Dorit Ben-Shachar

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study
    Rachel Karry
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Biol Psychiatry 55:676-84. 2004
  2. ncbi request reprint Iron-binding characteristics of neuromelanin of the human substantia nigra
    Kay L Double
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Biochem Pharmacol 66:489-94. 2003
  3. doi request reprint Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion IIT, Haifa, Israel Electronic address
    Schizophr Res . 2016
  4. doi request reprint Analysis of mitochondrial network by imaging: proof of technique in schizophrenia
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, B Rappaport Faculty of Medicine, Rambam Medical Center, Technion IIT, 9649, Haifa, 31096, Israel
    Methods Mol Biol 1265:425-39. 2015
  5. doi request reprint The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion IIT, Haifa, Israel
    J Neural Transm (Vienna) 116:1383-96. 2009
  6. pmc Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry Rambam Medical Center and B Rappaport Faculty of Medicine Technion, Haifa, Israel
    PLoS ONE 3:e3676. 2008
  7. doi request reprint Mitochondrial complex I subunits are altered in rats with neonatal ventral hippocampal damage but not in rats exposed to oxygen restriction at neonatal age
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion ITT, P O Box 9649, Haifa, 31096, Israel
    J Mol Neurosci 38:143-51. 2009
  8. pmc Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 2:e817. 2007
  9. ncbi request reprint Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine Technion IIT, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:807-13. 2007
  10. ncbi request reprint Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders
    D Ben-Shachar
    Research Lab of Psychobiology, Department of Psychiatry, Bruce Rappaport Faculty of Medicine, Rambam Medical Center, Technion ITT, P O Box 9649, Haifa, Israel
    Biochem Pharmacol 67:1965-74. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study
    Rachel Karry
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Biol Psychiatry 55:676-84. 2004
    ....
  2. ncbi request reprint Iron-binding characteristics of neuromelanin of the human substantia nigra
    Kay L Double
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Biochem Pharmacol 66:489-94. 2003
    ..The interaction between NM and iron has implications for disorders such as Parkinson's disease where an increase in iron in the SN is associated with increased indices of oxidative stress...
  3. doi request reprint Mitochondrial multifaceted dysfunction in schizophrenia; complex I as a possible pathological target
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion IIT, Haifa, Israel Electronic address
    Schizophr Res . 2016
    ..Mitochondrial function in schizophrenia may advance our knowledge of the disease pathophysiology and open the road for new treatment targets for the benefit of the patients...
  4. doi request reprint Analysis of mitochondrial network by imaging: proof of technique in schizophrenia
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, B Rappaport Faculty of Medicine, Rambam Medical Center, Technion IIT, 9649, Haifa, 31096, Israel
    Methods Mol Biol 1265:425-39. 2015
    ..We demonstrate various applications of JC-1 staining to study mitochondrial abnormalities in different cell types derived from schizophrenia patients and healthy subjects...
  5. doi request reprint The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion IIT, Haifa, Israel
    J Neural Transm (Vienna) 116:1383-96. 2009
    ..Finally, this review discusses the question of disease specificity of mitochondrial pathologies and suggests that mitochondria dysfunction could cause or arise from anomalities in processes involved in brain connectivity...
  6. pmc Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry Rambam Medical Center and B Rappaport Faculty of Medicine Technion, Haifa, Israel
    PLoS ONE 3:e3676. 2008
    ..Mitochondrial dysfunction was reported in schizophrenia, bipolar disorderand major depression. The present study investigated whether mitochondrial complex I abnormalities show disease-specific characteristics...
  7. doi request reprint Mitochondrial complex I subunits are altered in rats with neonatal ventral hippocampal damage but not in rats exposed to oxygen restriction at neonatal age
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion ITT, P O Box 9649, Haifa, 31096, Israel
    J Mol Neurosci 38:143-51. 2009
    ..The results of this study support previous findings suggesting abnormal complex I expression as a pathological characteristic of schizophrenia rather than an effect of medication...
  8. pmc Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 2:e817. 2007
    ..We investigated whether the ubiquitous transcription factor Sp1 is abnormally expressed in schizophrenia, and consequently can affect the expression of genes implicated in this disorder...
  9. ncbi request reprint Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine Technion IIT, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:807-13. 2007
    ..These results suggest that the correlation between peripheral complex I activity and rCGM in regions implicated in schizophrenia, could be a pathological factor that is differentially expressed in subgroups of schizophrenic patients...
  10. ncbi request reprint Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders
    D Ben-Shachar
    Research Lab of Psychobiology, Department of Psychiatry, Bruce Rappaport Faculty of Medicine, Rambam Medical Center, Technion ITT, P O Box 9649, Haifa, Israel
    Biochem Pharmacol 67:1965-74. 2004
    ..We further hypothesize that this interaction between dopamine and mitochondria is associated with mitochondrial dysfunction observed in dopamine-related neuropsychiatric disorders, such as schizophrenia and Parkinson's disease...
  11. ncbi request reprint Mitochondrial dysfunction in schizophrenia: a possible linkage to dopamine
    Dorit Ben-Shachar
    Laboratory of Psychobiology, The Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    J Neurochem 83:1241-51. 2002
    ..Understanding the role of mitochondria in schizophrenia may encourage novel treatment approaches, the identification of candidate genes and new insights into the pathophysiology and etiology of the disorder...
  12. ncbi request reprint Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study
    Daphna Laifenfeld
    Laboratory of Psychobiology, The Department of Psychiatry, Rambam Medical Center, and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Biol Psychiatry 57:716-25. 2005
    ..Presently we hypothesized that CAM-L1, CREB, and laminin may be altered in post mortem brains of depressed subjects...
  13. ncbi request reprint Dopamine modulates mitochondrial function in viable SH-SY5Y cells possibly via its interaction with complex I: relevance to dopamine pathology in schizophrenia
    Hanit Brenner-Lavie
    Research Lab of Psychobiology, Department of Psychiatry Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Biochim Biophys Acta 1777:173-85. 2008
    ..These results suggest a non-lethal interaction between DA and mitochondria possibly via complex I, which can better explain DA-related pathological processes observed in non-degenerative disorders, such as schizophrenia...
  14. doi request reprint Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat
    Alexandra Kavushansky
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, B Rappaport Faculty of Medicine, Bat Galim, Technion, Haifa, 31096, Israel
    Stress 12:412-25. 2009
    ..These results indicate stressor-specific time-dependent changes in different neuronal pathways, and suggest consideration of a cause-specific approach to the treatment of stress-related disorders...
  15. doi request reprint Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action
    Shiri P Yaniv
    Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cell Biol 89:712-22. 2010
    ..These results show a novel complex interaction by which GCs augment NE-induced intracellular signaling that may be relevant to antidepressant mode of action...
  16. doi request reprint Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophrenia
    Marina Rosenfeld
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Technion, Haifa, Israel
    Biol Psychiatry 69:980-8. 2011
    ..This study aimed to investigate mitochondrial network dynamics and its plausible association with abnormal cellular oxygen consumption in schizophrenia...
  17. doi request reprint β-endorphin degradation and the individual reactivity to traumatic stress
    Alexandra Kavushansky
    Department of Internal Medicine, Rambam Medical Center, Laboratory of Psychobiology, B Rappaport Faculty of Medicine and B Rappaport Research Institute, Technion, Haifa, Israel
    Eur Neuropsychopharmacol 23:1779-88. 2013
    ..Modulation of opioid degradation may thus present a potential novel target for interference with extreme anxiety. ..
  18. doi request reprint Mitochondrial complex I as a novel target for intraneuronal DA: modulation of respiration in intact cells
    Hanit Brenner-Lavie
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Biochem Pharmacol 78:85-95. 2009
    ..Such a mechanism may be of relevance to DA-related non-degenerative pathologies such as schizophrenia...
  19. doi request reprint Norepinephrine-glucocorticoids interaction does not annul the opposite effects of the individual treatments on cellular plasticity in neuroblastoma cells
    Shiri P Yaniv
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Pharmacol 596:14-24. 2008
    ..These results suggest that in order for cells to combat the deleterious effects of glucocorticoids, a hyperactivation of pCREB may be necessary to restore differentiation and plasticity...
  20. doi request reprint DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2
    Yael Chertkow-Deutsher
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Int J Neuropsychopharmacol 13:347-59. 2010
    ..These results suggest that alterations in global methylation pattern are involved in behavioural adaptation to environmental stress and pinpoint Dlgap2 as a possible target in PTSD...
  21. ncbi request reprint Modulation of frequency and duration of repetitive magnetic stimulation affects catecholamine levels and tyrosine hydroxylase activity in human neuroblastoma cells: implication for the antidepressant effect of rTMS
    Uri Shaul
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Int J Neuropsychopharmacol 6:233-41. 2003
    ..Considering the major role of catecholamine in the pathophysiology of depression, these findings may be of relevance to the application of rTMS in humans with major depression...
  22. ncbi request reprint Mitochondria, synaptic plasticity, and schizophrenia
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Int Rev Neurobiol 59:273-96. 2004
    ..This review proposes that mitochondrial dysfunction in schizophrenia could cause, or arise from, anomalies in processes of plasticity in this disorder...
  23. doi request reprint Early postnatal interference with the expression of multiple Sp1 regulated genes leads to disparate behavioral response to sub-chronic and chronic stress in rats
    Eyal Asor
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa 31096, Israel
    Psychoneuroendocrinology 38:2173-83. 2013
    ..We suggest that an alternative approach is interference with the expression of multiple genes followed by exposure to environmental insults...
  24. ncbi request reprint Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28
    Moussa B H Youdim
    Eve Topf and US National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, and Department of Pharmacology, Technion Rappaport Faculty of Medicine, Haifa, Israel
    Ann N Y Acad Sci 1012:306-25. 2004
    ....
  25. doi request reprint The role of branched chain amino acid and tryptophan metabolism in rat's behavioral diversity: Intertwined peripheral and brain effects
    Eyal Asor
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Tel Aviv University, Tel Aviv, Israel B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Eur Neuropsychopharmacol 25:1695-705. 2015
    ....
  26. doi request reprint Dexamethasone in the presence of desipramine enhances MAPK/ERK1/2 signaling possibly via its interference with β-arrestin
    Anat Lucki
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine and B Rappaport Research Institute, Technion IIT, POB 9649, 31096, Haifa, Israel
    J Neural Transm (Vienna) 121:289-98. 2014
    ..We suggest that such an interaction in the presence of DMI can enhance MAPK/ERK1/2 signaling, a key player in neural plasticity and neurogenesis processes, which is impaired in MDD, while stimulated by antidepressants...
  27. ncbi request reprint Major depression as a disorder of serotonin resistance: inference from diabetes mellitus type II
    Bella Smolin
    Department of Internal Medicine Rambam Medical Center, B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Int J Neuropsychopharmacol 10:839-50. 2007
    ....
  28. ncbi request reprint Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms
    Daphna Laifenfeld
    Laboratory of Psychobiology, The Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    J Neurochem 83:1054-64. 2002
    ..Taken together, the results support a role for NE in processes of synaptic connectivity, and may point to a role for this neurotransmitter in mediating the suggested neuronal plasticity in depression and in antidepressant treatment...
  29. pmc Gene environment interaction in periphery and brain converge to modulate behavioral outcomes: Insights from the SP1 transient early in life interference rat model
    Eyal Asor
    Eyal Asor, Dorit Ben Shachar, Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Haifa 31096, Israel
    World J Psychiatry 6:294-302. 2016
    ..We suggest that models, which take into account the tripartite reciprocal interaction between the central nervous system, peripheral systems and environmental stimuli will advance our understanding of the complexity of behavior. ..
  30. doi request reprint Entacapone augmentation of antipsychotic treatment in schizophrenic patients with negative symptoms; a double-blind placebo-controlled study
    Hanoch Kaphzan
    Sagol Department of Neurobiology, University of Haifa, Haifa, Israel
    Int J Neuropsychopharmacol 17:337-40. 2014
    ..However, entacapone did not demonstrate a beneficial effect compared to placebo. Therefore, this study does not support a therapeutic role for entacapone in residual schizophrenia. ..
  31. ncbi request reprint Increased mRNA levels of the mitochondrial complex I 75-kDa subunit. A potential peripheral marker of early onset schizophrenia?
    Claudia Mehler-Wex
    Dept of Child and Adolescent Psychiatry, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Child Adolesc Psychiatry 15:504-7. 2006
    ..Our preliminary findings suggest the mitochondrial complex I as a potential peripheral marker of schizophrenia and its involvement in the pathophysiology of this illness...
  32. ncbi request reprint Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease
    Manfred Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, D 97080 Wurzburg, Germany
    Neurotox Res 5:35-44. 2003
    ..The resultant radical-mediated cytotoxicity may contribute to cellular damage observed in PD...