Giuliano Binetti

Summary

Country: Italy

Publications

  1. ncbi request reprint Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patients
    Giuliano Binetti
    Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 338:85-7. 2003
  2. ncbi request reprint Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
    Neurobiol Aging 28:371-6. 2007
  3. ncbi request reprint The H2 MAPT haplotype is associated with familial frontotemporal dementia
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Dis 22:357-62. 2006
  4. ncbi request reprint Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Exp Cell Res 308:78-84. 2005
  5. ncbi request reprint A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
  6. pmc H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers
    Elisa Canu
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Eur J Hum Genet 17:287-94. 2009
  7. doi request reprint Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 18:295-303. 2009
  8. ncbi request reprint The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:266-76. 2009
  9. pmc A window into the heterogeneity of human cerebrospinal fluid Aβ peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Biomed Biotechnol 2011:697036. 2011
  10. ncbi request reprint Optimization protocol for amyloid-β peptides detection in human cerebrospinal fluid using SELDI TOF MS
    Valentina Albertini
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Proteomics Clin Appl 4:352-7. 2010

Collaborators

  • Roberta Ghidoni
  • Simone Lista
  • Ferdinando Squitieri
  • Flavia Mattioli
  • Efrat Levy
  • Enzo Emanuele
  • G B Frisoni
  • Rosanna Squitti
  • Gilberto Corbellini
  • Amalia C Bruni
  • Barbara Borroni
  • Davide Seripa
  • Giorgio Bono
  • Giuseppe Micieli
  • Luisa Benussi
  • Marina Boccardi
  • Catia Scassellati
  • Matteo Bonetti
  • Cristina Testa
  • Anna Paterlini
  • Massimo Gennarelli
  • Francesca Nicosia
  • Valentina Albertini
  • Elisa Canu
  • Samantha Galluzzi
  • Antonella Alberici
  • Simona Signorini
  • Luisella Bocchio-Chiavetto
  • Laura Barbiero
  • Marta Giacomello
  • Mariacarla Ventriglia
  • Andreas Papassotiropoulos
  • Cristina Cereda
  • Anna Bruno
  • Michela Pievani
  • Lorena Bresciani
  • Enrico Piovan
  • Giuseppe Magnani
  • Alberto Beltramello
  • Giorgio Minonzio
  • Andrea Falini
  • Thomas Bettecken
  • Thomas Meitinger
  • Elena Sina
  • Lara Gigola
  • John H Growdon
  • Maria Cotelli
  • Alessandro Padovani
  • Carlo P Trevisan
  • Cristina Geroldi
  • Paolo M Rossini
  • Mario Armani
  • Tullio Pozzan
  • Giancarlo Zatti
  • Paola Pizzo
  • Luisella Bocchio Chiavetto
  • Paolo Maria Rossini
  • Antonella C Alberici
  • Cristina Fasolato
  • Cristian Bonvicini
  • Roberta Zanardini
  • Emanuele Cassetta
  • Orazio Zanetti
  • Magdalini Tsolaki
  • Thomas Hegi
  • Johannes R Streffer
  • Dieter Lutjohann
  • Annette Brühl
  • Alessia Maddalena
  • Simon Schmid
  • Thomas Pasch
  • Muriel Träxler
  • Estifanos Ghebremedhin
  • Dietmar Thal
  • Christoph Hock
  • Heiko Braak
  • Vassiliki Iakovidou
  • Roger M Nitsch

Detail Information

Publications24

  1. ncbi request reprint Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patients
    Giuliano Binetti
    Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 338:85-7. 2003
    ..6%); based on our results we could argue the existence of other mutations in regulatory regions in the TAU gene or, on the other hand, other genes might be responsible for the most cases of familial FTD...
  2. ncbi request reprint Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
    Neurobiol Aging 28:371-6. 2007
    ..The consequent reduction in the cystatin C extracellular levels might result in a failure of neuroregeneration. Understanding the interplay of PS2 and cystatin C in the pathogenesis of AD might highlight new therapeutic prospective...
  3. ncbi request reprint The H2 MAPT haplotype is associated with familial frontotemporal dementia
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Dis 22:357-62. 2006
    ..67, P = 0.001). Our results support idea that the MAPT H2 haplotype is a risk factor for FFTD. This locus could contain this or other inheritable genetic determinants contributing to increase risk of developing dementia...
  4. ncbi request reprint Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Exp Cell Res 308:78-84. 2005
    ..We restored the impaired interaction by inducing heat shock proteins 70 and 90. In addition, we show that P301L tau mutation strongly affects tau and alpha-synuclein neuronal distribution...
  5. ncbi request reprint A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
    ..Despite the profound differences in the biological functions of the encoded proteins, it is not possible to define a clinical phenotype distinguishing the disease caused by mutations in MAPT and PGRN genes...
  6. pmc H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers
    Elisa Canu
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Eur J Hum Genet 17:287-94. 2009
    ..The data suggest that H1 haplotype is associated with a particular cerebral morphology that may increase the susceptibility of the healthy carriers to develop neurodegenerative diseases such as sporadic tauopathies...
  7. doi request reprint Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 18:295-303. 2009
    ..The AbetaPP T719P mutation is of particular interest because it is the only mutation located in close proximity to the AbetaPP epsilon-cleavage site...
  8. ncbi request reprint The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:266-76. 2009
    ....
  9. pmc A window into the heterogeneity of human cerebrospinal fluid Aβ peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Biomed Biotechnol 2011:697036. 2011
    ..Finally, we suggest that Aβ peptides as well as other key signals in the central nervous system (CNS), mainly involved in learning and hence plasticity, may have a double-edged sword action on neuron survival and function...
  10. ncbi request reprint Optimization protocol for amyloid-β peptides detection in human cerebrospinal fluid using SELDI TOF MS
    Valentina Albertini
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Proteomics Clin Appl 4:352-7. 2010
    ..The aim of the present work was to set up an optimized protocol for human cerebrospinal fluid amyloid-β (Aβ) profiling...
  11. ncbi request reprint Atypical dementia associated with a novel presenilin-2 mutation
    Giuliano Binetti
    Neurobiology Lab and Memory Clinic, IRCCS Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Ann Neurol 54:832-6. 2003
    ..These observations suggest the importance of still unknown biological and perhaps environmental factors in the disease determination...
  12. doi request reprint Plasma cystatin C and risk of developing Alzheimer's disease in subjects with mild cognitive impairment
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 22:985-91. 2010
    ....
  13. ncbi request reprint Presenilin 2 is secreted in mouse primary neurons: a release enhanced by apoptosis
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
    Mech Ageing Dev 128:350-3. 2007
    ..8-fold more than PS1. During apoptosis either proteins were colocalized especially within shedded vesicles. The present study suggest an active role for the presenilins CTF on putative target cells...
  14. ncbi request reprint Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
    Neurobiol Dis 18:638-48. 2005
    ..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated...
  15. ncbi request reprint Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
    Neurosci Lett 353:201-4. 2003
    ..011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD...
  16. ncbi request reprint Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    Catia Scassellati
    Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurosci Lett 356:119-22. 2004
    ..Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD...
  17. ncbi request reprint Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Dement Geriatr Cogn Disord 18:189-96. 2004
    ..Our results demonstrate that possession of at least one LMW apo(a) isoform is significantly associated with dementia and specifically offer new evidence of a strong association between the lipoprotein system and post-stroke dementia...
  18. doi request reprint Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurosci Lett 434:304-9. 2008
    ..This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve...
  19. ncbi request reprint Tau missing from CSF: a case report
    Antonella Alberici
    J Neurol 254:107-9. 2007
  20. ncbi request reprint The heterogeneity and natural history of mild cognitive impairment
    Giovanni B Frisoni
    Arch Neurol 62:163; author reply 163-4. 2005
  21. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006
    ....
  22. ncbi request reprint Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
    Davide Seripa
    Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
    Neurobiol Aging 26:455-64. 2005
    ....
  23. ncbi request reprint Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease
    Mariacarla Ventriglia
    Genetics Unit, IRCCS S Giovanni di Dio, Ospedale Fatebenefratelli, Brescia, Italy
    Aging Clin Exp Res 17:445-8. 2005
    ..The object of this study was to investigate the association between this polymorphism of the MnSOD gene and AD in the Italian population...
  24. ncbi request reprint Increased brain beta-amyloid load, phosphorylated tau, and risk of Alzheimer disease associated with an intronic CYP46 polymorphism
    Andreas Papassotiropoulos
    Division of Pychiatry Research, University of Zurich, Switzerland
    Arch Neurol 60:29-35. 2003
    ..CYP46, the gene encoding cholesterol 24-hydroxylase, plays a key role in the hydroxylation of cholesterol and thereby mediates its removal from brain...