Laura Amato

Summary

Affiliation: Agency for Public Health
Country: Italy

Publications

  1. ncbi Methadone at tapered doses for the management of opioid withdrawal
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2004
  2. ncbi Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2004
  3. ncbi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, 00198, Lazio, Italy
    Cochrane Database Syst Rev . 2004
  4. ncbi Methadone at tapered doses for the management of opioid withdrawal
    L Amato
    Cochrane Drugs and Alcohol Group, Department of Epidemiology ASL RME, Via di Santa Costanza, 53, Roma, Italy, 00198
    Cochrane Database Syst Rev . 2005
  5. doi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2008
  6. doi Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2008
  7. ncbi Antipsychotic medications for cocaine dependence
    L Amato
    ASL RM E, Deparment of Epidemiology, Via di Santa Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2007
  8. doi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2008
  9. doi Cochrane systematic reviews in the field of addiction: what's there and what should be
    Laura Amato
    Department of Epidemiology, Lazio Region, via di S Costanza 53, 00198 Rome, Italy
    Drug Alcohol Depend 113:96-103. 2011
  10. ncbi An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research
    Laura Amato
    Department of Epidemiology, 00198 Rome, Italy
    J Subst Abuse Treat 28:321-9. 2005

Collaborators

Detail Information

Publications38

  1. ncbi Methadone at tapered doses for the management of opioid withdrawal
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2004
    ..Despite widespread use in many countries of tapered methadone for detoxification from opiate dependence, the evidence of efficacy to prevent relapse and promote lifestyle change has not been systematically evaluated...
  2. ncbi Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2004
    ..Methadone maintenance at proper doses is effective in retaining patients in treatment and suppressing heroin use. Questions remain regarding the efficacy of the psychosocial services that are offered by most maintenance programs...
  3. ncbi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    L Amato
    Dep of Epidemiology, ASL RM E, via di S Costanza 53, Rome, 00198, Lazio, Italy
    Cochrane Database Syst Rev . 2004
    ..Some studies have suggested that the sorts of symptoms which are most distressing to addicts during detoxification are psychological symptoms rather than physiological symptoms associated with the withdrawal syndrome...
  4. ncbi Methadone at tapered doses for the management of opioid withdrawal
    L Amato
    Cochrane Drugs and Alcohol Group, Department of Epidemiology ASL RME, Via di Santa Costanza, 53, Roma, Italy, 00198
    Cochrane Database Syst Rev . 2005
    ..Despite widespread use in many countries the evidence of tapered methadone's efficacy in managing opioid withdrawal has not been systematically evaluated...
  5. doi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2008
    ..Some studies have suggested that the sorts of symptoms which are most distressing to addicts during detoxification are psychological rather than physiological symptoms associated with the withdrawal syndrome...
  6. doi Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2008
    ..Maintenance treatments are effective in retaining patients in treatment and suppressing heroin use. Questions remain regarding the efficacy of additional psychosocial services offered by most maintenance programs...
  7. ncbi Antipsychotic medications for cocaine dependence
    L Amato
    ASL RM E, Deparment of Epidemiology, Via di Santa Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2007
    ..Cocaine dependence remains a disorder for which no pharmacological treatment of proven efficacy exists, although considerable advances in the neurobiology of this addiction could guide future medication development..
  8. doi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    Laura Amato
    Deparment of Epidemiology, ASL RM E, Via di Santa Costanza 53, Rome, Lazio, Italy, 00198
    Cochrane Database Syst Rev . 2008
    ..Some studies have suggested that the sorts of symptoms which are most distressing to addicts during detoxification are psychological rather than physiological symptoms associated with the withdrawal syndrome...
  9. doi Cochrane systematic reviews in the field of addiction: what's there and what should be
    Laura Amato
    Department of Epidemiology, Lazio Region, via di S Costanza 53, 00198 Rome, Italy
    Drug Alcohol Depend 113:96-103. 2011
    ..Cochrane reviews provide information on the most effective treatments, particularly in the area of opioid and alcohol dependence, and help clarify areas for further research...
  10. ncbi An overview of systematic reviews of the effectiveness of opiate maintenance therapies: available evidence to inform clinical practice and research
    Laura Amato
    Department of Epidemiology, 00198 Rome, Italy
    J Subst Abuse Treat 28:321-9. 2005
    ..To summarize the major findings of the five Cochrane reviews on substitution maintenance treatments for opioid dependence...
  11. ncbi VEdeTTE, a longitudinal study on effectiveness of treatments for heroin addiction in Italy: study protocol and characteristics of study population
    Anna Maria Bargagli
    Department of Epidemiology, ASL Rome E, Rome, Italy
    Subst Use Misuse 41:1861-79. 2006
    ..The Italian heroin-addicted population under treatment seems to have low level of education but good social integration. Compared with men, women show a higher severity. Participants show a beneficial effect of treatment...
  12. ncbi Effectiveness of interventions on opiate withdrawal treatment: an overview of systematic reviews
    Laura Amato
    Department of Epidemiology, Via S Costanza, 53, 00198 Rome, Italy
    Drug Alcohol Depend 73:219-26. 2004
    ..To provide an overview of 5 Cochrane reviews of different approaches for treating opioid withdrawal...
  13. doi Methadone at tapered doses for the management of opioid withdrawal
    Laura Amato
    Department of Epidemiology, Lazio Regional Health Service, Rome
    Cochrane Database Syst Rev . 2013
    ..The evidence of tapered methadone's efficacy in managing opioid withdrawal has been systematically evaluated in the previous version of this review that needs to be updated..
  14. doi Dopamine agonists for the treatment of cocaine dependence
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 5:CD003352. 2015
    ..Cocaine misuse is a disorder for which no pharmacological treatment of proven efficacy exists. Advances in neurobiology could guide future medication development...
  15. doi Maintenance agonist treatments for opiate-dependent pregnant women
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 12:CD006318. 2013
    ..Neonatal complications include narcotic withdrawal, postnatal growth deficiency, microcephaly, neuro-behavioural problems, increased neonatal mortality and a 74-fold increase in sudden infant death syndrome...
  16. ncbi Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
    Laura Amato
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 9:CD005031. 2011
    ..Some studies have suggested that the sorts of symptoms which are most distressing to addicts during detoxification are psychological rather than physiological symptoms associated with the withdrawal syndrome...
  17. doi Anticonvulsants for cocaine dependence
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 4:CD006754. 2015
    ..Anticonvulsants have been candidates for use in the treatment of addiction based on the hypothesis that seizure kindling-like mechanisms contribute to addiction...
  18. ncbi Methadone treatment in clinical practice in Italy: need for improvement
    Patrizia Schifano
    Department of Epidemiology, ASL Rome E, Rome, Italy
    Eur Addict Res 12:121-7. 2006
    ..Methadone at appropriate doses has been demonstrated to be the most effective means for retaining patients in treatment and suppressing heroin use...
  19. ncbi Anticonvulsants for alcohol withdrawal
    Silvia Minozzi
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 3:CD005064. 2010
    ..Anticonvulsants seem to have limited side effects, although adverse effects are not rigorously reported in the analysed trials...
  20. ncbi Oral naltrexone maintenance treatment for opioid dependence
    Silvia Minozzi
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 4:CD001333. 2011
    ..Research on clinical application of oral naltrexone agrees on several things. From a pharmacological perspective, naltrexone works. From an applied perspective, the medication compliance and the retention rates are poor...
  21. doi The role of Cochrane reviews in informing international guidelines: a case study of using the Grading of Recommendations, Assessment, Development and Evaluation system to develop World Health Organization guidelines for the psychosocially assisted pharmac
    Marina Davoli
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
    Addiction 110:891-8. 2015
    ..We consider how successful this approach has been...
  22. doi WITHDRAWN: Anticonvulsants for cocaine dependence
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 3:CD006754. 2015
    ..Anticonvulsants have been candidates for the treatment of addiction based on the hypothesis that seizure kindling-like mechanisms contribute to addiction...
  23. pmc Does direction of results of abstracts submitted to scientific conferences on drug addiction predict full publication?
    Simona Vecchi
    Department of Epidemiology, Italian National Health Service, Local Health Unit Rome E, Via di S, Costanza, 53, 00198 Rome, Italy
    BMC Med Res Methodol 9:23. 2009
    ..Some studies have indicated that full publication is associated with the direction of results (publication bias). No study has looked into the occurrence of publication bias in the field of addiction...
  24. doi An overview of systematic reviews on cannabis and psychosis: discussing apparently conflicting results
    Silvia Minozzi
    Department of Epidemiology, Local Health Unit Roma E, Roma, Italy
    Drug Alcohol Rev 29:304-17. 2010
    ..Cannabis intoxication can lead to acute, transient psychotic symptoms and the short-term exacerbation of pre-existing psychotic symptoms. However, controversy exists about whether cannabis can actually cause long-term psychosis...
  25. ncbi Oral naltrexone maintenance treatment for opioid dependence
    Silvia Minozzi
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 2:CD001333. 2011
    ..Research on the clinical application of oral naltrexone agrees on several things. From a pharmacological perspective, naltrexone works. From an applied perspective, however, the medication compliance and the retention rates are very poor...
  26. doi Detoxification treatments for opiate dependent adolescents
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 4:CD006749. 2014
    ..Nevertheless, no studies have been published that systematically assess the effectiveness of the pharmacological detoxification among adolescents...
  27. doi Maintenance treatments for opiate -dependent adolescents
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 6:CD007210. 2014
    ..Nevertheless, no reviews have been published that systematically assess the effectiveness of pharmacological maintenance treatment in adolescents...
  28. ncbi Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
    Laura Amato
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 10:CD004147. 2011
    ..Maintenance treatments are effective in retaining patients in treatment and suppressing heroin use. Questions remain regarding the efficacy of additional psychosocial services...
  29. ncbi Dopamine agonists for the treatment of cocaine dependence
    Laura Amato
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 12:CD003352. 2011
    ..Cocaine dependence is a disorder for which no pharmacological treatment of proven efficacy exists, advances in the neurobiology could guide future medication development..
  30. ncbi Benzodiazepines for alcohol withdrawal
    Laura Amato
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 3:CD005063. 2010
    ..Nevertheless, no definite conclusions about the effectiveness and safety of benzodiazepines was possible, because of the heterogeneity of the trials both in interventions and the assessment of outcomes...
  31. doi Maintenance treatments for opiate dependent adolescent
    Silvia Minozzi
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2009
    ..Nevertheless no studies have been published which systematically assess the effectiveness of the pharmacological maintenance treatment among adolescent...
  32. ncbi Psychosocial interventions for psychostimulant misuse
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo, 112, Rome, Italy, 00154
    Cochrane Database Syst Rev 9:CD011866. 2016
    ..There is no evidence proving the efficacy of pharmacotherapy. Psychosocial interventions could be a valid approach to help patients in reducing or ceasing drug consumption...
  33. doi Detoxification treatments for opiate dependent adolescents
    Silvia Minozzi
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev . 2009
    ..Nevertheless no studies have been published which systematically assess the effectiveness of the pharmacological detoxification among adolescents...
  34. doi Cochrane systematic reviews in the field of addiction: past and future
    Laura Amato
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
    J Evid Based Med 6:221-8. 2013
    ..This paper describes what the Group has done since the 1990s to produce evidence to guide policy, practice, and research...
  35. doi Development of dependence following treatment with opioid analgesics for pain relief: a systematic review
    Silvia Minozzi
    Department of Epidemiology, Lazio Regional Health Service, Cochrane Drugs and Alcohol Group, Rome, Italy
    Addiction 108:688-98. 2013
    ..To assess the incidence or prevalence of opioid dependence syndrome in adults (with and without previous history of substance abuse) following treatment with opioid analgesics for pain relief...
  36. ncbi Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome
    Laura Amato
    Department of Epidemiology, ASL RM E, Via di Santa Costanza, 53, Rome, Italy, 00198
    Cochrane Database Syst Rev 6:CD008537. 2011
    ..Pharmacological treatments presently used are of uncertain effectiveness and there is even more doubt on the comparative effects and value for money...
  37. ncbi A systematic review on the efficacy of naltrexone maintenance treatment in opioid dependence
    Ursula Kirchmayer
    Department of Epidemiology, ASL RM E, Rome, Italy
    Addiction 97:1241-9. 2002
    ..To evaluate the efficacy of naltrexone maintenance treatment in preventing relapse in opioid addicts after detoxification...
  38. ncbi [Volume and health outcomes: an overview of systematic reviews]
    Marina Davoli
    Dipartimento di epidemiologia ASL RME
    Epidemiol Prev 29:3-63. 2005
    ..conditions or interventions (prevention, diagnostic, therapeutic, surgical or clinical) for which an association between volume and outcome has been investigated; those for which an association between volume and outcome has been proved..