Reza Meshkani

Summary

Affiliation: Tehran University of Medical Sciences
Country: Iran

Publications

  1. doi request reprint Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Electronic address
    Clin Chim Acta 462:77-89. 2016
  2. doi request reprint Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects
    Reza Meshkani
    The Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran
    Mol Cell Biochem 359:225-33. 2012
  3. doi request reprint The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
    Acta Diabetol 48:79-88. 2011
  4. ncbi request reprint 1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population
    Reza Meshkani
    Endocrinology and Metabolism Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, I R Iran
    Arch Med Res 38:556-62. 2007
  5. ncbi request reprint Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I R Iran
    Clin Chem 53:1585-92. 2007
  6. doi request reprint Hydrodynamic-based delivery of PTP1B shRNA reduces plasma glucose levels in diabetic mice
    Sanaz Vakili
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Mol Med Rep 7:211-6. 2013
  7. doi request reprint Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells
    Gholamreza Taheripak
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran
    Free Radic Biol Med 65:1435-46. 2013
  8. ncbi request reprint Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
    Reza Meshkani
    Endocrinology and Metabolism Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Clin Chem Lab Med 45:477-82. 2007
  9. doi request reprint Palmitate enhances protein tyrosine phosphatase 1B (PTP1B) gene expression at transcriptional level in C2C12 skeletal muscle cells
    Narges Mohammadtaghvaei
    Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, P O Box 14115 331, Tehran, Iran
    Inflammation 34:43-8. 2011
  10. doi request reprint SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I R Iran
    Free Radic Biol Med 89:679-89. 2015

Collaborators

  • Khosrow Adeli
  • Shohreh Khatami
  • Abolfazl Golestani
  • Mir Davood Omrani
  • Arash Hossein-Nezhad
  • Ali Akbar Pourfathollah
  • Bagher Larijani
  • Sattar Gorgani-Firuzjaee
  • Asie Sadeghi
  • Parvin Pasalar
  • Hossein Mazloom
  • Taghi Golmohammadi
  • Gholamreza Taheripak
  • Zahra Shokati Eshkiki
  • Behnam Alipoor
  • Hadi Khodabandehloo
  • Mehrnoosh Shanaki
  • Ensieh Nasli Esfahani
  • Samira Alizadeh
  • Shadi Sadat Seyyed Ebrahimi
  • Maani Beigy
  • Sanaz Vakili
  • Monireh Mani
  • Ahmad Nasimian
  • Salar Bakhtiyari
  • Narges Mohammadtaghvaei
  • Mostafa Haji Molla Hoseini
  • Sattar Gorgani Firuzjaee
  • Hossein Ghanbarian
  • Parisa Shabani
  • Mohammad Hossein Ghahremani
  • Mahmoud Shirzad
  • Farideh Razi
  • Hamid Ghaedi
  • Milad Bastami
  • Ghodratollah Panahi
  • Saeideh Ahmadi
  • Kayhan Azadmanesh
  • Shahnaz Khaghani
  • Zahra Zamani
  • Masoumeh Rajabibazl
  • Mohammad Taghikhani
  • Shahram Samiee
  • Mahnaz Aghaiepour
  • Sedigheh Amini
  • Mahin Nikoogoftar
  • Zahra Soheili
  • Minoo Mohraz

Detail Information

Publications27

  1. doi request reprint Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Electronic address
    Clin Chim Acta 462:77-89. 2016
    ..In addition, the contribution of macrophages to diabetes complications such as nephropathy, neuropathy, retinopathy and cardiovascular diseases is discussed...
  2. doi request reprint Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects
    Reza Meshkani
    The Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran
    Mol Cell Biochem 359:225-33. 2012
    ..37 (1.61-11.86), P=0.004]. No association was found between the XbaI polymorphism and diabetes in male group. Our results suggest that the ER1 polymorphisms might associate with T2D and fasting glucose among Iranian male subjects...
  3. doi request reprint The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
    Acta Diabetol 48:79-88. 2011
    ..General obesity was the major determinant of hyperuricemia in this population. The data from this study do not show the contribution of SUA as an additional component of the MetS...
  4. ncbi request reprint 1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population
    Reza Meshkani
    Endocrinology and Metabolism Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, I R Iran
    Arch Med Res 38:556-62. 2007
    ..The purpose of this study was to investigate the association of 1484insG polymorphism of the PTPN1 with obesity, insulin resistance, type 2 diabetes and other cardiovascular-related traits in an Iranian population...
  5. ncbi request reprint Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I R Iran
    Clin Chem 53:1585-92. 2007
    ..Polymorphisms in the coding sequence of PTPN1 have been variably associated with type 2 diabetes (T2D). We hypothesized that variations within the PTPN1 promoter might contribute to the development of T2D and related metabolic traits...
  6. doi request reprint Hydrodynamic-based delivery of PTP1B shRNA reduces plasma glucose levels in diabetic mice
    Sanaz Vakili
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Mol Med Rep 7:211-6. 2013
    ..However, further studies using non-viral carriers are required to deliver the plasmid safely into the liver. ..
  7. doi request reprint Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells
    Gholamreza Taheripak
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1416753955, Iran
    Free Radic Biol Med 65:1435-46. 2013
    ....
  8. ncbi request reprint Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
    Reza Meshkani
    Endocrinology and Metabolism Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Clin Chem Lab Med 45:477-82. 2007
    ..However, this association has not been studied in Iranian subjects and we hypothesized that this variation might be associated with insulin resistance, type 2 diabetes and related metabolic traits in this population...
  9. doi request reprint Palmitate enhances protein tyrosine phosphatase 1B (PTP1B) gene expression at transcriptional level in C2C12 skeletal muscle cells
    Narges Mohammadtaghvaei
    Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, P O Box 14115 331, Tehran, Iran
    Inflammation 34:43-8. 2011
    ..These data suggest that while palmitate treatment significantly induced PTP1B expression at the transcriptional level, the presence of an inflammatory process exerted by macrophages can augment this effect in the muscle cells...
  10. doi request reprint SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I R Iran
    Free Radic Biol Med 89:679-89. 2015
    ..Taken together, these findings suggest that SHIP2 is an important regulator of hepatic lipogenesis and lipoprotein secretion in insulin resistance state...
  11. doi request reprint Decreased expression of microRNA-21 is associated with increased cytokine production in peripheral blood mononuclear cells (PBMCs) of obese type 2 diabetic and non-diabetic subjects
    Hossein Mazloom
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Mol Cell Biochem 419:11-7. 2016
    ..These data suggest that miR-21 expression is decreased in PBMCs of obese subjects and reduced expression appears to be associated with increased secreted cytokine level in media of PBMCs of obese subjects. ..
  12. doi request reprint SH2 domain-containing inositol 5-phosphatase (SHIP2) regulates de-novo lipogenesis and secretion of apoB100 containing lipoproteins in HepG2 cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Biochem Biophys Res Commun 464:1028-33. 2015
    ..Collectively, these findings suggest that SHIP2 expression level is a key determinant of hepatic lipogenesis and lipoprotein secretion, and its inhibition could be considered as a potential target for treatment of dyslipidemia. ..
  13. doi request reprint Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Clin Biochem 42:1331-46. 2009
    ..The metabolic syndrome is a constellation of common metabolic disorders that is associated with cardiovascular disease. Insulin resistance has a central role in the pathophysiology of metabolic syndrome...
  14. pmc Effects of Resveratrol on Crosstalk between Canonical Β-Catenin/Wnt and FOXO Pathways in Coronary Artery Disease Patients with Metabolic Syndrome: A Case Control Study
    Mehrnoosh Shanaki
    Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Iran J Pharm Res 15:547-559. 2016
    ..Despite a modest improvement in the β-catenin/FOXO pathway after RES treatment, this pathway was not completely repaired in CAD patients...
  15. doi request reprint Rosiglitazone, a PPARγ agonist, ameliorates palmitate-induced insulin resistance and apoptosis in skeletal muscle cells
    Reza Meshkani
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IR, Iran
    Cell Biochem Funct 32:683-91. 2014
    ..These data suggest that RSG protects skeletal muscle cells against palmitate-induced apoptosis and this effect appears to be mediated via the PPARγ-dependent and PTP1B-independent mechanisms...
  16. doi request reprint Protein tyrosine phosphatase 1B (PTP1B) modulates palmitate-induced cytokine production in macrophage cells
    Ahmad Nasimian
    The Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Inflamm Res 62:239-46. 2013
    ..The aim of the study was to investigate the effect of PTP1B modulation on palmitate-induced cytokine production in macrophages...
  17. ncbi request reprint The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance
    Reza Meshkani
    Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
    Clin Chim Acta 371:169-75. 2006
    ..We investigated the relationship between homeostasis model assessment of insulin resistance (HOMA-IR) with cardiovascular risk factors in Iranian subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT)...
  18. doi request reprint Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-KB Pathway in a SIRT1-Independent Mechanism
    Asie Sadeghi
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, I R Iran
    J Cell Biochem . 2017
    ..Taken together, these findings suggest that resveratrol may represent a promising therapy for prevention of inflammation in skeletal muscle cells. This article is protected by copyright. All rights reserved...
  19. doi request reprint Protein tyrosine phosphatase 1B (PTP1B) is required for cardiac lineage differentiation of mouse embryonic stem cells
    Zahra Shokati Eshkiki
    Department of Molecular Medicine, School of Advanced Technologies in Medicine SATiM, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Mol Cell Biochem 425:95-102. 2017
    ..Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes...
  20. doi request reprint Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Biochem Biophys Res Commun 464:441-6. 2015
    ..Taken together, these findings suggest that SHIP2 expression level is an important determinant of hepatic lipoapotosis and its inhibition can potentially be a target in treatment of hepatic lipoapoptosis in diabetic patients...
  21. pmc A Bioinformatics Approach to Prioritize Single Nucleotide Polymorphisms in TLRs Signaling Pathway Genes
    Behnam Alipoor
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Int J Mol Cell Med 5:65-79. 2016
    ..These findings may facilitate the selection of proper variants for future functional and/or association studies. ..
  22. doi request reprint Downregulated microRNA-155 expression in peripheral blood mononuclear cells of type 2 diabetic patients is not correlated with increased inflammatory cytokine production
    Hossein Mazloom
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Cytokine 76:403-8. 2015
    ..The role of miR-155 in immune responses of PBMCs of type 2 diabetic (T2D) patients has not been studied...
  23. doi request reprint Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
    Hadi Khodabandehloo
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Transl Res 167:228-56. 2016
    ....
  24. pmc Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell
    Monireh Mani
    Dept of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran
    Iran Biomed J 17:93-100. 2013
    ..Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcription factor Nrf2, a principal inducer of anti-oxidant and phase II-related genes...
  25. doi request reprint Palmitate induces SHIP2 expression via the ceramide-mediated activation of NF-κB, and JNK in skeletal muscle cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran Student Scientific Research Center SSRC, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    Biochem Biophys Res Commun 450:494-9. 2014
    ..Here we investigated the effects of palmitate on SHIP2 expression and elucidated the underlying mechanisms in skeletal muscle cells...
  26. doi request reprint Leukocyte antigen-related inhibition attenuates palmitate-induced insulin resistance in muscle cells
    Sattar Gorgani-Firuzjaee
    Department of Biochemistry, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
    J Endocrinol 215:71-7. 2012
    ..In conclusion, these results reveal that palmitate induces LAR expression in C2C12 cells. We also provided evidence that the inhibition of LAR attenuates palmitate-induced insulin resistance in myotubes...
  27. ncbi request reprint Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study
    Mostafa Haji Molla Hoseini
    Department of Immunology, School of Medicine, Tarbiat Modarres University, Tehran, Iran
    Arch Med Res 38:868-75. 2007
    ..To address the possibility of immune-modulating effects of GBV-C coinfection in HIV patients, we evaluated interferon-producing cells in HIV/GBV-C coinfected patients and compared them to HIV-infected patients...