Ran Taube

Summary

Affiliation: Ben-Gurion University of the Negev
Country: Israel

Publications

  1. pmc A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
    Nina Verstraete
    Institut de Biologie de l Ecole Normale Supérieure, Paris F 75005, France
    Retrovirology 11:50. 2014
  2. pmc A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription
    Alona Kuzmina
    The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, P, O, Box 653, Beer Sheva 84105, Israel
    Retrovirology 11:51. 2014
  3. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
  4. doi request reprint Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1
    Alona Kuzmina
    Department of Virology and Developmental Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Virology 426:152-61. 2012
  5. pmc Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes
    Alona Kuzmina
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 10:e0144043. 2015
  6. doi request reprint Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin
    Avis Dafa-Berger
    Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel
    Virology 428:98-111. 2012
  7. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013

Collaborators

Detail Information

Publications7

  1. pmc A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat
    Nina Verstraete
    Institut de Biologie de l Ecole Normale Supérieure, Paris F 75005, France
    Retrovirology 11:50. 2014
    ..P-TEFb activity is inhibited by direct binding of its subunit Cyclin T (1 or 2) with Hexim (1 or 2), a cellular protein, bound to the 7SK small nuclear RNA. Hexim1 competes with Tat for P-TEFb binding...
  2. pmc A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription
    Alona Kuzmina
    The Shraga Segal Department of Microbiology, Immunology and Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, P, O, Box 653, Beer Sheva 84105, Israel
    Retrovirology 11:51. 2014
    ..The viral Tat protein recruits the Positive Transcription Elongation Factor b (P-TEFb) and the Super Elongation Complex (SEC) to the HIV promoter and enhances transcription by host RNA polymerase II...
  3. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
    ....
  4. doi request reprint Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1
    Alona Kuzmina
    Department of Virology and Developmental Genetics Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    Virology 426:152-61. 2012
    ..We conclude that cyclin T1-U7 sequesters Tat from P-TEFb and inhibits HIV transcription. Importantly, N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat...
  5. pmc Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes
    Alona Kuzmina
    The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    PLoS ONE 10:e0144043. 2015
    ..We concluded that CCR5-peptidoliposomes increase the efficiency of sCD4 to inhibit HIV infection by acting as bait for sCD4-primed virus, catalyzing the premature discharge of its fusion potential. ..
  6. doi request reprint Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin
    Avis Dafa-Berger
    Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva, Israel
    Virology 428:98-111. 2012
    ..5-BST-2. We conclude that BST-2 moderately restricts HCV production and release from Huh-7.5 hepatocytes, while the virus lacks mechanisms to counteract this restriction...
  7. pmc Preferential lentiviral targeting of astrocytes in the central nervous system
    Michael Fassler
    The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be er Sheva, Israel
    PLoS ONE 8:e76092. 2013
    ..As such, it can open a window to visualize and genetically manipulate astrocytes or other cells of the CNS as means of research and treatment. ..