- Purification and characterization of a hemoglobin degrading aspartic protease from the malarial parasite Plasmodium vivaxArun Sharma
Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
J Biochem 138:71-8. 2005..Ca2+ and Mg2+ ions enhance the protease activity, whereas Cu2+ and Hg2+ ions were found to be inhibitory. The pivotal role of aspartic protease in initiating hemoglobin degradation in P. vivax malaria parasite is also demonstrated...
- Involvement of caspase-3-like protein in rapid cell death of XanthomonasSatyendra Gautam
Food Technology Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
Mol Microbiol 44:393-401. 2002..Caspase-negative mutants of XcgAM2 did not display post-exponential RCD. The importance of RCD in Xanthomonas life cycle is not yet clear, however the phenomenon appears to have similarities with eukaryotic apoptosis...
- Stability of lipid constituents in radiation processed fenugreek seeds and turmeric: role of phenolic antioxidantsSuchandra Chatterjee
Food Technology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
J Agric Food Chem 57:9226-33. 2009..The role of phenolic antioxidants in preventing lipid oxidation in the above spices is discussed...
- Effect of Withania somnifera (L. Dunal) root as a feed additive on immunological parameters and disease resistance to Aeromonas hydrophila in Labeo rohita (Hamilton) fingerlingsArun Sharma
Department of Fish Health and Environment, College of Fisheries, Central Agricultural University, Tripura 799210, India
Fish Shellfish Immunol 29:508-12. 2010..hydrophila infection than control. The results suggest that the W. somnifera root powder have a stimulatory effect on immunological parameters and increases disease resistance in L. rohita fingerlings against A. hydrophila infection...
- Stage-specific cytosolic protein kinase C-like activity in human malarial parasite Plasmodium falciparumArun Sharma
Department of Protein Biochemistry, Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
Indian J Biochem Biophys 42:145-51. 2005..The results suggest that the PKC-like activity is developmentally expressed during the parasitic survival and development...
- Parasite killing in Plasmodium vivax malaria by nitric oxide: implication of aspartic protease inhibitionArun Sharma
Malaria Research Centre, 22 Sham Nath Marg, Delhi 110 054, India
J Biochem 136:329-34. 2004..vivax infections for antimalarial chemotherapy and also biochemical adaptations of the malaria parasite for survival in the host erythrocytes with a better understanding of the protease substrate interactions...
- Determination of nitric oxide metabolites, nitrate and nitrite, in Anopheles culicifacies mosquito midgut and haemolymph by anion exchange high-performance liquid chromatography: plausible mechanism of refractorinessArun Sharma
Protein Biochemistry Laboratory, National Institute of Malaria Research ICMR, 22 Sham Nath Marg, Delhi 110 054, India
Malar J 7:71. 2008..NO metabolites, nitrite (NO2-) and nitrate (NO3-) are produced by the action of an inducible Anopheles culicifacies NO synthase (AcNOS) in mosquito mid-guts and may be central to anti-parasitic arsenal of these mosquitoes...
- Parasite killing in malaria non-vector mosquito Anopheles culicifacies species B: implication of nitric oxide synthase upregulationSonam Vijay
Protein Biochemistry and Structural Biology Laboratory, National Institute of Malaria Research ICMR, Dwarka, New Delhi, India
PLoS ONE 6:e18400. 2011..Identification of the differences between genes and gene products that may impart refractory phenotype can facilitate development of novel malaria transmission blocking strategies...
- Imperfect duplicate insertions type of mutations in plasmepsin V modulates binding properties of PEXEL motifs of export proteins in Indian Plasmodium vivaxManmeet Rawat
Protein Biochemistry and Structural Biology Division, National Institute of Malaria Research ICMR, Dwarka, New Delhi, India
PLoS ONE 8:e60077. 2013..This study was undertaken to determine P. vivax plasmepsin V Ind (PvPM-V-Ind) PEXEL motif export pathway for pathogenicity-related proteins/antigens export thereby altering plasmodium exportome during erythrocytic stages...
- Role of transtympanic myringoplasty in modern otologyGautam Bir Singh
Department of Otorhinolaryngology and Head and Neck Surgery, Institute of Medical Sciences and Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, Uttar Pradesh, India
J Otolaryngol 35:408-12. 2006..This study evaluates the success rate of transtympanic myringoplasty and defines its role in the current era...
- Management of aural foreign body: an evaluative study in 738 consecutive casesGautam Bir Singh
Department of ENT and HNS, Institute of Medical Sciences and Sir Sunderlal Hospital, Banaras Hindu University, Varanasi, India
Am J Otolaryngol 28:87-90. 2007..The purpose of this study is to evaluate the effectiveness of treatment of this emergent problem by medical personnel other than otolaryngologist...
- Tympanoplasty type I in children--an evaluative studyGautam Bir Singh
Department of ENT and HNS, Institute of Medical Sciences and S S Hospital, BHU, Varanasi, India
Int J Pediatr Otorhinolaryngol 69:1071-6. 2005..Thus, a prospective study was planned to evaluate the success rate of paediatric tympanoplasty type I and analyse the factors suggested to influence the outcome of the said surgery...
- Towards a Proteomic Catalogue and Differential Annotation of Salivary Gland Proteins in Blood Fed Malaria Vector Anopheles culicifacies by Mass SpectrometryRitu Rawal
Protein Biochemistry and Structural Biology, National Institute of Malaria Research ICMR, Sector 8, Dwarka, New Delhi, India
PLoS ONE 11:e0161870. 2016....
- Annotated differentially expressed salivary proteins of susceptible and insecticide-resistant mosquitoes of Anopheles stephensiSonam Vijay
Protein Biochemistry and Structural Biology Laboratory, National Institute of Malaria Research ICMR, Sector 8, Dwarka, New Delhi, India
PLoS ONE 10:e0119666. 2015..These identified proteins may play a role in regulating mosquito biting behavior patterns and may have implications in the development of malaria parasites in resistant mosquitoes during parasite transmission. ..
- Mass spectrometry based proteomic analysis of salivary glands of urban malaria vector Anopheles stephensiSonam Vijay
Protein Biochemistry and Structural Biology Laboratory, National Institute of Malaria Research ICMR, Sector 8, Dwarka, New Delhi 110077, India
Biomed Res Int 2014:686319. 2014..Our results may serve as basis to provide a putative functional role of proteins in concept of blood feeding, biting behavior, and other aspects of vector-parasite host interactions for parasite development in anopheline mosquitoes. ..
- Malarial protease inhibitors: potential new chemotherapeutic agentsArun Sharma
Indian Council of Medical Research, National Institute of Malaria Research, 22 Sham Nath Marg, Delhi 110 054, India
Curr Opin Investig Drugs 8:642-52. 2007..This review summarizes experimental evidence to support the rational design and development of protease inhibitors as potential new antimalarial drugs...
- Molecular and phylogenetic analysis of a novel salivary defensin cDNA from malaria vector Anopheles stephensiRajnikant Dixit
Molecular Biology Unit, National Center for Cell Science, Ganeshkhind, Pune 411007, India
Acta Trop 106:75-9. 2008..Amino acid sequence similarity and phylogenetic analysis indicated a higher variation in the pre-propeptide region, as compared to the mature defensin peptide, assuring the presence of finely tuned immune responses to counter pathogens...
- Radiation-induced enhancement of antioxidant contents of soybean (Glycine max Merrill)Prasad S Variyar
Food Technology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India
J Agric Food Chem 52:3385-8. 2004....
- Flavoring components of raw monsooned arabica coffee and their changes during radiation processingPrasad S Variyar
Food Technology Division, BARC, Trombay, Mumbai 400 085, India
J Agric Food Chem 51:7945-50. 2003..A rationale behind the mechanism of monsooning and radiation-induced enhancement of the monsooning process is discussed...
- Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemiaD Ross Laybutt
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes 51:413-23. 2002..In conclusion, beta-cell adaptation to chronic hyperglycemia and, hence, increased insulin demand is accompanied by the induction of protective stress genes that may contribute to the survival of hypertrophied beta-cells...