Jennifer M Thompson
Affiliation: University College Dublin
- Effects of cadmium on formation of the ventral body wall in chick embryos and their prevention by zinc pretreatmentJ Thompson
Department of Human Anatomy and Physiology, National University of Ireland, University College, Earlsfort Terrace, Dublin 2, Ireland
Teratology 64:87-97. 2001..Mesodermal development is a frequently reported target for Cd teratogenicity. The aim of this study was to examine the mechanisms of Cd induced body wall defects in chick embryos...
- Effects of cadmium on cell death and cell proliferation in chick embryosJennifer Thompson
University College Dublin and Conway Institute of Biomolecular and Biomedical Research, Department of Anatomy, Earlsfort Terrace, Dublin, Ireland
Reprod Toxicol 20:539-48. 2005..We hypothesize that the ventral body wall defect resulting from Cd treatment in chick embryos is the result of changes in the somites perhaps following interruption of a signalling pathway originating in ectoderm...
- Omphalocele induction in the chick embryo by administration of cadmiumJennifer M Thompson
School of Medicine and Medical Sciences and Conway Institute of Biomedical and Biomolecular Research, University College Dublin, Dublin 4, Ireland
J Pediatr Surg 42:1703-9. 2007..Ventral body wall (VBW) defects occur in 1:2000 live births. We examined the association of VBW defect with somite abnormality and lordosis in the chick using in vitro and in ovo methods...
- Adherens junction breakdown in the periderm following cadmium administration in the chick embryo: distribution of cadherins and associated moleculesJennifer Thompson
School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
Reprod Toxicol 25:39-46. 2008..From 4h after Cd, affected embryos demonstrate varying degrees of cell junction breakdown and desquamation in the periderm. We examined the effect of Cd on tissue and cell distribution of cadherins and their intracellular associates...
- Cadmium: toxic effects on the reproductive system and the embryoJennifer Thompson
School of Medicine and Medical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Reprod Toxicol 25:304-15. 2008..In this paper, we examine the mechanisms by which Cd can affect reproductive health, and consider the use of micronutrients in prevention of these problems...
- Evidence against a direct role for oxidative stress in cadmium-induced axial malformation in the chick embryoJennifer Thompson
School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
Toxicol Appl Pharmacol 243:390-8. 2010..Furthermore, MDA levels 24 hours after treatment were identical in malformed and normal embryos exposed to Cd. Hence, we conclude that oxidative stress may not have a direct role in Cd teratogenesis...