Affiliation: Weizmann Institute of Science
- Strategies to discover regulatory circuits of the mammalian immune systemIdo Amit
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nat Rev Immunol 11:873-80. 2011..Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system...
- Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuliIrit Gat-Viks
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
Nat Biotechnol 31:342-9. 2013..Our approach charts an experimental and analytic path to decipher the mechanisms underlying genetic variation in circuits that control responses to stimuli...
- High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategiesMichal Rabani
The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02140, USA
Cell 159:1698-710. 2014..Our study provides a new quantitative approach to discover transcriptional and posttranscriptional events that control dynamic changes in transcript levels using RNA sequencing data. ..
- Semiconductor-based DNA sequencing of histone modification statesChristine S Cheng
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
Nat Commun 4:2672. 2013..We leverage this method for epigenetic profiling of tumour tissues. ..