Silvia Casati

Summary

Affiliation: European Commission
Country: Italy

Publications

  1. ncbi request reprint In vitro tests for haematotoxicity: prediction of drug-induced myelosuppression by the CFU-GM assay
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Altern Lab Anim 30:75-9. 2002
  2. ncbi request reprint Refinement of the colony-forming unit-megakaryocyte (CFU-MK) assay for its application to pharmaco-toxicological testing
    S Casati
    ECVAM, European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy
    Toxicol In Vitro 17:69-75. 2003
  3. ncbi request reprint Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
    Silvia Casati
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 33:47-62. 2005
  4. ncbi request reprint A modular approach to the ECVAM principles on test validity
    Thomas Hartung
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 32:467-72. 2004
  5. ncbi request reprint Overcoming barriers to validation of non-animal partial replacement methods/Integrated Testing Strategies: the report of an EPAA-ECVAM workshop
    Agnieszka Kinsner-Ovaskainen
    Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 37:437-44. 2009
  6. ncbi request reprint Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
    Sandra Coecke
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 34:49-84. 2006
  7. ncbi request reprint Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50
    Alessandra Gennari
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 32:437-59. 2004
  8. ncbi request reprint Management of an integrated project (Sens-it-iv) to develop in vitro tests to assess sensitisation
    Costanza Rovida
    ECVAM, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 35:317-22. 2007
  9. ncbi request reprint Report of the EPAA-ECVAM workshop on the validation of Integrated Testing Strategies (ITS)
    Agnieszka Kinsner-Ovaskainen
    Institute for Health and Consumer Protection, European Commission, Joint Research Centre, Ispra, Italy
    Altern Lab Anim 40:175-81. 2012
  10. ncbi request reprint ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies
    Thomas Hartung
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 31:473-81. 2003

Detail Information

Publications18

  1. ncbi request reprint In vitro tests for haematotoxicity: prediction of drug-induced myelosuppression by the CFU-GM assay
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Altern Lab Anim 30:75-9. 2002
    ....
  2. ncbi request reprint Refinement of the colony-forming unit-megakaryocyte (CFU-MK) assay for its application to pharmaco-toxicological testing
    S Casati
    ECVAM, European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy
    Toxicol In Vitro 17:69-75. 2003
    ..The present study demonstrates that the refined CFU-MK assay is reproducible and can be used for in vitro toxicology studies with CBC as well as BMC...
  3. ncbi request reprint Dendritic cells as a tool for the predictive identification of skin sensitisation hazard
    Silvia Casati
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 33:47-62. 2005
  4. ncbi request reprint A modular approach to the ECVAM principles on test validity
    Thomas Hartung
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 32:467-72. 2004
    ..This will permit the assessment of test validity by completing the missing information via the relevant validation procedure: prospective validation, retrospective validation, catch-up validation, or a combination of these procedures...
  5. ncbi request reprint Overcoming barriers to validation of non-animal partial replacement methods/Integrated Testing Strategies: the report of an EPAA-ECVAM workshop
    Agnieszka Kinsner-Ovaskainen
    Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 37:437-44. 2009
    ..Finally, several challenges and bottlenecks to the ITS validation were identified, and it was agreed that a roadmap on how to address these barriers would be established by the EPAA partners...
  6. ncbi request reprint Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54
    Sandra Coecke
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 34:49-84. 2006
  7. ncbi request reprint Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50
    Alessandra Gennari
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 32:437-59. 2004
  8. ncbi request reprint Management of an integrated project (Sens-it-iv) to develop in vitro tests to assess sensitisation
    Costanza Rovida
    ECVAM, European Commission Joint Research Centre, Ispra, Italy
    Altern Lab Anim 35:317-22. 2007
    ..This paper provides an overview of the structure of the project and a detailed description of the organisation of its management...
  9. ncbi request reprint Report of the EPAA-ECVAM workshop on the validation of Integrated Testing Strategies (ITS)
    Agnieszka Kinsner-Ovaskainen
    Institute for Health and Consumer Protection, European Commission, Joint Research Centre, Ispra, Italy
    Altern Lab Anim 40:175-81. 2012
    ....
  10. ncbi request reprint ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies
    Thomas Hartung
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 31:473-81. 2003
    ..In essence, steering groups formed by ECVAM senior staff, and complemented with external experts, will carry out the project management and will coordinate the various inputs...
  11. doi request reprint The regulatory use of the Local Lymph Node Assay for the notification of new chemicals in Europe
    Alexandre Angers-Loustau
    In Vitro Methods Unit ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy
    Regul Toxicol Pharmacol 60:300-7. 2011
    ..In addition the accuracy of the reduced LLNA when applied to new chemicals was investigated...
  12. doi request reprint Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches
    Coralie Dumont
    Joint Research Centre, European Commission, Ispra, Italy
    Toxicol In Vitro 34:220-8. 2016
    ..This study highlights the importance of considering the variability of the reference data when evaluating non-animal tests. ..
  13. ncbi request reprint An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay. The report and recommendations of ECVAM Workshop 65
    David Basketter
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Altern Lab Anim 36:243-57. 2008
  14. ncbi request reprint Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59
    David Basketter
    Unilever Safety and Environmental Assurance Centre, Bedfordshire, UK
    Altern Lab Anim 35:137-54. 2007
  15. pmc The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58
    Michael Balls
    FRAME, Russell and Burch House, 96 98 North Sherwood Street, Nottingham, NG1 4EE, UK
    Altern Lab Anim 34:603-20. 2006
  16. ncbi request reprint Chemical reactivity measurement and the predicitve identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64
    Frank Gerberick
    Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    Altern Lab Anim 36:215-42. 2008
  17. ncbi request reprint The FRAME alternatives laboratory database. 1. In vitro basal cytotoxicity determined by the Kenacid blue total protein assay
    Richard Clothier
    School of Biomedical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Altern Lab Anim 34:151-75. 2006
    ..However, there was a difference in ID50 value of more than one order of magnitude for 8 of 24 chemicals tested with an undifferentiated teratocarcinoma cell line, F9...
  18. ncbi request reprint Skin sensitisation
    David Basketter
    SEAC, Unilever Colworth Laboratory, Sharnbrook, Bedfordshire, MK44 1LQ, UK
    Altern Lab Anim 33:83-103. 2005