Mona Dvir-Ginzberg

Summary

Affiliation: The Hebrew University
Country: Israel

Publications

  1. ncbi request reprint Towards elucidating the role of SirT1 in osteoarthritis
    Mona Dvir-Ginzberg
    Head Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University Hadassah Ein Kerem P O Box 12272, Jerusalem 91120, Israel
    Front Biosci (Landmark Ed) 18:343-55. 2013
  2. pmc Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    Mona Dvir-Ginzberg
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 63:2363-73. 2011
  3. pmc Sirt1-deficient mice exhibit an altered cartilage phenotype
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD, USA Electronic address
    Joint Bone Spine 80:613-20. 2013
  4. pmc SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    Viktoria Gagarina
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 62:1383-92. 2010
  5. pmc Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 65:159-66. 2013
  6. pmc Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase
    Mona Dvir-Ginzberg
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopaedics Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:36300-10. 2008
  7. pmc 75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes
    Hanna Oppenheimer
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University, Hadassah Ein Kerem, Jerusalem, Israel
    Arthritis Rheum 64:718-28. 2012
  8. doi request reprint Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation
    Hanna Oppenheimer
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Bone Miner Res 29:348-60. 2014
  9. pmc Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    Odile Gabay
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease, Bethesda, Maryland, USA
    Ann Rheum Dis 71:613-6. 2012
  10. pmc Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes
    Michal Bar Oz
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Aging Cell 15:499-508. 2016

Collaborators

  • Odile Gabay
  • Ashok Kumar
  • Michael W McBurney
  • Meir Liebergall
  • Leonid Kandel
  • Hanna Oppenheimer
  • Amir Haze
  • Viktoria Gagarina
  • Michal Bar Oz
  • Juergen Steinmeyer
  • Eli Reich
  • Louisa Ben-Aderet
  • Hadar Meir
  • Eun Jin Lee
  • Veronique Lefebvre
  • Jinan Elayyan
  • Milana Binyamin
  • Emmanuelle Merquiol
  • Boris Turk
  • Duha Fahham
  • Galia Blum
  • Yael Ben-Nun
  • Marta K Kosińska
  • Avi Zini
  • Yoav Mattan
  • Israel Schwartz
  • Michael J Quon
  • David J Hall
  • Jillian K Brady

Detail Information

Publications12

  1. ncbi request reprint Towards elucidating the role of SirT1 in osteoarthritis
    Mona Dvir-Ginzberg
    Head Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University Hadassah Ein Kerem P O Box 12272, Jerusalem 91120, Israel
    Front Biosci (Landmark Ed) 18:343-55. 2013
    ....
  2. pmc Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    Mona Dvir-Ginzberg
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 63:2363-73. 2011
    ..This study was undertaken to test the hypothesis that SirT1 is adversely affected by TNFα, resulting in altered gene expression...
  3. pmc Sirt1-deficient mice exhibit an altered cartilage phenotype
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD, USA Electronic address
    Joint Bone Spine 80:613-20. 2013
    ..We previously demonstrated that Sirt1 regulates apoptosis in cartilage in vitro. Here we attempt to examine in vivo cartilage homeostasis, using Sirt1 total body knockout (KO) mice...
  4. pmc SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    Viktoria Gagarina
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 62:1383-92. 2010
    ..We undertook the present study to assess the role of SirT1 in the survival of osteoarthritic (OA) chondrocytes in humans...
  5. pmc Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model
    Odile Gabay
    Cartilage Biology and Orthopedic Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 65:159-66. 2013
    ..This study was undertaken to determine if SIRT-1 enzymatic activity plays a protective role in cartilage homeostasis in vivo, by investigating mice with SIRT-1 mutations to characterize their cartilage...
  6. pmc Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase
    Mona Dvir-Ginzberg
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopaedics Branch, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:36300-10. 2008
    ..SirT1, nicotinamide phosphoribosyltransferase, and NAD may, therefore, provide a positive function in human cartilage by elevating expression of genes encoding cartilage extracellular matrix...
  7. pmc 75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes
    Hanna Oppenheimer
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University, Hadassah Ein Kerem, Jerusalem, Israel
    Arthritis Rheum 64:718-28. 2012
    ..Because 75SirT1 is resistant to further degradation, we hypothesized that it has a distinct role in OA, and the present study was undertaken to identify this role...
  8. doi request reprint Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation
    Hanna Oppenheimer
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    J Bone Miner Res 29:348-60. 2014
    ..Our study indicates that Set7/9 prevents the histone deacetylase activity of SirT1, potentiating euchromatin formation on the promoter site of COL2A1 and resulting in morphology-dependent COL2A1 gene transactivation...
  9. pmc Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    Odile Gabay
    Cartilage Molecular Genetics Group, Cartilage Biology and Orthopedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Disease, Bethesda, Maryland, USA
    Ann Rheum Dis 71:613-6. 2012
    ..A growing body of evidence indicates that the protein deacetylase, SirT1, affects chondrocyte biology and survival. This report aims to evaluate in vivo attributes of SirT1 in cartilage biology of 129/J murine strains...
  10. pmc Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes
    Michal Bar Oz
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Aging Cell 15:499-508. 2016
    ..Inhibition of importin β by importazole maintained SOX9 in the cytoplasm, even in the presence of NAD. Based on these data, we conclude that deacetylation promotes SOX9 nuclear translocation and hence its ability to activate ACAN...
  11. pmc Detecting cathepsin activity in human osteoarthritis via activity-based probes
    Louisa Ben-Aderet
    Laboratory of Cartilage Biology, Institute of Dental Sciences, Hebrew University of Jerusalem, PO Box 12272, Ein Kerem Campus, Jerusalem, 9112001, Israel
    Arthritis Res Ther 17:69. 2015
    ..Given the causal role of cathepsins in OA, monitoring their specific activity could provide means for assessing OA severity. To this end, we herein sought to assess a cathepsin activity-based probe (ABP), GB123, in vitro and in vivo...
  12. pmc Chopping off the chondrocyte proteome
    Mona Dvir-Ginzberg
    a Laboratory of Cartilage Biology, Faculty of Dental Medicine, Institute of Dental Sciences, Hebrew University of Jerusalem, Jerusalem, Israel
    Biomarkers 20:526-32. 2015
    ..Therefore, it is envisioned that combined biomarkers composed of both cell and extracellular-degraded secretome could provide a valuable platform for testing drug efficacy to halt disease progression at its early stages. ..