Mostafa Saadat

Summary

Affiliation: Shiraz University
Country: Iran

Publications

  1. doi request reprint Genetic Polymorphism of CAT C-262 T and Susceptibility to Breast Cancer, a Case-Control Study and Meta-Analysis of the Literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Pathol Oncol Res 21:433-7. 2015
  2. doi request reprint Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Pathol Oncol Res 21:689-93. 2015
  3. doi request reprint Chromosomal distribution of schizophrenia susceptibility loci
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    J Mol Neurosci 51:401-2. 2013
  4. doi request reprint Alteration of serum sex hormonal profile in male gasoline filling station workers in respect to their polymorphism of glutathione S-transferase M1
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Environ Toxicol Pharmacol 35:265-9. 2013
  5. doi request reprint Association between genetic polymorphism of GSTT1 and depression score in individuals chronically exposed to natural sour gas
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Neurosci Lett 435:65-8. 2008
  6. ncbi request reprint Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and alterations of sex hormones in filling-station workers
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Fertil Steril 89:1777-80. 2008
  7. pmc Association between exudative age-related macular degeneration and the G6721T polymorphism of XRCC7 in outdoor subjects
    Iraj Saadat
    Department of Biology, Shiraz University College of Sciences, Shiraz, Iran
    Korean J Ophthalmol 26:423-7. 2012
  8. ncbi request reprint Genetic polymorphism of GSTT1 may be under natural selection in a population chronically exposed to natural sour gas
    Zahra Zendeh-Boodi
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Mol Biol Rep 35:673-6. 2008
  9. doi request reprint Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Breast Cancer Res Treat 115:137-44. 2009
  10. doi request reprint Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder
    Zahra Rezaei
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 198:166-8. 2012

Collaborators

Detail Information

Publications69

  1. doi request reprint Genetic Polymorphism of CAT C-262 T and Susceptibility to Breast Cancer, a Case-Control Study and Meta-Analysis of the Literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Pathol Oncol Res 21:433-7. 2015
    ..05; OR = 1.01, 95% CI: 0.92-1.09, P = 0.862) and TT (Q-statistic = 2.57, df = 6, P > 0.05; OR = 1.03, 95% CI: 0.85-1.24, P = 0.770) genotypes. There was no association between C-262 T polymorphism of the CAT and risk of breast cancer...
  2. doi request reprint Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Pathol Oncol Res 21:689-93. 2015
    ..The present study suggests that both polymorphisms of the XRCC4 and XRCC5 might be risk factors for gastric cancer development especially among persons with positive FH...
  3. doi request reprint Chromosomal distribution of schizophrenia susceptibility loci
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    J Mol Neurosci 51:401-2. 2013
    ..Statistical analysis revealed that the schizophrenia susceptible loci distributed non-randomly on human chromosomes. Human chromosome segments 6p21.1-p22.3 (P < 0.001) bear significantly higher number of susceptible loci...
  4. doi request reprint Alteration of serum sex hormonal profile in male gasoline filling station workers in respect to their polymorphism of glutathione S-transferase M1
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Environ Toxicol Pharmacol 35:265-9. 2013
    ..91, df=23, P<0.001) combinations had a lower testosterone compared with the controls. It seems that GSTM1 polymorphism has more effect on serum testosterone compared to the GSTT1 polymorphism, in exposed workers...
  5. doi request reprint Association between genetic polymorphism of GSTT1 and depression score in individuals chronically exposed to natural sour gas
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Neurosci Lett 435:65-8. 2008
    ....
  6. ncbi request reprint Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and alterations of sex hormones in filling-station workers
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Fertil Steril 89:1777-80. 2008
    ..To determine the health effects of gasoline exposure as measured by levels of sex hormones (total testosterone, follicle-stimulating hormone [FSH], and luteinizing hormone [LH]) of male filling-station workers...
  7. pmc Association between exudative age-related macular degeneration and the G6721T polymorphism of XRCC7 in outdoor subjects
    Iraj Saadat
    Department of Biology, Shiraz University College of Sciences, Shiraz, Iran
    Korean J Ophthalmol 26:423-7. 2012
    ..To investigate whether the G6721T polymorphism (rs.7003908) of the non-homologous end-joining DNA repair XRCC7 gene contributes to the development of exudative age-related macular degeneration (ARMD)...
  8. ncbi request reprint Genetic polymorphism of GSTT1 may be under natural selection in a population chronically exposed to natural sour gas
    Zahra Zendeh-Boodi
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Mol Biol Rep 35:673-6. 2008
    ..In order to examine whether chronic exposure to natural sour gas containing sulfur compounds act as natural selection force on genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1), the present study was done...
  9. doi request reprint Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Breast Cancer Res Treat 115:137-44. 2009
    ..46, 95% CI: 1.19-1.79) and Gln/Gln versus Arg/Gln+Arg/Arg (OR = 1.49, 95% CI: 1.22-1.81) increased the risk. Therefore, it could be concluded that 399Gln allele might act as a recessive allele in its association with breast cancer risk...
  10. doi request reprint Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder
    Zahra Rezaei
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 198:166-8. 2012
    ..The haplotype "-1002G, 32Glu, 42Gly" versus the other haplotypes was significantly decreased among early-onset patients compared to controls (P=0.016)...
  11. doi request reprint Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1)
    Hasan Othman
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Eur J Ophthalmol 22:431-5. 2012
    ..To investigate whether genetic polymorphisms of GSTZ1 contribute to the development of exudative age-related macular degeneration (AMD)...
  12. doi request reprint Genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to preeclampsia
    Mostafa Saadat
    Department of Biology, College of Sciences Shiraz University, 71454 Shiraz, Iran
    Mol Biol Rep 39:8995-8. 2012
    ..328, df = 1, P = 0.002). The present results indicate that the haplotype of "-1002A, 32Lys, 42Arg" (containing three variant alleles) of GSTZ1 have protective effect compared to the other haplotypes...
  13. pmc Association between cataract and genetic polymorphisms of GSTM1, GSTT1, and GSTO2 with respect of work place
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Mol Vis 18:1996-2000. 2012
    ..To investigate whether genetic polymorphisms of glutathione S-transferases (GSTM1, GSTT1, and GSTO2) in relation to the work place contribute to the development of cataract...
  14. doi request reprint Serum testosterone in females exposed to natural sour gas with respect to polymorphisms of XRCC1, GSTM1, and GSTT1
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Mol Biol Rep 38:89-94. 2011
    ..The polymorphisms of GSTM1 and GSTT1 modulate serum testosterone concentration in young females exposed to natural sour gas...
  15. ncbi request reprint Genetic polymorphism of glutathione S-transferase T1: a candidate genetic modifier of individual susceptibility to schizophrenia
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 153:87-91. 2007
    ..On the other word, the positive GSTT1 genotype significantly increased the risk of schizophrenia. The present finding indicated that GSTT1 is a candidate gene for susceptibility to schizophrenia...
  16. doi request reprint Influence of GSTO2 (N142D) genetic polymorphism on acute renal rejection
    Nioosha Nekooie-Marnany
    Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran
    Mol Biol Rep 40:4857-60. 2013
    ..004). The combination effect of donor type and GSTO2 polymorphism indicates DD genotype with cadaver donor type increase risk of acute rejection (OR=3.82, 95% CI 1.80-12.37, P=0.02)...
  17. doi request reprint Serum levels of testosterone and gonadotrophins with respect to smoking status and genetic polymorphism of GSTT1
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Mol Biol Rep 36:1353-6. 2009
    ..To determine the effect of cigarette smoke on serum levels of testosterone and gonadotrophins of smokers and possible association of these hormones levels with GSTT1 polymorphism, the present study was done...
  18. ncbi request reprint Polymorphisms of glutathione S-transferase M1 and T1 modulate blood pressure of individuals chronically exposed to natural sour gas containing sulfur compounds
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 316:749-52. 2004
    ..14; P=0.032). It is speculated about polymorphisms of GSTs in individuals chronically exposed to natural sour gas, which contains H2S, fulfilling a physiological role(s) in regulating blood pressure...
  19. doi request reprint Susceptibility to breast cancer and three polymorphisms of GSTZ1
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    DNA Cell Biol 31:337-41. 2012
    ..05). It seems there is no meaningful relationship between the genetic polymorphisms of GSTZ1 and risk of breast cancer...
  20. ncbi request reprint Influence of genetic polymorphisms of glutathione S-transferases T1 and M1 on serum lipid parameters
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Saudi Med J 28:1645-7. 2007
    ..To determine the effect of genetic polymorphisms of glutathione S-transferase theta 1 (GSTT1) and GSTM1 on serum levels of lipid parameters...
  21. doi request reprint Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Arch Gynecol Obstet 286:1459-62. 2012
    ..Functional polymorphisms in XRCC1 (Arg194Trp and Arg399Gln) and XRCC7 (G6721T) may be risk factors for PE. In the present study, the association between the genetic polymorphisms of XRCC1 and XRCC7 and risk of PE is investigated...
  22. ncbi request reprint Genetic polymorphisms of glutathione S-transferases M1 and T1 modulate hematological changes of individuals chronically exposed to natural sour gas
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 324:584-7. 2004
    ..There is no significant association between neither platelet nor WBC differential parameters and GSTs genotypes...
  23. ncbi request reprint Alterations of liver function test indices of filling station workers with respect of genetic polymorphisms of GSTM1 and GSTT1
    Mostafa Saadat
    Shiraz University, Shiraz 71454, Iran
    Cancer Lett 227:163-7. 2005
    ..Overall, due to detection of sub-clinical changes in hepatic test in gasoline station workers, exposure limitation and administrating safety device are recommended...
  24. ncbi request reprint Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 319:1287-91. 2004
    ..Female patients with null genotype for GSTM1 and no history of smoking had a 3.45-fold increased cataract risk (P < 0.05), whereas females who were null for GSTM1 and having history of smoking were not at increased risk of cataract...
  25. doi request reprint Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations
    Laleh Rafiee
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Mol Biol Rep 37:155-8. 2010
    ..328). The prevalence of GSTT1 null genotype in Iranian Georgians showed significant difference with Persians and other Asian countries, but it seems to be similar with the frequency which was reported from European populations...
  26. doi request reprint Haplotype analysis of XRCC1 (at codons 194 and 399) and susceptibility to breast cancer, a meta-analysis of the literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Breast Cancer Res Treat 124:785-91. 2010
    ..The present meta-analysis has indicated that the Arg194-Gln399 haplotype of XRCC1 might be a risk factor for breast cancer in Asian countries...
  27. doi request reprint Bipolar disorder and polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1)
    Parisa Mohammadynejad
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 186:144-6. 2011
    ..The present finding indicated that GSTM1 and GSTT1 are candidate polymorphisms for susceptibility to BDP among adolescents...
  28. doi request reprint Genetic polymorphism of glutathione S-transferase T1 (GSTT1) and QT-interval in schizophrenia patients
    Aminollah Bahaoddini
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    J Mol Neurosci 38:173-7. 2009
    ..328, t = -2.346, p = 0.024). Active genotype of GSTT1 decreased the QTc. Also, QTc was significantly associated with smoking status; it was decreased in smokers compared with nonsmokers (beta = -0.372, t = -2.372, p = 0.014)...
  29. doi request reprint Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Mol Biol Rep 37:249-53. 2010
    ..554; df = 2, 21; P = 0.012). Because elevated RBC count correlate well with risk of coronary heart disease, it might be concluded that GSTM1 and GSTT1 null genotypes have protective role(s) for developing coronary heart disease...
  30. ncbi request reprint Genetic polymorphisms of XRCC1 (at codons 194 and 399) in Shiraz population (Fars province, southern Iran)
    Parisa Mohamadynejad
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Mol Biol Rep 35:669-72. 2008
    ..Due to the association between the polymorphisms of XRCC1 and the risk of some types of cancers, the present study was done...
  31. doi request reprint Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) in selected populations of Afghanistan
    Khyber Saify
    Department of Biology, College of Sciences, Shiraz University, 71454 Shiraz, Iran
    Mol Biol Rep 39:7855-9. 2012
    ..54, df = 3, P < 0.001). In comparison with European and Asian populations, Afghanistan populations like Iranian populations showed intermediate frequency for GSTT1 and GSTM1 null genotypes...
  32. ncbi request reprint Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts
    Masood Bazrgar
    Human Genetic Research Group, Iranian Academic Center for Education, Culture and Research, Fars Province Branch, Zand Ave, P O Box 71345 1463, Shiraz, Iran
    Mol Biol Rep 35:495-9. 2008
    ..ApoE3 is known as the most frequent allele in all populations, while association of apoE gene polymorphism with reported diseases have mostly been related to other two major alleles especially apoE4...
  33. doi request reprint Introducing a novel allele for the polymorphism of variable number of tandem repeats in the promoter region of XRCC5
    Mehrdad Rajaei
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 427:503-5. 2012
    ..95, df=6, P=0.73). It is suggested that the prevalence of the novel allele (3R allele) among European populations may be higher than its prevalence among Iranians...
  34. doi request reprint Genetic polymorphisms of glutathione S-transferase Z1 in an Iranian population
    Samane Nafissi
    Department of Biology, College of Sciences, Shiraz University, 71454 Shiraz, Iran
    Mol Biol Rep 38:3391-4. 2011
    ..Iranian gene pool showed intermediate frequency for alleles and haplotypes of GSTZ1 polymorphisms in comparison with European and Asian countries, which confirmed our previous reports for other genetic polymorphisms...
  35. doi request reprint Genetic polymorphisms of GSTO2, GSTM1, and GSTT1 and risk of gastric cancer
    Mohammad Masoudi
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Mol Biol Rep 36:781-4. 2009
    ..In human GSTO2, GSTM1, and GSTT1 are polymorphic. In order to study whether GSTO2, GSTM1, and GSTT1 polymorphisms are associated with increased gastric cancer risk in Iranian patients, the present case-control study was done...
  36. ncbi request reprint Modulation of hematology changes by polymorphism of glutathione S-transferase M1 and T1
    Maryam Ansari-Lari
    Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
    Biochem Biophys Res Commun 312:299-302. 2003
    ..135, df=3, and P=0.028), and RBC (chi(2)=10.586, df=3, and P=0.014). These findings could indicate the possible protective effect of concurrent presence of GSTM1 and GSTT1 enzymes on the hematopoietic system of filling station workers...
  37. ncbi request reprint Genetic polymorphism of glutathione S-transferase T1, M1 and asthma, a meta-analysis of the literature
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Pak J Biol Sci 10:4183-9. 2007
    ..It seems that the GSTM1 and GSTT1 lack their protective values against development of asthma in adults with positive history of smoking. Present results also suggested that there is an additive effect for GSTT1 and GSTM1 genotypes...
  38. ncbi request reprint Genetic polymorphisms of XRCC1 (codon 399) and susceptibility to breast cancer in Iranian women, a case-control study
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Breast Cancer Res Treat 111:549-53. 2008
    ..Arg/Arg), Gln/Gln+Arg/Gln genotypes was not associated with the risk of breast cancer (OR = 0.95, 95% CI:0.63-1.42, P = 0.799). It is concluded that 399Gln allele may act as a recessive allele and increase the breast cancer risk...
  39. doi request reprint First survey of the two polymorphisms (Arg194Trp and Arg399Gln) in XRCC1 gene in four Afghanistan populations and comparison with worldwide data
    Khyber Saify
    Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran
    Mol Biol Rep 40:5281-4. 2013
    ..However, Uzbeks seems to be intermediate between Afghanis' Caucasian (Pashtuns and Tajiks) and Asians. ..
  40. doi request reprint The novel allele (3R) of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression
    Mehrdad Rajaei
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 430:640-1. 2013
    ..965, df=7, P<0.001). The mRNA level of XRCC5 decreased as function of number of tandem repeats. The 3R allele of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression...
  41. doi request reprint Genetic variation in DNA repair gene XRCC7 (G6721T) and susceptibility to breast cancer
    Meysam Nasiri
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Gene 505:195-7. 2012
    ..67-1.53, P=0.933) genotypes had no significant effect on risk of breast cancer, in comparison with the GG genotype. Our present findings indicate that the TT and TG genotypes were not associated with an altered breast cancer risk...
  42. ncbi request reprint Genetic polymorphism in the DNA repair gene XRCC1 and susceptibility to schizophrenia
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 157:241-5. 2008
    ..There was a significant linear trend in risk associated with zero, one, and two 399Gln alleles. The present finding indicates that XRCC1 is a candidate gene for susceptibility to schizophrenia...
  43. doi request reprint ECG alteration due to prolong exposure to natural gas leakage containing sulfur compounds in polluted areas of Masjid-I-Sulaiman (south of Iran)
    Aminollah Bahaoddini
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Ecotoxicol Environ Saf 72:885-8. 2009
    ..It can be concluded that chronic exposure to sour gas containing hydrogen sulfide contaminated air may provoke alterations of electrical activity of the heart...
  44. doi request reprint Consanguineous marriages in Afghanistan
    Khyber Saify
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    J Biosoc Sci 44:73-81. 2012
    ..0250) and highest (α=0.0297) mean inbreeding coefficients, respectively, among the ethnic groups in Afghanistan. The study shows that Afghanistan's populations, like other Islamic populations, have a high level of consanguinity...
  45. doi request reprint Age-related macular degeneration and genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1)
    Hasan Othman
    Department of Biology, College of Sciences, Shiraz University, 71454 Shiraz, Iran
    Mol Biol Rep 39:3299-303. 2012
    ..Since the age at onset is influenced by the GSTM1 polymorphism, this implies that GSTM1 is a modifier gene...
  46. ncbi request reprint Influence of polymorphism of glutathione S-transferase M1 on systolic blood pressure of normotensive individuals
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 326:449-54. 2005
    ..The present results suggest that the GSTM1 gene is one of the candidate genes that alter the baseline of SBP in normotensive individuals...
  47. ncbi request reprint Polymorphisms of glutathione S-transferases M1 and T1 do not account for interindividual differences for smoking behavior
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Pharmacol Biochem Behav 77:793-5. 2004
    ..The risk of being a smoker was to be equally frequent in each combination of the genotypes. The present results revealed that there was no difference between smokers and nonsmokers for these two genetic polymorphisms...
  48. ncbi request reprint High incidence of suicide by burning in Masjid-i-Sulaiman (southwest of Iran), a polluted area with natural sour gas leakage
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Burns 30:829-32. 2004
    ..00001). Analysis of correlation showed statistically positive correlation coefficient between mean values of all reactive sulfur compounds and seasonal frequency of suicide (r = 0.923, P((1)) = 0.038)...
  49. doi request reprint Association between N142D genetic polymorphism of GSTO2 and susceptibility to colorectal cancer
    Mohammad Masoudi
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Mol Biol Rep 38:4309-13. 2011
    ..003). Present findings indicating that GSTO2 NN genotype increase the risk of colorectal cancer in persons with positive family history for cancer in the first degree relatives...
  50. ncbi request reprint Epidemiology and mortality of hospitalized burn patients in Kohkiluye va Boyerahmad province (Iran): 2002-2004
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Burns 31:306-9. 2005
    ..0001). No definite correlation was found between the incidence of either accidental or self-inflicted burns and seasons (P((2))>0.05). Most of the burns occurred at home...
  51. doi request reprint Clinical response to chemotherapy in locally advanced breast cancer was not associated with several polymorphisms in detoxification enzymes and DNA repair genes
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Biochem Biophys Res Commun 419:117-9. 2012
    ..1). Clinical response was regarded as a response or no response. There was no difference between non-responders and responders for the prevalence of genotypes of the study polymorphisms...
  52. doi request reprint Influence of parental consanguineous marriages on age at onset of bipolar disorder
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 198:327-8. 2012
    ..However, there was no difference between consanguineous and unrelated marriages for intermediate age at onset...
  53. ncbi request reprint Environmental exposure to natural sour gas containing sulfur compounds results in elevated depression and hopelessness scores
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Ecotoxicol Environ Saf 65:288-91. 2006
    ..2% and 32.8% of subjects had no hopelessness at all and moderate to severe hopelessness, respectively, the difference was significant (chi2=11.49, df=3, P=0.009). Replication is necessary and health implications are discussed...
  54. doi request reprint Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer
    Mehrdad Rajaei
    Department of Biology, College of Sciences, Shiraz University, 71454, Shiraz, Iran
    Med Oncol 31:885. 2014
    ..90, df = 4, P = 0.008). The findings of the present study revealed that either breast cancer risk or age at diagnosis of breast cancer was associated with the VNTR polymorphism at promoter region of XRCC5...
  55. ncbi request reprint Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer: a meta-analysis
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Cancer Sci 97:505-9. 2006
    ..326, d.f. = 1, P = 0.0023). Those who had null genotypes of GSTM1 and GSTT1 had an increased gastric cancer risk compared with those who had both active genes (odds ratio = 2.08, 95% CI: 1.42-3.10)...
  56. ncbi request reprint Is consanguineous marriage historically encouraged?
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Iran
    J Biosoc Sci 40:153-4; discussion 155. 2008
  57. doi request reprint Parental consanguinity and susceptibility to drug abuse among offspring, a case-control study
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Psychiatry Res 180:57-9. 2010
    ..Our study supports a significant relationship between parental consanguinity and drug abuse among non-drinker subjects...
  58. doi request reprint Parental consanguineous marriages and clinical response to chemotherapy in locally advanced breast cancer patients
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Cancer Lett 302:109-12. 2011
    ..Number of courses of chemotherapy was considered as time, in the analysis. Kaplan-Meier analysis revealed that offspring of unrelated marriages had poorer response to chemotherapy (log rank statistic=5.10, df=1, P=0.023)...
  59. doi request reprint Effect of inbreeding on weight gain of offspring from birth to 12 months after birth: a study from Iran
    Samane Nafissi
    Department of Biology, College of Sciences, Shiraz University, Iran
    J Biosoc Sci 42:195-200. 2010
    ..46). There was significant interaction between inbreeding and time (p=0.034). Offspring of consanguineous marriages showed lower weight gain in comparison with those of unrelated marriages during 3-12 months after birth...
  60. ncbi request reprint Correlation between incidences of self-inflicted burns and means of inbreeding coefficients, an ecologic study
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Ann Epidemiol 16:708-11. 2006
    ..The aim of the study is to obtain more insight into the possible association between consanguinity and the incidence of deliberate self-burning...
  61. doi request reprint Prevalence of consanguineous marriages among Iranian Georgians
    Laleh Rafiee
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    J Biosoc Sci 43:47-50. 2011
    ..6%). The mean inbreeding coefficient (α) was calculated as 0.0104 for the population. The present study shows that the study population, as other Iranian populations, has a high level of consanguinity...
  62. doi request reprint Prevalence of consanguineous marriages among shi'a populations of Lebanon
    Ghadir El-Kheshen
    Department of Biology, College of Sciences, Shiraz University, Iran
    J Biosoc Sci 45:675-82. 2013
    ..There were no significant differences between the three studied territories for frequencies of different types of marriages (p>0.1), nor were there significant differences between the rural and urban areas (p>0.1)...
  63. doi request reprint Prevalence of consanguineous marriages in Syria
    Hasan Othman
    Department of Biology, College of Sciences, Shiraz University, Iran
    J Biosoc Sci 41:685-92. 2009
    ..First cousin marriages (with 20.9%) were the most common type of consanguineous marriages, followed by double first cousin (with 7.8%) and second cousin marriages (with 3.3%), and beyond second cousin was the least common type...
  64. ncbi request reprint Hematological changes due to chronic exposure to natural gas leakage in polluted areas of Masjid-i-Sulaiman (Khozestan province, Iran)
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran
    Ecotoxicol Environ Saf 58:273-6. 2004
    ..However, the absolute mean numbers of white blood cells, lymphocytes, and neutrophils were significantly decreased in the exposed group compared with the control...
  65. doi request reprint High resolution melting analysis for detection of variable number of tandem repeats polymorphism of XRCC5
    Mehrdad Rajaei
    Department of Biology, College of Sciences, and Institute of Biotechnology, Shiraz University, Shiraz, Iran
    Biochem Biophys Res Commun 425:398-400. 2012
    ..The results for genotyping using HRMA and conventional PCR showed 100% concordance. All genotypes of the XRCC5 VNTR polymorphism could be accurately detected by HRMA...
  66. ncbi request reprint Decline in sex ratio at birth after Bam (Kerman Province, Southern Iran) earthquake
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Iran
    J Biosoc Sci 40:935-7. 2008
    ..44, df=1, p=0.51) for a period of 33 month before the earthquake (from April 2001 to December 2003). It might be concluded that psychological tensions and stress are associated with a decrease in SRB...
  67. ncbi request reprint Consanguineous marriages in Iranian folktales
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Community Genet 10:38-40. 2007
    ..Using folktales we can find some aspects of social customs. Here, I show the situation of consanguineous marriages in folktales from different Iranian populations and try to compare it with the present situation of consanguineous marriages...
  68. doi request reprint Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Iran
    Cancer Epidemiol 36:e101-3. 2012
    ..We therefore carried out a meta-analysis of published studies to clarify this inconsistency and to establish a comprehensive picture of the relationship between PON1 gene variants and breast cancer risk...
  69. ncbi request reprint Offspring sex ratio is not associated with parental GSTT1 and GSTM1 null genotypes
    Mostafa Saadat
    Department of Biology, Shiraz University, Shiraz 71454, Iran
    Reprod Toxicol 17:345-7. 2003
    ..84), whereas there was a weak association between maternal GSTT1 null genotype and offspring sex ratio (OR=1.54; 95% CI=1.0-2.38; P=0.05). Combination of parental GSTT1 and GSTM1 genotypes showed no association with offspring sex ratio...