Amit Gefen

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint The biomechanics of sitting-acquired pressure ulcers in patients with spinal cord injury or lesions
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Int Wound J 4:222-31. 2007
  2. ncbi request reprint How much time does it take to get a pressure ulcer? Integrated evidence from human, animal, and in vitro studies
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Isreal
    Ostomy Wound Manage 54:26-8, 30-5. 2008
  3. doi request reprint The biomechanics of heel ulcers
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Tissue Viability 19:124-31. 2010
  4. doi request reprint Clinical and biomechanical perspectives on pressure injury prevention research: The case of prophylactic dressings
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel Electronic address
    Clin Biomech (Bristol, Avon) 38:29-34. 2016
  5. ncbi request reprint Pressure-sensing devices for assessment of soft tissue loading under bony prominences: technological concepts and clinical utilization
    Amit Gefen
    Tel Aviv University, Ramat Aviv Israel Email
    Wounds 19:350-62. 2007
  6. ncbi request reprint Tissue changes in patients following spinal cord injury and implications for wheelchair cushions and tissue loading: a literature review
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel and European Pressure Ulcer Advisory Panel email
    Ostomy Wound Manage 60:34-45. 2014
  7. doi request reprint Biomechanical analysis of the keratoconic cornea
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Mech Behav Biomed Mater 2:224-36. 2009
  8. ncbi request reprint The free diffusion of macromolecules in tissue-engineered skeletal muscle subjected to large compression strains
    Amit Gefen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Biomech 41:845-53. 2008
  9. ncbi request reprint Viscoelastic properties of ovine adipose tissue covering the gluteus muscles
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 129:924-30. 2007
  10. ncbi request reprint The false premise in measuring body-support interface pressures for preventing serious pressure ulcers
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Med Eng Technol 31:375-80. 2007

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint The biomechanics of sitting-acquired pressure ulcers in patients with spinal cord injury or lesions
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Int Wound J 4:222-31. 2007
    ....
  2. ncbi request reprint How much time does it take to get a pressure ulcer? Integrated evidence from human, animal, and in vitro studies
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Isreal
    Ostomy Wound Manage 54:26-8, 30-5. 2008
    ..Further fundamental research, employing animal and cell culture models, is required to narrow this range further and to correlate the time factor to the extent of tissue damage...
  3. doi request reprint The biomechanics of heel ulcers
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Tissue Viability 19:124-31. 2010
    ..This paper therefore demonstrated that a biomechanical theory can be used to explain and interpret clinical and epidemiological findings related to heel ulcers...
  4. doi request reprint Clinical and biomechanical perspectives on pressure injury prevention research: The case of prophylactic dressings
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 6997801, Israel Electronic address
    Clin Biomech (Bristol, Avon) 38:29-34. 2016
    ....
  5. ncbi request reprint Pressure-sensing devices for assessment of soft tissue loading under bony prominences: technological concepts and clinical utilization
    Amit Gefen
    Tel Aviv University, Ramat Aviv Israel Email
    Wounds 19:350-62. 2007
    ....
  6. ncbi request reprint Tissue changes in patients following spinal cord injury and implications for wheelchair cushions and tissue loading: a literature review
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel and European Pressure Ulcer Advisory Panel email
    Ostomy Wound Manage 60:34-45. 2014
    ..As understanding about PU risk in this population increases, study designs can be refined to develop a much-needed evidence-base for the appropriate use of support surfaces in general and wheelchair cushions in particular. ..
  7. doi request reprint Biomechanical analysis of the keratoconic cornea
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Mech Behav Biomed Mater 2:224-36. 2009
    ..The present FE studies allowed characterization of the biomechanical interactions in keratoconus, toward understanding the aetiology of this poorly studied malady...
  8. ncbi request reprint The free diffusion of macromolecules in tissue-engineered skeletal muscle subjected to large compression strains
    Amit Gefen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    J Biomech 41:845-53. 2008
    ....
  9. ncbi request reprint Viscoelastic properties of ovine adipose tissue covering the gluteus muscles
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 129:924-30. 2007
    ..The mechanical characteristics of white adipose tissue provided herein are useful for analytical as well as numerical models of DTI, which are essential for understanding this serious malady...
  10. ncbi request reprint The false premise in measuring body-support interface pressures for preventing serious pressure ulcers
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Med Eng Technol 31:375-80. 2007
    ....
  11. ncbi request reprint Inhomogeneity of tissue-level strain distributions in individual trabeculae: mathematical model studies of normal and osteoporosis cases
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Eng Phys 30:624-30. 2008
    ..We conclude that the intra-trabecula strain inhomogeneities are likely to be an important factor contributing to the overall increased strain inhomogeneity in osteoporotic cancellous bone, as previously observed in micro-FE studies...
  12. ncbi request reprint Mechanics of the normal woman's breast
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Technol Health Care 15:259-71. 2007
    ..The data presented in this paper are useful for biomechanical modeling of the breast as well as for evaluating the loads acting on surgical repairs and breast implants...
  13. ncbi request reprint Risk factors for a pressure-related deep tissue injury: a theoretical model
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel
    Med Biol Eng Comput 45:563-73. 2007
    ....
  14. ncbi request reprint The Compression Intensity Index: a practical anatomical estimate of the biomechanical risk for a deep tissue injury
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Technol Health Care 16:141-9. 2008
    ..Hence, CII measurements can be integrated into DTI-risk-assessment tools, the need of which is now being discussed intensively in the American and European Pressure Ulcer Advisory Panel meetings...
  15. doi request reprint Strain-time cell-death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury
    Amit Gefen
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
    J Biomech 41:2003-12. 2008
    ..The specific E(zz)(c)(t) curve obtained herein is necessary for extrapolating biological damage from muscle-strain data in biomechanical studies of pressure ulcers and DTI...
  16. doi request reprint The relationship between sperm velocity and pressures applied to the zona pellucida during early sperm-oocyte penetration
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 132:124501. 2010
    ..The modeling hence provided some useful insights regarding sperm biomechanics, which theoretically elucidate the well-recognized importance of sperm velocity measurements as being indicative of sperm quality...
  17. doi request reprint How do microclimate factors affect the risk for superficial pressure ulcers: a mathematical modeling study
    Amit Gefen
    Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv Campus, Israel
    J Tissue Viability 20:81-8. 2011
    ....
  18. doi request reprint Effects of virus size and cell stiffness on forces, work, and pressures driving membrane invagination in a receptor-mediated endocytosis
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 132:084501. 2010
    ..The present model may be useful in the fields of cellular biomechanics, virology and nanodrug delivery to evaluate mechanical factors during the early phase of membrane invagination...
  19. ncbi request reprint Reswick and Rogers pressure-time curve for pressure ulcer risk. Part 2
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Nurs Stand 23:40-4. 2009
    ..Clinical implications are also discussed, with particular reference to patients who are obese and those with muscle atrophy...
  20. ncbi request reprint Reswick and Rogers pressure-time curve for pressure ulcer risk. Part 1
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Nurs Stand 23:64, 66, 68 passim. 2009
    ..Clinical implications of current injury thresholds are also discussed, in relation to obese patients and patients with muscle atrophy...
  21. ncbi request reprint Deep tissue injury from a bioengineering point of view
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Ostomy Wound Manage 55:26-36. 2009
    ..The application of interdisciplinary research may help clinicians and researchers move from evolving jargons, staging systems, and injury definitions to valid and reliable clinical instruments, which will improve clinical practice...
  22. ncbi request reprint In vivo muscle stiffening under bone compression promotes deep pressure sores
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    J Biomech Eng 127:512-24. 2005
    ..S. Department of Health...
  23. ncbi request reprint Are in vivo and in situ brain tissues mechanically similar?
    Amit Gefen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Biomech 37:1339-52. 2004
    ..02), and perfusion had no effect on any other property. These findings support the concept that perfusion does not affect the stiffness of living cortical tissue...
  24. ncbi request reprint [Diffusion of ulcers in the diabetic foot is promoted by stiffening of plantar muscular tissue under excessive bone compression]
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    Orthopade 33:999-1012. 2004
    ....
  25. ncbi request reprint In vivo biomechanical behavior of the human heel pad during the stance phase of gait
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 34:1661-5. 2001
    ..8+/-0.8%. The present technique is useful for biomechanical as well as clinical evaluation of the stress-strain and energy absorption characteristics of the heel pad in vivo, during natural gait...
  26. ncbi request reprint Integration of plantar soft tissue stiffness measurements in routine MRI of the diabetic foot
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel
    Clin Biomech (Bristol, Avon) 16:921-5. 2001
    ..A method of measuring mechanical properties of plantar soft tissues in vivo by integrating a photoelastic technique into an MRI system is presented...
  27. ncbi request reprint Stress analysis of the standing foot following surgical plantar fascia release
    Amit Gefen
    Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, 69978 Tel Aviv, Israel
    J Biomech 35:629-37. 2002
    ....
  28. ncbi request reprint The in vivo elastic properties of the plantar fascia during the contact phase of walking
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Foot Ankle Int 24:238-44. 2003
    ....
  29. ncbi request reprint Simulations of foot stability during gait characteristic of ankle dorsiflexor weakness in the elderly
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    IEEE Trans Neural Syst Rehabil Eng 9:333-7. 2001
    ....
  30. doi request reprint Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway
    Naama Shoham
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    Am J Physiol Cell Physiol 302:C429-41. 2012
    ..21 ± 3.07%). Our results hence demonstrate that differentiation of adipocytes can be enhanced by sustained stretching, which activates the MEK signaling pathway...
  31. ncbi request reprint Biomechanical aspects of Peyronie's disease in development stages and following reconstructive surgeries
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Int J Impot Res 14:389-96. 2002
    ....
  32. ncbi request reprint Optimizing the biomechanical compatibility of orthopedic screws for bone fracture fixation
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Eng Phys 24:337-47. 2002
    ..Accordingly, the present work demonstrates that finite element computer simulations can be used as a powerful tool for design and evaluation of bone screws, including geometrical features, material characteristics and even coatings...
  33. ncbi request reprint Computational simulations of stress shielding and bone resorption around existing and computer-designed orthopaedic screws
    A Gefen
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel
    Med Biol Eng Comput 40:311-22. 2002
    ..Computer simulations of bone adaptation around orthopaedic screws are demonstrated to be effective means for objective and quantitative evaluation of the biomechanical aspects of implant-tissue compatibility...
  34. ncbi request reprint Biomechanical analysis of fatigue-related foot injury mechanisms in athletes and recruits during intensive marching
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Med Biol Eng Comput 40:302-10. 2002
    ..This may point to the mechanism by which stress fractures develop and provide the biomechanical tools for future clinical investigations...
  35. ncbi request reprint Plantar soft tissue loading under the medial metatarsals in the standing diabetic foot
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Eng Phys 25:491-9. 2003
    ....
  36. ncbi request reprint Comparison of the trabecular architecture and the isostatic stress flow in the human calcaneus
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Eng Phys 26:119-29. 2004
    ....
  37. doi request reprint Exposure to internal muscle tissue loads under the ischial tuberosities during sitting is elevated at abnormally high or low body mass indices
    Ran Sopher
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 43:280-6. 2010
    ....
  38. ncbi request reprint Strains and stresses in sub-dermal tissues of the buttocks are greater in paraplegics than in healthy during sitting
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 41:567-80. 2008
    ....
  39. ncbi request reprint Toward real-time detection of deep tissue injury risk in wheelchair users using Hertz contact theory
    Limor Agam
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    J Rehabil Res Dev 45:537-50, 8 p following 550. 2008
    ..We conclude that the present stress monitoring system has the potential to be a practical means for evaluating internal muscle stresses during everyday life of individuals with paraplegia...
  40. ncbi request reprint Evaluation of fatigue of respiratory and lower limb muscles during prolonged aerobic exercise
    Yaara Nadiv
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    J Appl Biomech 28:139-47. 2012
    ..05), which suggests that respiratory muscles should be trained in military recruits who are required to carry loaded backpacks while marching...
  41. pmc Effect of trabecular bone loss on cortical strain rate during impact in an in vitro model of avian femur
    Tal Reich
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Biomed Eng Online 5:45. 2006
    ....
  42. ncbi request reprint Assessment of mechanical conditions in sub-dermal tissues during sitting: a combined experimental-MRI and finite element approach
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 40:1443-54. 2007
    ..These data are essential for understanding the aetiology of pressure sores, particularly those that were recently termed "deep tissue injury" at the US National Pressure Ulcer Advisory Panel (NPUAP) 2005 Consensus Conference...
  43. doi request reprint Evaluation of the effect of trunk tilt on compressive soft tissue deformations under the ischial tuberosities using weight-bearing MRI
    Nogah Shabshin
    Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer 52621, affiliated to Sackler Faculty of Medicine Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Clin Biomech (Bristol, Avon) 25:402-8. 2010
    ..This has brought us to investigate buttocks tissue compressive deformations between the ischial tuberosities and skin during sitting in various body tilts, utilizing weight-bearing Magnetic resonance imaging (MRI)...
  44. doi request reprint The influence of foot posture, support stiffness, heel pad loading and tissue mechanical properties on biomechanical factors associated with a risk of heel ulceration
    Ran Sopher
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Mech Behav Biomed Mater 4:572-82. 2011
    ....
  45. ncbi request reprint Stress relaxation of porcine gluteus muscle subjected to sudden transverse deformation as related to pressure sore modeling
    Avital Palevski
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 128:782-7. 2006
    ....
  46. doi request reprint Real-time subject-specific analyses of dynamic internal tissue loads in the residual limb of transtibial amputees
    Sigal Portnoy
    Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel
    Med Eng Phys 32:312-23. 2010
    ..Pending integration of appropriate dynamic tissue injury thresholds, the device can be utilized for alerting to the danger of DTI...
  47. doi request reprint The mechanics of hyaluronic acid/adipic acid dihydrazide hydrogel: towards developing a vessel for delivery of preadipocytes to native tissues
    Naama Shoham
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Mech Behav Biomed Mater 28:320-31. 2013
    ..g. in research towards regenerative medicine in tissue reconstructions. ..
  48. doi request reprint Reducing musculoskeletal disorders among computer operators: comparison between ergonomics interventions at the workplace
    Yafa Levanon
    Department of Occupational Therapy, School of Health Professions, Tel Aviv University, P O B 39040, Tel Aviv, 69978 Israel
    Ergonomics 55:1571-85. 2012
    ..3; p = 0.001). Significant changes were found in UE kinematics and posture as well. Both ergonomics interventions effectively reduced MSD and improved body posture...
  49. doi request reprint Is obesity a risk factor for deep tissue injury in patients with spinal cord injury?
    Jonathan J Elsner
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 41:3322-31. 2008
    ..This result highlights that obesity and muscle atrophy, which are both typical of the chronic phase of SCI, contribute together to the state of elevated tissue loads, which consequently increases the likelihood of DTI in this population...
  50. doi request reprint Real-time finite element monitoring of sub-dermal tissue stresses in individuals with spinal cord injury: toward prevention of pressure ulcers
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Ann Biomed Eng 37:387-400. 2009
    ....
  51. ncbi request reprint Role of EVA viscoelastic properties in the protective performance of a sport shoe: computational studies
    Nurit Even-Tzur
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Biomed Mater Eng 16:289-99. 2006
    ..We conclude that modeling of the heel-shoe interaction should consider the viscoelastic properties of the tissue and shoe components, and the age of the studied shoe...
  52. doi request reprint Multi dimensional system for evaluating preventive program for upper extremity disorders among computer operators
    Yafa Levanon
    Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Work 41:669-75. 2012
    ..The ergonomic intervention with biofeedback had no unique contribution in comparison to other interventions. In conclusion; the proposed intervention program was found efficient for reducing pain among computer workers...
  53. doi request reprint The influence of mechanical stretching on mitosis, growth, and adipose conversion in adipocyte cultures
    Naama Shoham
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel
    Biomech Model Mechanobiol 11:1029-45. 2012
    ....
  54. doi request reprint Outdoor dynamic subject-specific evaluation of internal stresses in the residual limb: hydraulic energy-stored prosthetic foot compared to conventional energy-stored prosthetic feet
    Sigal Portnoy
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Gait Posture 35:121-5. 2012
    ..Our findings suggest that using a hydraulic prosthetic foot may protect the distal tibial end of the TTA residuum from high stresses, therefore preventing pressure-related injury and pain...
  55. ncbi request reprint Pressure-time cell death threshold for albino rat skeletal muscles as related to pressure sore biomechanics
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 39:2725-32. 2006
    ....
  56. doi request reprint Stress analyses coupled with damage laws to determine biomechanical risk factors for deep tissue injury during sitting
    Eran Linder-Ganz
    Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 131:011003. 2009
    ..The present methodology is a practical tool for evaluating the performances of cushions in reducing the risk for DTI in a manner that goes far beyond the commonly accepted measurements of sitting pressures...
  57. ncbi request reprint Analysis of muscular fatigue and foot stability during high-heeled gait
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel
    Gait Posture 15:56-63. 2002
    ....
  58. ncbi request reprint Computational studies of strain exposures in neonate and mature rat brains during closed head impact
    Anna Levchakov
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv Campus, Tel Aviv, Israel
    J Neurotrauma 23:1570-80. 2006
    ..Additionally, the larger peak stresses and larger strain volumetric exposures observed in the neonatal brain support the hypothesis that the smaller size and stiffer tissue of the infant brain makes it more susceptible to TBI...
  59. doi request reprint Effects of intramuscular fat infiltration, scarring, and spasticity on the risk for sitting-acquired deep tissue injury in spinal cord injury patients
    Ran Sopher
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 133:021011. 2011
    ..This information should be considered when prioritizing prevention means and resources for patients with SCI...
  60. doi request reprint A new technique for studying directional cell migration in a hydrogel-based three-dimensional matrix for tissue engineering model systems
    Gil Topman
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Micron 51:9-12. 2013
    ....
  61. ncbi request reprint The effects of pressure and shear on capillary closure in the microstructure of skeletal muscles
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel
    Ann Biomed Eng 35:2095-107. 2007
    ..Since there is evidence that DTI develops within a shorter time, ischemia is unlikely to be the only factor causing DTI...
  62. doi request reprint The natural medications for wound healing - Curcumin, Aloe-Vera and Ginger - do not induce a significant effect on the migration kinematics of cultured fibroblasts
    Gil Topman
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 46:170-4. 2013
    ..However, due to the complexity of a wound healing process in vivo, these NMs may still influence the healing through other pathways...
  63. doi request reprint Identification of capillary blood pressure levels at which capillary collapse is likely in a tissue subjected to large compressive and shear deformations
    Malka Shilo
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel
    Comput Methods Biomech Biomed Engin 15:59-71. 2012
    ..Our modelling therefore suggests that low CBP is a 'suspect' risk factor for PU in SCI and geriatric patients...
  64. doi request reprint Clinically oriented real-time monitoring of the individual's risk for deep tissue injury
    Sigal Portnoy
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Biol Eng Comput 49:473-83. 2011
    ..The heaviest subject had the highest maximal and average peak internal soft tissue stress. We believe that this method holds a high potential for clinical applications...
  65. doi request reprint Patient-specific modeling of deep tissue injury biomechanics in an unconscious patient who developed myonecrosis after prolonged lying
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv Campus, Tel Aviv 69978, Israel
    J Tissue Viability 18:62-71. 2009
    ..This case study also indicates that although both strain and stress measures can be considered adequate predictors of DTI, tissue stresses appear to perform better than strains...
  66. doi request reprint Confocal microscopy-based three-dimensional cell-specific modeling for large deformation analyses in cellular mechanics
    Noa Slomka
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 43:1806-16. 2010
    ....
  67. doi request reprint Changes in permeability of the plasma membrane of myoblasts to fluorescent dyes with different molecular masses under sustained uniaxial stretching
    Efrat Leopold
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Med Eng Phys 35:601-7. 2013
    ....
  68. doi request reprint Stretching affects intracellular oxygen levels: three-dimensional multiphysics studies
    Efrat Leopold
    Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 134:064501. 2012
    ..The changes in cell geometry due to externally applied deformations could, hence, theoretically affect cell respiration, which should be a consideration in cellular mechanics experiments...
  69. doi request reprint Deformations, mechanical strains and stresses across the different hierarchical scales in weight-bearing soft tissues
    Naama Shoham
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv Campus, Tel Aviv 69978, Israel
    J Tissue Viability 21:39-46. 2012
    ..Emerging relevant bioengineering methods of computer simulation such as multiscale and multiphysics modeling will undoubtedly contribute to the aetiological research in this field in the near future...
  70. doi request reprint Relationship between strain levels and permeability of the plasma membrane in statically stretched myoblasts
    Noa Slomka
    Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Ann Biomed Eng 40:606-18. 2012
    ....
  71. doi request reprint Cell-to-cell variability in deformations across compressed myoblasts
    Noa Slomka
    Department of Biomedical Engineering Faculty of Engineering Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 133:081007. 2011
    ..Better understanding of variabilities in mechanical performances of cells-either of the same type or of different types-is important for interpreting experimental data in any experiments involving delivery of mechanical loads to cells...
  72. doi request reprint Cellular-scale transport in deformed skeletal muscle following spinal cord injury
    Yael Ruschkewitz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Comput Methods Biomech Biomed Engin 14:411-24. 2011
    ..These findings overall suggest that microanatomical changes in muscles post-SCI play an important role in the vulnerability of the SCI patients to DTI...
  73. doi request reprint Utilization of the foot load monitor for evaluating deep plantar tissue stresses in patients with diabetes: proof-of-concept studies
    Eran Atlas
    Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel
    Gait Posture 29:377-82. 2009
    ..It may also be helpful in providing biofeedback to neuropathic diabetic patients...
  74. ncbi request reprint Bioengineering models of deep tissue injury
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Adv Skin Wound Care 21:30-6. 2008
  75. ncbi request reprint Inspiratory muscles experience fatigue faster than the calf muscles during treadmill marching
    Renana Perlovitch
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Respir Physiol Neurobiol 156:61-8. 2007
    ..Accordingly, this study supports the hypothesis that fatigue of the inspiratory muscles may be a limiting factor during exercise...
  76. ncbi request reprint A method of quantification of stress shielding in the proximal femur using hierarchical computational modeling
    Michal Be'ery-Lipperman
    Department of Biomedical Engineering, Tel Aviv University, Faculty of Engineering, Tel Aviv 69978, Israel
    Comput Methods Biomech Biomed Engin 9:35-44. 2006
    ....
  77. doi request reprint Measurements of the static friction coefficient between bone and muscle tissues
    Sharon Shacham
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 132:084502. 2010
    ..3 for loads exceeding 4 N. Hence, for FE modeling of bone-muscle contacts through which loads with magnitudes of kgs to 10s-of-kgs are transferred, assuming mu of approximately 0.3 appears to be appropriate...
  78. ncbi request reprint Real-time subject-specific monitoring of internal deformations and stresses in the soft tissues of the foot: a new approach in gait analysis
    G Yarnitzky
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    J Biomech 39:2673-89. 2006
    ....
  79. ncbi request reprint Pressure ulcers and deep tissue injury: a bioengineering perspective
    L Agam
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    J Wound Care 16:336-42. 2007
    ..Wheelchair users are highly susceptible to deep tissue injury. Interface pressures are unlikely to predict this, and an alternative assessment approach is needed that can easily monitor internal mechanical stresses and deformations...
  80. doi request reprint The effect of compressive deformations on the rate of build-up of oxygen in isolated skeletal muscle cells
    Efrat Leopold
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Med Eng Phys 33:1072-8. 2011
    ..In a real-world condition, a combination of the deformation and temperature factors should be anticipated, and their combined effect might substantially impair cell respiration functions...
  81. doi request reprint Confocal-based cell-specific finite element modeling extended to study variable cell shapes and intracellular structures: the example of the adipocyte
    Shira Or-Tzadikario
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech 44:567-73. 2011
    ....
  82. ncbi request reprint Tissue-level failure accumulation in vertebral cancellous bone: a theoretical model
    Noa Slomka
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Technol Health Care 16:47-60. 2008
    ....
  83. ncbi request reprint Mathematical functions and their properties as relevant to the biomechanical modeling of cell and tissue damage
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    J Appl Biomech 26:93-103. 2010
    ..Relevant properties of each adapted function type were extracted to allow efficient fitting of its parameters to empirical biomechanical data, and some practical examples are provided...
  84. ncbi request reprint Computational determination of the critical microcrack size that causes a remodeling response in a trabecula: a feasibility study
    Amit Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    J Appl Biomech 23:230-7. 2007
    ....
  85. doi request reprint Experimentally tested computer modeling of stress fractures in rats
    Michal Stern-Perry
    Dept of Biomedical Engineering, Faculty of Engineering, Tel Aviv Univ, Tel Aviv 69978, Israel
    J Appl Physiol (1985) 110:909-16. 2011
    ..The location of the identified SF in the rat limb verified the FE model. We find the suggested model a valuable tool in studying various aspects of SFs...
  86. ncbi request reprint Mechanical compression-induced pressure sores in rat hindlimb: muscle stiffness, histology, and computational models
    E Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Appl Physiol 96:2034-49. 2004
    ..g., longissimus or gluteus) stresses and injuring conditions. We conclude that information on internal muscle stresses is required to establish new criteria for pressure sore prevention...
  87. ncbi request reprint A three-dimensional model of the penis for analysis of tissue stresses during normal and abnormal erection
    Eran Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Ann N Y Acad Sci 1101:464-76. 2007
    ..The model's ability to determine internal stresses in the erect penis offers a new point of view on the mechanical factors involved with erection, and enables us to relate these data with different penile pathologies...
  88. ncbi request reprint Pulmonary oedema in SCUBA divers: pathophysiology and computed risk analysis
    Pinchas Halpern
    Department of Emergency Medicine Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur J Emerg Med 10:35-41. 2003
    ..The model predicted that the risk of injury is significantly increased in individuals who have a stiffer lung parenchyma or lower lung compliance values...
  89. doi request reprint Validity and reliability of upper extremity three-dimensional kinematics during a typing task
    Yafa Levanon
    Tel Aviv University, P O B 39040 Ramat Aviv, Tel Aviv, 69978, Israel
    Gait Posture 32:469-74. 2010
    ..70) for most variables. The CODA system has considerable potential for understanding movement patterns in the upper extremities. These findings can provide the basis for future studies on the efficacy of ergonomic intervention programs...
  90. ncbi request reprint Computational tools in rehabilitation of erectile dysfunction
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, 69978, Tel Aviv, Israel
    Med Eng Phys 23:69-82. 2001
    ....
  91. ncbi request reprint Contribution of muscular weakness to osteoporosis: computational and animal models
    M Be'ery-Lipperman
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Clin Biomech (Bristol, Avon) 20:984-97. 2005
    ..This study aims at quantifying long-term changes in thickness and mechanical properties of trabecular bone at the proximal femur due to muscular weakness...
  92. ncbi request reprint Microwave drilling of bones
    Yael Eshet
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    IEEE Trans Biomed Eng 53:1174-82. 2006
    ....
  93. ncbi request reprint Age-dependent changes in material properties of the brain and braincase of the rat
    Amit Gefen
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 20:1163-77. 2003
    ..Specifically, these results will assist in the selection of forces to induce comparable mechanical stresses, strains and consequent injury profiles in brain tissues of immature and adult animals...
  94. ncbi request reprint Trabecular bone contributes to strength of the proximal femur under mediolateral impact in the avian
    N Passi
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    J Biomech Eng 127:198-203. 2005
    ..However, it is unclear whether trabecular bone significantly contributes to the strength of whole bones under non-physiological impact loads...
  95. ncbi request reprint Real-time patient-specific finite element analysis of internal stresses in the soft tissues of a residual limb: a new tool for prosthetic fitting
    S Portnoy
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Ann Biomed Eng 35:120-35. 2007
    ..This method is promising for improving the fitting of prostheses in the clinical setting and for protecting the residual limb from pressure ulcers and DTI...
  96. doi request reprint Patient-specific analyses of deep tissue loads post transtibial amputation in residual limbs of multiple prosthetic users
    S Portnoy
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Biomech 42:2686-93. 2009
    ....
  97. doi request reprint Surgical and morphological factors that affect internal mechanical loads in soft tissues of the transtibial residuum
    S Portnoy
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel
    Ann Biomed Eng 37:2583-605. 2009
    ..Additionally, the present analyses can be used to guide or focus epidemiological research of PU and DTI risk factors in the TTA population...
  98. ncbi request reprint Single-trabecula building block for large-scale finite element models of cancellous bone
    D Dagan
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Israel
    Med Biol Eng Comput 42:549-56. 2004
    ..Based on these comparisons, it is concluded that the single-trabecula element developed in the present study is well-suited for representing cancellous bone in large-scale generic FE simulations...
  99. ncbi request reprint A method for patient-specific evaluation of vertebral cancellous bone strength: in vitro validation
    I Diamant
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Clin Biomech (Bristol, Avon) 22:282-91. 2007
    ..A better method for evaluating the patient-specific mechanical properties of cancellous bone is therefore required...
  100. ncbi request reprint How do normals move during prolonged wheelchair-sitting?
    E Linder-Ganz
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Technol Health Care 15:195-202. 2007
    ..This small study population therefore supports the hypothesis that prolonged immobilization contributes to PS onset...
  101. ncbi request reprint Analysis of mechanical stresses within the alveolar septa leading to pulmonary edema
    A Gefen
    Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel
    Technol Health Care 9:257-67. 2001
    ..The combination of elevated stress sites that are formed in the stiffer parenchyma of the aging lung, together with the cyclic loading of ventilation, may explain the gaps and breaks previously observed in pulmonary edema...