E Peles

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
    Aleksandra Ivanovic
    Department of Molecular Neurobiology and 2 Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 196:337-44. 2012
  2. pmc N-WASP is required for membrane wrapping and myelination by Schwann cells
    Nurit Novak
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 192:243-50. 2011
  3. pmc Secreted gliomedin is a perinodal matrix component of peripheral nerves
    Yael Eshed
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    J Cell Biol 177:551-62. 2007
  4. pmc Caspr regulates the processing of contactin and inhibits its binding to neurofascin
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100 Israel
    J Cell Biol 163:1213-8. 2003
  5. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
  6. pmc Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 159:361-72. 2002
  7. pmc Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 157:1247-56. 2002
  8. ncbi request reprint Molecular domains of myelinated axons
    E Peles
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Curr Opin Neurobiol 10:558-65. 2000
  9. ncbi request reprint Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
  10. ncbi request reprint Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Neuron 24:1037-47. 1999

Collaborators

  • James L Salzer
  • Colin L Stewart
  • Jack Rosenbluth
  • J S Trimmer
  • B Ranscht
  • S Einheber
  • M Grumet
  • A Faissner
  • Helena Sabanay
  • Sebastian Poliak
  • Leora Gollan
  • Aleksandra Ivanovic
  • Shahar Frechter
  • Nurit Novak
  • S Poliak
  • Yael Eshed
  • Daniela Salomon
  • Nobuo Terada
  • Nils Brose
  • Shinichi Ohno
  • K Adamsky
  • Ivo Spiegel
  • Ido Horresh
  • Neev Golan
  • Wiebke Mobius
  • Vered Bar
  • Dies Meijer
  • Scott B Snapper
  • Martine Jaegle
  • L Gollan
  • Konstantin Feinberg
  • David J Carey
  • Hadas Elhanany
  • Brent Kiernan
  • Larysa Pevny
  • Andrew J W Furley
  • Shing Yan Chiu
  • Peter Shrager
  • Xiaorong Xu
  • Sean Matlis
  • Christoph Ullmer
  • Erik O Berglund
  • Steven S Scherer
  • R Ohara
  • J Schilling
  • E O Berglund
  • D Salomon
  • J Garwood
  • R Martinez
  • A Custer
  • P Shrager
  • D Wen
  • S S Bacus
  • G Trail
  • S M Silbiger
  • Y Luo
  • R B Levy
  • R Cupples
  • S Hu
  • S V Suggs

Detail Information

Publications13

  1. pmc The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves
    Aleksandra Ivanovic
    Department of Molecular Neurobiology and 2 Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Cell Biol 196:337-44. 2012
    ..These findings suggest that protein 4.1G contributes to the organization of the internodal axolemma by targeting and/or maintaining glial transmembrane proteins along the axoglial interface...
  2. pmc N-WASP is required for membrane wrapping and myelination by Schwann cells
    Nurit Novak
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 192:243-50. 2011
    ..These data suggest that regulation of actin filament nucleation in Schwann cells by N-WASP is crucial for membrane wrapping, longitudinal extension, and myelination...
  3. pmc Secreted gliomedin is a perinodal matrix component of peripheral nerves
    Yael Eshed
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    J Cell Biol 177:551-62. 2007
    ..Our results indicate that the deposition of gliomedin multimers at the nodal gap by binding to HSPGs facilitates the clustering of the axonodal CAMs and Na(+) channels...
  4. pmc Caspr regulates the processing of contactin and inhibits its binding to neurofascin
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100 Israel
    J Cell Biol 163:1213-8. 2003
    ..These results demonstrate that Caspr regulates the intracellular processing and transport of contactin to the cell surface, thereby affecting its ability to interact with other cell adhesion molecules...
  5. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
    ....
  6. pmc Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 159:361-72. 2002
    ..The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells...
  7. pmc Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr
    Leora Gollan
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 157:1247-56. 2002
    ..These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon...
  8. ncbi request reprint Molecular domains of myelinated axons
    E Peles
    Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Curr Opin Neurobiol 10:558-65. 2000
    ....
  9. ncbi request reprint Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ....
  10. ncbi request reprint Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Neuron 24:1037-47. 1999
    ..This association involves the C-terminal sequence of Caspr2, which contains a putative PDZ binding site. These results suggest a role for Caspr family members in the local differentiation of the axon into distinct functional subdomains...
  11. ncbi request reprint Glial tumor cell adhesion is mediated by binding of the FNIII domain of receptor protein tyrosine phosphatase beta (RPTPbeta) to tenascin C
    K Adamsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 20:609-18. 2001
    ..These results demonstrate that the FNIII domain of RPTPbeta binds to tenascin C and suggest that RPTPbeta present on glial tumor cells is a primary adhesion receptor system to the extracellular matrix...
  12. ncbi request reprint Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling
    E Peles
    Dept of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Trends Biochem Sci 23:121-4. 1998
    ..Here, the authors discuss the implications of such complexes for intercellular signaling, and the regulation of RPTP activity by cell-cell and cell-ECM contact...
  13. ncbi request reprint Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit
    D Wen
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Cell 69:559-72. 1992
    ..Northern blot analysis indicated the existence of several NDF transcripts, the major ones being 1.8, 2.6, and 6.7 kb in size. Transformation by the ras oncogene dramatically elevated the expression of NDF in fibroblasts...