Joseph Yanai

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Toxicol Environ Health A 71:131-3. 2008
  2. ncbi request reprint Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91010 Jerusalem, Israel
    Ann N Y Acad Sci 1074:659-71. 2006
  3. ncbi request reprint Functional changes after prenatal opiate exposure related to opiate receptors' regulated alterations in cholinergic innervation
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Int J Neuropsychopharmacol 6:253-65. 2003
  4. pmc Neurobehavioral teratogenicity of sarin in an avian model
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research, Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neurotoxicol Teratol 31:406-12. 2009
  5. pmc A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Neurotoxicol Teratol 32:109-13. 2010
  6. ncbi request reprint Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy, and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Ann N Y Acad Sci 1025:595-601. 2004
  7. ncbi request reprint Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital
    Avital Beer
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neuropsychopharmacology 30:156-65. 2005
  8. pmc Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model
    Adi Pinkas
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research Israel Canada, The Hebrew University, Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Neurotoxicol Teratol 32:182-6. 2010
  9. ncbi request reprint Disruption of the development of cholinergic-induced translocation/activation of PKC isoforms after prenatal heroin exposure
    Rabab Huleihel
    Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Brain Res Bull 69:174-81. 2006
  10. ncbi request reprint Reversal of heroin neurobehavioral teratogenicity by grafting of neural progenitors
    Sophia Katz
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurochem 104:38-49. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Toxicol Environ Health A 71:131-3. 2008
    ..Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses...
  2. ncbi request reprint Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91010 Jerusalem, Israel
    Ann N Y Acad Sci 1074:659-71. 2006
    ..This is true even though the effect of pharmacological therapies is diffuse, affecting multiple areas of the brain. "Everybody is talking about the weather but nobody does anything about it." (Mark Twain)...
  3. ncbi request reprint Functional changes after prenatal opiate exposure related to opiate receptors' regulated alterations in cholinergic innervation
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Int J Neuropsychopharmacol 6:253-65. 2003
    ..However, the net cholinergic output is decreased because PKC is desensitized to the effect of the cholinergic agonist, and this is further evidenced by the extensive deficits in the related behaviours...
  4. pmc Neurobehavioral teratogenicity of sarin in an avian model
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research, Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neurotoxicol Teratol 31:406-12. 2009
    ....
  5. pmc A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Neurotoxicol Teratol 32:109-13. 2010
    ....
  6. ncbi request reprint Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models
    Joseph Yanai
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy, and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Ann N Y Acad Sci 1025:595-601. 2004
    ..The avian models can provide rapid screening of neuroteratogens, exploration of common mechanisms of behavioral disruption, and the potential design of therapies to reverse neurobehavioral deficits...
  7. ncbi request reprint Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital
    Avital Beer
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Neuropsychopharmacology 30:156-65. 2005
    ..Nicotine administration thus offers a potential therapy for reversing neurobehavioral deficits originating in septohippocampal cholinergic defects elicited by prenatal drug or toxicant exposures...
  8. pmc Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model
    Adi Pinkas
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research Israel Canada, The Hebrew University, Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Neurotoxicol Teratol 32:182-6. 2010
    ....
  9. ncbi request reprint Disruption of the development of cholinergic-induced translocation/activation of PKC isoforms after prenatal heroin exposure
    Rabab Huleihel
    Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Brain Res Bull 69:174-81. 2006
    ..Unlike findings on some other teratogens, the prenatal heroin effect on the isoforms function is similar throughout postnatal development...
  10. ncbi request reprint Reversal of heroin neurobehavioral teratogenicity by grafting of neural progenitors
    Sophia Katz
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurochem 104:38-49. 2008
    ..Neural progenitor grafting thus offers an animal model for reversing neurobehavioral deficits originating in septohippocampal cholinergic defects elicited by pre-natal exposure to insults...
  11. ncbi request reprint Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an
    Michal Izrael
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurosci Res 78:499-507. 2004
    ..e., not mediated by maternal confounds. The chick thus provides a suitable model for the rapid screening of neuroteratogens and elucidation of the mechanisms underlying behavioral anomalies...
  12. doi request reprint Survival, differentiation, and reversal of heroin neurobehavioral teratogenicity in mice by transplanted neural stem cells derived from embryonic stem cells
    Meital Kazma
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Neurosci Res 88:315-23. 2010
    ..The transplantation completely restored maze performance to normal; e.g., on day 3, transplantation improved the behavior from the deficient level of 11.9-sec latency to the control of 5.6-sec latency (44.5% improvement)...
  13. pmc Reversal of chlorpyrifos neurobehavioral teratogenicity in mice by nicotine administration and neural stem cell transplantation
    Hana Billauer-Haimovitch
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Behav Brain Res 205:499-504. 2009
    ..This study thus provides a model for the development and application of both pharmacologic and cell-based therapies to offset the effects of neurobehavioral teratogens...
  14. pmc An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells
    Sharon Dotan
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Medical Neurobiology, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Neurotoxicol Teratol 32:481-8. 2010
    ....
  15. ncbi request reprint A chick model for the mechanisms of mustard gas neurobehavioral teratogenicity
    Uri Wormser
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute of Life Sciences, The Hebrew University, Jerusalem, Israel
    Neurotoxicol Teratol 27:65-71. 2005
    ....
  16. ncbi request reprint Prenatal heroin exposure alters cholinergic receptor stimulated activation of the PKCbetaII and PKCgamma isoforms
    Shiri P Yaniv
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Brain Res Bull 63:339-49. 2004
    ....
  17. ncbi request reprint Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome
    Halit Shahak
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, P O Box 12272, 91120 Jerusalem, Israel
    Brain Res Dev Brain Res 140:117-25. 2003
    ..The present findings strongly point to abnormalities in the responsiveness of PKCgamma as a mechanism underlying the neurobehavioral teratogenicity of heroin...
  18. ncbi request reprint Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure
    Ori Vatury
    The Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Cell Biology, The Hebrew University Hadassah Medical School, Box 12272, 91120 Jerusalem, Israel
    Brain Res Bull 63:25-32. 2004
    ..Understanding the subregional selectivity of hippocampal defects can lead to the development of strategies that may potentially enable therapeutic interventions to offset or reverse the neurobehavioral defects...
  19. ncbi request reprint Heroin neuroteratogenicity: delayed-onset deficits in catecholaminergic synaptic activity
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 984:189-97. 2003
    ..These results may explain why apparently unrelated developmental neurotoxicants may ultimately produce a common set of neurochemical and behavioral anomalies...
  20. ncbi request reprint Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis
    Joseph Yanai
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 965:473-8. 2002
    ..Identification of these common targets may help in the design of pharmacologic interventions that, administered in adulthood, can reverse the impact of exposure to neurobehavioral teratogens...