E Ferrannini

Summary

Affiliation: CNR Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects
    E Ferrannini
    C N R Institute of Clinical Physiology, University of Pisa, Italy
    Endocr Rev 19:477-90. 1998
  2. ncbi How to measure insulin sensitivity
    E Ferrannini
    CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 16:895-906. 1998
  3. pmc Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    Eleni Rebelos
    Department of Internal Medicine, University of Pisa, Italy
    Diabetes 60:1938-45. 2011
  4. doi The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women
    Elza Muscelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:364-70. 2009
  5. ncbi Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets
    A Antonelli
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Diabetes 50:985-91. 2001
  6. pmc Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease
    A Antonelli
    Metabolism Unit, CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Immunol 126:426-31. 2001
  7. doi Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals
    A Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hum Hypertens 23:801-7. 2009
  8. doi Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 33:1001-6. 2009
  9. doi The role of beta-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 96:E1372-9. 2011
  10. doi Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Obes Surg 19:467-74. 2009

Detail Information

Publications77

  1. ncbi Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects
    E Ferrannini
    C N R Institute of Clinical Physiology, University of Pisa, Italy
    Endocr Rev 19:477-90. 1998
    ..Finally, the predictive power of early changes in insulin secretion for the development of typical NIDDM is generally lower than that of insulin..
  2. ncbi How to measure insulin sensitivity
    E Ferrannini
    CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 16:895-906. 1998
    ..Recent developments and future trends are mentioned. Criteria for choice and some reference data are given to aid the clinical investigator...
  3. pmc Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    Eleni Rebelos
    Department of Internal Medicine, University of Pisa, Italy
    Diabetes 60:1938-45. 2011
    ..Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes...
  4. doi The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women
    Elza Muscelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:364-70. 2009
    ....
  5. ncbi Human anti-CD38 autoantibodies raise intracellular calcium and stimulate insulin release in human pancreatic islets
    A Antonelli
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Diabetes 50:985-91. 2001
    ..002). We conclude that human anti-CD38 autoantibodies with agonistic properties on the CD38 effector system occur in nature; in human islets, their [Ca2+]i-mobilizing activity is coupled with the ability to stimulate insulin release...
  6. pmc Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease
    A Antonelli
    Metabolism Unit, CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Immunol 126:426-31. 2001
    ..Anti-CD38 autoantibodies are a new autoimmune marker in chronic autoimmune thyroiditis and Graves' disease. The specific role of CD38 and its autoantibodies in the modulation of thyroid cell function or growth remains to be investigated...
  7. doi Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals
    A Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hum Hypertens 23:801-7. 2009
    ....
  8. doi Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 33:1001-6. 2009
    ....
  9. doi The role of beta-cell function and insulin sensitivity in the remission of type 2 diabetes after gastric bypass surgery
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 96:E1372-9. 2011
    ..Bariatric surgery can induce remission in a high proportion of severely obese patients with type 2 diabetes mellitus (T2DM)...
  10. doi Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Obes Surg 19:467-74. 2009
    ..Adiponectin has antisteatosis-anti-inflammatory properties and its circulating levels are reduced in nonalcoholic steatohepatitis (NASH)...
  11. doi Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 54:1507-16. 2011
    ..The natural history and physiological determinants of glucose intolerance in subjects living in Europe have not been investigated. The aim of this study was to increase our understanding of this area...
  12. doi Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa, 56100, Italy
    Diabetologia 51:862-71. 2008
    ..Hyperglycaemia and hyperinsulinaemia have opposite effects on endothelium-dependent vasodilatation in microcirculation, but the net effect elicited by glucose ingestion and the separate influence of glucose tolerance are unknown...
  13. ncbi Effect of statins on soluble CD40 ligand in hypercholesterolemic Type 2 diabetic patients
    E Santini
    Department of Internal Medicine, University of Pisa, I 56100 Pisa, Italy
    J Endocrinol Invest 31:660-5. 2008
    ..In hypercholesterolemic Type 2 diabetic patients, sCD40L, a factor playing a pivotal role in the pathogenesis of atherosclerosis and associated with more rupture-prone lesions, is reduced by short-term treatment with rosuvastatin...
  14. ncbi Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach
    A Natali
    Metabolism Unit of the Consiglio Nazionale delle Ricerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, 56126 Pisa, Italy
    Am J Physiol Endocrinol Metab 278:E794-801. 2000
    ....
  15. ncbi Association of fasting glucagon and proinsulin concentrations with insulin resistance
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetologia 50:2342-7. 2007
    ..Hyperproinsulinaemia and relative hyperglucagonaemia are features of type 2 diabetes. We hypothesised that raised fasting glucagon and proinsulin concentrations may be associated with insulin resistance (IR) in non-diabetic individuals...
  16. ncbi Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss
    M Emdin
    Metabolism Unit and Coronary Division, CNR Institute of Clinical Physiology, and Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 103:513-9. 2001
    ..Reversal of these changes by weight loss suggests a causal role for insulin...
  17. doi Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study
    A Antonelli
    Department of Internal Medicine and Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabet Med 25:1349-53. 2008
    ..The aim of this study was to investigate whether circulating chemokines involved in T-helper 1 (CXCL10) and T-helper 2 (CCL2) autoimmunity are increased in children with Type 1 diabetes at onset and follow-up...
  18. doi Early and longer term effects of gastric bypass surgery on tissue-specific insulin sensitivity and beta cell function in morbidly obese patients with and without type 2 diabetes
    S Camastra
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Diabetologia 54:2093-102. 2011
    ..Bariatric surgery consistently induces remission of type 2 diabetes. We tested whether there are diabetes-specific mechanisms in addition to weight loss...
  19. ncbi Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study
    A Gastaldelli
    Metabolism Unit, C N R Institute of Clinical Physiology, Pisa, Italy
    Diabetologia 47:31-9. 2004
    ..The aim of the study was to define the level of glycaemia at which beta-cell dysfunction becomes evident in the context of existing insulin resistance...
  20. doi Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 95:4703-11. 2010
    ..What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD(+) with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain...
  21. doi Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa 56122, Italy
    Eur Heart J 31:1511-9. 2010
    ..This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) and with the 3-year IMT progression in different carotid segments...
  22. doi The amino acid response to a mixed meal in patients with type 2 diabetes: effect of sitagliptin treatment
    E Muscelli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 16:1140-7. 2014
    ..We investigated the changes in AA and α-HB induced by a mixed-meal tolerance test (MTT) and the effects of sitagliptin treatment...
  23. doi A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    E Ferrannini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 15:721-8. 2013
    ..This Phase IIb, randomized, double-blind, placebo-controlled trial evaluated the efficacy, safety, tolerability and pharmacokinetics of empagliflozin in patients with type 2 diabetes...
  24. doi Effects of short and prolonged mild intracellular nitric oxide manipulations on various aspects of insulin secretion in INS-1E β-cells
    A Natali
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
    Exp Clin Endocrinol Diabetes 120:210-6. 2012
    ..We aimed at evaluating the impact of short and prolonged mild manipulations of intracellular nitric oxide (NO) bioavailability on the main features of insulin secretion and whether NO promotes mitochondrial biogenesis in isolated β-cells...
  25. ncbi Long-term follow-up of 106 multiple sclerosis patients undergoing interferon-beta 1a or 1b therapy: predictive factors of thyroid disease development and duration
    N Caraccio
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 90:4133-7. 2005
    ..Conflicting data have been reported on the association between interferon (IFN)-beta therapy of multiple sclerosis (MS) patients and thyroid disease development...
  26. ncbi Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension
    A Natali
    CNR Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa, Italy
    Hypertension 31:632-6. 1998
    ..6). We conclude that in overweight male patients with essential hypertension, increasing forearm perfusion with sodium nitroprusside does not attenuate the insulin resistance of forearm tissues...
  27. ncbi High values of Th1 (CXCL10) and Th2 (CCL2) chemokines in patients with psoriatic arthtritis
    A Antonelli
    Department of Internal Medicine, University of Pisa, Italy
    Clin Exp Rheumatol 27:22-7. 2009
    ..To evaluate serum levels of CXCL10 and CCL2 in a large series of PsA patients, and to relate chemokines levels to the clinical phenotype of these patients...
  28. doi Effects of different LDL particles on inflammatory molecules in human mesangial cells
    E Santini
    Department of Internal Medicine, University of Pisa, Via Roma 67, I 56100, Pisa, Italy
    Diabetologia 51:2117-25. 2008
    ..LDL may increase the production of inflammatory cytokines in renal tissues. However, the relative role of native, oxidised and glycated LDL in promoting this process has been only partially elucidated...
  29. pmc HDL lipid composition is profoundly altered in patients with type 2 diabetes and atherosclerotic vascular disease
    C Morgantini
    Department of Internal Medicine, University of Pisa, Italy Scuola Superiore Sant Anna, Pisa, Italy
    Nutr Metab Cardiovasc Dis 24:594-9. 2014
    ..In this study, we examined whether HDL from T2D patients contains elevated levels of oxidized fatty acids and whether those levels correlate with cardiovascular disease (CVD)...
  30. ncbi Lipoprotein lipase gene variants and progression of nephropathy in hypercholesterolaemic patients with type 2 diabetes
    A Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Intern Med 256:30-6. 2004
    ..We evaluated the progression of renal disease in hypercholesterolaemic type 2 diabetic patients in relation to this polymorphism...
  31. ncbi Ultrasonic myocardial textural analysis in subclinical hypothyroidism
    V Di Bello
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Soc Echocardiogr 13:832-40. 2000
    ....
  32. doi Endothelial dysfunction in type 2 diabetes
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 55:1559-63. 2012
    ....
  33. doi Similar patterns of myocardial metabolism and perfusion in patients with type 2 diabetes and heart disease of ischaemic and non-ischaemic origin
    S Masi
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetologia 55:2494-500. 2012
    ..The aim of this study was to define the independent relationships between left ventricular dysfunction or ischaemia and patterns of myocardial perfusion and metabolism in type 2 diabetes...
  34. doi Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 11:157-66. 2009
    ..The primary objective was to demonstrate non-inferiority of vildagliptin vs. glimepiride in glycosylated haemoglobin (HbA(1c)) reduction at week 52...
  35. ncbi High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts
    A Solini
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Diabetologia 49:2499-506. 2006
    ....
  36. ncbi Thyroid involvement in patients with overt HCV-related mixed cryoglobulinaemia
    A Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    QJM 97:499-506. 2004
    ..The prevalence of thyroid disorders in MC has not yet been studied...
  37. ncbi The relationship of plasma catecholamine and lactate during anaerobic threshold exercise in mitochondrial myopathies
    G Siciliano
    Department of Neurosciences, Neurological Clinics, University of Pisa, Italy
    Neuromuscul Disord 9:411-6. 1999
    ..36 versus 1.48 and 2.40 versus 1.57, respectively). The study shows that the abnormal lactate production in mitochondrial myopathies is independent of the catecholaminergic response at the transition from aerobic to anaerobic exercise...
  38. ncbi Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertension
    A Quinones-Galvan
    CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    J Intern Med 250:322-6. 2001
    ..We tested whether blood pressure (BP) normalization can reverse this abnormality...
  39. ncbi Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state
    M Nannipieri
    Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 31:1843-8. 2007
    ....
  40. doi Body composition and common carotid artery remodeling in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 93:3325-32. 2008
    ..Body composition (BC) influences systemic hemodynamics and may participate in the remodeling of common carotid artery (CCA), independently of risk factors...
  41. ncbi Association between polymorphisms of the atrial natriuretic peptide gene and proteinuria: a population-based study
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetologia 46:429-32. 2003
    ..We evaluated the relationship between the ScaIand BstxI polymorphisms and albuminuria in the general population of the Mexico City Diabetes Study...
  42. ncbi Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures
    N Caraccio
    Metabolism and Endocrinology Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 90:1156-62. 2005
    ..Indeed, the development of hypothyroidism during type I IFN therapy may be related, at least in part, to an abnormal expression and function of key proteins involved in iodine uptake and organification...
  43. ncbi Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes
    A Antonelli
    Department of Internal Medicine and Metabolism Unit of the CNR Institute of Clinical Physiology, University of Pisa, Italy
    Diabetologia 45:1298-306. 2002
    ..We tested whether this new form of autoimmunity, (i). overlaps with anti-GAD autoimmunity, (ii). identifies an insulin-deficient phenotype, (iii). is under the influence of genetic factors...
  44. doi Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles
    L Pascoe
    The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 51:1989-92. 2008
    ..The aim of this study was to test the cumulative effects of diabetes-risk alleles on measures of beta cell function in non-diabetic individuals...
  45. doi Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
    Fabrice Bonnet
    Department of Medicine, Endocrinology Unit, Centre Hospitalier Universitaire, université Rennes, Rennes, France
    Diabetes Care 31:789-94. 2008
    ..The purpose of this study was to investigate the relationship between the ACE gene I/D polymorphism and both insulin sensitivity and glucose intolerance in a large cohort of healthy subjects...
  46. doi Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes
    A Mari
    C N R Institute of Biomedical Engineering, Padua, Italy
    Diabet Med 25:671-7. 2008
    ..To elucidate this phenomenon, we examined the relationships between fasting plasma glucose (FPG) and the secretory responses to an IVGTT and an oral glucose test (OGTT)...
  47. ncbi Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes
    A Gastaldelli
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Pharmacol Ther 81:205-12. 2007
    ..In mild-to-moderate T2D, pioglitazone monotherapy decreased fasting and post-prandial glycemia, principally via inhibition of gluconeogenesis, improved hepatic and peripheral insulin resistance...
  48. ncbi Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms
    E Bugianesi
    Division of Gastro Hepatology, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    Diabetologia 48:634-42. 2005
    ..However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition...
  49. ncbi CD38 autoimmunity: recent advances and relevance to human diabetes
    A Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    J Endocrinol Invest 27:695-707. 2004
    ..More information, however, is necessary to gauge the role of CD38 autoimmunity in the context of the natural history of human Type 1 or Type 2 diabetes...
  50. ncbi The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
    S A Hills
    EGIR RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetologia 47:566-70. 2004
    ....
  51. ncbi Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance
    E Ferrannini
    Metabolism Unit, C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 46:1211-9. 2003
    ..Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed...
  52. ncbi Mismatch between insulin-mediated glucose uptake and blood flow in the heart of patients with Type II diabetes
    P Iozzo
    Institute of Clinical Physiology, National Research Council CNR, Area di Ricerca San Cataldo, Via Moruzzi 1, 56100 Pisa, Italy
    Diabetologia 45:1404-9. 2002
    ..We investigated the effect of physiological hyperinsulinaemia on global and regional myocardial blood flow and glucose uptake in five patients with Type II (non-insulin-dependent) diabetes mellitus and seven healthy control subjects...
  53. ncbi Defective regulation and action of atrial natriuretic peptide in type 2 diabetes
    M Nannipieri
    Metabolism Unit of the C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi 8, 56100 Pisa, Italy
    Horm Metab Res 34:265-70. 2002
    ..We conclude that ANP release is resistant to volume stimulation in type 2 diabetic patients, and natriuresis is resistant to ANP action. This dual disruption of ANP control may play a role in blood pressure regulation in diabetes...
  54. ncbi Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    A Gastaldelli
    Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 50:1807-12. 2001
    ..In type 2 diabetes, the excess GNG of the fasting state is carried over to the insulinized state, thereby contributing to glucose overproduction under both conditions...
  55. ncbi Polymorphisms in the hANP (human atrial natriuretic peptide) gene, albuminuria, and hypertension
    M Nannipieri
    Department of Internal Medicine and Metabolism Unit of the CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pistoia, Italy
    Hypertension 37:1416-22. 2001
    ..hANP gene variants may exert a protective effect against the development and progression of kidney damage in diabetes...
  56. ncbi Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone
    Y Miyazaki
    University of Texas Health Science Center and Texas Diabetes Institute, San Antonio 78284-7886, USA
    Diabetes Care 24:710-9. 2001
    ..CONCLUSIONS: These results suggest that pioglitazone therapy in type 2 diabetic patients decreases lasting and postprandial plasma glucose levels by improving hepatic and peripheral (muscle) tissue sensitivity to insulin...
  57. ncbi The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
    R Kahn
    American Diabetes Association, 1701 N Beauregard Street, Alexandria, VA 22311, USA
    Diabetologia 48:1684-99. 2005
    ..The term 'metabolic syndrome' refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance...
  58. ncbi Hyperinsulinemia in glucose-tolerant women with preeclampsia. A controlled study
    E Martinez Abundis
    Hospital de Ginecoobstetricia, Centro Medico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico
    Am J Hypertens 9:610-4. 1996
    ..01). We conclude that preeclampsia is associated with marked hyperinsulinemia both in the fasting state and after oral glucose ingestion, suggesting that insulin resistance may play a role in pregnancy-induced hypertension...
  59. ncbi Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects
    M Walker
    Diabetes Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetologia 48:2470-6. 2005
    ..The aim of this prospective study was to investigate predictors of deteriorating glucose tolerance in subjects of British extraction...
  60. ncbi Insulin: in search of a syndrome
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School Medicine, Pisa, Italy
    Diabet Med 19:724-9. 2002
    ....
  61. ncbi Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function
    A Mari
    CNR Institute of Biomedical Engineering, Corso Stati Uniti 4, 35127, Padua, Italy
    Diabetologia 49:2136-43. 2006
    ..The aim of this study was to analyse the mechanisms underlying the improvement in glucose tolerance seen in morbidly obese patients undergoing bilio-pancreatic diversion (BPD)...
  62. ncbi Metabolic effects of glucose-insulin infusions: myocardium and whole body
    A Quinones-Galvan
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi, 8 I 56100 Pisa, Italy
    Curr Opin Clin Nutr Metab Care 4:157-63. 2001
    ..Its role as an adjunctive therapy in the management of myocardial infarction in non-diabetic individuals has been tested in several clinical trials; however, the evidence emerging from them is inconclusive...
  63. ncbi In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin
    P Iozzo
    MRC Clinical Sciences Centre, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Nucl Med Biol 29:73-82. 2002
    ..The heart, liver and kidneys were visualized using [(124)I]iodoinsulin with PET...
  64. ncbi Management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. Update regarding the thiazolidinediones
    D M Nathan
    Diabetes Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Diabetologia 51:8-11. 2008
  65. ncbi Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea
    A Mari
    National Research Council Institute of Biomedical Engineering, Padova, Italy
    Horm Metab Res 38:838-44. 2006
    ..This model suggests exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin+/-a sulfonylurea...
  66. ncbi Influence of gestational diabetes on the long-term control of glucose tolerance
    G Seghieri
    Division of Internal Medicine, Spedali Riuniti, Pistoia, Italy
    Diabetologia 50:2234-8. 2007
    ..Gestational diabetes (GDM) carries a high risk of subsequent diabetes. We asked what impact prior GDM has on beta cell function and insulin action in women who maintain normal glucose tolerance (NGT) for a long time...
  67. ncbi Effect of insulin on renal sodium and uric acid handling in essential hypertension
    E Muscelli
    Metabolism Unit, C.N.R. Institute of Clinical Physiology, Pisa, Italy
    Am J Hypertens 9:746-52. 1996
    ..Despite insulin resistance of glucose metabolism, acute physiological hyperinsulinemia causes normal antinatriuresis, antikaliuresis, and antiuricosuria in these patients...
  68. ncbi Acute vascular events and electrolytes variations in elderly patients
    A Solini
    Department of Internal Medicine University of Pisa, Italy
    Horm Metab Res 38:197-202. 2006
    ..This pattern is the physiological consequence of the attendant compensatory hyperinsulinemia. Its significance for the evolution of ischemic damage remains to be established...
  69. ncbi Anti-CD38 autoimmunity in children with newly diagnosed type 1 diabetes mellitus
    C Pupilli
    Endocrinology Unit, Azienda Ospedaliera Careggi and University of Florence, Italy
    J Pediatr Endocrinol Metab 18:1417-23. 2005
    ..To test for anti-CD38 autoimmunity in children with newly-diagnosed type 1 diabetes mellitus (DM1)...
  70. doi Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    Anushka Patel
    N Engl J Med 358:2560-72. 2008
    ..In patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain...
  71. ncbi Type 2 diabetes in hepatitis C-related mixed cryoglobulinaemia patients
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Rheumatology (Oxford) 43:238-40. 2004
    ..A possible link between HCV infection and type 2 diabetes has been suggested. This study evaluated the prevalence and clinical phenotype of diabetes in MC-HCV+ patients...
  72. ncbi Effect of short-term folic acid supplementation on insulin sensitivity and inflammatory markers in overweight subjects
    A Solini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Int J Obes (Lond) 30:1197-202. 2006
    ..In this study, we investigated the effect of folic acid supplementation on insulin sensitivity and peripheral markers of inflammation in overweight healthy subjects...
  73. ncbi Beta cell function and its relation to insulin action in humans: a critical appraisal
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Italy
    Diabetologia 47:943-56. 2004
    ..In fact, glucose excursions following glucose ingestion (i.e. glucose tolerance) are best explained by dynamic parameters of beta cell function...
  74. ncbi Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver
    P Iozzo
    Turku PET Centre, University of Turku, Finland
    Diabetologia 47:1149-56. 2004
    ..We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects...
  75. ncbi Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
    A Natali
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126, Pisa, Italy
    Diabetologia 49:434-41. 2006
    ..This review analyses the evidence relevant to these mechanisms in vivo...
  76. ncbi Rosiglitazone and lipid metabolism
    E Ferrannini
    Department of Internal Medicine and CNR, Institute of Clinical Physiology, University of Pisa School of Medicine, 56100 Pisa, Italy
    Diabetologia 48:6-7. 2005
  77. ncbi Visceral fat and beta cell function in non-diabetic humans
    A Gastaldelli
    CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 48:2090-6. 2005
    ..Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial...