Kay Ohlendieck

Summary

Affiliation: National University of Ireland
Country: Ireland

Publications

  1. doi Proteomics of skeletal muscle glycolysis
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochim Biophys Acta 1804:2089-101. 2010
  2. pmc Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins
    Caroline Lewis
    Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    J Biomed Biotechnol 2010:648501. 2010
  3. pmc Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    J Aging Res 2011:908035. 2011
  4. pmc Subproteomic analysis of basic proteins in aged skeletal muscle following offgel pre-fractionation
    Joan Gannon
    Laboratory of Systems Medicine and Cell Biology, Department of Medicine, Research Institute of McGill University Health Centre, Montreal, QC, Canada
    Mol Med Rep 5:993-1000. 2012
  5. pmc Proteomic Profiling of Fast-To-Slow Muscle Transitions during Aging
    Kay Ohlendieck
    Department of Biology, Muscle Biology Laboratory, National University of Ireland, Maynooth County Kildare, Ireland
    Front Physiol 2:105. 2011
  6. pmc Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    J Nutr Metab 2012:893876. 2012
  7. ncbi Proteomics of the dystrophin-glycoprotein complex and dystrophinopathy
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Curr Protein Pept Sci 14:680-97. 2013
  8. doi Proteomic identification of biomarkers of skeletal muscle disorders
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Biomark Med 7:169-86. 2013
  9. pmc Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Skelet Muscle 1:6. 2011
  10. doi Proteomics of skeletal muscle differentiation, neuromuscular disorders and fiber aging
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Expert Rev Proteomics 7:283-96. 2010

Collaborators

Detail Information

Publications58

  1. doi Proteomics of skeletal muscle glycolysis
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochim Biophys Acta 1804:2089-101. 2010
    ....
  2. pmc Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins
    Caroline Lewis
    Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    J Biomed Biotechnol 2010:648501. 2010
    ..Hence, the lack of cardiac dystrophin appears to trigger a generally perturbed protein expression pattern in the MDX heart, affecting especially energy metabolism and contractile proteins...
  3. pmc Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    J Aging Res 2011:908035. 2011
    ....
  4. pmc Subproteomic analysis of basic proteins in aged skeletal muscle following offgel pre-fractionation
    Joan Gannon
    Laboratory of Systems Medicine and Cell Biology, Department of Medicine, Research Institute of McGill University Health Centre, Montreal, QC, Canada
    Mol Med Rep 5:993-1000. 2012
    ..Thus, alterations in the abundance of metabolic enzymes appear to play a central role in the molecular pathogenesis of age‑dependent muscle wasting...
  5. pmc Proteomic Profiling of Fast-To-Slow Muscle Transitions during Aging
    Kay Ohlendieck
    Department of Biology, Muscle Biology Laboratory, National University of Ireland, Maynooth County Kildare, Ireland
    Front Physiol 2:105. 2011
    ..Both, newly identified protein factors and confirmed alterations in crucial metabolic and contractile elements can now be employed to establish a sarcopenia-specific biomarker signature...
  6. pmc Pathobiochemical changes in diabetic skeletal muscle as revealed by mass-spectrometry-based proteomics
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    J Nutr Metab 2012:893876. 2012
    ....
  7. ncbi Proteomics of the dystrophin-glycoprotein complex and dystrophinopathy
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Curr Protein Pept Sci 14:680-97. 2013
    ..The study of these new areas of muscle proteomics tends to improve our understanding of the normal function of dystrophin in contractile fibres and better define the molecular mechanism of X-linked muscular dystrophy. ..
  8. doi Proteomic identification of biomarkers of skeletal muscle disorders
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Biomark Med 7:169-86. 2013
    ..These mass spectrometric studies have clearly established skeletal muscle proteomics as a reliable method for the identification of novel indicators of neuromuscular diseases...
  9. pmc Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques
    Kay Ohlendieck
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Skelet Muscle 1:6. 2011
    ..abstract:..
  10. doi Proteomics of skeletal muscle differentiation, neuromuscular disorders and fiber aging
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Expert Rev Proteomics 7:283-96. 2010
    ..New muscle markers will be crucial for the development of improved diagnostics, the monitoring of disease progression, evaluation of drug action and the identification of novel therapeutic targets...
  11. ncbi Reduced expression of regucalcin in young and aged mdx diaphragm indicates abnormal cytosolic calcium handling in dystrophin-deficient muscle
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochim Biophys Acta 1764:773-85. 2006
    ....
  12. doi Proteomic profiling of x-linked muscular dystrophy
    Caroline Lewis
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    J Muscle Res Cell Motil 30:267-9. 2009
    ....
  13. ncbi Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Eur J Cell Biol 86:629-40. 2007
    ..These findings indicate that the increase in muscle-specific small heat shock proteins constitutes an essential cellular response to fibre aging and might therefore be a novel therapeutic option to treat sarcopenia of old age...
  14. doi Lectin-based proteomic profiling of aged skeletal muscle: decreased pyruvate kinase isozyme M1 exhibits drastically increased levels of N-glycosylation
    Kathleen O'Connell
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Eur J Cell Biol 87:793-805. 2008
    ..This agrees with the idea that abnormal post-translational modifications in key metabolic enzymes may be involved in the conversion of aged muscle to slower twitch patterns and a drastic shift to more aerobic-oxidative metabolism...
  15. ncbi Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle
    Kathleen O'Connell
    Department of Biology, National University of Ireland, Co Kildare, Ireland
    Int J Mol Med 20:145-53. 2007
    ....
  16. ncbi Phosphoproteomic analysis of aged skeletal muscle
    Joan Gannon
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Int J Mol Med 22:33-42. 2008
    ..This confirms that sarcopenia of old age is a complex neuromuscular pathology that is associated with drastic changes in the abundance and structure of key muscle proteins...
  17. doi Reduced expression of sarcalumenin and related Ca2+ -regulatory proteins in aged rat skeletal muscle
    Kathleen O'Connell
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Exp Gerontol 43:958-61. 2008
    ..This may trigger abnormal luminal Ca(2+)-buffering and/or decreased plasmalemmal Ca(2+)-removal, which could exacerbate impaired signaling or disturbed intracellular ion balance in aged fibres, thereby causing contractile weakness...
  18. doi Drastic increase of myosin light chain MLC-2 in senescent skeletal muscle indicates fast-to-slow fibre transition in sarcopenia of old age
    Joan Gannon
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Eur J Cell Biol 88:685-700. 2009
    ....
  19. ncbi Subproteomics analysis of Ca+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Eur J Biochem 271:3943-52. 2004
    ..The previously described impaired Ca(2+) buffering capacity of the dystrophic sarcoplasmic reticulum is probably caused by a reduction in luminal Ca(2+)-binding proteins, including calsequestrin...
  20. ncbi Proteomic profiling of pathological and aged skeletal muscle fibres by peptide mass fingerprinting (Review)
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Int J Mol Med 19:547-64. 2007
    ..Proteomics is one of the most promising new analytical ways of comparing large muscle protein complements and has the potential to decisively improve modern biochemical and biomedical research into neuromuscular disorders...
  21. doi Mass spectrometric identification of dystrophin isoform Dp427 by on-membrane digestion of sarcolemma from skeletal muscle
    Caroline Lewis
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Anal Biochem 404:197-203. 2010
    ..On-membrane digestion has the potential to develop into the method of choice for studying these classes of proteins, whose presence is otherwise missed by conventional gel electrophoresis-based proteomics...
  22. ncbi Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Proteomics 6:4610-21. 2006
    ..Stress response appears to be an important cellular mechanism in dystrophic muscle and may be exploitable as a new approach to counteract muscle degeneration...
  23. pmc Proteomic profiling of antisense-induced exon skipping reveals reversal of pathobiochemical abnormalities in dystrophic mdx diaphragm
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Proteomics 9:671-85. 2009
    ..This clearly establishes the exon-skipping approach as a realistic treatment strategy for diminishing diverse downstream alterations in dystrophinopathy...
  24. pmc Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    Int J Mol Med 30:723-33. 2012
    ..Increased levels of CA are indicative of an increased demand of CO₂-removal in senescent muscle, and also suggest age-related fibre type shifting to slower-contracting muscles during human aging...
  25. ncbi Opposite pathobiochemical fate of pyruvate kinase and adenylate kinase in aged rat skeletal muscle as revealed by proteomic DIGE analysis
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Proteomics 8:364-77. 2008
    ....
  26. doi Proteomic profiling of cardiomyopathic tissue from the aged mdx model of Duchenne muscular dystrophy reveals a drastic decrease in laminin, nidogen and annexin
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, Ireland
    Proteomics 13:2312-23. 2013
    ....
  27. ncbi Proteomic profiling of non-obese type 2 diabetic skeletal muscle
    Edel Mullen
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Int J Mol Med 25:445-58. 2010
    ..Reliable markers could be used for improving diagnostics, monitoring of disease progression and therapeutic evaluations...
  28. pmc Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy
    Sandra Murphy
    Department of Biology, Maynooth University, Maynooth, Co Kildare, Ireland
    Biology (Basel) 4:397-423. 2015
    ..Thus, the reduction of sample complexity in organelle-focused proteomics can be advantageous for the profiling of supramolecular protein complexes in highly intricate systems, such as skeletal muscle tissue...
  29. doi Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis
    Ashling Holland
    Department of Biology, Maynooth University, National University of Ireland, Maynooth, County Kildare, Ireland
    Proteomics 15:2318-31. 2015
    ..Immunoblotting confirmed a considerable increase of periostin in the dystrophin-deficient diaphragm from both mdx and mdx-4cv mice, suggesting an involvement of this matricellular protein in dystrophinopathy-related fibrosis. ..
  30. pmc Profiling of age-related changes in the tibialis anterior muscle proteome of the mdx mouse model of dystrophinopathy
    Steven Carberry
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    J Biomed Biotechnol 2012:691641. 2012
    ..The identification of novel indicators of progressive muscular dystrophy might be useful for the establishment of a muscle subtype-specific biomarker signature of dystrophinopathy...
  31. ncbi Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation
    Pamela Donoghue
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochim Biophys Acta 1752:166-76. 2005
    ....
  32. ncbi Mass spectrometric characterization of the sarcoplasmic reticulum from rabbit skeletal muscle by on-membrane digestion
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Protein Pept Lett 19:252-63. 2012
    ..Hence, on-membrane digestion is highly suitable as the method of choice for studying integral and high-molecular-mass proteins in proteomic studies...
  33. doi Identification of secondary effects of hyperexcitability by proteomic profiling of myotonic mouse muscle
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Mol Biosyst 7:2480-9. 2011
    ....
  34. doi Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle
    Kathleen O'Connell
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Proteomics 9:5509-24. 2009
    ..This suggests that mitochondrial markers are reliable candidates that should be included in the future establishment of a biomarker signature of skeletal muscle aging...
  35. pmc Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biosci Rep 34:. 2014
    ..Increases in slow myosin light chains and the troponin complex and a decrease in fast MBP (myosin-binding protein) probably reflect the initial preferential loss of the fast type of neuromuscular synapses in motor neuron disease...
  36. pmc Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy
    Steven Carberry
    Department of Biology, National University of Ireland, Maynooth, Kildare, Republic of Ireland
    Int J Mol Med 30:229-34. 2012
    ..These proteomic findings establish the aged mdx diaphragm as an excellent model system for studying secondary effects of dystrophin deficiency in skeletal muscle tissue...
  37. doi Proteomic profiling of naturally protected extraocular muscles from the dystrophin-deficient mdx mouse
    Caroline Lewis
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochem Biophys Res Commun 396:1024-9. 2010
    ..Interestingly, the adaptive mechanisms that cause the sparing of extraocular fibers seem to be closely linked to an enhanced cellular stress response...
  38. ncbi Extraction of membrane proteins
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth
    Methods Mol Biol 244:283-93. 2004
  39. doi Gel electrophoresis-based proteomics of senescent tissues
    Steven Carberry
    Department of Biology, National University of Ireland Maynooth, Maynooth, Kildare, Ireland
    Methods Mol Biol 1048:229-46. 2013
    ....
  40. doi Proteomic analysis of dystrophic muscle
    Caroline Lewis
    Department of Biology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Methods Mol Biol 798:357-69. 2012
    ....
  41. doi Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers
    Ashling Holland
    Department of Biology, Maynooth University, Maynooth, Co Kildare, Ireland
    Molecules 20:11317-44. 2015
    ..Annexin, lamin, and vimentin were identified as universal dystrophic markers. ..
  42. pmc Comparative proteomic profiling of soleus, extensor digitorum longus, flexor digitorum brevis and interosseus muscles from the mdx mouse model of Duchenne muscular dystrophy
    Steven Carberry
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Int J Mol Med 32:544-56. 2013
    ..The interosseus muscle from mdx mice possibly represents a naturally protected phenotype...
  43. doi Proteomic profiling of the contractile apparatus from skeletal muscle
    Ashling Holland
    Muscle Biology Laboratory, Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Expert Rev Proteomics 10:239-57. 2013
    ....
  44. doi Skeletal muscle tissue from the Goto-Kakizaki rat model of type-2 diabetes exhibits increased levels of the small heat shock protein Hsp27
    Edel Mullen
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Mol Med Rep 4:229-36. 2011
    ..Increased levels of molecular chaperones suggest considerably enhanced cellular stress levels in diabetic muscle fibres...
  45. doi Proteomic analysis of muscle affected by motor neuron degeneration: the wobbler mouse model of amyotrophic lateral sclerosis
    Lisa Staunton
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Biochem Biophys Res Commun 406:595-600. 2011
    ..The establishment of novel disease-specific biomarkers of motor neuron disease might be helpful in the design of improved diagnostic tools and the identification of novel therapeutic targets...
  46. pmc Application of fluorescence two-dimensional difference in-gel electrophoresis as a proteomic biomarker discovery tool in muscular dystrophy research
    Steven Carberry
    Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    Biology (Basel) 2:1438-64. 2013
    ..Novel molecular insights into dystrophic changes suggest increased cellular stress, impaired calcium buffering, cytostructural alterations and disturbances of mitochondrial metabolism in dystrophin-deficient muscle tissue. ..
  47. ncbi Purification of membrane proteins
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth
    Methods Mol Biol 244:301-8. 2004
  48. pmc Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy
    Paul Dowling
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Biochem J 379:479-88. 2004
    ..This confirms the idea that abnormal Ca2+ cycling is involved in Ca2+-induced myonecrosis. Hence, manipulating disturbed Ca2+ handling might represent new modes of abolishing proteolytic degradation in muscular dystrophy...
  49. doi Comparative proteomic analysis of the contractile-protein-depleted fraction from normal versus dystrophic skeletal muscle
    Steven Carberry
    Department of Biology, National University of Ireland, Maynooth, Kildare, Ireland
    Anal Biochem 446:108-15. 2014
    ..Interesting new biomarker candidates included Hsp70, transferrin, and ferritin, whereby their altered concentration levels in dystrophin-deficient muscle were confirmed by immunoblotting. ..
  50. doi Proteomic profiling of animal models mimicking skeletal muscle disorders
    Philip Doran
    Department of Biology, National University of Ireland, Maynooth Co Kildare, Ireland
    Proteomics Clin Appl 1:1169-84. 2007
    ....
  51. doi Pathoproteomic profiling of the skeletal muscle matrisome in dystrophinopathy associated myofibrosis
    Ashling Holland
    Department of Biology, Maynooth University, National University of Ireland, Maynooth, Co Kildare, Ireland
    Proteomics 16:345-66. 2016
    ..The elimination of secondary abnormalities in the matrisome promises to reduce tissue scarring and the loss of skeletal muscle elasticity. ..
  52. ncbi Removal of detergent from protein fractions
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth
    Methods Mol Biol 244:295-300. 2004
  53. ncbi Ca2+-regulatory muscle proteins in the alcohol-fed rat
    Kay Ohlendieck
    Department of Biology, National University of Ireland, Maynooth, Co Kildare
    Metabolism 52:1102-12. 2003
    ..0950). We conclude that upregulation of SERCA1 protein and Ca(2+)-ATPase activity may be an adaptive mechanism and/or a contributory process in the pathology of alcohol-induced muscle disease...
  54. ncbi Oligomerisation of sarcoplasmic reticulum Ca2+-ATPase monomers from skeletal muscle
    Daniela Schreiber
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Protein Pept Lett 14:219-26. 2007
    ..This suggests a preferential complex formation via homo-dimerization, rather than interactions with established oligomeric structures...
  55. ncbi Early effects of denervation on Ca(2+)-handling proteins in skeletal muscle
    Pamela Donoghue
    Department of Biology, National University of Ireland, Maynooth, Co Kildare, Ireland
    Int J Mol Med 13:767-72. 2004
    ..Hence, changes in muscle activity appear to have a profound effect on the abundance and isoform expression pattern of Ca(2+)-handling elements...
  56. ncbi Drastic reduction in the luminal Ca2+ -binding proteins calsequestrin and sarcalumenin in dystrophin-deficient cardiac muscle
    James Lohan
    Department of Biology, National University of Ireland, Maynooth, Co Kildare
    Biochim Biophys Acta 1689:252-8. 2004
    ..Abnormal Ca2+ -handling appears to play a major role in the molecular pathogenesis of the cardiac involvement in X-linked muscular dystrophy...
  57. doi Comparative profiling of the sperm proteome
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Proteomics 15:632-48. 2015
    ..New biomarker candidates might be useful to improve diagnostic, prognostic, and therapeutic aspects of infertility. ..
  58. pmc Proteomic profiling of the dystrophin-deficient mdx phenocopy of dystrophinopathy-associated cardiomyopathy
    Ashling Holland
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Biomed Res Int 2014:246195. 2014
    ....