Justin V McCarthy

Summary

Affiliation: University College Cork
Country: Ireland

Publications

  1. ncbi request reprint Apoptosis and development
    Justin V McCarthy
    Signal Transduction Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Essays Biochem 39:11-24. 2003
  2. doi request reprint Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    Cell Mol Life Sci 66:1534-55. 2009
  3. ncbi request reprint Involvement of presenilins in cell-survival signalling pathways
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 33:568-72. 2005
  4. doi request reprint Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis
    Baukje M Elzinga
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Biol Chem 284:1394-409. 2009
  5. doi request reprint Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor
    James C Powell
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Neurochem 108:216-30. 2009
  6. doi request reprint Presenilins are novel substrates for TRAF6-mediated ubiquitination
    Run Yan
    Signal Transduction Laboratory, Department of Biochemistry, Western Gate Building, Western Road, University College Cork, Cork, Ireland
    Cell Signal 25:1769-79. 2013
  7. doi request reprint Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness
    Vishal Agrawal
    Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, University College Cork, 3 41 Western Gateway Building, Western Road, Cork, Ireland
    Mol Neurobiol 53:3428-38. 2016
  8. ncbi request reprint Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    FEBS Lett 580:4015-20. 2006
  9. doi request reprint A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains
    Stephen P Duggan
    Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, Western Gateway Building, Western Road, University College Cork, Cork, Ireland
    FEBS Lett 589:1001-8. 2015
  10. doi request reprint TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, ABCRF, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 381:418-23. 2009

Collaborators

  • Ciara Twomey
  • Stephen P Duggan
  • James C Powell
  • Vishal Agrawal
  • Run Yan
  • Neha Sawhney
  • Emer Hickey
  • Jyoti Chhibber-Goel
  • Baukje M Elzinga
  • Brian McElroy
  • Caroline Coleman-Vaughan
  • Sean Farrelly
  • Si Qian
  • Frances Harte
  • Raunak Jain

Detail Information

Publications13

  1. ncbi request reprint Apoptosis and development
    Justin V McCarthy
    Signal Transduction Laboratory, Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Essays Biochem 39:11-24. 2003
    ....
  2. doi request reprint Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    Cell Mol Life Sci 66:1534-55. 2009
    ..We also discuss regulation of the gamma-secretase complexes, with an emphasis on the functional role of presenilins in cell biology...
  3. ncbi request reprint Involvement of presenilins in cell-survival signalling pathways
    J V McCarthy
    Signal Transduction Laboratory, Biochemistry Department, Biosciences Institute, University College Cork, Cork, Ireland
    Biochem Soc Trans 33:568-72. 2005
    ..In this paper, we review PS-regulated molecules, their role in cell signalling and possible involvement in neurodegeneration in patients suffering from AD...
  4. doi request reprint Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis
    Baukje M Elzinga
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Biol Chem 284:1394-409. 2009
    ..These findings also suggest that regulated intramembrane proteolysis may be a control mechanism for IL-1R1-mediated signaling...
  5. doi request reprint Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor
    James C Powell
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Neurochem 108:216-30. 2009
    ..In summary, our data suggest that an NGF-induced association between PS1 and TRAF6 influences regulated intramembrane proteolysis of p75(NTR)...
  6. doi request reprint Presenilins are novel substrates for TRAF6-mediated ubiquitination
    Run Yan
    Signal Transduction Laboratory, Department of Biochemistry, Western Gate Building, Western Road, University College Cork, Cork, Ireland
    Cell Signal 25:1769-79. 2013
    ....
  7. doi request reprint Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness
    Vishal Agrawal
    Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, University College Cork, 3 41 Western Gateway Building, Western Road, Cork, Ireland
    Mol Neurobiol 53:3428-38. 2016
    ..These observations illustrate a novel PS2-dependent means of modulating LPS-mediated immune responses and identify a functional distinction between PS1 and PS2 in innate immunity. ..
  8. ncbi request reprint Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    FEBS Lett 580:4015-20. 2006
    ..These findings have important implications for regulation of PS1 function and the pathogenesis of Alzheimer's disease...
  9. doi request reprint A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains
    Stephen P Duggan
    Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, Western Gateway Building, Western Road, University College Cork, Cork, Ireland
    FEBS Lett 589:1001-8. 2015
    ..Our results highlight a γ-secretase-independent function for non-covalent ubiquitin signaling in the regulation of PS1, and add new insights into the structure and function of the presenilin proteins. ..
  10. doi request reprint TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1
    Ciara Twomey
    Signal Transduction Laboratory, Biochemistry Department, ABCRF, Cavanagh Pharmacy Building, University College Cork, Cork, Ireland
    Biochem Biophys Res Commun 381:418-23. 2009
    ..Our results indicate that TRAF6-mediated ubiquitination of IL-1R1 has a decisive role in IL-1R1 signalling and propose a molecular mechanism whereby TRAF6 promotes ubiquitination and RIP of IL-1R1 through its ubiquitin ligase activity...
  11. doi request reprint Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
    Stephen P Duggan
    Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, Western Gateway Building, University College Cork, Cork, Ireland
    Cell Signal 28:1-11. 2016
    ....
  12. pmc γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling
    Jyoti Chhibber-Goel
    From the Signal Transduction Laboratory, School of Biochemistry and Cell Biology, ABCRF, 3 41 Western Gateway Building, Western Road, University College Cork, Cork T12 YN60, Ireland
    J Biol Chem 291:5971-85. 2016
    ....
  13. ncbi request reprint The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis
    Brian McElroy
    Signal Transduction Laboratory, Biochemistry Department, National University of Ireland, Cork, Ireland
    Biochem Biophys Res Commun 358:1136-41. 2007
    ..This study suggests that the IGF-IR is a substrate for gamma-secretase and may mediate a function independent of its role as a receptor tyrosine kinase...