Rachel M McLoughlin

Summary

Affiliation: Trinity College
Country: Ireland

Publications

  1. pmc IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
    John M Leech
    J Immunol 198:2352-2365. 2017
  2. pmc Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort
    R M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Exp Allergy 42:392-404. 2012
  3. doi Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma
    Rachel M McLoughlin
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 127:1097-107; quiz 1108-9. 2011
  4. pmc Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection
    Kate M O'Keeffe
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Infect Immun 83:3445-57. 2015
  5. pmc Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection
    Alison G Murphy
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin 2, Ireland
    J Immunol 192:3697-708. 2014
  6. pmc Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection
    Aisling F Brown
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 11:e1005226. 2015
  7. pmc The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens
    Keenan A Lacey
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Pathogens 5:. 2016
  8. pmc Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin
    Michelle E Mulcahy
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 8:e1003092. 2012
  9. doi Host-Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization
    Michelle E Mulcahy
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Trends Microbiol 24:872-886. 2016
  10. doi Memory γδ T Cells-Newly Appreciated Protagonists in Infection and Immunity
    Stephen J Lalor
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Trends Immunol 37:690-702. 2016

Collaborators

Detail Information

Publications16

  1. pmc IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
    John M Leech
    J Immunol 198:2352-2365. 2017
    ....
  2. pmc Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort
    R M McLoughlin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Exp Allergy 42:392-404. 2012
    ..Immunomodulatory T cells are thought to influence development of allergy and asthma, but early life longitudinal data on their phenotype and function are lacking...
  3. doi Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma
    Rachel M McLoughlin
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    J Allergy Clin Immunol 127:1097-107; quiz 1108-9. 2011
    ....
  4. pmc Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection
    Kate M O'Keeffe
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Infect Immun 83:3445-57. 2015
    ..Within these autophagosomes, the bacteria are protected from phagocytic killing, thus providing an intracellular survival niche within professional phagocytes, which ultimately facilitates dissemination. ..
  5. pmc Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection
    Alison G Murphy
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Dublin 2, Ireland
    J Immunol 192:3697-708. 2014
    ..aureus, in a fashion analogous to that associated with classical αβ T cells, and suggest that induction of IL-17-expressing γδ T cells may be an important property of a protective vaccine against S. aureus...
  6. pmc Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection
    Aisling F Brown
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 11:e1005226. 2015
    ..aureus infection in mice. This study notably advances our understanding of S. aureus cellular immunity, and demonstrates for the first time that a correlate of S. aureus protective immunity identified in mice may be relevant in humans. ..
  7. pmc The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens
    Keenan A Lacey
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    Pathogens 5:. 2016
    ..In this review, we highlight potential candidate antigens for vaccines targeted at protection against SSTIs. ..
  8. pmc Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin
    Michelle E Mulcahy
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 8:e1003092. 2012
    ..By combining in vitro biochemical analysis with animal model studies we have identified the squamous epithelial cell envelope protein loricrin as the target ligand for ClfB during nasal colonisation by S. aureus...
  9. doi Host-Bacterial Crosstalk Determines Staphylococcus aureus Nasal Colonization
    Michelle E Mulcahy
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Trends Microbiol 24:872-886. 2016
    ..It is clear that S. aureus maintains a unique, complex relationship with the host immune system and that S. aureus nasal colonization is overall a multifactorial process which is as yet incompletely understood...
  10. doi Memory γδ T Cells-Newly Appreciated Protagonists in Infection and Immunity
    Stephen J Lalor
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
    Trends Immunol 37:690-702. 2016
    ..This review discusses recent reports of memory-type responses attributed to γδ T cells and assesses this underappreciated facet of these enigmatic cells...
  11. pmc Staphylococcus aureus and Influenza A Virus: Partners in Coinfection
    Michelle E Mulcahy
    Host Pathogen Interactions Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    MBio 7:. 2016
    ..Overall, the study indicates that interkingdom signaling may occur following IAV infection and this likely contributes to sensitizing the IAV-infected host to secondary staphylococcal pneumonia...
  12. pmc TRAM is required for TLR2 endosomal signaling to type I IFN induction
    Julianne Stack
    School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
    J Immunol 193:6090-102. 2014
    ..Our work reveals that TRAM acts as a sorting adaptor not only for TLR4, but also for TLR2, to facilitate signaling to IRF7 at the endosome, which explains how TLR2 is capable of causing type I IFN induction. ..
  13. pmc The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism
    Christopher Weidenmaier
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13227. 2010
    ..An understanding of this novel T cell-dependent host response to staphylococcal abscess formation may lead to the development of new strategies to combat S. aureus skin and soft tissue infections...
  14. pmc Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine
    Pádraig J Ross
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 9:e1003264. 2013
    ..Our findings demonstrate that alum promotes protective immunity through IL-1β-induced IL-17A production, but also reveal that optimum protection against B. pertussis requires induction of Th1, but not Th2 cells...
  15. pmc Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
    Edel A McNeela
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    PLoS Pathog 6:e1001191. 2010
    ..Furthermore, NLRP3 was required for protective immunity against respiratory infection with S. pneumoniae. These results add significantly to our understanding of the interactions between PLY and the immune system...