N Singh

Summary

Affiliation: Central Food Technological Research Institute
Country: India

Publications

  1. pmc Infectious diseases and immunity: special reference to major histocompatibility complex
    N Singh
    Department of Biochemistry, Central Drug Research Institute, Lucknow, India
    Emerg Infect Dis 3:41-9. 1997
  2. ncbi request reprint Effect of compound CDRI 84/35 and synthetic estrogen on the seminiferous epithelium of immature rat
    F W Bansode
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Endocr Res 28:103-17. 2002
  3. ncbi request reprint Role of polypeptides in the treatment and diagnosis of osteoporosis
    B Kundu
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Peptides 20:523-37. 1999
  4. ncbi request reprint Disappearance of intramolecular stacking due to one-atom movement or increment of a 'propylene linker' in pyrazolo[3,4-d]pyrimidine-based flexible models
    P R Maulik
    Membrane Biology Division, Central Drug Research Institute, Lucknow 226 001, India
    Acta Crystallogr C 56:1361-3. 2000
  5. ncbi request reprint Characterization of iridoids by fast atom bombardment mass spectrometry followed by collision-induced dissociation of
    - Madhusudanan
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    J Mass Spectrom 35:321-9. 2000
  6. ncbi request reprint Carbanion-induced base-catalyzed synthesis of 1H-isothiochromenes, benzo[c]thiochromenes through ring-transformation reactions of 6-aryl-2H-pyran-2-ones
    V J Ram
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
    J Org Chem 66:5333-7. 2001
  7. ncbi request reprint Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents
    S Batra
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem 8:2195-209. 2000
  8. ncbi request reprint Behavioural and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey
    G Palit
    Primate Behaviour Laboratory, Division of Pharmacology, Central Drug Research Institute, Post Box 173, 226001, Lucknow, India
    Eur J Pharmacol 412:139-44. 2001
  9. ncbi request reprint Evaluation of integral membrane antigens of Mycobacterium habana for serodiagnosis of extrapulmonary tuberculosis: association between levels of antibodies and Mycobacterium tuberculosis antigens
    Vinita Chaturvedi
    Division of Microbiology, Central Drug Research Institute Chattar Manzil, Post Box 173, Lucknow 226001, India
    FEMS Immunol Med Microbiol 33:1-7. 2002
  10. ncbi request reprint Antifungal agents and immunomodulators in systemic mycoses
    Z K Khan
    Medical Mycology Division, Central Drug Research Institute, Lucknow
    Indian J Chest Dis Allied Sci 42:345-55. 2000

Collaborators

Detail Information

Publications41

  1. pmc Infectious diseases and immunity: special reference to major histocompatibility complex
    N Singh
    Department of Biochemistry, Central Drug Research Institute, Lucknow, India
    Emerg Infect Dis 3:41-9. 1997
    ....
  2. ncbi request reprint Effect of compound CDRI 84/35 and synthetic estrogen on the seminiferous epithelium of immature rat
    F W Bansode
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Endocr Res 28:103-17. 2002
    ..Marked inhibition in pachytene spermatocytes and other testicular parameters following synthetic estrogen treatment might be due to its antiandrogenic action, contrasting with the non-hormonal profile of CDRI compound...
  3. ncbi request reprint Role of polypeptides in the treatment and diagnosis of osteoporosis
    B Kundu
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Peptides 20:523-37. 1999
    ..Though it is unlikely that some of the compounds may ever be used clinically, development of safe and efficacious agents in each class will define the future course of therapy for osteoporosis...
  4. ncbi request reprint Disappearance of intramolecular stacking due to one-atom movement or increment of a 'propylene linker' in pyrazolo[3,4-d]pyrimidine-based flexible models
    P R Maulik
    Membrane Biology Division, Central Drug Research Institute, Lucknow 226 001, India
    Acta Crystallogr C 56:1361-3. 2000
    ....
  5. ncbi request reprint Characterization of iridoids by fast atom bombardment mass spectrometry followed by collision-induced dissociation of
    - Madhusudanan
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    J Mass Spectrom 35:321-9. 2000
    ..Elimination of two acyloxy radicals from the lithiated molecular ion is a characteristic fragmentation in the case of acyloxy derivatives...
  6. ncbi request reprint Carbanion-induced base-catalyzed synthesis of 1H-isothiochromenes, benzo[c]thiochromenes through ring-transformation reactions of 6-aryl-2H-pyran-2-ones
    V J Ram
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
    J Org Chem 66:5333-7. 2001
    ....
  7. ncbi request reprint Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents
    S Batra
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem 8:2195-209. 2000
    ....
  8. ncbi request reprint Behavioural and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey
    G Palit
    Primate Behaviour Laboratory, Division of Pharmacology, Central Drug Research Institute, Post Box 173, 226001, Lucknow, India
    Eur J Pharmacol 412:139-44. 2001
    ..These results suggest that verapamil has a definite antipsychotic effect without any extrapyramidal side effects and thus may be of clinical significance in the treatment of psychosis...
  9. ncbi request reprint Evaluation of integral membrane antigens of Mycobacterium habana for serodiagnosis of extrapulmonary tuberculosis: association between levels of antibodies and Mycobacterium tuberculosis antigens
    Vinita Chaturvedi
    Division of Microbiology, Central Drug Research Institute Chattar Manzil, Post Box 173, Lucknow 226001, India
    FEMS Immunol Med Microbiol 33:1-7. 2002
    ..M. habana IMAs may be promising non-tubercular candidate antigens in ELISA-based serodiagnosis of extrapulmonary tuberculosis with substantial sensitivity, specificity and safety...
  10. ncbi request reprint Antifungal agents and immunomodulators in systemic mycoses
    Z K Khan
    Medical Mycology Division, Central Drug Research Institute, Lucknow
    Indian J Chest Dis Allied Sci 42:345-55. 2000
    ..Currently, antifungals represent more than 6% of the total world market for anti-infective agents and with 20% annual expansion they are expected to cross the 15 billion US Dollars in value within a decade...
  11. ncbi request reprint Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys
    S K Puri
    Division of Microbiology, Central Drug Research Institute, Lucknow, 226001, India
    Exp Parasitol 94:8-14. 2000
    ..Azithromycin did not exhibit any hypnozoitocidal (dormant exoerythrocytic stages) activity at 25 mg/kg/day in a seven-dose regimen...
  12. ncbi request reprint Resolution, molecular structure and biological activities of the D- and L-enantiomers of potent anti-implantation agent, DL-2-[4-(2-piperidinoethoxy)phenyl]-3-phenyl-2H-1-benzopyran
    K Hajela
    Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem 7:2083-90. 1999
    ..The absolute stereochemistry determined by X-ray crystallographic analysis showed that the L-enantiomer has 2R configuration at its asymmetric centre...
  13. ncbi request reprint Alcohol-induced molten globule intermediates of proteins: are they real folding intermediates or off pathway products?
    V Bhakuni
    Division of Membrane Biology, Central Drug Research Institute, Lucknow, India
    Arch Biochem Biophys 357:274-84. 1998
    ....
  14. ncbi request reprint Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG
    A Dube
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Parasitology 116:219-21. 1998
    ..The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar...
  15. ncbi request reprint Cellular immune response of Mastomys and gerbils in experimental filariasis
    S Misra
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Trop Med Int Health 3:124-9. 1998
    ..Meriones unguiculatus and Mastomys coucha to assess the usefulness of the A. viteae/Mastomys model for cellular immune studies in experimental filariasis...
  16. ncbi request reprint Phenotypical response in different cell types of rat uterus to centchroman. A qualitative analysis
    P K Mehrotra
    Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    Contraception 58:137-45. 1998
    ..The observations revealed that some of the nongenomic responses, elicited by the rat uterus after CC treatment, seem to be unrelated to the hormonal attributes of the molecule...
  17. ncbi request reprint Kinetoplast DNA minicircles of Leishmania donovani express a protein product
    N Singh
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Biochim Biophys Acta 1444:263-8. 1999
    ..The encoded protein showed homologies to known transport proteins...
  18. ncbi request reprint Leishmania donovani: cellular and humoral immune responses in Indian langur monkeys, Presbytis entellus
    A Dube
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Acta Trop 73:37-48. 1999
    ..This makes the langur a potentially useful model for the evaluation of candidate anti-leishmanial drugs and vaccines...
  19. ncbi request reprint Diagnostic PCR with Leishmania donovani specificity using sequences from the variable region of kinetoplast minicircle DNA
    N Singh
    Division of Biochemistry, Central Drug Research Institute, Lucknow, India
    Trop Med Int Health 4:448-53. 1999
    ..We feel that PCR could assess the efficacy of new leishmanicidal drugs under investigation in these patients. PCR could also predict response to therapy which would be useful for both clinical and research applications...
  20. ncbi request reprint Longitudinal humoral immune responses of Indian leaf monkey (Presbytis entellus) to Brugia malayi infection
    P K Murthy
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Parasitology 119:53-60. 1999
    ..However, 2 non-reactive antigen molecules identified by symptomatic sera need further study to establish their possible involvement, if any, in the development of acute disease manifestations in this model...
  21. ncbi request reprint Proteophosphoglycan is differentially expressed in sodium stibogluconate-sensitive and resistant Indian clinical isolates of Leishmania donovani
    M Samant
    Divisions of Parasitology Central Drug Research Institute, Lucknow, India
    Parasitology 134:1175-84. 2007
    ..This study suggests the possibilities of involvement of PPG in drug-resistant mechanisms and of using PPG abundance as a marker for identifying drug-resistant clinical isolates in Indian kala azar...
  22. ncbi request reprint Characterization of kinetoplast DNA minicircles of an Indian isolate of Leishmania donovani
    N Singh
    Department of Biochemistry, Central Drug Research Institute, Lucknow, India
    Acta Trop 73:313-9. 1999
    ..with distantly related New World Leishmania species. Secondly, open reading frames were also identified, indicating the possibility that these minicircles may have more than a structural role to play within the kinetoplast network...
  23. ncbi request reprint Telomerase-A molecular marker for cervical cancer screening
    V G Reddy
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Int J Gynecol Cancer 11:100-6. 2001
    ..For the first time we have also shown the ability of telomerase to detect micro and probably occult metastasis in gynecological malignancies...
  24. ncbi request reprint Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarray
    N Singh
    Central Drug Research Institute, Lucknow, India
    Parasitology 134:777-87. 2007
    ..This study provides preliminary clues to the role of a thiol-dependent efflux system in antimonial resistant clinical isolates of Leishmania donovani...
  25. doi request reprint Role of metal resistant plant growth promoting bacteria in ameliorating fly ash to the growth of Brassica juncea
    Kalpna V Kumar
    Biomass Biology and Environmental Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow, UP, India
    J Hazard Mater 170:51-7. 2009
    ..e. B. juncea. Concurrent production of siderophores, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, indole acetic acid (IAA) and phosphate solubilization revealed their plant growth promotion potential...
  26. doi request reprint Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats
    V Lakshmi
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, U P, India
    Phytomedicine 17:569-74. 2010
    ..This study is the first of its kind to show significant anti-secretory effect of gedunin and photogedunin. Therefore it could act as a potent therapeutic agent against peptic ulcer disease...
  27. doi request reprint Phenotypic and RAPD diversity among 80 germplasm accessions of the medicinal plant isabgol (Plantago ovata, Plantaginaceae)
    N Singh
    Central Institute of Medicinal and Aromatic Plants Council of Scientific and Industrial Research, Lucknow, India
    Genet Mol Res 8:1273-84. 2009
    ..Intraspecific differences in all three species were smaller [range for P. ovata (2-17%), P. lanceolata (3-15%), P. major (2-11%)] than interspecific diversity. These highly divergent lines could be used to produce superior hybrids...
  28. ncbi request reprint In vitro and in vivo leishmanicidal activity of Dysoxylum binectariferum and its fractions against Leishmania donovani
    V Lakshmi
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India
    Phytomedicine 14:36-42. 2007
    ..o., respectively. The pure compound, rohitukine, obtained from chloroform fraction showed weaker in vitro activity and was ineffective in infected hamsters. The lead potential of this plant need further investigations...
  29. ncbi request reprint A comparative study of telomerase activity in sputum, bronchial washing and biopsy specimens of lung cancer
    S Sen
    Department of Biochemistry, All India Institute of Medical Sciences, Room No 3027-A, New Delhi 110 029, India
    Lung Cancer 33:41-9. 2001
    ..Sputum telomerase assay holds the potential for early and non-invasive diagnosis of lung cancer...
  30. doi request reprint Influence of plant growth promoting bacteria and its mutant on heavy metal toxicity in Brassica juncea grown in fly ash amended soil
    Kalpna V Kumar
    Biomass Biology and Environmental Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow, UP, India
    Chemosphere 72:678-83. 2008
    ..In most of the cases mutant of NBRI K28, exerted more pronounced effect on metal accumulation and growth performance of B. juncea plants than wild type...
  31. ncbi request reprint Identification of a gene linked to drug resistance in field isolates of Leishmania donovani
    N Singh
    Division of Biochemistry, Central Drug Research Institute, Chattar Manzil, P O Box 173, Lucknow 226 001, India
    Ann Trop Med Parasitol 96:839-41. 2002
  32. ncbi request reprint Vitamin C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53
    V G Reddy
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    Biochem Biophys Res Commun 282:409-15. 2001
    ..Increasing drug sensitivity of cervical carcinoma cells by stabilizing P53 using vitamin C is a novel approach and has potential clinical relevance...
  33. ncbi request reprint Differential gene expression in apoptosis: identification of ribosomal protein S29 as an apoptotic inducer
    N Khanna
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    Biochem Biophys Res Commun 277:476-86. 2000
    ..This was accompanied by upregulation of p53, Caspase 3, and bax, whereas bcl-2 was downregulated as revealed by Western blotting. The current findings provide the first hint of a role for ribosomal protein S29 in the apoptotic process...
  34. ncbi request reprint Evaluation of expression of apoptosis-related proteins and their correlation with HPV, telomerase activity, and apoptotic index in cervical cancer
    A Singh
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi 110029, India
    Pathobiology 71:314-22. 2004
    ....
  35. ncbi request reprint Differential sensitivity of murine myeloid FDC-P1 cells and apoptosis resistant mutant(s) to anticancer drugs
    N Singh
    Department of Biochemistry, A I I M S, Ansari Nagar, 110029, New Delhi, India
    Mutat Res 474:105-12. 2001
    ..Whereas, the higher constitutive level of antioxidant enzymes superoxide dismutase and catalase in the Apt- mutant may contribute at least in part to its resistance...
  36. ncbi request reprint Monovalent cation-induced conformational change in glucose oxidase leading to stabilization of the enzyme
    A Ahmad
    Division of Membrane Biology, Central Drug Research Institute, Lucknow 226 001, India
    Biochemistry 40:1945-55. 2001
    ..The effectiveness of monovalent cations in stabilizing GOD structure against urea and thermal denaturation was found to follow the Hofmeister series: K(+) > Na(+) > Li(+)...
  37. ncbi request reprint Efficacy of various amendments for amelioration of fly-ash toxicity: growth performance and metal composition of Cassia siamea Lamk
    R D Tripathi
    Ecotoxicology and Bioremediation Group, National Botanical Research Institute, Rana Pratap Marg, P O Box 436, Lucknow 226 001, India
    Chemosphere 54:1581-8. 2004
    ..This might be attributed to the some metal detoxification mechanism active in this treatment. The present study concluded that C. siamea seems to be a suitable plant for developing a vegetation cover on fly-ash dumps...
  38. doi request reprint Soil fungi for mycoremediation of arsenic pollution in agriculture soils
    M Singh
    CSIR National Botanical Research Institute, Lucknow, India
    J Appl Microbiol 119:1278-90. 2015
    ..To enumerate culturable soil fungi, soils were collected from the As-contaminated paddy fields (3-35 mg kg(-1) ) of the middle Indo-Gangetic Plains...
  39. doi request reprint Survivin siRNA increases sensitivity of primary cultures of ovarian cancer cells to paclitaxel
    R Kar
    Department of Biochemistry, University College of Medical Sciences, Room No 234, New Delhi, Delhi, 110095, India
    Clin Transl Oncol 17:737-42. 2015
    ..Survivin siRNA was used to down regulate survivin expression and effect on paclitaxel resistance was also evaluated...
  40. doi request reprint Genetics of quantitative and qualitative traits of isabgol (Plantago ovata)
    N Singh
    Department of Genetics and Plant Breeding Planting Material and Varieties Development, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
    Genet Mol Res 8:939-50. 2009
    ..We conclude that hybridizations, isolation of superior genotypes by sib selection and recurrent selection, and exploitation of hybrid vigor in specific parental-cross combinations are good strategies for isabgol crop improvement...
  41. ncbi request reprint Mineral profile and variability in vegetable amaranth (Amaranthus tricolor)
    Sudhir Shukla
    Division of Genetics and Plant Breeding, National Botanical Research Institute, Rana Pratap Marg, Lucknow, 226001, India
    Plant Foods Hum Nutr 61:23-8. 2006
    ..This study would be of use in enhancement of selected minerals in different regions according to local preferences and nutrient deficiency prevalent among the populations...