Eusebio Chiefari

Summary

Country: Italy

Publications

  1. ncbi request reprint Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
    Daniela Foti
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Via T Campanella 115, 88100 Catanzaro, Italy
    Nat Med 11:765-73. 2005
  2. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
  3. doi request reprint Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Græcia, Viale Europa Loc Germaneto, Catanzaro 88100, Italy
    Nat Commun 1:40. 2010
  4. ncbi request reprint Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer
    Francesco Paonessa
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    Cancer Res 66:5085-93. 2006
  5. pmc Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2
    Eusebio Chiefari
    Department of Health Sciences, University Magna Græcia of Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
    PLoS ONE 8:e83969. 2013
  6. doi request reprint HMGA1 is a novel candidate gene for myocardial infarction susceptibility
    Salvatore De Rosa
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Int J Cardiol . 2016
  7. pmc A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression
    Eusebio Chiefari
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Sci Rep 6:39429. 2016
  8. pmc The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis
    Aida Bianco
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    PLoS ONE 10:e0136077. 2015
  9. pmc A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription
    Daniela Foti
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università degli Studi di Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Mol Cell Biol 23:2720-32. 2003
  10. pmc Cooperation between HMGA1 and HIF-1 Contributes to Hypoxia-Induced VEGF and Visfatin Gene Expression in 3T3-L1 Adipocytes
    Sebastiano Messineo
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Front Endocrinol (Lausanne) 7:73. 2016

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice
    Daniela Foti
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Via T Campanella 115, 88100 Catanzaro, Italy
    Nat Med 11:765-73. 2005
    ....
  2. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
    ..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed...
  3. doi request reprint Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Græcia, Viale Europa Loc Germaneto, Catanzaro 88100, Italy
    Nat Commun 1:40. 2010
    ..These data provide evidence for a regulatory role of an expressed pseudogene in humans and establishes a novel mechanistic linkage between pseudogene HMGA1-p expression and type 2 diabetes mellitus...
  4. ncbi request reprint Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer
    Francesco Paonessa
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    Cancer Res 66:5085-93. 2006
    ..Our findings support this hypothesis and suggest that in affected individuals, hyperactivation of the AP-2 gene through the overexpression of IR may play a key role in breast carcinogenesis...
  5. pmc Transcriptional regulation of the HMGA1 gene by octamer-binding proteins Oct-1 and Oct-2
    Eusebio Chiefari
    Department of Health Sciences, University Magna Græcia of Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
    PLoS ONE 8:e83969. 2013
    ..Furthermore, they consistently support the hypothesis that a putative defect in Oct-1 and/or Oct-2, by affecting HMGA1 expression, may cause INSR dysfunction, leading to defects of the INSR signaling pathway. ..
  6. doi request reprint HMGA1 is a novel candidate gene for myocardial infarction susceptibility
    Salvatore De Rosa
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Int J Cardiol . 2016
    ..An association of the HMGA1 rs146052672 variant with T2DM has been recently reported. Thus, our aim was to evaluate whether this variant was also associated with AMI...
  7. pmc A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression
    Eusebio Chiefari
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Sci Rep 6:39429. 2016
    ..These data provide new insights into the pathogenesis and progression of DR, and may offer opportunities for discovering novel biomarkers and therapeutic targets for diagnosis, prevention and treatment of PDR...
  8. pmc The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis
    Aida Bianco
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    PLoS ONE 10:e0136077. 2015
    ..Also, in the light of this result, it would appear to be highly desirable that further in-depth investigations should be undertaken to elucidate the biological significance of the HMGA1 rs146052672 variant. ..
  9. pmc A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription
    Daniela Foti
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università degli Studi di Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Mol Cell Biol 23:2720-32. 2003
    ....
  10. pmc Cooperation between HMGA1 and HIF-1 Contributes to Hypoxia-Induced VEGF and Visfatin Gene Expression in 3T3-L1 Adipocytes
    Sebastiano Messineo
    Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Front Endocrinol (Lausanne) 7:73. 2016
    ..Therefore, our findings provide evidence for molecular cross-talk between HMGA1 and HIF-1, and this may be important for elucidating protein and gene networks relevant to obesity. ..
  11. doi request reprint Add-On Treatment with Liraglutide Improves Glycemic Control in Patients with Type 2 Diabetes on Metformin Therapy
    Eusebio Chiefari
    1 Department of Health Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Diabetes Technol Ther 17:468-74. 2015
    ..We aimed to assess the efficacy and safety of liraglutide versus glimepiride, as adjunct treatments to metformin, in achieving glycemic control in Italian patients with T2DM uncontrolled by metformin alone...