Elias Toubi

Summary

Affiliation: Bnai Zion Medical Center
Country: Israel

Publications

  1. ncbi request reprint Systemic Lupus Erythematosus Vasculitis: A Current Therapeutic Overview
    Elias Toubi
    Division of Clinical Immunology, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel
    Curr Treat Options Cardiovasc Med 6:87-97. 2004
  2. ncbi request reprint The role of CD4+CD25+ T regulatory cells in autoimmune diseases
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion, Rapaport, Faculty of Medicine, Haifa, Israel
    Clin Rev Allergy Immunol 34:338-44. 2008
  3. ncbi request reprint The 24th European Workshop for Rheumatology Research. Berlin, 26-29 February 2004
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 6:446-8. 2004
  4. pmc Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel
    Ann Rheum Dis 66:818-20. 2007
  5. ncbi request reprint High-dose intravenous immunoglobulins: an option in the treatment of systemic lupus erythematosus
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Hum Immunol 66:395-402. 2005
  6. ncbi request reprint Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Golomb Str 47, P O Box 4, Haifa, Israel
    Ann N Y Acad Sci 1051:506-14. 2005
  7. ncbi request reprint Targeting T regulatory cells in autoimmune diseases
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 10:73-6. 2008
  8. ncbi request reprint The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Haifa, Israel
    Scand J Immunol 63:299-303. 2006
  9. ncbi request reprint Elevated serum B-Lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: association with autoimmunity
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Autoimmun 27:134-9. 2006
  10. doi request reprint Etanercept impairs maturation of human monocyte-derived dendritic cells by inhibiting the autocrine TNFalpha-mediated signaling
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Inflammation 32:146-50. 2009

Detail Information

Publications78

  1. ncbi request reprint Systemic Lupus Erythematosus Vasculitis: A Current Therapeutic Overview
    Elias Toubi
    Division of Clinical Immunology, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel
    Curr Treat Options Cardiovasc Med 6:87-97. 2004
    ..Specific B-cell therapies (eg, anti-Blys, B-cell depletion) may also emerge as potential treatments for SLE vasculitis...
  2. ncbi request reprint The role of CD4+CD25+ T regulatory cells in autoimmune diseases
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion, Rapaport, Faculty of Medicine, Haifa, Israel
    Clin Rev Allergy Immunol 34:338-44. 2008
    ..Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve that course of autoimmune diseases...
  3. ncbi request reprint The 24th European Workshop for Rheumatology Research. Berlin, 26-29 February 2004
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 6:446-8. 2004
  4. pmc Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel
    Ann Rheum Dis 66:818-20. 2007
    ..To assess changes in macrophage phenotype and function after rituximab-induced B cell depletion in patients with rheumatoid arthritis (RA)...
  5. ncbi request reprint High-dose intravenous immunoglobulins: an option in the treatment of systemic lupus erythematosus
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Hum Immunol 66:395-402. 2005
    ..However, this needs to be confirmed in double-blind, placebo-controlled studies...
  6. ncbi request reprint Increased spontaneous apoptosis of CD4+CD25+ T cells in patients with active rheumatoid arthritis is reduced by infliximab
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Golomb Str 47, P O Box 4, Haifa, Israel
    Ann N Y Acad Sci 1051:506-14. 2005
    ..Alterations in CD4(+)CD25(+) cell apoptosis and cell count were found to correlate with RA disease activity. Reversal of these deviations from normal was documented in association with the beneficial outcome of infliximab therapy...
  7. ncbi request reprint Targeting T regulatory cells in autoimmune diseases
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 10:73-6. 2008
    ..Therapies that could possibly increase the suppressive ability of T regulatory cells were proven to improve the course of autoimmune diseases...
  8. ncbi request reprint The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Haifa, Israel
    Scand J Immunol 63:299-303. 2006
    ....
  9. ncbi request reprint Elevated serum B-Lymphocyte activating factor (BAFF) in chronic hepatitis C virus infection: association with autoimmunity
    E Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Autoimmun 27:134-9. 2006
    ..Elevated serum BAFF levels were associated with clinical and laboratory features of autoimmunity, suggesting that BAFF may play a role in HCV-related autoimmunity...
  10. doi request reprint Etanercept impairs maturation of human monocyte-derived dendritic cells by inhibiting the autocrine TNFalpha-mediated signaling
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Inflammation 32:146-50. 2009
    ..The data also suggests the presence of TNFalpha-mediated autocrine signaling, serving to accelerate or catalyze the maturation process of MDDCs...
  11. pmc Enhanced apoptosis of peripheral CD5-negative B lymphocytes from chronically hepatitis C virus-infected patients: reversal after antiviral treatment
    Elias Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Golomb St 47, P O B 4940, Haifa 31048, Israel
    J Virol 78:11379-84. 2004
    ..The relative resistance of the CD5(pos) B-cell subpopulation to apoptosis may play a role in HCV-related autoimmunity and lymphoproliferation...
  12. doi request reprint Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Cell Immunol 261:77-80. 2010
    ..The role and function of T regulatory (Treg) cells have not been fully investigated in patients with systemic sclerosis (SSc)...
  13. doi request reprint Antibody clustering helps refine lupus prognosis
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
    Semin Arthritis Rheum 39:66-70. 2009
    ....
  14. doi request reprint Higher expression of latency-associated peptide on the surface of peripheral blood monocytes in patients with rheumatoid arthritis may be protective against articular erosions
    Gleb Slobodin
    Internal Medicine A, Bnai Zion Medical Center, P O Box 4940, Haifa, 31048, Israel
    Inflammation 36:1075-8. 2013
    ..Higher expression of LAP on the surface of the cells of monocyte lineage may be protective of formation of articular erosions in RA. Further studies are needed to elaborate the mechanism of this phenomenon...
  15. doi request reprint Elevated serum B-cell activating factor in patients with chronic urticaria
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa 31048, Israel
    Hum Immunol 73:620-2. 2012
    ..We conclude that CU patients have higher levels of serum BAFF which associate with disease severity...
  16. doi request reprint Phenotype of resting and activated monocyte-derived dendritic cells grown from peripheral blood of patients with ankylosing spondylitis
    Gleb Slobodin
    Internal Medicine A, Bnai Zion Medical Center, Haifa 31048, P O Box 4940, Israel
    Inflammation 35:772-5. 2012
    ..Functional studies on DCs from patients with AS are needed to evaluate the integrity of their antigen-presenting function...
  17. ncbi request reprint Anti-C-reactive protein antibodies in chronic hepatitis C infection: correlation with severity and autoimmunity
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Hum Immunol 68:844-8. 2007
    ..3 versus 6 +/- 2.9, p = 0.01). An increased prevalence of anti-CRP antibodies was manifested in HCV-infected patients. The presence of anti-CRP antibodies correlated with the presence RF, cryoglobulinemia, and severity of liver disease...
  18. doi request reprint Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Autoimmun Rev 11:670-7. 2012
    ..In conclusion, human Breg cells decrease the proliferation of CD4(+) T cells and also enhance the expression of Foxp3 and CTLA-4 in Treg cells by cell-to-cell contact...
  19. ncbi request reprint Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Centre, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Immunol 179:5571-5. 2007
    ..We hereby demonstrate an additional mechanism by which IVIg could maintain self-tolerance and decrease immune-mediated inflammation...
  20. doi request reprint Endothelin-1 does not change the function of monocyte-derived dendritic cells grown from patients with systemic sclerosis
    Gleb Slobodin
    Department of Internal Medicine, Bnai Zion Medical Center and Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Immunol Invest 37:841-8. 2008
    ..The examined function of MDDCs from SSc patients and healthy volunteers did not differ under these conditions and was not dependent on the presence of ET-1...
  21. doi request reprint A regulatory role for CD72 expression on B cells in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Semin Arthritis Rheum 43:767-71. 2014
    ....
  22. pmc Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
    Arthritis Res Ther 14:R146. 2012
    ..This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific effect of sema3A on the auto-reactive properties of B cells in SLE patients...
  23. doi request reprint IVIg attenuates TLR-9 activation in B cells from SLE patients
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa 31048, Israel
    J Clin Immunol 31:30-8. 2011
    ..The aim of this study was to evaluate the influence of intravenous immunoglobulin (IVIg) on CpG oligodeoxynucleotides (ODN-CpG) activated B cells from SLE patients...
  24. doi request reprint Elevated serum total IgE--a potential marker for severe chronic urticaria
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Int Arch Allergy Immunol 153:288-93. 2010
    ..Elevated IgE levels in patients with chronic urticaria have been noted previously, but the significance of these findings has not been appreciated...
  25. pmc Age-related autoimmunity
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Golomb Street 47, Haifa, 31048, Israel
    BMC Med 11:94. 2013
    ..Whatever the reason, the expansion of T-regulatory cells requires payment in terms of an increased incidence of cancer and higher susceptibility to infections...
  26. doi request reprint B-regulatory cells in autoimmunity and immune mediated inflammation
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    FEBS Lett 587:2074-8. 2013
    ..Finally, the potentiation of B-reg function should become the aim of many immunomodulatory drugs, contributing to a better control of autoimmune diseases...
  27. ncbi request reprint LPS-stimulated production of TNF-alpha by peripheral blood monocytes in patients with Behcet's disease
    Gleb Slobodin
    Department of Internal Medicine A, Bnai Zion Medical Center, P O Box 4940, Technion, Haifa 31048, Israel
    Clin Rheumatol 26:764-7. 2007
    ..03). PBM of BD patients in the present study did not overproduce TNF-alpha upon stimulation with LPS. However, BD patients with a higher TNF-alpha-producing capacity had worse sense of well-being...
  28. pmc Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection
    Eli Zuckerman
    Department of Internal Medicine A Institute of Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Virol 77:10432-6. 2003
    ..The overexpression of CD81 and the expansion of the population of CD5(+) peripheral B cells in HCV-infected patients may possibly play a role in the development of HCV-associated autoimmunity and lymphoproliferation...
  29. doi request reprint Cogan syndrome--pathogenesis, clinical variants and treatment approaches
    Aharon Kessel
    Bnai Zion Medical Center, Faculty of Medicine, Technion Haifa, Israel
    Autoimmun Rev 13:351-4. 2014
    ....
  30. ncbi request reprint Sjögren's syndrome in the community: can serology replace salivary gland biopsy?
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, 47 Golomb Street, P O Box 4940, Haifa, 31048, Israel
    Rheumatol Int 26:337-9. 2006
    ..It is relatively difficult in a community setting to perform salivary gland biopsy or reliable diagnostic tests for salivary gland involvement in a patient suspected to suffer from Sjögren's syndrome (SS)...
  31. doi request reprint Laquinimod modulates B cells and their regulatory effects on T cells in multiple sclerosis
    Elias Toubi
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    J Neuroimmunol 251:45-54. 2012
    ..These findings shed additional light on the mechanisms underlying the effects of laquinimod in MS and potentially other immune-mediated diseases...
  32. doi request reprint Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: a prospective, randomized, controlled study
    Amir Kugelman
    Department of Neonatology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    J Perinat Med 37:281-7. 2009
    ..To evaluate the immunologic and infectious consequences of delayed versus immediate cord clamping in premature infants (<35 weeks) during the neonatal period...
  33. ncbi request reprint The role of CD40-CD154 interactions in autoimmunity and the benefit of disrupting this pathway
    Elias Toubi
    Divison of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Autoimmunity 37:457-64. 2004
    ..However, the etiology of the higher than expected number of thromboembolic events in anti-CD154 treated SLE patients should be investigated and preventive measures should be considered...
  34. ncbi request reprint Quinacrine added to ongoing therapeutic regimens attenuates anticardiolipin antibody production in SLE
    E Toubi
    Division of Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Lupus 12:297-301. 2003
    ..18). We conclude that the added Qn treatment to former established therapeutic protocols may eliminate aCL response in SLE patients. Whether this agent's effect is permanent needs further elucidation...
  35. ncbi request reprint Cogan's syndrome: a rare atypical presentation
    Rabia Shihada
    Department of Otolaryngology Head and Neck Surgery, Bnai Zion Medical Center, Haifa, Israel
    Isr Med Assoc J 9:52-3. 2007
  36. doi request reprint The role of T regulatory cells in human sepsis
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Autoimmun 32:211-5. 2009
    ..Preliminary studies in animal models suggest that more work is needed to understand the conditions under which such a therapy may be effective...
  37. ncbi request reprint The case for hepatitis C arthritis
    Itzhak Rosner
    Department of Rheumatology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Semin Arthritis Rheum 33:375-87. 2004
    ..To present the data available supporting the existence of an arthropathy associated with hepatitis C infection...
  38. ncbi request reprint Toll-like receptors and their role in the development of autoimmune diseases
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center Haifa, Israel
    Autoimmunity 37:183-8. 2004
    ..The contribution of TLRs to the production of auto antibodies by such dual-engagement suggests that this signaling pathway may become a target for new therapeutic approaches in autoimmune diseases...
  39. ncbi request reprint Protective autoimmunity in cancer (review)
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center Technion Faculty of Medicine, Haifa, Israel
    Oncol Rep 17:245-51. 2007
    ..Therefore, the efficacy of intravenous immunoglobulins or CTLA-4 blockade was also employed as a treatment for prevention of malignancy and metastases spread...
  40. pmc Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection
    E Zuckerman
    Liver Unit, Department of Internal Medicine A, Haifa, Israel
    Clin Exp Immunol 128:353-8. 2002
    ..The overexpression of CD81 and the expansion of CD5+ peripheral B-cells in HCV-infected patients may possibly play a role in the development of HCV-associated autoimmunity and lymphoproliferation...
  41. ncbi request reprint Increased plasma levels of matrix metalloproteinase-9 are associated with the severity of chronic urticaria
    A Kessel
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel
    Clin Exp Allergy 35:221-5. 2005
    ..Activated T cells are capable, through cell-cell contact, of inducing MMP-9 expression in human mast cells...
  42. ncbi request reprint Prolonged cyclosporin-A treatment for severe chronic urticaria
    E Toubi
    Clinical Immunology Division, Bnai Zion Medical Center, Golomb Str 47 P O B 4110 Haifa, Israel
    Allergy 58:535-6. 2003
  43. pmc Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat
    A Kessel
    Allergy and Clinical Immunology, Bnai Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Clin Exp Immunol 151:341-7. 2008
    ..We conclude that treatment with Gln was associated with down-regulation of TLR-4, MyD88 and TRAF6 expression and concomitant decrease in intestinal mucosal injury caused by LPS endotoxaemia in a rat...
  44. pmc Increased susceptibility of cord blood B lymphocytes to undergo spontaneous apoptosis
    A Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel
    Clin Exp Immunol 145:563-70. 2006
    ..This rescue was strengthened when BAFF (100 microg/ml) was further added. Thus, alterations in Bcl-2 or serum BAFF level may explain the increased rate of cord blood B cell apoptosis...
  45. doi request reprint Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel Electronic address
    Clin Immunol 164:114-8. 2016
    ..B cell receptor (BCR) -mediated signals are enhanced when CD72 expression is deficient on B cells in autoimmune diseases. The significance of soluble CD72 (sCD72) has not been elucidated...
  46. pmc The Expansion of CD25 high IL-10 high FoxP3 high B Regulatory Cells Is in Association with SLE Disease Activity
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, 4940 Haifa, Israel
    J Immunol Res 2015:254245. 2015
    ..Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. Further studies are required in order to assess the relation between high serum IL-10 and CD25(high)FoxP3(high) Breg cells. ..
  47. doi request reprint The role of B regulatory cells and Semaphorin3A in atopic diseases
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center and the Technion, Haifa, Israel
    Int Arch Allergy Immunol 163:245-51. 2014
    ..We also show how sema3A plays a role in the pathogenesis of allergic rhinitis and atopic dermatitis. Determining the above processes could facilitate the use of regulatory molecules as therapeutic tools in treating these diseases...
  48. ncbi request reprint Immune-mediated disorders associated with idiopathic sudden sensorineural hearing loss
    Elias Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Faculty of Medicine, Technion Haifa Institute of Technology, Haifa, Israel
    Ann Otol Rhinol Laryngol 113:445-9. 2004
    ..However, the presence of aCL antibodies, especially in conjunction with anti-beta2 GP1 antibodies, suggests that in some patients, SSNHL is included among the rare symptoms of the antiphospholipid syndrome...
  49. ncbi request reprint [Extended cyclosporine-A--treatment for severe chronic urticaria]
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel
    Harefuah 145:411-4, 471. 2006
    ..In such patients CsA given for 1-3 months (3mg/kg/d) was reported to induce in 2/3 of patients a full remission, lasting 3-6 months, and in 1/4 of patients a long-lasting full remission...
  50. ncbi request reprint Clinical and biological aspects of anti-P-ribosomal protein autoantibodies
    Elias Toubi
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Autoimmun Rev 6:119-25. 2007
    ..These biological aspects may play an important role in the pathogenesis of SLE...
  51. ncbi request reprint Enhanced peripheral T-cell apoptosis in chronic hepatitis C virus infection: association with liver disease severity
    E Toubi
    Department of Internal Medicine, Bnai Zion Medical Center, Faculty of Medicine, Technion, 31048, Haifa, Israel
    J Hepatol 35:774-80. 2001
    ..In the present study we have investigated the role of bcl-2 and nuclear factor kappa B (NFkappaB) in dexamethasone-induced apoptosis of peripheral T cells in chronic HCV infection...
  52. doi request reprint Seasonal Exacerbation of Asthma Is Frequently Associated with Recurrent Episodes of Acute Urticaria
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion, Haifa, Israel
    Int Arch Allergy Immunol 169:263-6. 2016
    ..They are pathophysiologically different, as mast cell degranulation in these 2 disorders results from different mechanisms...
  53. pmc The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs)
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion, Haifa, Israel
    PLoS ONE 10:e0125860. 2015
    ..We aim to assess the possible involvement of semaphorin3A (sema3A) and 4A (sema4A) in peripheral immune responses and bowel tissue inflammation of patients suffering from Crohn's disease (CD) and ulcerative colitis (UC)...
  54. ncbi request reprint Increased CD8+ T cell apoptosis in scleroderma is associated with low levels of NF-kappa B
    Aharon Kessel
    Division of Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Clin Immunol 24:30-6. 2004
    ..53, P = 0.029). The increased CD4:CD8 ratio in SSC may result from increased CD8+ T cell apoptosis. Increased SSc CD8 T cell apoptosis is associated with low levels of NF-kappa B...
  55. ncbi request reprint Abnormal spirometry in children with persistent allergic rhinitis due to mite sensitization: the benefit of nasal corticosteroids
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Department of Clinical Microbiology, Faculty of Medicine Technion, Haifa, Israel
    Pediatr Allergy Immunol 19:61-6. 2008
    ..Nasal corticosteroids improve the pulmonary function tests of these children with impaired lung function...
  56. ncbi request reprint Leptin and cytokines levels in children with failure to thrive
    Ron Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Pediatr Gastroenterol Nutr 37:487-91. 2003
    ..Many of these patients present with significant decreased caloric intake. It appears as if the appetite regulation center in the hypothalamus is not attuned to the calorie requirements of the infant...
  57. ncbi request reprint Tacrolimus in the treatment of severe chronic idiopathic urticaria: an open-label prospective study
    Aharon Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    J Am Acad Dermatol 52:145-8. 2005
    ..Our preliminary results suggest tacrolimus as a treatment option for patients with severe CIU...
  58. ncbi request reprint BLyS/BAFF: a potential target in the treatment of active systemic lupus erythematosus
    Elias Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Isr Med Assoc J 6:99-102. 2004
  59. ncbi request reprint Chronic HCV-related autoimmunity: a consequence of viral persistence and lymphotropism
    A Kessel
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine Technion, Haifa, Israel
    Curr Med Chem 14:547-54. 2007
    ..In this review our aim is to summarize the data on the mechanisms responsible for HCV persistence and HCV-related autoimmunity. We will try to determine the importance of autoimmunity in the evaluation of chronic HCV infected patients...
  60. doi request reprint Rituximab: beyond simple B cell depletion
    A Kessel
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Technion, Rappaport Faculty of Medicine, Haifa, P O B 4940, Israel
    Clin Rev Allergy Immunol 34:74-9. 2008
    ..The available data on rituximab's action in autoimmune diseases is reviewed...
  61. ncbi request reprint Predictive and protective autoimmunity in cardiovascular diseases: is vaccination therapy a reality?
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa, Israel
    Lupus 14:665-9. 2005
    ....
  62. ncbi request reprint Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients
    E Toubi
    Division of Allergy and Clinical Immunology, Faculty of Medicine, Technion, Israel
    Allergy 59:869-73. 2004
    ..Despite the disabling nature of chronic urticaria (CU), little is known about the disease's duration or the efficacy of adopting aggressive therapeutic regimens such as cyclosporine A...
  63. ncbi request reprint The association of serum matrix metalloproteinases and their tissue inhibitor levels with scleroderma disease severity
    E Toubi
    Division of Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion Haifa, Israel
    Clin Exp Rheumatol 20:221-4. 2002
    ..The aim of this study was to evaluate the correlation of serum MMP-1, 3 and TIMP-1 with severity and disease specific markers of SSc and RA...
  64. ncbi request reprint The autoimmune characteristics of progressive or sudden sensorineural hearing loss
    D Yehudai
    Bnai Zion Medical Center Affiliated with the Technion Faculty of Medicine, Division of Clinical Immunology and Allergy, Haifa, Israel
    Autoimmunity 39:153-8. 2006
    ..Moreover, the decision of whether anti-inflammatory drugs or anti-coagulation should be given is also discussed...
  65. ncbi request reprint FoxP3 Expression in Macrophages, Cancer, and B Cells-Is It Real?
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Clin Rev Allergy Immunol . 2016
    ..In this review, we present the existing data on FoxP3 expression in non-T-regulatory cells, but we suggest that further studies are needed to better establish this concept...
  66. doi request reprint Semaphorins: their dual role in regulating immune-mediated diseases
    Zahava Vadasz
    Bnai Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Clin Rev Allergy Immunol 47:17-25. 2014
    ..In this review, we will focus on several immune semaphorins--their role in immune homeostasis and in immune-mediated diseases...
  67. doi request reprint A8.39 Regulatory role for CD72 Expression on B cells in SLE
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Ann Rheum Dis 73:A92. 2014
    ..B regulatory cells and their regulatory products/markers, such us semaphorin3A (sema3A) and its receptor NP-1, FcγIIB, IL-10, and others, act at the very base of self-tolerance maintenance and prevention of autoimmune disease development...
  68. ncbi request reprint Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death
    Ron Gonen
    Department of Obstetrics and Gynecology, Bnai Zion Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Obstet Gynecol 192:742-6. 2005
    ..The purpose of this study was to investigate the alleged association between thrombophilia and unexplained third-trimester stillbirth...
  69. ncbi request reprint Intravenous immunoglobulin in immunodeficiency states: state of the art
    Elias Toubi
    Department of Immunology, Rappaport Medical School, Technion, Haifa, Israel
    Clin Rev Allergy Immunol 29:167-72. 2005
    ..The route of immunoglobulin G replacement (intravenously vs subcutaneously) was reported to be of similar benefit. However, guidelines for usage and choice of route should be established and might be of help...
  70. pmc Increased thromboembolic incidence in anti-cardiolipin-positive patients with malignancy
    E Zuckerman
    Department of Internal Medicine A, Bnai Zion Medical Centre, Haifa, Israel
    Br J Cancer 72:447-51. 1995
    ..Patients with malignancies show an increased prevalence of ACLA. Furthermore, ACLA-positive patients, mainly those with high titres, are much more prone to thromboembolic events...
  71. ncbi request reprint Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholipid syndrome
    E Toubi
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Haifa Israel
    Clin Exp Rheumatol 23:499-504. 2005
    ..e. Sneddon's syndrome)...
  72. ncbi request reprint Looking into the eyes of patients with antiphospholipid syndrome
    D Yehudai
    Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, Technion School of Medicine, Haifa, Israel
    Clin Rev Allergy Immunol 32:192-7. 2007
    ..The treatment of isolated ocular APS should be based on the same principles as in all patients with systemic APS. Anticoagulation is aimed to prevent recurrent ocular or cerebral thromboses...
  73. ncbi request reprint Protective autoantibodies: role in homeostasis, clinical importance, and therapeutic potential
    Yehuda Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Arthritis Rheum 52:2599-606. 2005
  74. ncbi request reprint The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:13-9. 2008
  75. ncbi request reprint Autoantibodies in nonautoimmune individuals during infections
    Tatiana Berlin
    Department of Medicine E, Meir Hospital, Kfar Saba, Israel
    Ann N Y Acad Sci 1108:584-93. 2007
    ..In nonautoimmune individuals with various (bacterial, viral, parasitic, and rickettsial) infections, elevated titers of Abs to annexin-V, prothrombin, laminin, ASCA, ANA, and phospholipids were most frequently detected...
  76. ncbi request reprint The mosaic of autoimmunity: genetic factors involved in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:3-7. 2008
  77. ncbi request reprint The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:8-12. 2008
  78. ncbi request reprint [Leflunomide in systemic lupus erythematosus]
    Aharon Kessel
    Harefuah 141:355-7, 409. 2002
    ..Recently pilot studies have demonstrated the benefit of leflunomide in systemic lupus erythematosus patients. Herein we describe the successful treatment of two lupus patients with leflunomide and review the current literature...