Antonella Zucchetto

Summary

Affiliation: Centro di Riferimento Oncologico
Country: Italy

Publications

  1. doi request reprint Screening patterns within organized programs and survival of Italian women with invasive cervical cancer
    Antonella Zucchetto
    Epidemiology and Biostatistics Unit, Aviano National Cancer Institute Centro di riferimento oncologico, Via Gallini 2, 33081 Aviano PN, Italy
    Prev Med 57:220-6. 2013
  2. ncbi request reprint [AIDS and injecting drug use: survival determinants in the highly active antiretroviral therapy era]
    Antonella Zucchetto
    Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, Via F Gallini 2, Aviano PN
    Epidemiol Prev 33:184-9. 2009
  3. doi request reprint Excess mortality for non–AIDS-defining cancers among people with AIDS
    Antonella Zucchetto
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Clin Infect Dis 51:1099-101. 2010
  4. ncbi request reprint Cigarette smoking and endometrial cancer risk: the modifying effect of obesity
    Jerry Polesel
    SOC Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Eur J Cancer Prev 18:476-81. 2009
  5. doi request reprint Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features
    Riccardo Bomben
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Clin Cancer Res 16:620-8. 2010
  6. doi request reprint Effect of obesity and other lifestyle factors on mortality in women with breast cancer
    Luigino Dal Maso
    Unita di Epidemiologia e Biostatistica, Centro Riferimento Oncologico, Aviano, Italy
    Int J Cancer 123:2188-94. 2008
  7. doi request reprint Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer
    Antonella Zucchetto
    SOC Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, Aviano PN, Italy
    Int J Cancer 123:2213-6. 2008
  8. doi request reprint Fiber intake and endometrial cancer risk
    Ettore Bidoli
    Struttura Operativa Complessa di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, PN, Italy
    Acta Oncol 49:441-6. 2010
  9. ncbi request reprint Hormone-related factors and gynecological conditions in relation to endometrial cancer risk
    Antonella Zucchetto
    SOC Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Eur J Cancer Prev 18:316-21. 2009
  10. doi request reprint The impact of Kaposi sarcoma and non-Hodgkin lymphoma on mortality of people with AIDS in the highly active antiretroviral therapies era
    Diego Serraino
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Via F Gallini 2, Aviano PN, Italy
    Cancer Epidemiol 34:257-61. 2010

Detail Information

Publications44

  1. doi request reprint Screening patterns within organized programs and survival of Italian women with invasive cervical cancer
    Antonella Zucchetto
    Epidemiology and Biostatistics Unit, Aviano National Cancer Institute Centro di riferimento oncologico, Via Gallini 2, 33081 Aviano PN, Italy
    Prev Med 57:220-6. 2013
    ..To evaluate screening patterns within organized cervical screening programs (OCSPs) and survival of women with invasive cervical cancer (ICC)...
  2. ncbi request reprint [AIDS and injecting drug use: survival determinants in the highly active antiretroviral therapy era]
    Antonella Zucchetto
    Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, Via F Gallini 2, Aviano PN
    Epidemiol Prev 33:184-9. 2009
    ....
  3. doi request reprint Excess mortality for non–AIDS-defining cancers among people with AIDS
    Antonella Zucchetto
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Clin Infect Dis 51:1099-101. 2010
    ..The risk of death was 6.6-fold higher than in the general population, being particularly elevated for virus-related cancers. The study findings highlighted the importance of monitoring the cancer burden on mortality for people with AIDS...
  4. ncbi request reprint Cigarette smoking and endometrial cancer risk: the modifying effect of obesity
    Jerry Polesel
    SOC Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Eur J Cancer Prev 18:476-81. 2009
    ..This finding calls for caution in interpreting the favorable effects of cigarette smoking, considering the toxic and carcinogenic effects of tobacco...
  5. doi request reprint Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features
    Riccardo Bomben
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Clin Cancer Res 16:620-8. 2010
    ..Here we investigated novel associations between usage of specific IGHV genes and clinical features in CLL...
  6. doi request reprint Effect of obesity and other lifestyle factors on mortality in women with breast cancer
    Luigino Dal Maso
    Unita di Epidemiologia e Biostatistica, Centro Riferimento Oncologico, Aviano, Italy
    Int J Cancer 123:2188-94. 2008
    ..High BMI was the lifestyle risk factor that most consistently modified breast cancer prognosis in our study...
  7. doi request reprint Reproductive, menstrual, and other hormone-related factors and risk of renal cell cancer
    Antonella Zucchetto
    SOC Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, Aviano PN, Italy
    Int J Cancer 123:2213-6. 2008
    ..Our findings give support to a role of hysterectomy in increasing RCC risk without corroborating, however, a major role of female hormone-related factors...
  8. doi request reprint Fiber intake and endometrial cancer risk
    Ettore Bidoli
    Struttura Operativa Complessa di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, PN, Italy
    Acta Oncol 49:441-6. 2010
    ..Consequently, a case-control study was carried out to further investigate the role of dietary fiber intake in the etiology of endometrial cancer...
  9. ncbi request reprint Hormone-related factors and gynecological conditions in relation to endometrial cancer risk
    Antonella Zucchetto
    SOC Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Eur J Cancer Prev 18:316-21. 2009
    ..In conclusion, this study confirms the importance of multiparity, years of menstruation, and oral contraceptive use in endometrial cancer etiology, thus contributing to identify women at elevated risk of such neoplasm...
  10. doi request reprint The impact of Kaposi sarcoma and non-Hodgkin lymphoma on mortality of people with AIDS in the highly active antiretroviral therapies era
    Diego Serraino
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Via F Gallini 2, Aviano PN, Italy
    Cancer Epidemiol 34:257-61. 2010
    ..We aimed at quantifying the burden of KS and NHL on mortality of PWA in the HAART period in Italy...
  11. doi request reprint Macronutrients, fatty acids, cholesterol and renal cell cancer risk
    Ettore Bidoli
    Unita di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano PN, Italy
    Int J Cancer 122:2586-9. 2008
    ..Results were consistent in strata of age, body mass index, treated hypertension, energy intake, stage and family history of RCC...
  12. doi request reprint Consumption of fruit, vegetables, and other food groups and the risk of nasopharyngeal carcinoma
    Jerry Polesel
    Unit of Epidemiology and Biostatistics, Centro di Riferimento OncologicoI, IRCCS, Via Franco Gallini, 2, 33081, Aviano, PN, Italy
    Cancer Causes Control 24:1157-65. 2013
    ..This study aimed to investigate the relationship between NPC risk and a wide range of food groups in the Italian population...
  13. pmc Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells
    Francesca M Rossi
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    J Transl Med 8:23. 2010
    ..The aim of this study was to assess the prognostic significance of these methods in comparison with another in which ZAP-70 expression was evaluated as a Mean-Fluorescence-Intensity Ratio between gated T and CLL cells (T/B Ratio-method)...
  14. doi request reprint Dietary vitamins E and C and prostate cancer risk
    Ettore Bidoli
    Unita di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy
    Acta Oncol 48:890-4. 2009
    ..The epidemiologic evidence on dietary vitamins E and C and prostate cancer is controversial. Therefore, a case-control study was carried out to investigate the role of dietary intake of vitamins E and C in the etiology of prostate cancer...
  15. doi request reprint Survival after AIDS diagnosis in Italy, 1999-2006: a population-based study
    Diego Serraino
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    J Acquir Immune Defic Syndr 52:99-105. 2009
    ..To provide survival estimates of Italian people with AIDS (PWA) in the highly active antiretroviral therapy era and to identify prognostic factors at diagnosis and illnesses present at death...
  16. doi request reprint Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study
    Riccardo Bomben
    Clinical and Experimental Onco Haematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Br J Haematol 144:492-506. 2009
    ..Altogether, our analysis identified additional molecular and clinical features for CLL expressing stereotyped BCR...
  17. ncbi request reprint The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma
    Renato Talamini
    Unit of Epidemiology and Biostatistics, National Cancer Institute, Aviano, Italy
    Int J Cancer 122:1624-9. 2008
    ..Our findings strongly encourage physicians to advice NHL patients to stop smoking and diminish alcohol consumption to obtain improvements in the course of NHL...
  18. doi request reprint Microenvironmental interactions in chronic lymphocytic leukemia: the master role of CD49d
    Michele Dal Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Semin Hematol 51:168-76. 2014
    ....
  19. ncbi request reprint Renal cell cancer and body size at different ages: an Italian multicenter case-control study
    Luigino Dal Maso
    S O C Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano PN, Italy
    Am J Epidemiol 166:582-91. 2007
    ..RCC risks among overweight and obese persons were apparently higher in never smokers, persons with the clear-cell histologic type, and persons with a Fuhrman nuclear grade of G3-G4...
  20. doi request reprint Changes in cervical cancer incidence following the introduction of organized screening in Italy
    Diego Serraino
    Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, Aviano, Italy
    Prev Med 75:56-63. 2015
    ..To quantify the impact of organized cervical screening programs (OCSPs) on the incidence of invasive cervical cancer (ICC), comparing rates before and after activation of OCSPs...
  21. doi request reprint Screening history of women with invasive cervical cancer in north-east Italy
    Antonella Zucchetto
    Epidemiology and Biostatistics Unit, Centro di Riferimento Oncologico, Aviano PN 33081, Italy
    Eur J Obstet Gynecol Reprod Biol 152:200-4. 2010
    ..To investigate associations between screening histories in relation to women's survival and tumor characteristics, with a focus on organized and opportunistic screenings...
  22. doi request reprint Cancer incidence in people with AIDS in Italy
    Jerry Polesel
    Epidemiology and Biostatistics Unit, Centro di Riferimento Oncologico IRCCS, Aviano, Pordenone, Italy
    Int J Cancer 127:1437-45. 2010
    ..This scenario calls, however, for the intensification of cancer-prevention strategies, notably smoking cessation and screening programs, in middle-aged HIV-patients...
  23. pmc Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases
    Diego Serraino
    Unit of Epidemiology and Biostatistics, Centro di Riferimento Onocologico, IRCCS, Aviano, Italy
    AIDS Res Ther 7:11. 2010
    ..In comparison with the general population, the risks of death were 6.4-fold higher for DM (95% CI:3.5-10.8), 2.3-fold higher for myocardial infarction (95% CI:1.4-3.7) and 3.0 for chronic ischemic heart diseases (95% CI: 1.5-5.2)...
  24. doi request reprint CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival
    Antonella Zucchetto
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy
    Cancer Res 69:4001-9. 2009
    ..Altogether, CD38 and CD49d can be thought of as parts of a consecutive chain of events ultimately leading to improved survival of CLL cells...
  25. doi request reprint CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism
    Antonella Zucchetto
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Blood 122:3317-21. 2013
    ..This may help explain the clinicobiological features of trisomy 12 CLL, including the high rates of cell proliferation and disease progression, lymph node involvement, and predisposition to Richter syndrome transformation...
  26. ncbi request reprint Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy
    Michele Dal Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano, PN, Italy
    Curr Pharm Des 18:3323-34. 2012
    ..An overview of the putative drugs that could be employed to target specific molecules involved in CLL cells/tumor microenvironment interactions is also proposed in the closing chapter of the review...
  27. pmc Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance
    Michele Dal-Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    J Transl Med 7:76. 2009
    ..g. specific receptor/ligand interactions, such as CD38/CD31 or CD49d/VCAM-1. A putative final model, discussing the pathogenesis and the clinicobiological features of CLL in relationship of these factors, is also provided...
  28. doi request reprint Cluster analysis of immunophenotypic data: the example of chronic lymphocytic leukemia
    Antonella Zucchetto
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Via Franco Gallini 2, Aviano PN, Italy
    Immunol Lett 134:137-44. 2011
    ..These suggestions need to be confirmed: (i) in a new set of clinically characterized CLL cases; (ii) in combination with other prognostic markers in the context of comprehensive scoring systems for clinical outcome prediction...
  29. doi request reprint NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment
    Michele Dal Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano, PN, Italy
    Ann Hematol 93:1765-74. 2014
    ..001). The presence of NOTCH1 mutations identifies a CLL subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment...
  30. doi request reprint Duration and intensity of tobacco smoking and the risk of papillary and non-papillary transitional cell carcinoma of the bladder
    Jerry Polesel
    Unit of Epidemiology and Biostatistics, IRCCS CRO Aviano National Cancer Institute, Via F Gallini 2, 33081, Aviano, PN, Italy
    Cancer Causes Control 25:1151-8. 2014
    ..To evaluate the impact of tobacco smoking on specific histological subtypes of transitional cell carcinoma of the bladder (TCC)...
  31. ncbi request reprint ZAP-70 expression in B-cell chronic lymphocytic leukemia: evaluation by external (isotypic) or internal (T/NK cells) controls and correlation with IgV(H) mutations
    Antonella Zucchetto
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Cytometry B Clin Cytom 70:284-92. 2006
    ....
  32. ncbi request reprint Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
    Valter Gattei
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico Aviano, Italy
    Blood 111:865-73. 2008
    ..95; P=.002) cases. These findings support the introduction of CD49d detection in routine prognostic assessment of CLL patients, and suggest both pathogenetic and therapeutic implications for CD49d expression in CLL...
  33. pmc The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells
    Michele Dal Bo
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano, Pordenone, Italy
    Oncotarget 6:19102-17. 2015
    ..41; P = 0.02). Collectively, the miR-132/SIRT1/TP53 axis was identified as a novel pathway triggered by BCR engagement that further increases the complexity of the interactions between tumor microenvironments and CLL cells. ..
  34. ncbi request reprint Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
    Riccardo Bomben
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Aviano PN, Italy
    Blood 109:2989-98. 2007
    ..Altogether, IGHV3-21 CLLs, including those with homHCDR3, had a peculiar global phenotype in part explaining their worse clinical outcome...
  35. ncbi request reprint Lifetime occupational and recreational physical activity and risk of benign prostatic hyperplasia
    Luigino Dal Maso
    Unita di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano PN, Italy
    Int J Cancer 118:2632-5. 2006
    ..A moderate PA at any ages may help reducing a sizeable number of BPH...
  36. pmc Pattern of cancer risk in persons with AIDS in Italy in the HAART era
    L Dal Maso
    Epidemiology and Biostatistics Unit, Centro di Riferimento Oncologico IRCCS, Aviano, Italy
    Br J Cancer 100:840-7. 2009
    ..Improvements in the timely identification of HIV-positive individuals are also a priority in Italy to avoid the adverse consequences of delayed HAART use...
  37. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
    ..Our results indicate that stathmin plays a significant role in tumor metastasis formation, a finding that could lead to exploitation of stathmin as a target of new antimetastatic drugs...
  38. doi request reprint The negative impact of tobacco smoking on survival after prostate cancer diagnosis
    Jerry Polesel
    Epidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, IRCCS, via F Gallini no 2, 33081, Aviano, Italy
    Cancer Causes Control 26:1299-305. 2015
    ..This study investigated the role of smoking on long-term survival after PCa diagnosis...
  39. pmc Potential therapeutic role of antagomiR17 for the treatment of chronic lymphocytic leukemia
    Sara Dereani
    Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, I, R, C, C, S, Via Franco Gallini 2, Aviano, PN, Italy
    J Hematol Oncol 7:79. 2014
    ..Altogether, our results provide the rationale for the use of antagomiR17 as a novel potential therapeutic tool in CLL and in other lymphoproliferative disorders where miR-17 has a driver role in tumor progression. ..
  40. ncbi request reprint Laminin-332 (Laminin-5) is the major motility ligand for B cell chronic lymphocytic leukemia
    Paola Spessotto
    Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Matrix Biol 26:473-84. 2007
    ....
  41. ncbi request reprint A scoring system based on the expression of six surface molecules allows the identification of three prognostic risk groups in B-cell chronic lymphocytic leukemia
    Antonella Zucchetto
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    J Cell Physiol 207:354-63. 2006
    ..The proposed immunophenotypic scoring system may be an additional useful tool in routine diagnostic/prognostic procedures for B-CLL...
  42. ncbi request reprint Estimating dose-response relationship between ethanol and risk of cancer using regression spline models
    Jerry Polesel
    Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Italy
    Int J Cancer 114:836-41. 2005
    ....
  43. ncbi request reprint Signature of B-CLL with different prognosis by Shrunken centroids of surface antigen expression profiling
    Antonella Zucchetto
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    J Cell Physiol 204:113-23. 2005
    ..Our findings contribute to improve the immunophenotypical identification of disease subsets with different prognosis and suggest a set of surface antigens to be employed as prognosticators in routine diagnostic/prognostic procedures...
  44. ncbi request reprint Surface-antigen expression profiling (SEP) in B-cell chronic lymphocytic leukemia (B-CLL): Identification of markers with prognostic relevance
    Antonella Zucchetto
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Via Pedemontana Occidentale, 12, Aviano PN, Italy
    J Immunol Methods 305:20-32. 2005
    ..These mAbs may represent potentially novel markers with prognostic relevance in B-CLLs...