A Samali

Summary

Affiliation: National University of Ireland
Country: Ireland

Publications

  1. pmc Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM
    DONNA KENNEDY
    Apoptosis Research Centre, NUI Galway, Ireland
    FEBS Open Bio 4:813-21. 2014
  2. pmc Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
    Sanjeev Gupta
    Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland
    Int J Cell Biol 2010:170215. 2010
  3. pmc HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
    Sanjeev Gupta
    Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland
    PLoS Biol 8:e1000410. 2010
  4. pmc TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt
    E Szegezdi
    Department of Biochemistry, National University of Ireland, University Road, Galway, Ireland
    Br J Cancer 94:398-406. 2006
  5. pmc Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL
    Eva Szegezdi
    School of Natural Sciences, National University of Ireland, Galway, Ireland
    Mol Cell Proteomics 11:M111.013730. 2012
  6. pmc Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion
    Karen Cawley
    Apoptosis Research Centre, National University of Ireland, Galway, Ireland
    PLoS ONE 8:e73870. 2013
  7. pmc Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli
    A Samali
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cell Stress Chaperones 6:49-58. 2001
  8. ncbi request reprint Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c
    C G Concannon
    Department of Biochemistry, National University of Ireland, Galway
    Gene Expr 9:195-201. 2001
  9. pmc Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells
    A Samali
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S 171 77, Stockholm, Sweden
    EMBO J 18:2040-8. 1999
  10. pmc Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells
    D Mahalingam
    Department of Biochemistry and National Centre of Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Br J Cancer 102:754-64. 2010

Collaborators

Detail Information

Publications23

  1. pmc Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM
    DONNA KENNEDY
    Apoptosis Research Centre, NUI Galway, Ireland
    FEBS Open Bio 4:813-21. 2014
    ..Further, overexpression of HSPA1 could not mimic the effect of HS on BIM expression, suggesting that other HS factors may play a role in inhibiting ER stress-induced apoptosis by regulating BIM...
  2. pmc Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
    Sanjeev Gupta
    Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland
    Int J Cell Biol 2010:170215. 2010
    ..These data suggest a role for caspase-9 and -2, Bcl-2 family members and the mitochondrial permeability transition pore in loss of mitochondrial membrane potential during ER stress-induced apoptosis...
  3. pmc HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction
    Sanjeev Gupta
    Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland
    PLoS Biol 8:e1000410. 2010
    ..Our data show that binding of Hsp72 to IRE1alpha enhances IRE1alpha/XBP1 signaling at the ER and inhibits ER stress-induced apoptosis. These results provide a physical connection between cytosolic chaperones and the ER stress response...
  4. pmc TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt
    E Szegezdi
    Department of Biochemistry, National University of Ireland, University Road, Galway, Ireland
    Br J Cancer 94:398-406. 2006
    ..These findings offer a promising and novel strategy involving a combination of TRAIL and ATO, or more specific Akt inhibitors in the treatment of various haematopoietic malignancies...
  5. pmc Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL
    Eva Szegezdi
    School of Natural Sciences, National University of Ireland, Galway, Ireland
    Mol Cell Proteomics 11:M111.013730. 2012
    ..It also implies that more effective treatments using protein therapeutics could be achieved simply by altering specificity...
  6. pmc Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion
    Karen Cawley
    Apoptosis Research Centre, National University of Ireland, Galway, Ireland
    PLoS ONE 8:e73870. 2013
    ..In our model, downregulation of miRNA biogenesis delays ER stress-induced apoptosis. This suggests that disrupted miRNA biogenesis may contribute to cancer progression by inhibiting ER stress-induced cell death. ..
  7. pmc Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli
    A Samali
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cell Stress Chaperones 6:49-58. 2001
    ..A model is presented for the inhibition of apoptosis during thermotolerance in which Hsp27 preferentially blocks mitochondrial cytochrome c release, whereas Hsp72 interferes with apoptosomal caspase activation...
  8. ncbi request reprint Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c
    C G Concannon
    Department of Biochemistry, National University of Ireland, Galway
    Gene Expr 9:195-201. 2001
    ..These results point to Hsp27 mediating its inhibition of procaspase-3 activation through its ability to sequester both cytochrome c and procaspase-3, and thus prevent the correct formation/function of the apoptosome complex...
  9. pmc Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells
    A Samali
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S 171 77, Stockholm, Sweden
    EMBO J 18:2040-8. 1999
    ..This finding suggests that the release of mitochondrial Hsps may also accelerate caspase activation in the cytoplasm of intact cells...
  10. pmc Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells
    D Mahalingam
    Department of Biochemistry and National Centre of Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Br J Cancer 102:754-64. 2010
    ..DR4 and DR5 activation however can also induce inflammatory and pro-survival signalling. It is not known how these different cellular responses are regulated and what the individual role of DR4 vs DR5 is in these processes...
  11. ncbi request reprint Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins
    A Samali
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Box 210, S 171 77, Stockholm, Sweden
    FEBS Lett 461:306-10. 1999
    ..Furthermore, accumulation of Hsps after incubation at 42 degrees C rendered the cells resistant to apoptosis. These results suggest that lack of Hsp induction is the cause rather than the consequence of cell death...
  12. pmc Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL
    C Holohan
    Department of Biochemistry, National University of Ireland Galway, Galway, Ireland
    J Cell Mol Med 12:591-606. 2008
    ..We conclude that cytokine-induced nitric oxide production is both essential and sufficient for caspase activation and beta-cell death, and have identified Bcl-X(L) as a potential target to combat beta-cell apoptosis...
  13. ncbi request reprint Cleavage of the calpain inhibitor, calpastatin, during apoptosis
    M I Pörn-Ares
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cell Death Differ 5:1028-33. 1998
    ..In conclusion, the results of the present study suggest that caspases may cleave calpastatin and thus, regulate calpain activity during apoptotic cell death...
  14. pmc Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines
    D Mahalingam
    Cell Stress and Apoptosis Research Group, Department of Biochemistry and National Centre of Biomedical Engineering Science, National University of Ireland, University Road, Galway, Ireland
    Br J Cancer 100:1415-24. 2009
    ..These data indicate that the short JNK1 isoforms transmit an antiapoptotic signal, whereas the long isoforms (JNK1alpha2 or JNK1beta2) act in a proapoptotic manner...
  15. pmc Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim
    E Szegezdi
    Department of Biochemistry, National University of Ireland, Galway, Ireland
    J Cell Mol Med 12:2482-96. 2008
    ..These data indicate that NGF-mediated protection against ER stress-induced apoptosis occurs at the level of the mitochondria by regulating induction and activation of Bim and mitochondrial translocation of Bax...
  16. ncbi request reprint Detection of pro-caspase-3 in cytosol and mitochondria of various tissues
    A Samali
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Stockholm, Sweden
    FEBS Lett 431:167-9. 1998
    ..e. tissues in which spontaneous apoptosis plays an important role. Our findings provide further support for mitochondrial localization of pro-caspase-3 and the critical role of this organelle in apoptosis...
  17. ncbi request reprint On the role of Hsp27 in regulating apoptosis
    C G Concannon
    Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland
    Apoptosis 8:61-70. 2003
    ..This article will review recent advances in the field and will address some of the potential mechanisms by which Hsp27 functions as an anti-apoptotic molecule...
  18. pmc Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
    M van Dijk
    Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland
    Cell Death Dis 4:e702. 2013
    ....
  19. pmc Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
    K Mnich
    1 Apoptosis Research Centre, School of Natural Sciences, National University of Ireland, Galway, Ireland 2 Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
    Cell Death Dis 5:e1202. 2014
    ..The involvement of macroautophagy and chaperone-mediated autophagy were ruled out. Taken together, these findings suggest an anti-apoptotic mechanism by which NGF induces removal of active caspase-3 in a lysosome-dependent manner. ..
  20. ncbi request reprint Interleukin-1, interleukin-8, tumour necrosis factor alpha and interferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines
    K Zachrisson
    Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Gastroenterol Hepatol 13:551-9. 2001
    ..Our findings indicate that pro-inflammatory cytokines may participate in the regulation of the gastrointestinal epithelial cell proliferation in health and disease...
  21. ncbi request reprint Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins
    A Duffy
    Regenrative Medicine Institute, REMEDI, National Centre of Biomedical Engineering Sciences, NCBES, and the Department of Medicine, National University of Ireland, NUI, Galway, Ireland
    Endothelium 13:9-16. 2006
    ..In contrast, high-glucose increases viability in HRECs and inhibits apoptosis, which may contribute to the development of diabetic retinopathy...
  22. pmc Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
    S Gupta
    School of Medicine Pathology, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
    Cell Death Dis 3:e333. 2012
    ..Our results suggest a molecular mechanism whereby repression of miR-106b-25 cluster has an important role in ER stress-mediated increase in Bim and apoptosis...