities has been never investigated...
  68. ncbi Effect of a six-month treatment with lanreotide on cardiovascular risk factors and arterial intima-media thickness in patients with acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via Sergio Pansini 5, 80131, Naples, Italy
    Eur J Endocrinol 146:303-9. 2002
    ..4 +/- 12.6 mU/l, IGF--I=866.0 +/- 55.8 microg/l) and 24 healthy subjects sex-, age- and body mass index-matched with the patients (as controls)...
  69. ncbi The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:1088-93. 2002
    ..A similar period of GH deprivation induced a further impairment of lipid profile and cardiac performance. This finding strongly supports the need of GH replacement in adult GHD patients...
  70. ncbi Dopamine receptor agonists for treating prolactinomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Expert Opin Investig Drugs 11:787-800. 2002
    ..The great efficacy of this compound together with its excellent tolerability makes this drug the current treatment of choice for the majority of patients with hyperprolactinaemic disorders...
  71. ncbi (99m)Technetium pentavalent dimercaptosuccinic acid scintigraphy in the follow-up of clinically nonfunctioning pituitary adenomas after radiotherapy
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, Italy
    Clin Endocrinol (Oxf) 56:713-21. 2002
    ....
  72. ncbi Cardiovascular consequences of early-onset growth hormone excess
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:3097-104. 2002
    ..These deleterious effects of early-onset acromegaly are ameliorated by suppressing GH/IGF-I levels for 6 months...
  73. ncbi Gender- and age-related differences in the endocrine parameters of acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 25:532-8. 2002
    ..Women have lower IGF-I levels but higher GH nadir after glucose load than men. These age and gender differences should be considered to appropriately evaluate the activity of acromegaly throughout a life-span...
  74. ncbi Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, Federico II University of Naples, Italy
    J Clin Endocrinol Metab 88:88-94. 2003
    ..In these cases, GH replacement might be performed sequentially to reduce the hypertrophic effect of combining GH and testosterone...
  75. ncbi Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Endocrine 20:279-83. 2003
    ..No evident effect of tumor shrinkage has been reported. At present, the use of somatostatin analogs in clinically nonfunctioning adenomas is questioned...
  76. ncbi Systemic complications of acromegaly: epidemiology, pathogenesis, and management
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
    Endocr Rev 25:102-52. 2004
    ..Finally, the most important cause of morbidity and functional disability of the disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years...
  77. ncbi Hypothalamic-pituitary-gonadal axis function after successful kidney transplantation in men and women
    Libuse Tauchmanova
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Cantazaro, Italy
    Hum Reprod 19:867-73. 2004
    ..Renal transplantation (RT) is the most common solid organ transplant procedure. Several studies have reported on gonadal function in male and female RT recipients with controversial results...
  78. ncbi Prolactin and prostate hypertrophy: a pilot observational, prospective, case-control study in men with prolactinoma
    Annamaria Colao
    Department of Clinical and Molecular Endocrinology and Oncology, University Federico II of Naples, 80131 Naples, Italy
    J Clin Endocrinol Metab 89:2770-5. 2004
    ..In conclusion, in young men with prolactinoma PRL excess is unlikely to have effects on the prostate per se, because it is accompanied by low testosterone and DHT levels that produce the major effects...
  79. ncbi The treatment algorithm of acromegaly
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University, Naples, Italy
    J Endocrinol Invest 26:39-45. 2003
  80. ncbi The heart: an end-organ of GH action
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 151:S93-101. 2004
    ..These beneficial effects appear earlier in young patients with short disease duration than in elderly patients. In conclusion, GH and IGF-I play a main role in the regulation of cardiac development and performance...
  81. ncbi Insulin-like growth factor-1 deficiency determines increased intima-media thickness at common carotid arteries in adult patients with growth hormone deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Clin Endocrinol (Oxf) 61:360-6. 2004
    ..To investigate the role of IGF-1 on intima-media thickness (IMT) at common carotid arteries by Doppler ultrasonography...
  82. ncbi The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Napoli, Italy
    J Clin Endocrinol Metab 89:5998-6004. 2004
    ..5% of non-GHD, and 90% of controls. In conclusion, cardiac performance is correlated with the GH status because significant impairment was found in patients with severe and partial GHD but not in non-GHD hypopituitary patients...
  83. ncbi Growth hormone/insulin-like growth factor-I system and connective tissues: basic aspects and clinical implications
    Annamaria Colao
    Unit of Neuroendocrinology, Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pancini C, Naples 80131, Italy
    Rheum Dis Clin North Am 31:29-42, viii. 2005
    ..This article reviews basic and clinical aspects of the effects of growth hormone and insulin-like growth factor-I on the connective tissues...
  84. ncbi Short-term effects of growth hormone (GH) treatment or deprivation on cardiovascular risk parameters and intima-media thickness at carotid arteries in patients with severe GH deficiency
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:2056-62. 2005
    ..These findings support the indication for GH replacement in severe GH deficiency adult patients...
  85. ncbi Influence of growth hormone on cardiovascular health and disease
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Treat Endocrinol 2:347-56. 2003
    ..Although these data need to be confirmed in more extensive studies, such promising results open new perspectives for somatropin therapy. The role of GH secretagogues in heart failure is still unknown...
  86. ncbi Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH defici
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:5146-55. 2005
    ..GH secretion and response to GH replacement are gender-related...
  87. ncbi Circulating insulin-like growth factor-I levels are correlated with the atherosclerotic profile in healthy subjects independently of age
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    J Endocrinol Invest 28:440-8. 2005
    ..Our results support a role of the IGF/IGFBP-3 axis in the pathogenesis of atherosclerosis...
  88. ncbi Effect of gender and gonadal status on the long-term response to somatostatin analogue treatment in acromegaly
    Annamaria Colao
    Departments of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 63:342-9. 2005
    ..GH and IGF-I secretion is related to gender and age...
  89. ncbi Partial surgical removal of growth hormone-secreting pituitary tumors enhances the response to somatostatin analogs in acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:85-92. 2006
    ..Surgery is a cornerstone in the treatment of acromegaly, but its efficacy in large, invasive tumors is scant...
  90. ncbi The acromegalic arthropathy
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology, Federico II, University of Naples, Naples, Italy
    J Endocrinol Invest 28:24-31. 2005
    ..Arthropathy can be reversed by normalizing GH and IGF-I levels only at the initial stage. If the disease is left untreated for long time, the osteo-articular sequelae cannot be modified by any treatment of acromegaly...
  91. ncbi Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, Federico II University of Naples, Italy
    Eur J Endocrinol 154:467-77. 2006
    ..We aimed to investigate the efficacy of pegvisomant in patients with acromegaly resistant to long-term (> or = 24-month), high-dose treatment with octreotide-LAR (40 mg/month) or lanreotide (120 mg/month)...
  92. ncbi The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 91:2191-200. 2006
    ..Partial GH deficiency (GHD) in adults is poorly studied...
  93. ncbi New perspectives in the medical treatment of acromegaly
    A Colao
    Section of Endocrinology, Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    J Endocrinol Invest 28:58-66. 2005
    ..These drugs have been also shown to possess strong GH-inhibitory activity in primary cultures from GH-secreting adenomas. These drugs are the future perspectives in the treatment of patients with GH-secreting or GH/PRL-secreting tumors...
  94. ncbi Beginning to end: cardiovascular implications of growth hormone (GH) deficiency and GH therapy
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Via S Pansini 5, 80123 Naples, Italy
    Growth Horm IGF Res 16:S41-8. 2006
    ..This review discusses the roles of GHD and GH replacement therapy in the development of cardiovascular disease...
  95. ncbi Drug insight: Cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 2:200-10. 2006
    ..Fewer results are available for men than for women, but there is no evidence that men are less responsive to dopamine agonists than are women...
  96. ncbi The role of somatostatin and dopamine receptors as molecular targets for the treatment of patients with pituitary adenomas
    A Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy
    Eur J Endocrinol 156:S1. 2007
  97. ncbi Combined therapy of somatostatin analogues and dopamine agonists in the treatment of pituitary tumours
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Eur J Endocrinol 156:S57-63. 2007
    ..No data are available in other pituitary tumour histotypes. Preliminary observations in patients with clinically non-functioning adenomas are very promising...
  98. ncbi Pregnancy outcomes following cabergoline treatment: extended results from a 12-year observational study
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Section of Endocrinology, University Federico II of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 68:66-71. 2008
    ..Although cabergoline has been used to treat hyperprolactinaemia since the mid-1990s, safety data related to maternal and foetal exposure to this agent are still limited...
  99. doi No greater incidence or worsening of cardiac valve regurgitation with somatostatin analog treatment of acromegaly
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Via S Pansini 5, Naples, Italy
    J Clin Endocrinol Metab 93:2243-8. 2008
    ..Excess GH and IGF-I in acromegaly are associated with reduced life expectancy due to cardiovascular complications...
  100. doi GH and IGF-I excess control contributes to blood pressure control: results of an observational, retrospective, multicentre study in 105 hypertensive acromegalic patients on hypertensive treatment
    Annamaria Colao
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Clin Endocrinol (Oxf) 69:613-20. 2008
    ..Approximately one-third of patients with acromegaly have concomitant hypertension. The outcome of hypertension after treatment of acromegaly is unknown...