Lucio Frydman

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. pmc The effects of molecular diffusion in ultrafast two-dimensional nuclear magnetic resonance
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Chem Phys 128:164513. 2008
  2. ncbi request reprint Principles and features of single-scan two-dimensional NMR spectroscopy
    Lucio Frydman
    Contribution from the Departments of Chemical Physics and Chemical Services, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 125:9204-17. 2003
  3. ncbi request reprint A continuous phase-modulated approach to spatial encoding in ultrafast 2D NMR spectroscopy
    Assaf Tal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 176:107-14. 2005
  4. pmc The acquisition of multidimensional NMR spectra within a single scan
    Lucio Frydman
    Departments of Chemical Physics and Chemical Services, Weizmann Institute of Science, 76100 Rehovot, Israel Middle East
    Proc Natl Acad Sci U S A 99:15858-62. 2002
  5. ncbi request reprint Principles and progress in ultrafast multidimensional nuclear magnetic resonance
    Mor Mishkovsky
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel email
    Annu Rev Phys Chem 60:429-48. 2009
  6. doi request reprint An improved ultrafast 2D NMR experiment: towards atom-resolved real-time studies of protein kinetics at multi-Hz rates
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Biomol NMR 43:1-10. 2009
  7. doi request reprint Measuring small compartment dimensions by probing diffusion dynamics via Non-uniform Oscillating-Gradient Spin-Echo (NOGSE) NMR
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 237:49-62. 2013
  8. doi request reprint Magnetization transfer magic-angle-spinning z-spectroscopy of excised tissues
    Reut Avni
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 199:1-9. 2009
  9. doi request reprint Single-scan 2D DOSY NMR spectroscopy
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 195:226-31. 2008
  10. pmc Super-resolved parallel MRI by spatiotemporal encoding
    Rita Schmidt
    Chemical Physics Department, Weizmann Institute of Science, 76100 Rehovot, Israel
    Magn Reson Imaging 32:60-70. 2014

Research Grants

Collaborators

Detail Information

Publications85

  1. pmc The effects of molecular diffusion in ultrafast two-dimensional nuclear magnetic resonance
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Chem Phys 128:164513. 2008
    ....
  2. ncbi request reprint Principles and features of single-scan two-dimensional NMR spectroscopy
    Lucio Frydman
    Contribution from the Departments of Chemical Physics and Chemical Services, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 125:9204-17. 2003
    ..Extensions to higher-dimensional experiments are also briefly noted...
  3. ncbi request reprint A continuous phase-modulated approach to spatial encoding in ultrafast 2D NMR spectroscopy
    Assaf Tal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 176:107-14. 2005
    ..The main features underlying this new spatial encoding protocol are derived, and its potential demonstrated with a series of phase-modulated homonuclear single-scan 2D NMR examples...
  4. pmc The acquisition of multidimensional NMR spectra within a single scan
    Lucio Frydman
    Departments of Chemical Physics and Chemical Services, Weizmann Institute of Science, 76100 Rehovot, Israel Middle East
    Proc Natl Acad Sci U S A 99:15858-62. 2002
    ..The protocol is compatible with existing multidimensional pulse sequences and can be implemented by using conventional hardware; its performance is exemplified here with a variety of homonuclear 2D NMR acquisitions...
  5. ncbi request reprint Principles and progress in ultrafast multidimensional nuclear magnetic resonance
    Mor Mishkovsky
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel email
    Annu Rev Phys Chem 60:429-48. 2009
    ..The present survey introduces the main principles of this subsecond approach to spectroscopy, focusing on the applications that have hitherto been demonstrated for single-scan two-dimensional NMR in different areas of chemistry...
  6. doi request reprint An improved ultrafast 2D NMR experiment: towards atom-resolved real-time studies of protein kinetics at multi-Hz rates
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Biomol NMR 43:1-10. 2009
    ....
  7. doi request reprint Measuring small compartment dimensions by probing diffusion dynamics via Non-uniform Oscillating-Gradient Spin-Echo (NOGSE) NMR
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 237:49-62. 2013
    ..An MR imaging version of NOGSE was also implemented in ex vivo pig spinal cords and mouse brains, affording maps based on compartment sizes. The effects of size distributions on NOGSE are also briefly analyzed. ..
  8. doi request reprint Magnetization transfer magic-angle-spinning z-spectroscopy of excised tissues
    Reut Avni
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 199:1-9. 2009
    ..Concurrently, histological examinations are reported validating the limits of HRMAS NMR procedures to the analysis of tissue samples preserved in a number of different ways...
  9. doi request reprint Single-scan 2D DOSY NMR spectroscopy
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 195:226-31. 2008
    ....
  10. pmc Super-resolved parallel MRI by spatiotemporal encoding
    Rita Schmidt
    Chemical Physics Department, Weizmann Institute of Science, 76100 Rehovot, Israel
    Magn Reson Imaging 32:60-70. 2014
    ..The gains of the parallelized approach were particularly evident when dealing with heterogeneous systems subject to major T2/T2* effects, as is the case upon single-scan imaging near tissue/air interfaces...
  11. doi request reprint Longitudinal relaxation enhancement in 1H NMR spectroscopy of tissue metabolites via spectrally selective excitation
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 Israel
    Chemistry 19:13002-8. 2013
    ..These LRE effects suggest a novel means of increasing the sensitivity of tissue-oriented experiments, and open new vistas to investigate the nature of interactions among metabolites, water and macromolecules at a molecular level...
  12. doi request reprint Kinetics from indirectly detected hyperpolarized NMR spectroscopy by using spatially selective coherence transfers
    Talia Harris
    Department of Chemical Physics, Weizmann Institute, Rehovot, 76100, Israel
    Chemistry 17:697-703. 2011
    ....
  13. ncbi request reprint Spatially encoded NMR and the acquisition of 2D magnetic resonance images within a single scan
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 172:179-90. 2005
    ....
  14. ncbi request reprint Ultrafast 2D NMR spectroscopy using a continuous spatial encoding of the spin interactions
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 171:163-70. 2004
    ..The principles underlying this new spatial encoding protocol are derived, and its applicability is demonstrated with homo- and heteronuclear 2D ultrafast NMR applications on small molecule and on protein samples...
  15. ncbi request reprint UltraSOFAST HMQC NMR and the repetitive acquisition of 2D protein spectra at Hz rates
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 129:1372-7. 2007
    ..The principles, relative advantages, and current limitations of this new approach are discussed, and its application is exemplified with a study of the fast hydrogen-deuterium exchange characterizing amide sites in Ubiquitin...
  16. pmc Dissolution DNP NMR with solvent mixtures: substrate concentration and radical extraction
    Talia Harris
    Department of Chemical Physics, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 211:96-100. 2011
    ..Examples of these principles are given, and further potential extensions of this approach are discussed...
  17. doi request reprint New developments in the spatial encoding of spin interactions for single-scan 2D NMR
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Magn Reson Chem 47:415-22. 2009
    ..The overall principles underlying these new spatially encoding protocols are derived, and their performance demonstrated with single-scan 2D NMR TOCSY and HSQC experiments on model compounds...
  18. pmc Removing silicone artifacts in diffusion-weighted breast MRI by means of shift-resolved spatiotemporally encoding
    Eddy Solomon
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 75:2064-71. 2016
    ..Evaluate the usefulness of diffusion-weighted spatiotemporally encoded (SPEN) methods to obtain apparent diffusion coefficient (ADC) maps of fibroglandular human breast tissue, in the presence of silicone implants...
  19. pmc Metabolic T1 dynamics and longitudinal relaxation enhancement in vivo at ultrahigh magnetic fields on ischemia
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Cereb Blood Flow Metab 34:1810-7. 2014
    ..The potential of such measurements to understand stroke at a molecular level and assist in its diagnosis, is discussed. ..
  20. doi request reprint Ultrafast in vivo diffusion imaging of stroke at 21.1 T by spatiotemporal encoding
    Avigdor Leftin
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 73:1483-9. 2015
    ..This study quantifies in vivo ischemic stroke brain injuries in rats using ultrahigh-field single-scan MRI methods to assess variations in apparent diffusion coefficients (ADCs)...
  21. doi request reprint Alleviating artifacts in 1H MRI thermometry by single scan spatiotemporal encoding
    Rita Schmidt
    Chemical Physics Department, Weizmann Institute of Science, 76100, Rehovot, Israel
    MAGMA 26:477-90. 2013
    ..This article explores the potential advantages of relying on spatiotemporally encoded (SPEN) sequences for retrieving real-time thermometric images based on the water's proton resonance frequency (PRF) shifts...
  22. pmc Compressed sensing and the reconstruction of ultrafast 2D NMR data: Principles and biomolecular applications
    Yoav Shrot
    Department of Chemical Physics, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 209:352-8. 2011
    ....
  23. doi request reprint Spatial encoding strategies for ultrafast multidimensional nuclear magnetic resonance
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Chem Phys 128:052209. 2008
    ....
  24. pmc Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells
    Talia Harris
    Department of Chemical Physics, Weizmann Institute, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 106:18131-6. 2009
    ..These results suggest that hyperpolarized (13)C(1)-pyruvate may be a useful magnetic resonance biomarker of MCT regulation and malignant transformations in breast cancer...
  25. ncbi request reprint Spectroscopic imaging from spatially-encoded single-scan multidimensional MRI data
    Assaf Tal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 189:46-58. 2007
    ..Demonstrations of these new multidimensional spectroscopic MRI experiments on simple phantoms are also given...
  26. doi request reprint Nearly 10(6)-fold enhancements in intermolecular (1)H double-quantum NMR experiments by nuclear hyperpolarization
    Mor Mishkovsky
    Chemical Physics Department, Weizmann Institute, 76100 Rehovot, Israel
    J Magn Reson 200:142-6. 2009
    ..The fact that DNP endows iMQC-based (1)H NMR spectra with a sensitivity that amply exceeds that of their thermally polarized single-quantum counterpart, is confirmed in a number of simple single-scan 2D imaging experiments...
  27. ncbi request reprint Spatially resolved multidimensional NMR spectroscopy within a single scan
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 167:42-8. 2004
    ..Potential extensions of this approach to higher dimensions are also briefly addressed...
  28. doi request reprint Single-scan 2D NMR correlations by multiple coherence transfers
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 203:311-5. 2010
    ..Advantages, opportunities, and main drawbacks of this new ultrafast approach to 2D NMR, are briefly discussed...
  29. ncbi request reprint Symmetric spatial encoding in ultrafast 2D NMR spectroscopy
    Boaz Shapira
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 178:33-41. 2006
    ..The main features underlying this new spatially symmetric encoding protocol are derived, and its advantages are demonstrated with a series of amplitude-modulated homo- and hetero-nuclear 2D ultrafast NMR examples...
  30. ncbi request reprint Ultrafast two-dimensional NMR spectroscopy using constant acquisition gradients
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Chem Phys 125:204507. 2006
    ..Principles and examples of this new approach are given; sensitivity limitations and signal-enhancing prospects of such constant-gradient acquisitions are also discussed and exemplified...
  31. doi request reprint A fast approach to 3D HSQC-based spectroscopy based on a Fourier phase encoding of pre-targeted resonances
    Yulan Lin
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel Department of Electronic Science, Xiamen University, Xiamen 361005, China Electronic address
    J Magn Reson 274:95-102. 2016
    ..The theoretical basis of this new approach is given, and experimental demonstrations are presented on small molecule and protein-based model systems...
  32. doi request reprint Overcoming limitations in diffusion-weighted MRI of breast by spatio-temporal encoding
    Eddy Solomon
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 73:2163-73. 2015
    ....
  33. doi request reprint Referenceless reconstruction of spatiotemporally encoded imaging data: principles and applications to real-time MRI
    Amir Seginer
    Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel, 76100
    Magn Reson Med 72:1687-95. 2014
    ..A referenceless method to eliminate these artifacts in Hybrid SPEN is demonstrated...
  34. doi request reprint In vivo 3D spatial/1D spectral imaging by spatiotemporal encoding: a new single-shot experimental and processing approach
    Rita Schmidt
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 70:382-91. 2013
    ..In vivo results of fat and water separation on abdominal imaging of mice at 7 T and on human breast imaging at 3 T are presented...
  35. doi request reprint Two-dimensional RF pulses: a new approach to selectively exciting J-coupled spins in nuclear magnetic resonance
    Adonis Lupulescu
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Chem Phys 139:144204. 2013
    ..Additional instances where such pulses could be applied, as well as main limitations of this new approach, are briefly discussed...
  36. doi request reprint Fully refocused multi-shot spatiotemporally encoded MRI: robust imaging in the presence of metallic implants
    Noam Ben-Eliezer
    Chemical Physics Department, Weizmann Institute of Science, 76100 Rehovot, Israel
    MAGMA 25:433-42. 2012
    ..The present study investigates the use of this full-refocusing aspect of SPEN-based imaging in the multi-shot MRI of objects, subject to sizable field inhomogeneities that complicate conventional imaging approaches...
  37. ncbi request reprint Spatially encoded strategies in the execution of biomolecular-oriented 3D NMR experiments
    Mor Mishkovsky
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biomol NMR 39:291-301. 2007
    ..Limitations and prospects of these various schemes are briefly addressed...
  38. ncbi request reprint Sensitivity enhancement in 1D heteronuclear NMR spectroscopy via single-scan inverse experiments
    Mor Mishkovsky
    Department of Chemical Physics, Weizmann Institute of Science 76100 Rehovot, Israel
    Chemphyschem 5:779-86. 2004
    ....
  39. ncbi request reprint Spatially encoded pulse sequences for the acquisition of high resolution NMR spectra in inhomogeneous fields
    Boaz Shapira
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 182:12-21. 2006
    ..The principles of the different compensation methods are reviewed and experimentally demonstrated for one-dimensional inhomogeneities; further improvements and extensions are briefly discussed...
  40. ncbi request reprint Interlaced Fourier transformation of ultrafast 2D NMR data
    Mor Mishkovsky
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 173:344-50. 2005
    ..The robustness and conditions that allow the interlaced numerical procedure to be implemented in routine analytical applications were explored and are briefly discussed...
  41. doi request reprint Spatial/spectral encoding of the spin interactions in ultrafast multidimensional NMR
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Chem Phys 131:224516. 2009
    ..We denote this as "spatial/spectral encoding"; the underlying principles of this new approach, together with experimental results based on uni- and multidimensional rf pulse schemes, are presented...
  42. doi request reprint Multiple ultrafast, broadband 2D NMR spectra of hyperpolarized natural products
    Patrick Giraudeau
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 131:13902-3. 2009
    ....
  43. doi request reprint High-definition, single-scan 2D MRI in inhomogeneous fields using spatial encoding methods
    Noam Ben-Eliezer
    Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Imaging 28:77-86. 2010
    ..Initial results suggest that this acquisition scheme has the potential to overcome strong field inhomogeneities acting over extended acquisition durations, exceeding 100 ms for a single-shot image...
  44. pmc Robust diffusion tensor imaging by spatiotemporal encoding: Principles and in vivo demonstrations
    Eddy Solomon
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med . 2016
    ..Evaluate the usefulness of single-shot and of interleaved spatiotemporally encoded (SPEN) methods to perform diffusion tensor imaging (DTI) under various preclinical and clinical settings...
  45. pmc Single-scan MRI with exceptional resilience to field heterogeneities
    Zhiyong Zhang
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med . 2016
    ..This study introduces a methodology, cross-term spatiotemporal encoding (xSPEN), that delivers such images under much poorer external field conditions...
  46. doi request reprint Interleaved multishot imaging by spatiotemporal encoding: A fast, self-referenced method for high-definition diffusion and functional MRI
    Rita Schmidt
    Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 75:1935-48. 2016
    ..To explore this option, an interleaved SPEN version was developed that was capable of delivering optimized images due to its use of a referenceless correction algorithm...
  47. pmc Efficient spectroscopic imaging by an optimized encoding of pretargeted resonances
    Zhiyong Zhang
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Magn Reson Med . 2016
    ..This is hereby illustrated by Spectroscopically Encoded Chemical Shift Imaging (SECSI)...
  48. ncbi request reprint Acquiring and processing ultrafast biomolecular 2D NMR experiments using a referenced-based correction
    Amir Seginer
    Department of Chemical Physics, Weizmann Institute of Science, 76100, Rehovot, Israel
    J Biomol NMR 66:141-157. 2016
    ..This algorithm was verified experimentally using an [Formula: see text]-[Formula: see text] UF-HSQC variant on ubiquitin at 600 MHz. Features of this method as well as of the interlaced Fourier transformation in general, are discussed...
  49. doi request reprint Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective
    Maria Baias
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Am Chem Soc . 2017
    ....
  50. pmc Size Distribution Imaging by Non-Uniform Oscillating-Gradient Spin Echo (NOGSE) MRI
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
    PLoS ONE 10:e0133201. 2015
    ..Such findings highlight NOGSE's potential for characterizing aberrations in cellular size distributions upon disease, or during normal processes such as development...
  51. pmc Correcting surface coil excitation inhomogeneities in single-shot SPEN MRI
    Rita Schmidt
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Magn Reson 259:199-206. 2015
    ....
  52. pmc Local and bulk (13)C hyperpolarization in nitrogen-vacancy-centred diamonds at variable fields and orientations
    Gonzalo A Alvarez
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Commun 6:8456. 2015
    ..This method opens new perspectives for applications of diamond nitrogen-vacancy centres in nuclear magnetic resonance, and in quantum information processing. ..
  53. doi request reprint Optimizing water hyperpolarization and dissolution for sensitivity-enhanced 2D biomolecular NMR
    Greg Olsen
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Magn Reson 264:49-58. 2016
    ....
  54. doi request reprint Metabolic properties in stroked rats revealed by relaxation-enhanced magnetic resonance spectroscopy at ultrahigh fields
    Noam Shemesh
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Commun 5:4958. 2014
    ..These results demonstrate potential of (1)H MRS at ultrahigh fields. ..
  55. doi request reprint Simultaneous spatial and spectral selectivity by spatiotemporal encoding
    Jean Nicolas Dumez
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Magn Reson Med 71:746-55. 2014
    ..To introduce a method that provides simultaneous spatial and spectral selectivity, whose implementation is less demanding than-and quality comparable to-conventional 2D spectral-spatial counterparts...
  56. pmc In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding
    Rita Schmidt
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    J Magn Reson 240:8-15. 2014
    ..Multi-slice chemical-shift images of healthy rats were obtained at 4.7T in the region of the kidney, and 4D (2D spatial, 1D spectral, 1D temporal) data sets were obtained at 7T from a murine lymphoma tumor model. ..
  57. pmc On the potential of hyperpolarized water in biomolecular NMR studies
    Talia Harris
    Chemical Physics Department, Weizmann Institute of Science, 205 Herzl Street, Rehovot 76100, Israel
    J Phys Chem B 118:3281-90. 2014
    ..Besides potential bioanalytical uses, this approach opens interesting possibilities in the monitoring of dynamic biomolecular processes, including solvent accessibility and exchange process. ..
  58. doi request reprint Diffusion-assisted selective dynamical recoupling: a new approach to measure background gradients in magnetic resonance
    Gonzalo A Alvarez
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Chem Phys 140:084205. 2014
    ..Additional features and limitations of this new method are discussed. ..
  59. pmc Diffusion weighted MRI by spatiotemporal encoding: analytical description and in vivo validations
    Eddy Solomon
    Chemical Physics Department, Weizmann Institute of Science, Rehovot 76100, Israel
    J Magn Reson 232:76-86. 2013
    ..These studies demonstrate the increased robustness of dSPEN vis-à-vis comparable DW echo planar imaging, and demonstrate the value of this new methodology for medium- or high-field diffusion measurements in heterogeneous systems...
  60. ncbi request reprint Coherent dynamical recoupling of diffusion-driven decoherence in magnetic resonance
    Gonzalo A Alvarez
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Phys Rev Lett 111:080404. 2013
    ....
  61. pmc Functional MRI using super-resolved spatiotemporal encoding
    Noam Ben-Eliezer
    Chemical Physics Department, Weizmann Institute of Science, 76100 Rehovot, Israel
    Magn Reson Imaging 30:1401-8. 2012
    ....
  62. pmc Controlling spin-spin network dynamics by repeated projective measurements
    Christian O Bretschneider
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, 76100, Israel
    Phys Rev Lett 108:140403. 2012
    ..Experimental implementations yield coupling constant determinations for complex spin-coupling topologies, as demonstrated within the field of liquid-state nuclear magnetic resonance...
  63. pmc Shift-driven modulations of spin-echo signals
    Pieter E S Smith
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Proc Natl Acad Sci U S A 109:5958-61. 2012
    ....
  64. ncbi request reprint Sub-second 2D NMR spectroscopy at sub-millimolar concentrations
    Boaz Shapira
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 126:11756-7. 2004
    ..It is demonstrated that the speed and sensitivity enhancement afforded by these combined processes enables the acquisition of quality 2D NMR data sets within a fraction of a second, at analyte concentrations that are under 1 mM...
  65. ncbi request reprint Ultrafast 2D NMR spectroscopy using sinusoidal gradients: principles and ex vivo brain investigations
    Noa Sela
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 52:893-7. 2004
    ....
  66. ncbi request reprint Single-Scan 2D Hadamard NMR Spectroscopy
    Assaf Tal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot Israel, Fax 972 8 934 4123
    Angew Chem Int Ed Engl 48:2732-6. 2009
    ..This approach can give homo- or heteronuclear correlations with an enhanced sensitivity over conventional ultrafast 2D NMR spectroscopy...
  67. ncbi request reprint Real-time monitoring of chemical transformations by ultrafast 2D NMR spectroscopy
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 128:951-6. 2006
    ..The real-time dynamic experiments hereby introduced thus add to an increasing family of fast characterization techniques based on 2D NMR; their potential and limitations are briefly discussed...
  68. ncbi request reprint Ghost-peak suppression in ultrafast two-dimensional NMR spectroscopy
    Yoav Shrot
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 164:351-7. 2003
    ..Brief mathematical descriptions of the ghost-peak generation and ghost-peak suppression mechanisms are described, followed by experimental tests on a number of samples using various pulse sequences...
  69. pmc Reducing acquisition times in multidimensional NMR with a time-optimized Fourier encoding algorithm
    Zhiyong Zhang
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Chem Phys 141:194201. 2014
    ..This method can be readily automated to deal with complex samples such as those occurring in metabolomics, in in-cell as well as in in vivo NMR applications, where speed and temporal stability are often primary concerns. ..
  70. pmc MRSI via fully-refocused spatiotemporal encoding with polychromatic spectral pulses
    Zhiyong Zhang
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005, China
    J Magn Reson 259:24-31. 2015
    ..The expected SPEN advantages were observed in both phantom-based models, and in in vivo results of fat and water separation in mice at 7 T...
  71. doi request reprint A double-Fourier approach to enhance the efficiency of the indirect domain sampling in 2D NMR
    Srinivasan Chandrashekar
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    Magn Reson Chem 49:477-82. 2011
    ..Copyright © 2011 John Wiley & Sons, Ltd. ..
  72. pmc New spatiotemporal approaches for fully refocused, multislice ultrafast 2D MRI
    Rita Schmidt
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    Magn Reson Med 71:711-22. 2014
    ..This work extends this modality from the single-slice acquisitions in which it has hitherto been implemented, by introducing a variety of multislice schemes scanning 3D volumes...
  73. pmc Ultrafast NMR T1 relaxation measurements: probing molecular properties in real time
    Pieter E S Smith
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100 Israel
    Chemphyschem 14:3138-45. 2013
    ..The method is applied to the real-time investigation of the reaction between D-xylose and sodium borate, which is in turn elucidated with the aid of ancillary ultrafast and conventional 2D TOCSY measurements...
  74. ncbi request reprint Toward single-shot pure-shift solution 1H NMR by trains of BIRD-based homonuclear decoupling
    Adonis Lupulescu
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 218:141-6. 2012
    ..Dependable homonuclear decoupling performance can then be achieved, with minimal line width, fine-tuning, and sensitivity penalties...
  75. ncbi request reprint Ultrafast solid-state 2D NMR experiments via orientational encoding
    Rangeet Bhattacharyya
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 128:16014-5. 2006
    ..Principles and preliminary examples of the new orientationally encoded ultrafast 2D NMR principle thus resulting are presented and discussed...
  76. ncbi request reprint Line shape considerations in ultrafast 2D NMR
    Boaz Shapira
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Magn Reson 166:152-63. 2004
    ....
  77. ncbi request reprint Real-time 2D NMR identification of analytes undergoing continuous chromatographic separation
    Boaz Shapira
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Am Chem Soc 126:1262-5. 2004
    ....
  78. doi request reprint A capacitively coupled temperature-jump arrangement for high-resolution biomolecular NMR
    Maayan Gal
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel
    Magn Reson Chem 48:842-7. 2010
    ....
  79. pmc Spatiotemporal encoding as a robust basis for fast three-dimensional in vivo MRI
    Noam Ben-Eliezer
    Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
    NMR Biomed 24:1191-201. 2011
    ..Further features, extensions and applications of these principles are also addressed...
  80. ncbi request reprint Sensitizing solid state nuclear magnetic resonance of dilute nuclei by spin-diffusion assisted polarization transfers
    Adonis Lupulescu
    Department of Chemical Physics, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Chem Phys 135:134202. 2011
    ..These measurements also highlight a number of limitations that will have to be overcome for transforming selective polarization transfers of this kind into analytical methods of choice...
  81. ncbi request reprint 59Co solid-state NMR as a new probe for elucidating metal binding in polynucleotides
    Christopher V Grant
    Department of Chemical Physics, Weizmann Institute of Sciences, 76100 Rehovot, Israel
    J Am Chem Soc 124:4458-62. 2002
    ..These characterizations were assisted by studies on model compounds and by multinuclear 31P-59Co recoupling experiments...
  82. ncbi request reprint Solid state separated-local-field NMR spectroscopy on half-integer quadrupolar nuclei: principles and applications to borane analysis
    Julia Grinshtein
    Department of Chemical Physics, Weizmann Institute of Sciences, 76100 Rehovot, Israel
    J Am Chem Soc 125:7451-60. 2003
    ....
  83. ncbi request reprint Separate-local-field NMR spectroscopy on half-integer quadrupolar nuclei
    Julia Grinshtein
    Department of Chemical Physics, Weizmann Institute of Sciences, 76100 Rehovot, Israel
    J Am Chem Soc 124:13344-5. 2002
    ..Details about these 2D and 3D NMR experiments are given, and their application is illustrated with 1H-23Na recoupling experiments on mononucleotides possessing multiple bound cations...
  84. ncbi request reprint A solid-state 13C NMR analysis of molecular dynamics in aramide polymers
    Dan McElheny
    Division of Biological Sciences, University of Chicago, Chicago, IL 60637, USA
    Solid State Nucl Magn Reson 29:132-41. 2006
    ..The mechanism underlying this behavior and implications towards the (13)C analysis of motions in aramides in particular and complex polymers in general, is briefly discussed...
  85. ncbi request reprint Solid-state NMR investigation of sodium nucleotide complexes
    Christopher V Grant
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Magn Reson Chem 44:366-74. 2006
    ....

Research Grants1

  1. ULTRAFAST MULTIDIMENSIONAL NMR: A NEW BIOMEDICAL TOOL
    Lucio Frydman; Fiscal Year: 2006
    ..abstract_text> ..