Affiliation: University College Dublin
- The effects of ethanol on CNS development in the chick embryoSeamus Giles
School of Medicine and Medical Science, Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Reprod Toxicol 25:224-30. 2008..No gross malformations were observed. We conclude that these results further highlight the stage-specific effects of ethanol on neurodevelopment...
- Ocular involvement in fetal alcohol spectrum disorder: a reviewDeirdre Brennan
School of Medicine and Medical Science, Health Sciences Building, University College Dublin, Belfield, Donnybrook, Dublin 4 Ireland
Curr Pharm Des 20:5377-87. 2014..Lastly, we review how current knowledge of early eye development can be used to gain new insights into the molecular mechanisms of ethanol teratogenicity with particular reference to the sonic hedgehog pathway...
- Teratogenic and developmental effects of lithiumJames J Giles
Department of Human Anatomy and Physiology and Conway Institute of Biomolecular and Biomedical Research, National University of Ireland, Dublin, Ireland
Curr Pharm Des 12:1531-41. 2006..More recent findings have shown that the effects of lithium on invertebrates may be mediated through inhibition of GSK-3beta in the Wnt-GSK-3 pathway...
- Sonic hedgehog expression is disrupted following in ovo ethanol exposure during early chick eye developmentDeirdre Brennan
School of Medicine and Medical Science, University College Dublin, Belfield, Ireland
Reprod Toxicol 41:49-56. 2013..Thus, in conclusion, our findings are discussed in relation to the varied and often conflicting reports of ethanol-induced Shh perturbation found in the literature. ..
- Histological characterisation of the ethanol-induced microphthalmia phenotype in a chick embryo model systemKevin Kennelly
School of Medicine and Medical Science, Health Sciences Building, University College Dublin, Belfield, Dublin 4, Ireland
Reprod Toxicol 32:227-34. 2011..The possible involvement of Shh, Fgf8, Bmp4 and Pax6 is discussed in relation to these outcomes...