Abolfazl Akbarzadeh

Summary

Affiliation: Tabriz University of Medical Sciences
Country: Iran

Publications

  1. ncbi request reprint Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells
    Hassan Mellatyar
    Department of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 17:2453-7. 2016
  2. ncbi request reprint Anti-Proliferative Effects of Hesa-A on Human Cancer Cells with Different Metastatic Potential
    Rana Jahanban-Esfahlan
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 16:6963-6. 2015
  3. ncbi request reprint PLGA-based nanoparticles as cancer drug delivery systems
    Fatemeh Sadat Tabatabaei Mirakabad
    Department of Medical Hematology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:517-35. 2014
  4. ncbi request reprint Physicochemical characteristics of Fe3O4 magnetic nanocomposites based on Poly(N-isopropylacrylamide) for anti-cancer drug delivery
    Soodabeh Davaran
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:49-54. 2014
  5. pmc Liposome: classification, preparation, and applications
    Abolfazl Akbarzadeh
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Nanoscale Res Lett 8:102. 2013
  6. pmc Quantum dots: synthesis, bioapplications, and toxicity
    Alireza Valizadeh
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, 51664, Iran
    Nanoscale Res Lett 7:480. 2012
  7. doi request reprint PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells
    Vahideh Zeighamian
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:735-42. 2016
  8. doi request reprint A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line
    Fatemeh Sadat Tabatabaei Mirakabad
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:423-30. 2016
  9. doi request reprint Comparison, synthesis and evaluation of anticancer drug-loaded polymeric nanoparticles on breast cancer cell lines
    Ali Eatemadi
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1008-17. 2016
  10. doi request reprint A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR
    Shirafkan Kordi
    d Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:695-703. 2016

Collaborators

  • Mohammad Rahmati-Yamchi
  • Mohamadreza Baghaban Eslaminejad
  • Rana Jahanban-Esfahlan
  • Abolfazl Barzegar
  • Sang Woo Joo
  • Khosro Adibkia
  • Parvaneh Havasi
  • Nosratalah Zarghami
  • Saeed Kachalaki
  • Mehdi Yousefi
  • Masoud Soleimani
  • Hamed Hamishehkar
  • Soodabeh Davaran
  • Kazem Nejati-Koshki
  • Elham Abbasi
  • Effat Alizadeh
  • Hadis Daraee
  • Yunes Panahi
  • Morteza Milani
  • Roya Salehi
  • Fatemeh Sadat Tabatabaei Mirakabad
  • Fariba Badrzadeh
  • Mohammad Kouhi
  • Hassan Mellatyar
  • Alireza Valizadeh
  • Sima Majidi
  • Hamid Tayefi Nasrabadi
  • Eommolbanin Ebrahimi
  • Vahideh Zeighamian
  • Amir Ahmad Khandaghi
  • Younes Hanifehpour
  • Farideh Mohammadian
  • Fatemeh Zeinali Sehrig
  • Sedigheh Fekri Aval
  • Fatemeh Gorjikhah
  • Amirbahman Rahimzadeh
  • Neda Mousavi Niri
  • Mohammad Samiei
  • Jalil Karnoosh-Yamchi
  • Samad Mussa Farkhani
  • Masoud Gandomkar Ghalhar
  • Amin Barkhordari
  • Leila Eskandari
  • Fatemeh Asghari
  • Arash Hasanzadeh
  • Yones Pilehvar-Soltanahmadi
  • Roya Herizchi
  • Taiebeh Kafshdooz
  • Faraz Zarghami
  • Nasrin Nikzamir
  • Saber Kariminekoo
  • Leila Kafshdooz
  • Ali Eatemadi
  • Soheila Motaali
  • Shirafkan Kordi
  • Mohammad Rahmati Yamchi
  • Hassan Dariushnejad
  • Sonia Fathi Karkan
  • Nahideh Asadi
  • Majid Mohammadhosseini
  • Elham Abasi
  • Zeynab Aliyari
  • Fatemeh Safari
  • Shivadokht Askari
  • Elham Anari
  • Mehrak Zare
  • Karim Shamsasenjan
  • Mohammad Nikzamir
  • Masoud Darabi
  • Fateme Ahmadi-Aghkand
  • Mohammadreza Alizadeh-Ghodsi
  • Nasim Nikzamir
  • Seyed Mohsen Aberoumandi
  • Mortaza Taheri-Anganeh
  • Nasrin Sohrabi
  • Mohsen Bakhtiary
  • Mozhdeh Mohammadian
  • AliAkbar Movassaghpour
  • Mehdi Talebi
  • Kaveh Kurd
  • Alireza Abhari
  • Arash Memarnejadian
  • Jamshid Hadjati
  • Ali Etemadi
  • Samira Alimirzalu
  • Sina Mohammadinejad
  • Majid Mobasseri
  • Zahra Bahmani
  • Zohre Sadeghi
  • Majid Tozihi

Detail Information

Publications70

  1. ncbi request reprint Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells
    Hassan Mellatyar
    Department of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 17:2453-7. 2016
    ..The purpose was to determine whether nanoencapsulating 17DMAG improves the anti-cancer effects as compared to free 17DMAG...
  2. ncbi request reprint Anti-Proliferative Effects of Hesa-A on Human Cancer Cells with Different Metastatic Potential
    Rana Jahanban-Esfahlan
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 16:6963-6. 2015
    ..To test this hypothesis, we investigated the selective anticancer effects of Hesa-A on several cancer cell lines with different metastatic potential...
  3. ncbi request reprint PLGA-based nanoparticles as cancer drug delivery systems
    Fatemeh Sadat Tabatabaei Mirakabad
    Department of Medical Hematology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:517-35. 2014
    ..Increasing experience in the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer treatment, with high efficacy and few side effects. ..
  4. ncbi request reprint Physicochemical characteristics of Fe3O4 magnetic nanocomposites based on Poly(N-isopropylacrylamide) for anti-cancer drug delivery
    Soodabeh Davaran
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:49-54. 2014
    ..The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation...
  5. pmc Liposome: classification, preparation, and applications
    Abolfazl Akbarzadeh
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Nanoscale Res Lett 8:102. 2013
    ....
  6. pmc Quantum dots: synthesis, bioapplications, and toxicity
    Alireza Valizadeh
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, 51664, Iran
    Nanoscale Res Lett 7:480. 2012
    ..Due to the small structures of QDs, some physical properties such as optical and electron transport characteristics are quite different from those of the bulk materials...
  7. doi request reprint PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells
    Vahideh Zeighamian
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:735-42. 2016
    ..Overall, it is concluded that encapsulating curcumin into the NIPAAm-MAA copolymer could open up new avenues for breast cancer treatment. ..
  8. doi request reprint A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line
    Fatemeh Sadat Tabatabaei Mirakabad
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:423-30. 2016
    ..Our study confirmed that curcumin-loaded PLGA-PEG has more cytotoxic effects on the MCF-7 breast cancer cell line and could be exploited as a potential source for developing novel drugs against breast cancer. ..
  9. doi request reprint Comparison, synthesis and evaluation of anticancer drug-loaded polymeric nanoparticles on breast cancer cell lines
    Ali Eatemadi
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1008-17. 2016
    ..05). However, the IC50 value of all drugs on T47D were lower than those on MCF7. ..
  10. doi request reprint A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR
    Shirafkan Kordi
    d Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:695-703. 2016
    ..The purpose of this study was to examine whether nano encapsulating helenalin improves the anti-cancer effect of free helenalin in the T47D breast cancer cell line...
  11. doi request reprint Application of gold nanoparticles in biomedical and drug delivery
    Hadis Daraee
    b Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:410-22. 2016
    ..In this review, we have explained some important applications of gold nanoparticles. ..
  12. doi request reprint In vitro study and characterization of doxorubicin-loaded magnetic nanoparticles modified with biodegradable copolymers
    Eommolbanin Ebrahimi
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz 5154853431, Iran
    Artif Cells Nanomed Biotechnol 44:550-8. 2016
    ..Doxorubicin was encapsulated within nanoparticles made of Fe3O4-PLGA-PEG, using the double emulsion method (w/o/w). The nanoparticles were characterized in terms of size, and the in vitro release of doxorubicin. ..
  13. doi request reprint Biomedical and biological applications of quantum dots
    Elham Abbasi
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:885-91. 2016
    ..This article reviews biomedical applications of QDs, especially the application of QDs in cell targeting, delivery, diagnostics, cancer therapy, and imaging for cancer research. ..
  14. doi request reprint Silver nanoparticles: Synthesis methods, bio-applications and properties
    Elham Abbasi
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Crit Rev Microbiol 42:173-80. 2016
    ..This article summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations with respect to the biomedical applicability and regulatory requirements concerning silver nanoparticles. ..
  15. doi request reprint The anticancer effects of biodegradable nanomagnetic dual natural components on the leptin gene expression in lung cancer
    Shivadokht Askari
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1753-63. 2016
    ..CUR-SIL loaded MNPs reduced LEP expression more than net CUR-SIL. These results revealed the possibilities of CUR-SIL-loaded MNPs as a natural and effective antitumor drug delivery system to fight lung tumors. ..
  16. pmc Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line
    Abolfazl Akbarzadeh
    Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
    J Nanobiotechnology 10:46. 2012
    ..These modified SPIONs were used for encapsulation of anticancer drug doxorubicin...
  17. doi request reprint Recent prospective of nanofiber scaffolds fabrication approaches for skin regeneration
    Fateme Ahmadi-Aghkand
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1635-41. 2016
    ..This review details recent advances of nanofiber scaffolds in skin regeneration and repair strategies, and describes a synthesis method of nanofiber scaffolds. ..
  18. doi request reprint Drug delivery and nanodetection in lung cancer
    Fariba Badrzadeh
    b Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:618-34. 2016
    ..Nanotechnology also offers the ability to detect diseases, such as tumors, much earlier than ever imaginable. This article presents nano devices for lung cancer detection and drug delivery systems. ..
  19. doi request reprint Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer
    Eommolbanin Ebrahimi
    b Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:290-7. 2016
    ..The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX. ..
  20. doi request reprint Gene silencing effect of SiRNA-magnetic modified with biodegradable copolymer nanoparticles on hTERT gene expression in lung cancer cell line
    Sedigheh Fekri Aval
    a Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:188-93. 2016
    ..In this study, a potential carrier for efficient delivery was assessed by siRNA encapsulating into Iron MNPs modified with biodegradable polyester nanoparticles consisting of PLGA and PEG...
  21. doi request reprint Implications of mesenchymal stem cells in regenerative medicine
    Saber Kariminekoo
    a Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:749-57. 2016
    ..In this review, we discuss the main applications of mesenchymal stem in Regenerative Medicine and known mechanisms of homing and Immunomodulation of MSCs. ..
  22. doi request reprint Design and development of PCR-free highly sensitive electrochemical assay for detection of telomerase activity using Nano-based (liposomal) signal amplification platform
    Mohammadreza Alizadeh-Ghodsi
    Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Biosens Bioelectron 80:426-32. 2016
    ..Therefore, this approach affords high sensitivity for telomerase activity detection and it can be regarded as an alternative to telomeric repeat amplification protocol assay, having the advantages of simplicity and less assay time. ..
  23. doi request reprint Chrysin-loaded PLGA-PEG nanoparticles designed for enhanced effect on the breast cancer cell line
    Elham Anari
    a Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1410-6. 2016
    ..In conclusion, the nanochrysin therapy developed is a novel method that could increase cytotoxicity to cancer cells without damaging the normal cells, and would be promising in breast cancer therapy. ..
  24. doi request reprint Magnetic nanoparticles: Applications in gene delivery and gene therapy
    Sima Majidi
    b Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1186-93. 2016
    ..Delivery technologies that have been used with MNPs contain polymeric, viral, as well as non-viral platforms. In this review, we focus on targeted gene delivery using MNPs. ..
  25. ncbi request reprint Inhibitory effects of β-cyclodextrin-helenalin complexes on H-TERT gene expression in the T47D breast cancer cell line - results of real time quantitative PCR
    Samaneh Ghasemali
    Drug Applied Research Center, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 14:6949-53. 2013
    ..Cyclodextrin (β-CD) is a cyclic oligosaccharide comprising seven D-glucopyranoside units, linked through 1,4-glycosidic bonds...
  26. doi request reprint Upregulation of MiR-122 via Trichostatin A Treatments in Hepatocyte-like Cells Derived from Mesenchymal Stem Cells
    Effat Alizadeh
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Golgasht AVE, Tabriz 3137851656, I R Iran
    Chem Biol Drug Des 87:296-305. 2016
    ..05). In conclusion, administration of TSA in hepatogenic differentiation of hAT-MSCs resulted in higher expression levels of miR-122, facilitation of differentiation, and subsequently attenuation of AFP levels. ..
  27. ncbi request reprint PAMAM dendrimers augment inhibitory effects of curcumin on cancer cell proliferation: possible inhibition of telomerase
    Mahdie Mollazade
    Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 14:6925-8. 2013
    ..In this study, we investigated the comparative antiproliferative effect of PAMAM encapsulating curcumin with naked curcumin on the T47D breast cancer cell line...
  28. doi request reprint Preparation and characterization of novel electrospun poly(ϵ-caprolactone)-based nanofibrous scaffolds
    Alireza Valizadeh
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:504-9. 2016
    ..Increasing the molecular weight of PEG blocks from 2000 to 6000 led to a decrease of the diameter of the fibers and the formation of beads. ..
  29. doi request reprint Application of liposomes in medicine and drug delivery
    Hadis Daraee
    b Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:381-91. 2016
    ..In this review, we summarize the main applications and liposome-based commercial products that are currently used in the medical field. ..
  30. doi request reprint Improving "lab-on-a-chip" techniques using biomedical nanotechnology: a review
    Fatemeh Gorjikhah
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1609-14. 2016
    ..Finally, are discussed the applications of biomedical nanotechnology in improving "lab-on-a-chip" techniques. ..
  31. ncbi request reprint Preparation and characterization of PLGA-β-CD polymeric nanoparticles containing methotrexate and evaluation of their effects on T47D cell line
    Fatemeh Gorjikhah
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol . 2016
    ..These results indicate that encapsulated drugs could be effective in controlled drug release for a sustained period would serve the purpose for long-term treatment of many diseases such as breast cancer...
  32. ncbi request reprint Comparison of inhibitory effect of 17-DMAG nanoparticles and free 17-DMAG in HSP90 gene expression in lung cancer
    Hassan Mellatyar
    Department of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:8693-8. 2014
    ..The purpose of this study was to examine whether nanocapsulating 17DMAG improves the anti cancer effect over free 17DMAG in the A549 lung cancer cell line...
  33. doi request reprint Synthesis, characterization, and in vitro studies of PLGA-PEG nanoparticles for oral insulin delivery
    Sara Hosseininasab
    Department of Medicinal Chemistry and Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51368, Iran
    Chem Biol Drug Des 84:307-15. 2014
    ..The focus of this research is synthetization and characterization of hydrogels PLGA-PEG insulin nanoparticles and also pH sensitivity of insulin nanoparticles was investigated. ..
  34. doi request reprint Current methods for synthesis of gold nanoparticles
    Roya Herizchi
    b Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:596-602. 2016
    ..Metal nanoparticles have gathered extensive attention due to their uncommon properties and promising applications in photonics, electronics, biochemical sensing, and imaging. This review covers recent advances in the synthesis of GNPs. ..
  35. pmc Protein detection through different platforms of immuno-loop-mediated isothermal amplification
    Mohammad Pourhassan-Moghaddam
    Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 51656, Iran
    Nanoscale Res Lett 8:485. 2013
    ..In this paper we also offer various configurations in order to improve the applicability of this method in real-world sample analyses. Important potential applications of this method are stated as well. ..
  36. doi request reprint Basics of DNA biosensors and cancer diagnosis
    Nasrin Sohrabi
    a Department of Medical Genetics, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:654-63. 2016
    ..In this review, we discuss DNA biosensors based on peptide nucleic acids that have an important role in cancer diagnosis. ..
  37. doi request reprint The effect of dimethyl sulfoxide on hepatic differentiation of mesenchymal stem cells
    Effat Alizadeh
    a Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:157-64. 2016
    ..However, the effect of DMSO on hepatogenic differentiation of AT-MSCs were not surveyed, previously. In the present study, we aimed at evaluation of the effect of DMSO on differentiation of AT-MSCs into hepatic lineage...
  38. ncbi request reprint An update on applications of nanostructured drug delivery systems in cancer therapy: a review
    Seyed Mohsen Aberoumandi
    a Department of Clinical Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
    Artif Cells Nanomed Biotechnol . 2016
    ..Nanofibers are used for different medical applications such as drug delivery systems...
  39. ncbi request reprint Magnetic nanoparticles in cancer diagnosis and treatment: a review
    Sonia Fathi Karkan
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 45:1-5. 2017
    ..This paper seeks to establish the role of MNPs in diagnosis and treatment of lung cancer. It proposes that the existing challenges in the diagnosis and treatment of lung cancer can be addressed through application of MNPs in the process...
  40. doi request reprint Polyelectrolyte complexes of hTERT siRNA and polyethyleneimine: Effect of degree of PEG grafting on biological and cellular activity
    Fatemeh Safari
    a Medical Biotechnology Department, Tabriz Advanced Medical Science Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1561-8. 2016
    ..PEC nanoparticles of hTERT siRNA and PEG-g-PEI could act as a promising weapon against A549 cells, which has to be considered for an in vivo evaluation. ..
  41. doi request reprint Gold nanoprobe-based method for sensing activated leukocyte cell adhesion molecule (ALCAM) gene expression, as a breast cancer biomarker
    Leila Eskandari
    a Department of Medical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 45:277-282. 2017
    ..This method is simple, fast, selective, and quantitative and can be done with small concentrations of the target (fmol/μL). Limit of detection of the method corresponded to 300 fmol/μL of synthetic ALCAM target...
  42. ncbi request reprint pH sensitive insulin-loaded nanohydrogel increases the effect of oral insulin in diabetic rats
    Jalil Karnoosh-Yamchi
    a Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol . 2016
    ..There are different methods for insulin administration in diabetic patient. Nano-hydrogel is one of the most talented drug carrier for its sensitivity to environmental stimulus...
  43. ncbi request reprint Application of nanostructured drug delivery systems in immunotherapy of cancer: a review
    Nahideh Asadi
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 45:18-23. 2017
    ..In this review, we explained application of nanotechnology in immunotherapy of cancer...
  44. doi request reprint The application of gold nanoparticles as a promising therapeutic approach in breast and ovarian cancer
    Leila Kafshdooz
    b Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1222-7. 2016
    ..In this review, we summarize the characteristics of AuNPs, their contributions to tumor destruction, their toxicity, and their potential in the treatment of breast and ovarian cancer. ..
  45. pmc Construction and Production of Foxp3-Fc (IgG) DNA Vaccine/Fusion Protein
    Neda Mousavi Niri
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Avicenna J Med Biotechnol 8:57-64. 2016
    ..In this study, a DNA vaccine and its respective protein were constructed in which Foxp3 fused to Fc(IgG) can be efficiently captured and processed by DC via receptor mediated endocytosis and presented to MHCII and I (cross priming)...
  46. doi request reprint Biodegradable and biocompatible polymers for tissue engineering application: a review
    Fatemeh Asghari
    a Department of Medical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 45:185-192. 2017
    ..Biodegradable polymers are dominant scaffolding materials in tissue engineering field. In this review, we explained about biodegradable polymers and their application as scaffolds...
  47. doi request reprint Biotechnological and biomedical applications of mesenchymal stem cells as a therapeutic system
    Amirbahman Rahimzadeh
    a Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:559-70. 2016
    ..As a result, this review emphasizes the functional role of MSCs in modulating immune responses, their capability in homing to injured tissue, and their clinical therapeutic potential. ..
  48. doi request reprint Applications of nanoparticle systems in gene delivery and gene therapy
    Taiebeh Kafshdooz
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:581-7. 2016
    ..This study explores the current status of development of polymeric gene carriers, and presents guidelines for the prospective use of the polymer-based gene delivery systems in gene therapy. ..
  49. doi request reprint Bimetallic nanoparticles: Preparation, properties, and biomedical applications
    Hamid Tayefi Nasrabadi
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:376-80. 2016
    ..In this study, we focus on the preparation, properties, and bio-application of BMNPs and introduction of the recent advance in these NPs. ..
  50. pmc Preparation and in vitro evaluation of doxorubicin-loaded Fe₃O₄ magnetic nanoparticles modified with biocompatible copolymers
    Abolfazl Akbarzadeh
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Int J Nanomedicine 7:511-26. 2012
    ..The magnetic properties conferred by superparamagnetic iron oxide nanoparticles could help to maintain the nanoparticles in the joint with an external magnet...
  51. doi request reprint Current methods for synthesis of magnetic nanoparticles
    Sima Majidi
    b Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:722-34. 2016
    ....
  52. ncbi request reprint Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer
    Masoud Gandomkar Ghalhar
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:7113-8. 2014
    ..17-AAG has poor water-solubility which is a potential problem for clinical practice. In this study for improving the stability and solubility of molecules in drug delivery systems we used a β-cyclodextrin- 17AAG complex...
  53. doi request reprint Cisplatin release from dual-responsive magnetic nanocomposites
    Kaveh Kurd
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1031-9. 2016
    ....
  54. doi request reprint Graphene: Synthesis, bio-applications, and properties
    Elham Abbasi
    a Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:150-6. 2016
    ..The following review introduces the many potential applications of graphene. ..
  55. ncbi request reprint Upregulation of miR-9 and Let-7a by nanoencapsulated chrysin in gastric cancer cells
    Farideh Mohammadian
    a Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol . 2016
    ..Therefore, PLGA-PEG could be a superior carrier for this kind of hydrophobic agent...
  56. doi request reprint New state of nanofibers in regenerative medicine
    Farideh Mohammadian
    a Department of Medical Biotechnology, Faculty of Advance Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 45:204-210. 2017
    ..The focus of this review is on the application of nanofiber scaffolds...
  57. doi request reprint An update on clinical applications of electrospun nanofibers for skin bioengineering
    Yones Pilehvar-Soltanahmadi
    a Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1350-64. 2016
    ..In addition, current applications of electrospun nanofibrous matrices for skin bioengineering are detailed in this review. ..
  58. doi request reprint Synthesis and in vitro study of cisplatin-loaded Fe3O4 nanoparticles modified with PLGA-PEG6000 copolymers in treatment of lung cancer
    Kazem Nejati-Koshki
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    J Microencapsul 31:815-23. 2014
    ..This approach has the prospective to overcome some major limitations of conventional chemotherapy and may be a promising strategy for future applications in lung cancer therapy...
  59. doi request reprint Up regulation of liver-enriched transcription factors HNF4a and HNF6 and liver-specific microRNA (miR-122) by inhibition of let-7b in mesenchymal stem cells
    Effat Alizadeh
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
    Chem Biol Drug Des 85:268-79. 2015
    ..The findings of this work might help optimization of in vitro hepatogenic differentiation utilizing microRNAs and hAT-MSCs that could be used for therapeutic purposes...
  60. ncbi request reprint Molecular target therapy of AKT and NF-kB signaling pathways and multidrug resistance by specific cell penetrating inhibitor peptides in HL-60 cells
    Zahra Davoudi
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:4353-8. 2014
    ..We therefore used cell penetrating inhibitor peptides to define the contributions of AKT and NF-kB to survival and multi drug resistance (MDR) in HL-60 cells...
  61. doi request reprint Magnetic nanoparticles as potential candidates for biomedical and biological applications
    Fatemeh Zeinali Sehrig
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:918-27. 2016
    ..In this review, we focus mostly on the potential use of MNPs for biomedical and biotechnological applications, and the improvements made in using these nanoparticles (NPs) in biological applications. ..
  62. doi request reprint Key immune cell cytokines have a significant role in the expansion of CD26 population of cord blood mononuclear cells
    Zeynab Aliyari
    a Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:1303-10. 2016
    ..This study aimed to investigate the effect of key immune cell cytokines on CD26 expansion...
  63. ncbi request reprint Synthesis and characterization of smart N-isopropylacrylamide-based magnetic nanocomposites containing doxorubicin anti-cancer drug
    Soheila Motaali
    a Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol . 2016
    ..The results showed that this thermo/pH-sensitive magnetic nanocomposite has a high drug-loading efficiency. Doxorubicin was released at 40 °C and pH 5.8 more than the 37 °C and pH 7.4...
  64. ncbi request reprint Comparison between effects of free curcumin and curcumin loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in lung cancer cells
    Fariba Badrzadeh
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 15:8931-6. 2014
    ..In this article, we compared the effects of pure curcumin and curcumin-loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in a lung cancer cell line...
  65. doi request reprint Preparation of pH sensitive insulin-loaded nano hydrogels and evaluation of insulin releasing in different pH conditions
    Jalil Karnoosh-Yamchi
    Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Mol Biol Rep 41:6705-12. 2014
    ..8 is the most. Results showed that by opting suitable polymerization method and selecting the best nanohydrogels, we could obtain a suitable insulin loaded nanohydrogels for oral administration...
  66. doi request reprint Efficient biotechnological approach for lentiviral transduction of induced pluripotent stem cells
    Mehrak Zare
    a Department of Clinical Biochemistry and Laboratory, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    Artif Cells Nanomed Biotechnol 44:743-8. 2016
    ..Altogether, it seems that lentiviral transduction of challenging iPS cells using the hanging drop method offers a suitable and sufficient strategy in their gene transfer, with less toxicity than the conventional suspension method. ..
  67. doi request reprint Inducing Humoral Immune Responses Against Regulatory T Cells by Foxp3-Fc(IgG) Fusion Protein
    Neda Mousavi Niri
    1 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, University of Medical Sciences, Tabriz, Iran
    Monoclon Antib Immunodiagn Immunother 34:381-5. 2015
    ....
  68. ncbi request reprint Preparation and Evaluation of Chrysin Encapsulated in PLGA- PEG Nanoparticles in the T47-D Breast Cancer Cell Line
    Sina Mohammadinejad
    Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 16:3753-8. 2015
    ..In our study, polymeric nanoparticles and the anticancer drug, chrysin, were encapsulated into poly (D, L-lactic-co-glycolic acid) poly (ethylene glycol) (PLGA-PEG) nanoparticles for local treatment...
  69. ncbi request reprint Inhibition of leptin and leptin receptor gene expression by silibinin-curcumin combination
    Kazem Nejati-Koshki
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran E mail
    Asian Pac J Cancer Prev 14:6595-9. 2014
    ..In conclusion, these herbal compounds inhibit the expression and secretion of leptin and it could probably be used as drug candidates for breast cancer therapy through leptin targeting in the future. ..
  70. pmc Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine
    Abolfazl Akbarzadeh
    Faculty of Pharmacy, Department of Medicinal Chemistry and Drug Applied Research Center Tabriz University of Medical Sciences, Tabriz, 51368, Iran
    Nanoscale Res Lett 7:144. 2012
    ..Then, different methodologies for the functionalization of the prepared MNPs together with the characterization techniques are explained. Theorical views on the magnetism of nanoparticles are considered...