Rifaat Safadi

Summary

Affiliation: Hadassah University Hospital
Country: Israel

Publications

  1. ncbi request reprint [Neurologic complications following liver transplantation]
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Harefuah 141:30-3, 127. 2002
  2. ncbi request reprint Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking
    Chamutal Gur
    Liver Unit, Hadassah University Hospital, Jerusalem, Israel
    Clin Immunol 118:307-16. 2006
  3. ncbi request reprint Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
    Alaa Melhem
    Division of Medicine, Liver and Gastroenterology Units, Hadassah University Hospital, POB 12000, 91120 Jerusalem, Israel
    J Hepatol 45:60-71. 2006
  4. ncbi request reprint Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis
    Amjad Horani
    Liver and Gastroenterology Units, Div of Medicine, Hadassah University Hospital, 91120 Jerusalem, Israel
    Am J Physiol Gastrointest Liver Physiol 292:G628-38. 2007
  5. ncbi request reprint Clinical evaluation (Phase I) of a human monoclonal antibody against hepatitis C virus: safety and antiviral activity
    Eithan Galun
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    J Hepatol 46:37-44. 2007
  6. doi request reprint The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    Rifaat Safadi
    Liver and Gastroenterology Unit, Division of Medicine, Hadassah University Medical Center, Jerusalem, Israel Holy Family Hospital, Nazareth, Israel Electronic address
    Clin Gastroenterol Hepatol 12:2085-91.e1. 2014
  7. ncbi request reprint Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution
    Rifaat Safadi
    Liver Unit, Department of Medicine, Haassah Medical Center, Jerusalem, Israel
    Int Immunol 19:1021-9. 2007
  8. doi request reprint Efficacy of switching to telbivudine in chronic hepatitis B patients treated previously with lamivudine
    Rifaat Safadi
    Hadassah Medical Center, Jerusalem, Israel
    Liver Int 31:667-75. 2011
  9. pmc Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis
    Nidal Muhanna
    Liver and Gastroenterology Units Division of Medicine, Hadassah Hospital, Jerusalem, Israel
    Hepatology 48:963-77. 2008
  10. ncbi request reprint Induction of oral immune regulation towards liver-extracted proteins for treatment of chronic HBV and HCV hepatitis: results of a phase I clinical trial
    Eran Israeli
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Int 24:295-307. 2004

Collaborators

Detail Information

Publications45

  1. ncbi request reprint [Neurologic complications following liver transplantation]
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Harefuah 141:30-3, 127. 2002
    ..We review the current literature on the subject...
  2. ncbi request reprint Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking
    Chamutal Gur
    Liver Unit, Hadassah University Hospital, Jerusalem, Israel
    Clin Immunol 118:307-16. 2006
    ..Copaxone modifies TH1 immune response in multiple sclerosis. As Crohn's disease shares TH1 predominance, this study came to investigate the anti-inflammatory response of Copaxone in animal model of colitis...
  3. ncbi request reprint Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC
    Alaa Melhem
    Division of Medicine, Liver and Gastroenterology Units, Hadassah University Hospital, POB 12000, 91120 Jerusalem, Israel
    J Hepatol 45:60-71. 2006
    ..We have investigated the role of natural killer (NK) cells in hepatic fibrogenesis. Mouse NK cells express both inhibitory/activating-killing-immunoglobulin-related-receptors (iKIR/aKIR) specific for Class-I-molecules...
  4. ncbi request reprint Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis
    Amjad Horani
    Liver and Gastroenterology Units, Div of Medicine, Hadassah University Hospital, 91120 Jerusalem, Israel
    Am J Physiol Gastrointest Liver Physiol 292:G628-38. 2007
    ..In an animal model of hepatic fibrosis, GA has an antifibrotic effect associated with decreased CD8 cells and reduced serum IL-4 levels and increased NK cells, CD4(+)CD25(+)FoxP3(+) cells, TRAIL, and elevated serum IL-10 levels...
  5. ncbi request reprint Clinical evaluation (Phase I) of a human monoclonal antibody against hepatitis C virus: safety and antiviral activity
    Eithan Galun
    Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Hospital, Jerusalem, Israel
    J Hepatol 46:37-44. 2007
    ..A Phase 1 clinical trial was designed to test safety, tolerability, and antiviral activity of HCV-AB68 in patients with chronic HCV-infection...
  6. doi request reprint The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    Rifaat Safadi
    Liver and Gastroenterology Unit, Division of Medicine, Hadassah University Medical Center, Jerusalem, Israel Holy Family Hospital, Nazareth, Israel Electronic address
    Clin Gastroenterol Hepatol 12:2085-91.e1. 2014
    ....
  7. ncbi request reprint Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution
    Rifaat Safadi
    Liver Unit, Department of Medicine, Haassah Medical Center, Jerusalem, Israel
    Int Immunol 19:1021-9. 2007
    ..Beta-glucosylceramide (GC), a naturally occurring glycolipid, exerts modulatory effects on these cells...
  8. doi request reprint Efficacy of switching to telbivudine in chronic hepatitis B patients treated previously with lamivudine
    Rifaat Safadi
    Hadassah Medical Center, Jerusalem, Israel
    Liver Int 31:667-75. 2011
    ..Telbivudine showed greater antiviral suppression than lamivudine in phase II and III clinical trials...
  9. pmc Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis
    Nidal Muhanna
    Liver and Gastroenterology Units Division of Medicine, Hadassah Hospital, Jerusalem, Israel
    Hepatology 48:963-77. 2008
    ..LX2 knockdown of either Cdc42 or Rac1 [members of the Rho-guanosine triphosphatase (GTPase) family] prevented both phagocytosis and the activation of HSC by HCV-derived lymphocytes...
  10. ncbi request reprint Induction of oral immune regulation towards liver-extracted proteins for treatment of chronic HBV and HCV hepatitis: results of a phase I clinical trial
    Eran Israeli
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Int 24:295-307. 2004
    ..Anti-viral immunity can be modulated via oral feeding of viral proteins. Hepatitis B and C viral (HBV, HCV)-associated hepatocellular injury is mediated by a defective host anti-viral immune response...
  11. doi request reprint Early fibrosis inhibits hepatocellular carcinoma mediated by free radical effects
    Nidal Muhanna
    Liver and Gastroenterology Units, Division of Medicine, Hadassah University Medical Center, Jerusalem, Israel
    Mitochondrion 13:391-8. 2013
    ..At early-fibrosis stages, activated-HSCs express direct anti-tumor effects by phagocytosis and apoptosis of tumor-cells mediated by oxidative stress. ..
  12. doi request reprint Immune modulation of ovalbumin-induced lung injury in mice using β-glucosylceramide and a potential role of the liver
    Amjad Horani
    Department of Pediatrics and Pediatric Respiratory Research, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Immunobiology 216:548-57. 2011
    ..GC has an immunomodulatory effect on a murine model of experimental asthma. We also suggest that the liver acts as an immunomodulatory organ and might have a regulatory effect on pulmonary diseases...
  13. ncbi request reprint Impact of HLA-C and Bw epitopes disparity on liver transplantation outcome
    Amal Bishara
    Tissue Typing Unit, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Hum Immunol 66:1099-105. 2005
    ..This finding may be helpful in the choice of appropriate liver donor and planning immune suppression...
  14. doi request reprint Leptin modulates lymphocytes' adherence to hepatic stellate cells is associated with oxidative status alterations
    Lina Abu-Tair
    Liver Unit, Hadassah Medical Center, Jerusalem, Israel
    Mitochondrion 13:473-80. 2013
    ..db/db-lymphocytes however showed fewer adherences to HSCs when compared to WT-counterparts. This study presents immune and oxidative modulatory effects of leptin on lymphocytes and their consequent interaction with HSCs. ..
  15. doi request reprint The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor
    Yosefa Avraham
    Department of Human Nutrition and Metabolism, Braun School of Public Health, Faculty of Medicine, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Am J Physiol Gastrointest Liver Physiol 302:G1364-72. 2012
    ..These findings broaden our understanding of cannabinoid signaling in hepatic fibrosis beyond their activity solely in HSCs...
  16. ncbi request reprint Late cytomegalovirus disease following liver transplantation
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, P O Box 12000, 91120, Jerusalem, Israel
    Transpl Int 16:861-5. 2003
    ..Late-onset CMV disease can occur several years after OLT. Although it manifests classic clinical features of early disease, it is not associated with traditional risk factors and its pathogenesis may differ from that of early disease...
  17. ncbi request reprint Air transportation of patients with end-stage liver disease to distant liver transplantation centers
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Transpl 11:650-5. 2005
    ..Therefore, allocation regions may be broadened to include larger and more distant populations...
  18. ncbi request reprint Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study
    Oren Shibolet
    Liver Unit, Department of Medicine, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel
    Transplantation 77:1576-80. 2004
    ..In contrast, they are seldom reported following orthotopic liver transplantation (OLT)...
  19. doi request reprint Amelioration of hepatic fibrosis by NK cell activation
    Nidal Muhanna
    Liver and Gastroenterology Units, Division of Medicine, Hadasaah University Medical Center, Jerusalem, Israel
    Gut 60:90-8. 2011
    ..The aim of this study was to amplify the antifibrotic activity of NK cells and ameliorate hepatic fibrosis by iKIR silencing...
  20. doi request reprint Triphala (PADMA) extract alleviates bronchial hyperreactivity in a mouse model through liver and spleen immune modulation and increased anti-oxidative effects
    Amjad Horani
    Division of Allergy, Immunology and Pulmonary Medicine, Washington University in Saint Louis, Saint Louis, MO, USA
    Ther Adv Respir Dis 6:199-210. 2012
    ..Triphala (TRP), a herbal extract from Tibetan medicine, has been shown to affect lymphocytes and natural killer T (NKT) cell function. We hypothesize that TRP could ameliorate bronchial hyperreactivity through immune-cell modulations...
  21. doi request reprint The pro-fibrotic effects of pregnancy in a carbon-tetrachloride-induced liver injury in mouse model
    Johnny Amer
    The Liver and Gastroenterology Units, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Liver Int 34:1232-40. 2014
    ..Little is known about the influence of pregnancy on the development and progression of hepatic-fibrosis. In this study, we explored the influence of pregnancy on progression of hepatic fibrosis...
  22. ncbi request reprint Treatment of chronic hepatitis B virus infection via oral immune regulation toward hepatitis B virus proteins
    Rifaat Safadi
    Liver Unit, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Gastroenterol 98:2505-15. 2003
    ..The aims of this study were to determine the safety and efficacy of treatment of patients with chronic HBV by means of p.o. administration of HBV envelope proteins...
  23. pmc Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9
    Lina Abu-Tair
    Liver and Gastroenterology Units Division of Medicine, Hadassah Medical Center, Jerusalem, Israel
    PLoS ONE 8:e82571. 2013
    ..The pro-fibrotic and pro-inflammatory properties of TLR9(-/-) lymphocytes fail to activate HSCs with an early senescence in TLR9(-/-) mice...
  24. ncbi request reprint Association between consumption of Herbalife nutritional supplements and acute hepatotoxicity
    Eran Elinav
    Liver Unit, Hadassah Hebrew University Medical Center, Ein Kerem, P O Box 12000, Jerusalem 91120, Israel
    J Hepatol 47:514-20. 2007
    ..Nutritional supplements are frequently considered to be harmless but indiscriminate use of unlabelled ingredients may lead to significant adverse reactions...
  25. doi request reprint Hepatic effects of rosiglitazone in rats with the metabolic syndrome
    Zvi Ackerman
    Department of Medicine, Mount Scopus Campus, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Basic Clin Pharmacol Toxicol 107:663-8. 2010
    ....
  26. ncbi request reprint [Benign recurrent intrahepatic cholestasis type-II--a rare cause of direct hyperbilirubinemia exacerbations with hepatic fibrosis]
    Meir Mizrahi
    Hadassah Ein Karem Medical Center Jerusalem
    Harefuah 147:381-3, 480. 2008
    ..Treatment modalities range from expectant management, medication (cholestyramine, ursolit) or even surgery (biliary bypass/liver transplantation). This report describes a patient with BRIC type-II and reviews the relevant literature...
  27. doi request reprint NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis
    Chamutal Gur
    The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel Canada IMRIC, Hadassah Medical School, Jerusalem, Israel
    Gut 61:885-93. 2012
    ..NKp46, one of the major NK activating receptors expressed by NK cells, is also a specific NK marker that discriminates NK cells from all other lymphocyte subsets. It recognises viral haemagglutinins and unknown cellular ligands...
  28. ncbi request reprint [Vertical HBV transmission in Jerusalem in the vaccine era]
    Rani Michaiel
    Liver Unit, Institute of Gastroenterology and Liver Diseases, Division of Medicine, Hadassah Hebrew University Medical Center, Jerusalem
    Harefuah 151:671-4, 722, 721. 2012
    ..We evaluated the vertical transmission of hepatitis B virus (HBV) in the vaccine era after 1992...
  29. ncbi request reprint Caustic sclerosing cholangitis treated with orthotopic liver transplantation
    Gilles Morali
    Department of Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel
    Isr Med Assoc J 4:1152-3. 2002
  30. ncbi request reprint Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus
    Ori Wald
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Eur J Immunol 34:1164-74. 2004
    ..These observations suggest an important role for the CXCL12/CXCR4 pathway in recruitment and retention of immune cells in the liver during chronic HCV and HBV infection...
  31. ncbi request reprint Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers
    Oren Shibolet
    Liver Unit, Division of Medicine, Hadassah University Hospital, Jerusalem, Israel
    Blood 100:391-6. 2002
    ..In contrast, 2 of 5 control patients had HBV reactivation. Lamivudine prophylaxis in HBsAg carriers receiving immunosuppressive therapy may prevent HBV reactivation and hepatic failure...
  32. pmc Low Serum Lysosomal Acid Lipase Activity Correlates with Advanced Liver Disease
    Eyal Shteyer
    The Liver Unit, Gastroenterology Institute, Hadassah Medical Center, Hadassah Medical School, The Hebrew University, Jerusalem 9112001, Israel
    Int J Mol Sci 17:312. 2016
    ..Serum LAL activity <0.5 indicates severe liver injury in patients with fatty liver and cirrhosis. Further studies should define the direct role of LAL in liver disease severity and consider the possibility of replacement therapy. ..
  33. pmc The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis
    Nidal Muhanna
    Liver and Gastroenterology Units, Division of Medicine, Hadassah University Medical Center, Jerusalem, Israel Department of Otolaryngology, Head and Neck Surgery, Shaare Zedek Medical Center, Jerusalem, Israel
    PLoS ONE 10:e0132463. 2015
    ..A high prevalence of thyroid papillary cancer was reported in hepatitis-C-virus (HCV) positive patients. However, the mechanistic role of hepatic-fibrosis in thyroid malignancy progressions is still unclear...
  34. ncbi request reprint Serum vitamin D levels in kidney transplant recipients: the importance of an immunosuppression regimen and sun exposure
    Ophir Eyal
    Nephrology Service, Gastroenterology Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Isr Med Assoc J 15:628-33. 2013
    ..Vitamin D deficiency was shown to be prevalent among renal transplant recipients in northern countries, but little is known regarding risk factors...
  35. pmc A transgenic model for conditional induction and rescue of portal hypertension reveals a role of VEGF-mediated regulation of sinusoidal fenestrations
    Dalit May
    Department of Molecular Biology, The Hebrew University Hadassah University Hospital, Jerusalem, Israel
    PLoS ONE 6:e21478. 2011
    ..Unprecedented ability to rescue PH and its secondary manifestations via manipulating a single vascular factor may also be harnessed for examining the potential utility of de-capillarization treatment modalities...
  36. ncbi request reprint Malignancy after liver transplantation in patients with premalignant conditions
    Yoram Menachem
    Liver Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel
    J Clin Gastroenterol 36:436-9. 2003
    ..The aim of the current study was to evaluate the role of premalignant states, not associated with the liver disease prior to transplantation, in the development of posttransplantation malignancy...
  37. pmc Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions
    Mahmud Mahamid
    Liver Unit, Holy Family Hospital, Nazareth, Israel
    Clin Pharmacol 3:39-43. 2011
    ..Similarly, the factors involved in decisions regarding discontinuation of treatment and outcome have not been discussed in the literature to any significant extent...
  38. pmc Hepatotoxicity due to tocilizumab and anakinra in rheumatoid arthritis: two case reports
    Mahmud Mahamid
    Liver Unit, Holy Family Hospital, Nazareth, Israel
    Int J Gen Med 4:657-60. 2011
    ..The biological agents, tocilizumab and anakinra, may result in significant histological hepatic changes, including necrosis, but despite this, the outcome appears to be good...
  39. ncbi request reprint Is presensitization relevant to liver transplantation outcome?
    Amal Bishara
    Tissue Typing Unit, Hadassah University Hospital, Jerusalem, Israel
    Hum Immunol 63:742-50. 2002
    ..031). The presence of anti-HLA antibodies suggests a deleterious effect on LT outcome, and was associated with an increased incidence of early graft loss and rejection episodes...
  40. ncbi request reprint Hepatic fibrosis--role of hepatic stellate cell activation
    Rifaat Safadi
    Faculty, Hebrew University School of Medicine, Hadassah Medical Center, Jerusalem, Israel
    MedGenMed 4:27. 2002
    ..Emerging therapies will be targeted to those patients with reversible disease. The paradigm of stellate cell activation provides an important framework for defining therapeutic targets...
  41. ncbi request reprint Clinical evaluation (phase I) of a combination of two human monoclonal antibodies to HBV: safety and antiviral properties
    Eithan Galun
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel
    Hepatology 35:673-9. 2002
    ..In conclusion, these data suggest that HBV-AB(XTL) binds HBV particles and reduces serum viral titers and HBsAg levels. HBV-AB(XTL) could be combined with other monotherapies that are currently used to treat HBV carriers...
  42. ncbi request reprint Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
    Rifaat Safadi
    Division of Liver Diseases, The Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 127:870-82. 2004
    ..Immunomodulatory cytokines, including interleukin-10 (IL-10), may mediate hepatic fibrosis...
  43. pmc Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression
    Meena B Bansal
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA
    J Hepatol 42:548-56. 2005
    ..Because studies suggest matrix metalloproteinase-2 (MMP-2) may promote liver injury, we examined whether IL-6 exerted its protective effects via regulation of MMP-2...
  44. ncbi request reprint The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort
    Amir Karban
    Department of Gastroenterology, Rambam Medical Center, Haifa
    Dig Dis Sci 50:1692-7. 2005
    ....
  45. ncbi request reprint Treatment of hepatic fibrosis: almost there
    Efsevia Albanis
    Division of Liver Diseases, Mount Sinai School of Medicine, Box 1123, 1425 Madison Avenue, Room 1170F, New York, NY 10029 6574, USA
    Curr Gastroenterol Rep 5:48-56. 2003
    ..This review describes the ways in which insights into the cellular basis of hepatic fibrosis are leading to realistic strategies for antifibrotic treatment that may revolutionize the management of patients with chronic liver disease...