Yehonatan Sharabi

Summary

Country: Israel

Publications

  1. pmc Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Neurol Sci 310:123-8. 2011
  2. doi Management of the unholy trinity diabetes-obesity-hypertension (diabesotension)
    Yehonatan Sharabi
    Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Metab Res Rev . 2012
  3. ncbi Effect of PPAR-gamma agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model
    Yehonatan Sharabi
    Hypertension Unit, C Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 20:206-10. 2007
  4. ncbi Sleep apnea-induced hypertension: mechanisms of vascular changes
    Yehonatan Sharabi
    Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Expert Rev Cardiovasc Ther 3:937-40. 2005
  5. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
  6. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
  7. ncbi Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
  8. pmc Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 14:600-7. 2008
  9. pmc Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:57-61. 2012
  10. pmc Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervation
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1148:486-9. 2008

Detail Information

Publications69

  1. pmc Mechanisms of orthostatic hypotension and supine hypertension in Parkinson disease
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Neurol Sci 310:123-8. 2011
    ..Future research is needed to understand better and attenuate blood pressure fluctuations through manipulations that improve baroreflex function...
  2. doi Management of the unholy trinity diabetes-obesity-hypertension (diabesotension)
    Yehonatan Sharabi
    Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Metab Res Rev . 2012
    ..A novel procedure such as renal denervation is a promising option due to its antihypertensive and metabolic benefits. Copyright © 2012 John Wiley & Sons, Ltd...
  3. ncbi Effect of PPAR-gamma agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model
    Yehonatan Sharabi
    Hypertension Unit, C Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 20:206-10. 2007
    ..We studied the effect of the PPAR-gamma agonist rosiglitazone on adiponectin and the metabolic profile in the fructose-induced hypertensive, hyperinsulinemic, hypertriglyceridemic rat model...
  4. ncbi Sleep apnea-induced hypertension: mechanisms of vascular changes
    Yehonatan Sharabi
    Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Expert Rev Cardiovasc Ther 3:937-40. 2005
    ..This review will clarify the unique set of features of hypertension associated with obstructive sleep apnea and examine the mechanisms that contribute to its cardiovascular consequences...
  5. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
    ..In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH...
  6. pmc Functional effects of cardiac sympathetic denervation in neurogenic orthostatic hypotension
    Richard Imrich
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Parkinsonism Relat Disord 15:122-7. 2009
    ..We studied the impact of such denervation on cardiac chronotropic and inotropic function...
  7. ncbi Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma
    Yehonatan Sharabi
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Hypertens 25:2286-95. 2007
    ..We therefore examined sympathoadrenal function in patients with pseudopheochromocytoma compared with age-matched control subjects in whom there was no suspicion of pheochromocytoma...
  8. pmc Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Parkinsonism Relat Disord 14:600-7. 2008
    ..This study compared neuroimaging, neurochemical, and olfactory potential biomarkers to detect central dopamine (DA) deficiency and distinguish PD from multiple system atrophy (MSA)...
  9. pmc Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 22:57-61. 2012
    ..In this case, neuroimaging evidence of cardiac noradrenergic denervation and subsequent progressive striatal dopaminergic denervation fit with Braak staging...
  10. pmc Attenuated pre-ejection period response to tyramine in patients with cardiac sympathetic denervation
    Richard Imrich
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Ann N Y Acad Sci 1148:486-9. 2008
    ..05). One of the functional consequences of cardiac sympathetic denervation is failure to increase contractility in response to stimuli that depend on endogenous norepinephrine release...
  11. ncbi Neurocirculatory abnormalities in Parkinson disease with orthostatic hypotension: independence from levodopa treatment
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 46:1333-9. 2005
    ..Parkinson disease with orthostatic hypotension features reflexive cardiovagal and sympathoneural failure and cardiac and partial extracardiac sympathetic denervation, independent of levodopa treatment...
  12. doi Effect of telmisartan, angiotensin II receptor antagonist, on metabolic profile in fructose-induced hypertensive, hyperinsulinemic, hyperlipidemic rats
    Yehuda Kamari
    Hypertension Unit, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Hypertens Res 31:135-40. 2008
    ....
  13. ncbi Neurocirculatory abnormalities in chronic orthostatic intolerance
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, National Institutes of Health, Bethesda, MD, USA
    Circulation 111:839-45. 2005
    ..This study addressed whether patients with COI and POTS or NCS have neurocirculatory abnormalities during supine rest...
  14. pmc Cerebrospinal fluid biomarkers of central catecholamine deficiency in Parkinson's disease and other synucleinopathies
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disordersand Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Brain 135:1900-13. 2012
    ..Parkinson's disease and pure autonomic failure involve differential dopaminergic versus noradrenergic lesions. Cerebrospinal fluid dihydroxyphenylacetic acid seems to provide a sensitive means to identify even early Parkinson's disease...
  15. pmc Low-frequency power of heart rate variability is not a measure of cardiac sympathetic tone but may be a measure of modulation of cardiac autonomic outflows by baroreflexes
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Exp Physiol 96:1255-61. 2011
    ..Manipulations and drugs that change LF power or LF:HF may do so not by affecting cardiac autonomic outflows directly but by affecting modulation of those outflows by baroreflexes...
  16. doi Metabolic syndrome: comparison of the two commonly used animal models
    Mor Oron-Herman
    Hypertension Unit, C Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
    Am J Hypertens 21:1018-22. 2008
    ..The two most commonly studied animal models of the MS are the high-sucrose diet given to spontaneously hypertensive rats (SHRs) and high-fructose diet given to Sprague Dawley rats (SDRs). This study compares between these two models...
  17. pmc Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1620, USA
    J Neurochem 126:591-603. 2013
    ..Elevated DOPAL levels in PD putamen reflect a combination of decreased vesicular uptake of cytosolic DA and decreased DOPAL detoxification by ALDH...
  18. ncbi Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats
    Amitai Elkayam
    Hypertension Unit, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 15:170-3. 2013
    ..However, the data on the significance of these effects are inconsistent due to methodological limitations, especially the use of whole garlic cloves which does not allow controlled dosing of the active compound...
  19. ncbi Association between supine hypertension and orthostatic hypotension in autonomic failure
    David S Goldstein
    the Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:136-42. 2003
    ..The finding of lower plasma NE levels in patients with than without supine hypertension suggests involvement of pressor mechanisms independent of the sympathetic nervous system...
  20. pmc Cardiac sympathetic hypo-innervation in familial dysautonomia
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive MSC 1620, Building 10 Room 6N252, Bethesda, MD 20892 1620, USA
    Clin Auton Res 18:115-9. 2008
    ..Whether such loss extends to sympathetic innervation of the heart has been unknown. This study used 6-[(18)F]fluorodopamine neuroimaging to assess cardiac sympathetic innervation and function in FD...
  21. doi High-salt diet increases plasma adiponectin levels independent of blood pressure in hypertensive rats: the role of the renin-angiotensin-aldosterone system
    Yehuda Kamari
    Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Hypertens 28:95-101. 2010
    ..The aim of the present study was to examine the effect of high-salt diet on adiponectin levels in Sprague-Dawley rats and explore the mechanisms that regulate adiponectin levels under salt loading...
  22. ncbi Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Neuropharmacol 29:97-105. 2006
    ....
  23. doi Normal adiponectin levels in kidney transplant patients with hypertension
    Avshalom Leibowitz
    Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Clin Transplant 27:562-6. 2013
    ..Patients with essential hypertension (HTN) have low adiponectin levels that are associated with a high CV risk. The aim of this study was to assess adiponectin levels in hypertensive renal transplant recipients...
  24. doi Orthostatic hypotension is associated with nocturnal change in systolic blood pressure
    Shilo Voichanski
    Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 25:159-64. 2012
    ..The circadian pattern of blood pressure (BP) has yet to be defined among individuals with orthostatic hypotension (OH). The objective of this study was to evaluate whether OH is associated with nocturnal change in systolic BP...
  25. ncbi Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  26. pmc Vesicular uptake blockade generates the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde in PC12 cells: relevance to the pathogenesis of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA
    J Neurochem 123:932-43. 2012
    ....
  27. doi Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC 1620, Building 10, Room 6N252, Bethesda, MD 20892 1620, USA
    Cleve Clin J Med 76:S47-50. 2009
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  28. doi Production and secretion of adiponectin from 3T3-L1 adipocytes: comparison of antihypertensive drugs
    Raphaelle Brody
    Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Hypertens 22:1126-9. 2009
    ..The aim of this study was to evaluate the effect of various antihypertensive drugs on the production and secretion of adiponectin from adipocytes...
  29. doi Central dopamine deficiency in pure autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 18:58-65. 2008
    ..A patient with PAF and another with PD had rapid postmortem striatal, nigral, and sympathetic ganglion sampling, with assays of catechols and tyrosine hydroxylase activity...
  30. pmc Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, Maryland 20892 1620, USA
    J Clin Invest 121:3320-30. 2011
    ..Vesicular uptake may constitute a novel target for diagnosis, treatment, and prevention...
  31. pmc 3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, 9000 Rockville Pike, Bldg 10 Rm 5N220, Bethesda, MD, 20892 1620, USA
    Neurochem Res 41:2173-8. 2016
    ..Hydroxytyrosol therefore inhibits both enzymatic and spontaneous oxidation of endogenous dopamine and mitigates the increase in spontaneous oxidation during MAO inhibition. ..
  32. pmc Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA Electronic address
    Parkinsonism Relat Disord 31:79-86. 2016
    ..We examined whether an elevated Cys-DA/DOPAC ratio provides a specific biomarker of parkinsonism in synucleinopathy patients...
  33. doi Determinants of denervation-independent depletion of putamen dopamine in Parkinson's disease and multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, MD 20892 1620, USA Electronic address
    Parkinsonism Relat Disord . 2016
    ..5-S-Cysteinyldopa (Cys-DOPA) is produced from spontaneous oxidation of DOPA and 5-S-cysteinyldopamine (Cys-DA) from spontaneous oxidation of DA...
  34. pmc Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA Electronic address
    Parkinsonism Relat Disord 21:567-72. 2015
    ..In this study we asked whether MSA entails a similar abnormal neurochemical pattern...
  35. pmc Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neuroscience Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland D S G, Y J, P S, C H, I J K and Hypertension Unit, Chaim Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel Y S
    J Pharmacol Exp Ther 356:483-92. 2016
    ....
  36. pmc Deficient vesicular storage: A common theme in catecholaminergic neurodegeneration
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA Electronic address
    Parkinsonism Relat Disord 21:1013-22. 2015
    ..Thus, across neurodegenerative diseases, loss of catecholaminergic neurons seems to be associated with decreased vesicular storage in the residual neurons...
  37. pmc A vesicular sequestration to oxidative deamination shift in myocardial sympathetic nerves in Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, Maryland, USA
    J Neurochem 131:219-28. 2014
    ..This shift may be part of a final common pathogenetic pathway in the loss of catecholaminergic neurons that characterizes PD. ..
  38. pmc Rotenone decreases intracellular aldehyde dehydrogenase activity: implications for the pathogenesis of Parkinson's disease
    David S Goldstein
    Clinical Neurocardiology Section, CNP DIR NINDS NIH, Bethesda, Maryland, USA
    J Neurochem 133:14-25. 2015
    ..The results provide a novel mechanism for rotenone-induced toxicity in dopaminergic neurons...
  39. ncbi Melatonin reduces night blood pressure in patients with nocturnal hypertension
    Ehud Grossman
    Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Affiliated with Sackler School of Medicine, Tel Aviv University, Israel
    Am J Med 119:898-902. 2006
    ..We therefore studied the potency of melatonin to reduce nighttime blood pressure (BP) in treated hypertensive patients with nocturnal hypertension...
  40. ncbi Susceptibility of the influence of weight on blood pressure in men versus women: lessons from a large-scale study of young adults
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke NIH, 10 Center Drive, MSC 1620, Building 10, Room 6N252, Bethesda, MD 20892 1620, USA
    Am J Hypertens 17:404-8. 2004
    ..Weight and blood pressure (BP) are closely related. The aim of this study was to quantify this relationship and compare it to other factors in a population of relatively young adults, with particular focus on the possible role of gender...
  41. ncbi Autoimmunity-associated autonomic failure with sympathetic denervation
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike MSC 1620, Building 10 Room 5N220, Bethesda, MD, 20892 1620, USA
    Clin Auton Res . 2016
    ..Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years...
  42. pmc The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein
    Yunden Jinsmaa
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 USA
    Neurosci Lett 590:134-7. 2015
    ..5-HIAL oligomerizes alpha-synuclein both in vitro and in synuclein-overexpressing PC12 cells, in a manner similar to DOPAL. The findings may help explain loss of serotonergic neurons in PD. ..
  43. doi Autonomic dysfunction in PD: a window to early detection?
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    J Neurol Sci 310:118-22. 2011
    ..In elderly patients with unexplained OH or other evidence of autonomic failure, it is reasonable for clinicians to look for subtle signs of parkinsonism, such as masked facies, cogwheel rigidity, and shuffling gate...
  44. ncbi Baroreflex failure as a late sequela of neck irradiation
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Hypertension 42:110-6. 2003
    ..Splinting of carotid sinus mechanoreceptors in rigidified arterial walls would impede detection of alterations in blood pressure and thereby disrupt baroreflex regulation of cardiovagal and sympathetic outflows...
  45. pmc Dopamine contamination of infused tyramine
    Courtney Holmes
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:1733-5. 2005
  46. ncbi Adiponectin: linking the metabolic syndrome to its cardiovascular consequences
    Karen R Rabin
    The C Sheba Medical Center, Tel Hashomer, 52621, Israel
    Expert Rev Cardiovasc Ther 3:465-71. 2005
    ..This review will detail the relationship of adiponectin to various features of obesity and insulin-resistance syndromes, as well as its relationship to the cardiovascular complications of these disorders...
  47. ncbi Sleep apnea as a risk factor for hypertension
    Yehonatan Sharabi
    Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer Sackler School of Medicine, Tel Aviv University, Israel
    Curr Opin Nephrol Hypertens 13:359-64. 2004
    ....
  48. ncbi Antianxiety treatment in patients with excessive hypertension
    Ehud Grossman
    Internal Medicine D and the Hypertension Unit, The Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Hashomer 52621, Israel
    Am J Hypertens 18:1174-7. 2005
    ..We therefore compared the efficacy and safety of antianxiety treatment with sublingual captopril administration in patients with excessive hypertension and no evidence of acute target organ damage...
  49. pmc Cardiac sympathetic denervation preceding motor signs in Parkinson disease
    David S Goldstein
    Clinical Neurocardiology Section, NINDS, NIH, Bethesda, MD 20892 1620, USA
    Clin Auton Res 17:118-21. 2007
    ..The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD...
  50. pmc DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells
    Yunden Jinsmaa
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Auton Neurosci 194:46-51. 2016
    ..In this study we tested whether DOPAL is taken up by human glial cells and augments intracellular oligomerization of AS...
  51. pmc Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health NINDS, NIH, 10 Center Drive MSC 1620, Building 10 Room 5N220, Bethesda, MD, 20892 1620, USA
    Clin Auton Res 25:61-7. 2015
    ..We assessed whether plasma biomarkers of a vesicular storage defect can separate PD + OH from MSA-P...
  52. doi Serum potassium levels predict blood pressure response to aldosterone antagonists in resistant hypertension
    Gadi Shlomai
    Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hypertens Res 37:1037-41. 2014
    ..033) and high baseline systolic BP (P=0.004). Our results support the use of add-on spironolactone therapy in patients with resistant HTN who are elderly and obese and have high systolic BP and serum potassium levels <4.5 mEq l(-1)...
  53. pmc Divalent metal ions enhance DOPAL-induced oligomerization of alpha-synuclein
    Yunden Jinsmaa
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC 1620, Bethesda, MD 20892 1620, USA
    Neurosci Lett 569:27-32. 2014
    ..01). We conclude that divalent metal ions augment DOPAL-induced oligomerization of alpha-synuclein. Drugs that interfere with this interaction might constitute a novel approach for future treatment or prevention approaches. ..
  54. ncbi Peripartum hypertension from pheochromocytoma: a rare and challenging entity
    Yehuda Kamari
    Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, affiliated to the Sackler School of Medicine, Tel Aviv University, Israel
    Am J Hypertens 18:1306-12. 2005
    ..Pregnancy can elicit clinical manifestations of otherwise unrecognized pheochromocytoma...
  55. ncbi Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism
    Yehuda Kamari
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer 52621, Israel
    Atherosclerosis 195:31-8. 2007
    ..We examined the role of IL-1alpha and IL-1beta expressed by bone marrow-derived cells in atherogenesis and lipid metabolism...
  56. ncbi The prevalence of erectile dysfunction among hypertensive and prehypertensive men aged 25-40 years
    Rafi J Heruti
    Reuth Medical Center Rehabilitation, Tel Aviv, Israel
    J Sex Med 4:596-601. 2007
    ..Erectile dysfunction (ED) and hypertension (HTN) are common and associated among men aged 40-70 years. Data on the prevalence of ED among younger hypertensive and prehypertensive men are limited...
  57. doi Neutral endopeptidase inhibitor versus angiotensin converting enzyme inhibitor in a rat model of the metabolic syndrome
    Yoav Eizenberg
    Institute of Endocrinology and Metabolism, Beilinson Campus, Rabin Medical Center, Petach Tikva 49100, Israel Affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    J Am Soc Hypertens 8:227-31. 2014
    ..8%, respectively), but only high-dose candoxatril decreased plasma insulin levels significantly (by 25.3%). High-dose candoxatril is a metabolically favorable option for lowering blood pressure in a rat model of metabolic syndrome. ..
  58. pmc Survival in synucleinopathies: A prospective cohort study
    David S Goldstein
    From the Clinical Neurocardiology Section D S G, C H and Office of the Clinical Director T W, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD and Hypertension Unit Y S, Chaim Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
    Neurology 85:1554-61. 2015
    ..Approximately 40% of patients with PD, most patients with MSA, and all patients with PAF have neurogenic orthostatic hypotension (OH). This study compared long-term survival in these synucleinopathies...
  59. doi Limited reproducibility of 24-h ambulatory blood pressure monitoring
    Shay Keren
    a Hypertension unit, Chaim Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Tel Aviv, Israel
    Clin Exp Hypertens 37:599-603. 2015
    ..Clinical decision-making based on single ABPM datasets should be made with caution, and repetition of ABPM seems justified in some cases. ..
  60. pmc Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders
    David S Goldstein
    Clinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA Electronic address
    Pharmacol Ther 144:268-82. 2014
    ..The notion of catecholamine autotoxicity has several implications for treatment, disease modification, and prevention. Conversely, disease modification clinical trials would provide key tests of the catecholaldehyde hypothesis. ..
  61. doi The association between ambulatory systolic blood pressure and cardiovascular events in a selected population with intensive control of cardiovascular risk factors
    Wasseem Rock
    Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Am Soc Hypertens 8:498-502. 2014
    ..We found that, in a population aggressively managed for CV risk factors, 24H ABPM systolic BP ≥150 mm Hg is associated with increased CV events. ..
  62. ncbi Does acetylcholinesterase inhibition affect catecholamine secretion by adrenomedullary cells?
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Isr Med Assoc J 6:396-9. 2004
    ..Splanchnic nerve stimulation evokes adrenomedullary catecholamine secretion via acetylcholine release and occupation of nicotinic cholinergic receptors on chromaffin cells...
  63. doi Impact of acute caffeine ingestion on endothelial function in subjects with and without coronary artery disease
    Michael Shechter
    Leviev Heart Center, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Cardiol 107:1255-61. 2011
    ..In conclusion, acute caffeine ingestion significantly improved endothelial function assessed by brachial artery FMD in subjects with and without CAD and was associated with lower plasma markers of inflammation...
  64. ncbi Eosinophilia, myositis, and myasthenia gravis associated with a thymoma
    Irit Avni
    Internal Medicine D, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Muscle Nerve 34:242-5. 2006
    ..Thymoma-associated T-cell abnormalities may well have contributed to this rare association. This case underscores the need to reevaluate constantly the presumed cause of clinical complaints, as more than one cause may be present...
  65. ncbi Diastolic blood pressure is the first to rise in association with early subclinical obstructive sleep apnea: lessons from periodic examination screening
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Hypertens 16:236-9. 2003
    ..We conducted a case-control study in which we analyzed the clinical characteristics of young adults who underwent a periodic health examination and were screened for, and eventually found to experience, OSAS...
  66. ncbi Prevalence of prehypertension and associated cardiovascular risk profiles among young Israeli adults
    Itamar Grotto
    Department of Epidemiology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Hypertension 48:254-9. 2006
    ..Our findings support the recommendation of lifestyle modification for prehypertensive patients. Further prospective studies are required to determine the role of pharmacotherapy in prehypertension...
  67. ncbi Efficacy of add-on aldosterone receptor blocker in uncontrolled hypertension
    Yehonatan Sharabi
    Hypertension Unit and Internal Medicine D, Chaim Sheba Medical affiliated to the Chaim Sheba Medical Center, Tel Hashomer
    Am J Hypertens 19:750-5. 2006
    ..The purpose of this study was to evaluate the efficacy of this approach and to characterize those who respond effectively to an add-on aldosterone antagonist...
  68. ncbi Relative impact of socioeconomic status on blood pressure lessons from a large-scale survey of young adults
    Itamar Grotto
    Department of Epidemiology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Am J Hypertens 20:1140-5. 2007
    ..We aimed to assess the influence of SES on blood pressure in a large population of young adults...
  69. doi Hypertension and socioeconomic status
    Itamar Grotto
    Department of Epidemiology, Ben Gurion University of the Negev, Beer Sheva, Israel
    Curr Opin Cardiol 23:335-9. 2008
    ..We also review several mechanisms through which the effects of socioeconomic status on hypertension may be mediated...