Yosef Sarne

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Cannabinoids: between neuroprotection and neurotoxicity
    Yosef Sarne
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Drug Targets CNS Neurol Disord 4:677-84. 2005
  2. ncbi request reprint The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Brain Res Mol Brain Res 120:138-44. 2004
  3. ncbi request reprint Are cannabinoid drugs neurotoxic or neuroprotective?
    Y Sarne
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Med Hypotheses 63:187-92. 2004
  4. pmc The dual neuroprotective-neurotoxic profile of cannabinoid drugs
    Yosef Sarne
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Br J Pharmacol 163:1391-401. 2011
  5. ncbi request reprint Reexamination of opioid stimulation of cGMP formation in cell lines of neuronal origin
    Y Sarne
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel
    Cell Mol Neurobiol 18:425-8. 1998
  6. ncbi request reprint Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell
    Alexander Korzh
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 1189:23-32. 2008
  7. doi request reprint Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage
    Fadi Assaf
    The Adelson Center for Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Behav Brain Res 220:194-201. 2011
  8. ncbi request reprint The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res Mol Brain Res 101:93-102. 2002
  9. ncbi request reprint Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): behavioral, pharmacological and biochemical studies in mice
    Roey Senn
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Pharmacol Biochem Behav 88:230-7. 2008
  10. doi request reprint Long-term consequences of a single treatment of mice with an ultra-low dose of Delta9-tetrahydrocannabinol (THC)
    Haitham Amal
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Behav Brain Res 206:245-53. 2010

Collaborators

  • Vardit Rubovitch
  • Ma anit Shapira
  • Chaim G Pick
  • R Mechoulam
  • Ora Keren
  • Mikhal Gafni
  • Miriam Fishbein
  • Fadi Assaf
  • Binyamin Binyaminy
  • Roey Senn
  • Anastasia Bologov
  • Elena Kaplan
  • Haitham Amal
  • Alexander Korzh
  • Aya Hefetz
  • Isabella Tselnicker
  • O Keren
  • Roni Bash
  • Sahar Gov
  • Anastasia Strelnikov
  • Lilach Fridman-Rozevich
  • Hilla Bar-Josef
  • M Gafni

Detail Information

Publications23

  1. ncbi request reprint Cannabinoids: between neuroprotection and neurotoxicity
    Yosef Sarne
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Drug Targets CNS Neurol Disord 4:677-84. 2005
    ..The current review attempts to shed light on this dual activity, and to dissociate between the two contradictory effects...
  2. ncbi request reprint The involvement of VEGF receptors and MAPK in the cannabinoid potentiation of Ca2+ flux into N18TG2 neuroblastoma cells
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Brain Res Mol Brain Res 120:138-44. 2004
    ..The pharmacological implications of this novel mechanism of cannabinoid activity are discussed...
  3. ncbi request reprint Are cannabinoid drugs neurotoxic or neuroprotective?
    Y Sarne
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Med Hypotheses 63:187-92. 2004
    ..The outcome of these experiments may have practical applications when considering the use of cannabinoids as therapeutic agents and in evaluating the consequences of their use as recreational drugs...
  4. pmc The dual neuroprotective-neurotoxic profile of cannabinoid drugs
    Yosef Sarne
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Br J Pharmacol 163:1391-401. 2011
    ..The future therapeutical potential of these findings is discussed...
  5. ncbi request reprint Reexamination of opioid stimulation of cGMP formation in cell lines of neuronal origin
    Y Sarne
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel
    Cell Mol Neurobiol 18:425-8. 1998
    ..The nitric oxide donor nitroprusside elevated cGMP in both cell lines. 3. The implication of the opioid-Ca(2+)-NO-cGMP cellular pathway for opioid activity in vivo is discussed...
  6. ncbi request reprint Modulation of extracellular signal-regulated kinase (ERK) by opioid and cannabinoid receptors that are expressed in the same cell
    Alexander Korzh
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 1189:23-32. 2008
    ..The characterization of cannabinoid- and opioid-induced ERK activation in these two cell-lines enables future studies into possible interactions between these two groups of drugs at the level of MAPK signaling...
  7. doi request reprint Pre- and post-conditioning treatment with an ultra-low dose of Δ9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage
    Fadi Assaf
    The Adelson Center for Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Behav Brain Res 220:194-201. 2011
    ..Our results suggest that a pre- or post-conditioning treatment with extremely low doses of THC, several days before or after brain injury, may provide safe and effective long-term neuroprotection...
  8. ncbi request reprint The cannabinoid agonist DALN positively modulates L-type voltage-dependent calcium-channels in N18TG2 neuroblastoma cells
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res Mol Brain Res 101:93-102. 2002
    ..Hence, we suggest a cannabinoid-specific, PTX-insensitive, stimulatory effect on L-type voltage-dependent calcium channels, which is mediated by PKA and modulated by PKC and calmodulin...
  9. ncbi request reprint Long-term cognitive deficits induced by a single, extremely low dose of tetrahydrocannabinol (THC): behavioral, pharmacological and biochemical studies in mice
    Roey Senn
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Pharmacol Biochem Behav 88:230-7. 2008
    ..001 mg/kg THC. These findings lead to further studies into the neuronal mechanisms underlying the long-term deleterious effects of THC and should be taken into consideration when evaluating the therapeutic benefits of cannabinoid drugs...
  10. doi request reprint Long-term consequences of a single treatment of mice with an ultra-low dose of Delta9-tetrahydrocannabinol (THC)
    Haitham Amal
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Behav Brain Res 206:245-53. 2010
    ..The relevance of these findings to the behavioral consequences of chronic exposure to marijuana is discussed...
  11. ncbi request reprint The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway
    Vardit Rubovitch
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res Mol Brain Res 110:261-6. 2003
    ....
  12. doi request reprint Long-term behavioral and biochemical effects of an ultra-low dose of Δ9-tetrahydrocannabinol (THC): neuroprotection and ERK signaling
    Miriam Fishbein
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Exp Brain Res 221:437-48. 2012
    ..These long-lasting effects indicate that a single treatment with an ultra-low dose of THC can modify brain plasticity and induce long-term behavioral and developmental effects in the brain...
  13. doi request reprint Agonist-specific down regulation of mu-opioid receptors: Different cellular pathways are activated by different opioid agonists
    Binyamin Binyaminy
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Life Sci 82:831-9. 2008
    ..This agonist-specific membrane-delimited regulatory process appears to be physiologically relevant and should be taken into account when studying long term effects of opioid drugs...
  14. ncbi request reprint Multiple mechanisms of CB1 cannabinoid receptors regulation
    Ora Keren
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 980:197-205. 2003
    ..Heterologous, opioid-induced, downregulation of CB1 receptors was evident in HEK-293 but not N18TG2 cells. The data demonstrate the existence of multiple pathways of CB1 receptors regulation...
  15. ncbi request reprint The stimulatory effect of cannabinoids on calcium uptake is mediated by Gs GTP-binding proteins and cAMP formation
    Roni Bash
    Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neurosignals 12:39-44. 2003
    ..The relevance of the cellular stimulatory activity of DALN to the pharmacological profile of cannabinoid drugs is discussed...
  16. doi request reprint Is withdrawal hyperalgesia in morphine-dependent mice a direct effect of a low concentration of the residual drug?
    Vardit Rubovitch
    Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel
    Addict Biol 14:438-46. 2009
    ..Our findings offer a novel, alternative approach to opiate detoxifications that may prevent withdrawal symptoms by a complete blockage of the opioid receptors using a high dose of the opioid antagonist...
  17. doi request reprint Dual neuroprotective and neurotoxic effects of cannabinoid drugs in vitro
    Anastasia Bologov
    The Adelson Center for the Biology of Addictive Diseases and The Mauerberger Chair in Neuropharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Cell Mol Neurobiol 31:195-202. 2011
    ....
  18. doi request reprint Membrane-delimited proteolytic regulation of opioid receptors
    Elena Kaplan
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 1386:25-34. 2011
    ....
  19. ncbi request reprint Long-term interactions between opioid and cannabinoid agonists at the cellular level: cross-desensitization and downregulation
    Ma anit Shapira
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Brain Res 960:190-200. 2003
    ..These results suggest that, under the present experimental conditions, the reduction in cell responsiveness resulted primarily from downregulation of the receptors...
  20. ncbi request reprint Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels
    O Keren
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Brain Res 843:193-8. 1999
    ....
  21. ncbi request reprint Opioids potentiate transmitter release from SK-N-SH human neuroblastoma cells by modulating N-type calcium channels
    O Keren
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel
    Brain Res 764:277-82. 1997
    ..Removal of the excitatory opioid effect by blockade with omega-conotoxin, an N-channel antagonist, reveals the inhibitory effect of opioids on release, thus suggesting that both modulatory effects of opioids are exerted in parallel...
  22. ncbi request reprint Divers pathways mediate delta-opioid receptor down regulation within the same cell
    M Shapira
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel
    Brain Res Mol Brain Res 96:142-50. 2001
    ....
  23. ncbi request reprint A single low dose of tetrahydrocannabinol induces long-term cognitive deficits
    Isabella Tselnicker
    The Mauerberger Chair in Neuropharmacology, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Neurosci Lett 411:108-11. 2007
    ..The THC-injected mice showed both longer escape latencies and lower scores in the probe tests compared to their matched controls, indicating the induction of cognitive deficits...