Vegesna Radha

Summary

Affiliation: Centre for Cellular and Molecular Biology
Country: India

Publications

  1. ncbi request reprint C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India
    Exp Cell Res 313:2476-92. 2007
  2. doi request reprint Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor
    Vegesna Radha
    Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500 007, India
    Biosci Rep 31:231-44. 2011
  3. pmc C3G shows regulated nucleocytoplasmic exchange and represses histone modifications associated with euchromatin.
    Dhruv Kumar Shakyawar
    Mol Biol Cell 28:984-995. 2017
  4. doi request reprint Use of Dominant-Negative/Substrate Trapping PTP Mutations to Search for PTP Interactors/Substrates
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
    Methods Mol Biol 1447:243-65. 2016
  5. pmc Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007 India
    BMC Cell Biol 5:31. 2004
  6. doi request reprint The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    J Neurochem 107:1424-35. 2008
  7. pmc Regulation of p73 by Hck through kinase-dependent and independent mechanisms
    Preeti Paliwal
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India
    BMC Mol Biol 8:45. 2007
  8. ncbi request reprint Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain
    R Shivakrupa
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    J Biol Chem 278:52188-94. 2003
  9. pmc TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
    Aninda Mitra
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, Andhra Pradesh, India
    PLoS ONE 6:e23681. 2011
  10. pmc M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells
    Kapil Sirohi
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    Autophagy 9:510-27. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India
    Exp Cell Res 313:2476-92. 2007
    ..We suggest that C3G and c-Abl function in an interdependent manner, in linking external signals to remodeling the cytoskeleton to induce filopodia...
  2. doi request reprint Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor
    Vegesna Radha
    Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500 007, India
    Biosci Rep 31:231-44. 2011
    ..Deregulated C3G may also contribute to pathogenesis of human disorders and therefore could be a potential therapeutic target...
  3. pmc C3G shows regulated nucleocytoplasmic exchange and represses histone modifications associated with euchromatin.
    Dhruv Kumar Shakyawar
    Mol Biol Cell 28:984-995. 2017
    ..Our results document regulated nucleocytoplasmic exchange of C3G in response to physiological stimuli and provide insights into nuclear functions for C3G...
  4. doi request reprint Use of Dominant-Negative/Substrate Trapping PTP Mutations to Search for PTP Interactors/Substrates
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
    Methods Mol Biol 1447:243-65. 2016
    ..We provide a description of methods that will be useful to design strategies of using dominant-negative and substrate-trapping mutants for identifying novel interacting partners and substrates of PTPs. ..
  5. pmc Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007 India
    BMC Cell Biol 5:31. 2004
    ..C3G is activated upon phosphorylation at tyrosine 504 and therefore, determining the localization of phosphorylated C3G would provide an insight into its site of action in the cellular context...
  6. doi request reprint The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells
    Vegesna Radha
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    J Neurochem 107:1424-35. 2008
    ..These findings demonstrate a novel function for C3G in regulating survival and differentiation of human neuroblastoma cells...
  7. pmc Regulation of p73 by Hck through kinase-dependent and independent mechanisms
    Preeti Paliwal
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India
    BMC Mol Biol 8:45. 2007
    ..c-Abl is the only known tyrosine kinase that phosphorylates and activates p73. Here we have analyzed the role of Src family kinases, which are involved in diverse signaling pathways, in regulating p73...
  8. ncbi request reprint Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain
    R Shivakrupa
    Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    J Biol Chem 278:52188-94. 2003
    ..These results suggest that C3G and Hck interact physically and functionally in vivo to activate kinase-dependent and caspase-mediated apoptosis, which is independent of catalytic domain of C3G...
  9. pmc TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
    Aninda Mitra
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, Andhra Pradesh, India
    PLoS ONE 6:e23681. 2011
    ..Our results identify a novel Golgi localized substrate of TC48 and delineate a role for TC48 in dephosphorylation of substrates required during differentiation of human neuroblastoma cells...
  10. pmc M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells
    Kapil Sirohi
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    Autophagy 9:510-27. 2013
    ..These results also show that transferrin receptor degradation and autophagy play a crucial role in RGC-5 cell death induced by M98K variant of OPTN...
  11. ncbi request reprint Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
    Subhash Thalappilly
    Centre for Cellular and Molecular Biology, Hyderabad, India
    FEBS J 273:2766-78. 2006
    ....
  12. pmc Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant
    Ananthamurthy Nagabhushana
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    BMC Cell Biol 11:4. 2010
    ..However, functional alterations caused by mutations in optineurin are not known. Here, we have analyzed the role of optineurin in endocytic recycling and the effect of E50K mutant on this process...
  13. doi request reprint Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
    Yatender Kumar
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    Biochem J 427:91-104. 2010
    ..Our results suggest a role for ubiquitination of Ipaf that is enabled by its interaction with Sug1, leading to caspase 8 activation and cell death...
  14. ncbi request reprint Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin
    Nishant Jain
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    J Biol Chem 280:36664-73. 2005
    ..Our results show that p73 is a regulator of caspase-1 gene transcription, and is required for optimal activation of the caspase-1 promoter by interferon-gamma...
  15. doi request reprint Cytoskeletal remodeling by C3G to induce neurite-like extensions and inhibit motility in highly invasive breast carcinoma cells
    Kunal Dayma
    Centre for Cellular and Molecular Biology CSIR, Uppal Road, Hyderabad 500007, India
    Biochim Biophys Acta 1813:456-65. 2011
    ..Our results suggest that C3G overexpression can induce phenotypic characteristics of neuronal cells in highly invasive breast cancer cells and inhibit their motility...
  16. ncbi request reprint A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants
    Madhavi Latha Chalasani
    L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 48:1607-14. 2007
    ..Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants...
  17. doi request reprint The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl
    Aninda Mitra
    Council of Scientific and Industrial Research, Hyderabad, India
    Biochim Biophys Acta 1832:275-84. 2013
    ..This study identifies a novel cellular regulator that specifically inhibits the activity of oncogenic BCR-Abl but not that of the cellular Abl kinase...
  18. ncbi request reprint Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
    Subhashini Sadasivam
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Oncogene 24:627-36. 2005
    ..Doxorubicin-induced apoptosis was also inhibited by Ipaf-directed small hairpin RNA. Our results show that p53 can directly induce Ipaf gene transcription, which contributes to p53-dependent apoptosis in at least some human cells...
  19. pmc A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
    Kapil Sirohi
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, 500 007, India
    PLoS ONE 10:e0138289. 2015
    ..In addition, we provide evidence for cross talk between two glaucoma associated proteins and their inter-dependence to mediate autophagy-dependent cell death. ..
  20. pmc Reciprocal Negative Regulation between the Guanine Nucleotide Exchange Factor C3G and β-Catenin
    Kunal Dayma
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Genes Cancer 3:564-77. 2012
    ..Our results identify a novel property of C3G in functioning as a negative regulator of β-catenin signaling by promoting its degradation. In addition, we show that β-catenin inhibits C3G expression, forming a feedback loop...
  21. pmc E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy
    Madhavi Latha Somaraju Chalasani
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India
    PLoS ONE 9:e95758. 2014
    ..TBC1D17, a GTPase-activating protein for Rab GTPases, plays a crucial role in E50K-induced impaired autophagy and cell death. ..
  22. ncbi request reprint A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis
    Sanjeev Gupta
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    FEBS Lett 532:61-6. 2002
    ..These results suggest that caspase-1 may be one of the mediators of p53-dependent apoptosis in human cells...