Research Topics
Species  Saharon RossetSummaryAffiliation: Tel Aviv University Country: Israel Publications
 Collaborators

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Publications
 Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populationsShay Tzur
Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, 31096, Israel
BMC Nephrol 13:142. 2012..A recent metaanalysis described a variant (p.Ile2984Val) in the cubilin gene (CUBN) that is associated with levels of albuminuria in the general population and in diabetics...  Maximumlikelihood estimation of sitespecific mutation rates in human mitochondrial DNA from partial phylogenetic classificationSaharon Rosset
Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel
Genetics 180:151124. 2008..Potential extensions of our methodology include its application to estimation of mutation rates in other genetic regions, like Y chromosome short tandem repeats...  Statistical modeling of coverage in highthroughput dataDavid Golan
School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
Methods Mol Biol 1038:6179. 2013..In this chapter we describe the fundamentals of statistical modeling of coverage depth and discuss the problems of estimation and inference in the relevant experimental scenarios...  Weighted poolingpractical and costeffective techniques for pooled highthroughput sequencingDavid Golan
School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
Bioinformatics 28:i197206. 2012..One can then infer the number of carriers in a pool, and by combining information across pools, reconstruct the identity of the carriers...  Accurate estimation of heritability in genome wide studies using random effects modelsDavid Golan
School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
Bioinformatics 27:i31723. 2011..2010) have demonstrated that the heritability of height is much higher than the ~10% associated with identified genetic factors. However, Yang et al. (2010) relied on a heuristic for performing estimation in this model...  Maximum likelihood estimation of locusspecific mutation rates in Ychromosome short tandem repeatsOsnat RavidAmir
Department of Statistics and Operation Research, Tel Aviv, Israel
Bioinformatics 26:i4405. 2010..Here we show a novel method for estimation of sitespecific YSTR mutation rates from partial phylogenetic information, via the maximum likelihood framework...  Measuring missing heritability: inferring the contribution of common variantsDavid Golan
Department of Statistics and Operations Research, School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel 69978
Proc Natl Acad Sci U S A 111:E527281. 2014..PCGC regression also is readily applicable to other settings, including analyzing extremephenotype studies and adjusting for covariates such as sex, age, and population structure. ..  Dyskinesias in patients with Parkinson's disease: effect of the leucinerich repeat kinase 2 (LRRK2) G2019S mutationGilad Yahalom
The Parkinson Disease and Movement Disorders Clinic, Sagol Neuroscience Center and Department of Neurology, Tel Aviv University, Israel
Parkinsonism Relat Disord 18:103941. 2012....  Comment on "the predictive capacity of personal genome sequencing"David Golan
Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
Sci Transl Med 4:135le4. 2012..Recalculation of the results in Roberts et al. shows that the true predictive capacity of genomes may be higher than their maximal estimates...  The population genetics of chronic kidney disease: insights from the MYH9APOL1 locusSaharon Rosset
Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
Nat Rev Nephrol 7:31326. 2011..We describe the data sources, process of discovery, and reasons for initial misidentification of the candidate gene, as well as the lessons that can be learned for future population genetics research...