L Vecsei

Summary

Affiliation: University of Szeged
Country: Hungary

Publications

  1. ncbi request reprint CGRP antagonists and antibodies for the treatment of migraine
    Laszlo Vecsei
    University of Szeged, Department of Neurology, MTA SZTE Neuroscience Research Group, Semmelweis u 6, H 6725, Szeged, Hungary 36 62 545348 36 62 545597
    Expert Opin Investig Drugs 24:31-41. 2015
  2. ncbi request reprint Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System
    Zsófia Majláth
    Department of Neurology, University of Szeged, Semmelweis u 6, H 6725, Szeged Hungary and MTA SZTE Neuroscience Research Group of the Hungarian Academy of Sciences and University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Med Chem 23:874-83. 2016
  3. ncbi request reprint Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism
    Nóra Török
    Department of Neurology, Faculty of Medicine, University of Szeged, 6 Semmelweis u, H 6725 Szeged, Hungary
    Curr Drug Metab 17:412-29. 2016
  4. ncbi request reprint Tryptophan Catabolites and Migraine
    Zsuzsanna Bohar
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Pharm Des 22:1013-21. 2016
  5. pmc Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
    Zsófia Majláth
    Department of Neurology, Faculty of Medicine, University of Szeged, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6 H 6725 Szeged, Hungary
    Curr Neuropharmacol 14:200-9. 2016
  6. ncbi request reprint Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine
    Janos Tajti
    Department of Neurology, Faculty of Medicine, University of Szeged, Albert Szent Gyorgyi Clinical Centre, Semmelweis u 6, H 6725 Szeged, Hungary
    CNS Neurol Disord Drug Targets 14:540-53. 2015
  7. ncbi request reprint Drug targets of migraine and neuropathy: treatment of hyperexcitability
    Laszlo Vecsei
    Department of Neurology, University of Szeged, Semmelweis u 6, H 6725, Szeged, Hungary
    CNS Neurol Disord Drug Targets 14:664-76. 2015
  8. ncbi request reprint Novel kynurenic acid analogues in the treatment of migraine and neurodegenerative disorders: preclinical studies and pharmaceutical design
    Janos Tajti
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Centre, Semmelweis u 6 H 6725 Szeged, Hungary
    Curr Pharm Des 21:2250-8. 2015
  9. doi request reprint Drug-induced movement disorders
    Denes Zadori
    University of Szeged, Albert Szent Gyorgyi Clinical Center, Department of Neurology, Faculty of Medicine, Semmelweis u 6, H 6725 Szeged, Hungary 36 62 545351 36 62 545597
    Expert Opin Drug Saf 14:877-90. 2015
  10. ncbi request reprint Alzheimer's disease, astrocytes and kynurenines
    Livia Dézsi
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Alzheimer Res 12:462-80. 2015

Collaborators

Detail Information

Publications64

  1. ncbi request reprint CGRP antagonists and antibodies for the treatment of migraine
    Laszlo Vecsei
    University of Szeged, Department of Neurology, MTA SZTE Neuroscience Research Group, Semmelweis u 6, H 6725, Szeged, Hungary 36 62 545348 36 62 545597
    Expert Opin Investig Drugs 24:31-41. 2015
    ..The use of fully humanized monoclonal antibodies (mAbs) that target CGRP and its receptors may also be possible. However, while Phase I and II clinical trials are promising, a long-term follow-up of these therapies is still needed...
  2. ncbi request reprint Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System
    Zsófia Majláth
    Department of Neurology, University of Szeged, Semmelweis u 6, H 6725, Szeged Hungary and MTA SZTE Neuroscience Research Group of the Hungarian Academy of Sciences and University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Med Chem 23:874-83. 2016
    ....
  3. ncbi request reprint Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism
    Nóra Török
    Department of Neurology, Faculty of Medicine, University of Szeged, 6 Semmelweis u, H 6725 Szeged, Hungary
    Curr Drug Metab 17:412-29. 2016
    ....
  4. ncbi request reprint Tryptophan Catabolites and Migraine
    Zsuzsanna Bohar
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Pharm Des 22:1013-21. 2016
    ..The current work attempts to collect recent data on both serotonin and kynurenine research related to migraine and emphasizes the importance of further research on this topic. ..
  5. pmc Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
    Zsófia Majláth
    Department of Neurology, Faculty of Medicine, University of Szeged, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6 H 6725 Szeged, Hungary
    Curr Neuropharmacol 14:200-9. 2016
    ..The development of a well-tolerated NMDA antagonist may offer a novel therapeutic option for the treatment of neurodegenerative disease and pain syndromes. KYNA may be a valuable candidate for future drug development. ..
  6. ncbi request reprint Role of pituitary adenylate cyclase-activating polypeptide in nociception and migraine
    Janos Tajti
    Department of Neurology, Faculty of Medicine, University of Szeged, Albert Szent Gyorgyi Clinical Centre, Semmelweis u 6, H 6725 Szeged, Hungary
    CNS Neurol Disord Drug Targets 14:540-53. 2015
    ..Identification of its up- and downstream regulations and receptorial molecular mechanisms might open up future perspectives for the development of novel analgesic drugs. ..
  7. ncbi request reprint Drug targets of migraine and neuropathy: treatment of hyperexcitability
    Laszlo Vecsei
    Department of Neurology, University of Szeged, Semmelweis u 6, H 6725, Szeged, Hungary
    CNS Neurol Disord Drug Targets 14:664-76. 2015
    ..Kynurenine pathway metabolites are capable of influencing the glutamate receptors, and might therefore be novel candidates for future drug development. ..
  8. ncbi request reprint Novel kynurenic acid analogues in the treatment of migraine and neurodegenerative disorders: preclinical studies and pharmaceutical design
    Janos Tajti
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Centre, Semmelweis u 6 H 6725 Szeged, Hungary
    Curr Pharm Des 21:2250-8. 2015
    ..The synthesis of kynurenic acid analogues may offer a valuable tool for drug development. ..
  9. doi request reprint Drug-induced movement disorders
    Denes Zadori
    University of Szeged, Albert Szent Gyorgyi Clinical Center, Department of Neurology, Faculty of Medicine, Semmelweis u 6, H 6725 Szeged, Hungary 36 62 545351 36 62 545597
    Expert Opin Drug Saf 14:877-90. 2015
    ..The major groups of offending drugs include antidepressants, antipsychotics, antiepileptics, antimicrobials, antiarrhythmics, mood stabilisers and gastrointestinal drugs among others...
  10. ncbi request reprint Alzheimer's disease, astrocytes and kynurenines
    Livia Dézsi
    Department of Neurology, University of Szeged, Faculty of Medicine, Albert Szent Gyorgyi Clinical Center, Semmelweis u 6, H 6725 Szeged, Hungary
    Curr Alzheimer Res 12:462-80. 2015
    ..The correction of the neuroprotective/neurotoxic imbalance in the kynurenine pathway may represent a novel target for pharmaceutical interventions in dementia related to neurodegenerative disorders. ..
  11. ncbi request reprint Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat
    Annamária Fejes-Szabó
    Department of Neurology, Faculty of Medicine, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    CNS Neurol Disord Drug Targets 14:350-9. 2015
    ..Four hours after formalin injection, the caudal part of spinal trigeminal nucleus was removed and subjected to c-Fos and neuronal nitric oxide synthase (nNOS) immunohistochemistry and to interleukin-1β and..
  12. doi request reprint Drug safety and tolerability in prophylactic migraine treatment
    Laszlo Vecsei
    University of Szeged, Department of Neurology, Semmelweis u 6, H 6725 Szeged, Hungary 36 62 545348 36 62 545597
    Expert Opin Drug Saf 14:667-81. 2015
    ..Migraine is a frequent, disabling primary headache disorder, whose pathomechanism is not yet fully understood. Prophylactic treatment is advisable for migraineurs with severe or highly frequent attacks, which impair the quality of life...
  13. pmc B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women
    Enikő Grozdics
    First Department of Pediatrics, Semmelweis University, Bókay u, 53 54, Budapest H 1083, Hungary
    BMC Pregnancy Childbirth 14:306. 2014
    ....
  14. pmc White matter disintegration in cluster headache
    Nikoletta Szabó
    Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Szeged, Hungary
    J Headache Pain 14:64. 2013
    ..Therefore, in the current study we examined white matter microstructure in cluster headache patients...
  15. ncbi request reprint Kynurenines in cognitive functions: their possible role in depression
    Imola Plangar
    Department of Neurology, Faculty of Medicine, University of Szeged, H 6725 Szeged, Semmelweis u 6, Hungary
    Neuropsychopharmacol Hung 14:239-44. 2012
    ..The aim of this review is to survey the role of the KP in depression and its relationships with cognitive functions...
  16. ncbi request reprint Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction
    Levente Szalárdy
    Department of Neurology, University of Szeged, H 6725 Szeged, Semmelweis u 6, Hungary
    Curr Top Med Chem 12:1797-806. 2012
    ....
  17. doi request reprint N-Methyl-D-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat
    G Varga
    Institute of Surgical Research, Szent Györgyi Albert Medical and Pharmaceutical Centre, University of Szeged, Szeged, Hungary
    Neurogastroenterol Motil 22:217-25, e68. 2010
    ....
  18. ncbi request reprint Effect of a serotonin agonist (sumatriptan) on the peptidergic innervation of the rat cerebral dura mater and on the expression of c-fos in the caudal trigeminal nucleus in an experimental migraine model
    E Knyihar-Csillik
    Department of Clinical Neurology, Albert Szent Gyorgyi University Medical School, Szeged, Hungary
    J Neurosci Res 48:449-64. 1997
    ..Disparate findings regarding this effect are partly due to the fact that sumatriptan very poorly passes the blood-brain barrier and partly to different experimental paradigms used by different authors...
  19. ncbi request reprint Kynurenine administered together with probenecid markedly inhibits pentylenetetrazol-induced seizures. An electrophysiological and behavioural study
    H Nemeth
    Department of Neurology, University of Szeged, POB 427, H 6701 Szeged, Hungary
    Neuropharmacology 47:916-25. 2004
    ..This study has furnished the first electrophysiological proof that systemic kynurenine (300 mg/kg, i.p.) and probenecid (200 mg/kg, i.p.) administration protects against pentylenetetrazol-induced (60 mg/kg, i.p.) epileptic seizures...
  20. doi request reprint Factors influencing the health-related quality of life in Hungarian multiple sclerosis patients
    J Füvesi
    Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary
    J Neurol Sci 293:59-64. 2010
    ..The aim of the present study was to examine the impact on their overall quality of life (QoL) of the demographic and clinical data on these patients, and their scores on different QoL scales...
  21. doi request reprint Paradox effects of kynurenines on LTP induction in the Wistar rat. An in vivo study
    I Demeter
    Department of Physiology, Anatomy and Neuroscience, University of Szeged, H 6726 Szeged, Közép fasor 52, Hungary Department of Neurology, University of Szeged, H 6725 Szeged, Semmelweis u 6, Hungary
    Neurosci Lett 553:138-41. 2013
    ..This might be the explanation why the treatment with the prodrug of KYNA or the KYNA derivative in a dosage which induced neuroprotection did not reduce the cognitive functions or the LTP...
  22. doi request reprint Targeting of the kynurenic acid across the blood-brain barrier by core-shell nanoparticles
    N Varga
    MTA SZTE Supramolecular and Nanostructured Materials Research Group, Department of Medical Chemistry, Faculty of Medicine, University of Szeged, H 6720 Dóm tér 8, Szeged, Hungary
    Eur J Pharm Sci 86:67-74. 2016
    ..As the neuroprotective properties of KYNA nowadays are proven, the importance of the results is obvious...
  23. doi request reprint The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acid
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Szeged, 6 Semmelweis utca, H 6726 Szeged, Hungary
    Neurosci Res 61:429-32. 2008
    ....
  24. doi request reprint Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies
    D Zadori
    Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary
    J Neural Transm (Vienna) 116:1403-9. 2009
    ..The experimental data indicate that neuroprotection can be achieved by both alternatives, suggesting opportunities for further drug development in this field...
  25. ncbi request reprint Decreased expression of kynurenine aminotransferase-I (KAT-I) in the substantia nigra of mice after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi Medical School, University of Szeged, Semmelweis u 6, H 6701 Szeged, Hungary
    Neuroscience 126:899-914. 2004
    ..We conclude that MPTP treatment may have a dual effect: in addition to being deleterious for neurons expressing TH and KAT-I, it also affects glial cells which could exacerbate the neurodegenerative process characterizing PD...
  26. ncbi request reprint Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Neuroscience 94:269-77. 1999
    ..The accumulation of kynurenine aminotransferase-I reaction product around the ribosomes of neuronal endoplasmic reticulum suggests de novo synthesis of kynurenine aminotransferase-I in the reactive nerve cells...
  27. ncbi request reprint The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets
    Z Szupera
    Department of Neurology, Albert Szent Gyorgyi Medical University, P O Box 397, H 6701, Szeged, Hungary
    Eur J Pharmacol 387:205-10. 2000
    ..Modifications of the arachidonate cascade in platelets and brain microvessels may contribute to the cell function alterations caused by valproate...
  28. doi request reprint Migraine is a neuronal disease
    J Tajti
    Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Semmelweis u 6, Szeged, 6725, Hungary
    J Neural Transm (Vienna) 118:511-24. 2011
    ..In light of our findings and the literature data, therefore, we can assume that migraine is mainly a neuronal disease...
  29. ncbi request reprint Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: medicinal chemistry aspects
    L Szalardy
    Department of Neurology, University of Szeged, Hungary
    Curr Med Chem 19:1899-920. 2012
    ....
  30. ncbi request reprint Effect of a nitric oxide donor on nitroxergic nerve fibers in the rat dura mater
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi University Medical School, Szeged, Hungary
    Neurosci Lett 260:97-100. 1999
    ....
  31. doi request reprint Neuroprotective effect of oxaloacetate in a focal brain ischemic model in the rat
    L Knapp
    Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, H 6726, Hungary
    Cell Mol Neurobiol 35:17-22. 2015
    ....
  32. ncbi request reprint Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, H 6701 Szeged, Hungary
    Microsc Res Tech 53:193-211. 2001
    ..Structural alterations of nitroxidergic axons innervating blood vessels of the dura mater support the idea that nitric oxide (NO) is involved in the induction of headache, a well-known side effect of coronary dilator agents...
  33. doi request reprint Genetic polymorphisms of human β-defensins in patients with ischemic stroke
    Z Tiszlavicz
    Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 126:109-15. 2012
    ....
  34. doi request reprint Where does a migraine attack originate? In the brainstem
    J Tajti
    Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Semmelweis u 6, Szeged 6725, Hungary
    J Neural Transm (Vienna) 119:557-68. 2012
    ..In light of our findings and the literature data, we can assume that migraine is a subcortical disorder of a specific brainstem area...
  35. doi request reprint Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments. Part 2: Interaction of GluR1270-300 with KYNA
    E Csapo
    MTA SZTE Supramolecular and Nanostructured Materials Research Group, University of Szeged, H 6720 Dóm tér 8, Szeged, Hungary Electronic address
    Colloids Surf B Biointerfaces 133:66-72. 2015
    ..The binding abilities of KYNA with all three peptide fragments immobilized on the gold surface were estimated by a molecular docking procedure and the binding free energies of these AMPA receptor subunits with KYNA were determined. ..
  36. doi request reprint Post-ischemic treatment with L-kynurenine sulfate exacerbates neuronal damage after transient middle cerebral artery occlusion
    L Gellert
    Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, H 6726 Szeged, Hungary
    Neuroscience 247:95-101. 2013
    ..This contradictory result indicates that post-ischemic treatment with L-KYNs may be harmful. ..
  37. doi request reprint Acetyl-L-carnitine and oxaloacetate in post-treatment against LTP impairment in a rat ischemia model. An in vitro electrophysiological study
    K Kocsis
    Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, 6726, Szeged, Hungary
    J Neural Transm (Vienna) 122:867-72. 2015
    ..Many previous studies have concluded that ALC can be protective only as pretreatment. The strategy described here reveals that ALC can also be neuroprotective when utilized as post-treatment against ischemia...
  38. ncbi request reprint Depletion of calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat after electrical stimulation of the Gasserian ganglion
    E Knyihar-Csillik
    Department of Clinical Neurology, Albert Szent Gyorgyi University Medical School, Szeged, Hungary
    Exp Brain Res 118:111-4. 1998
    ....
  39. ncbi request reprint Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives
    F Fulop
    Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, H 6720 Szeged, Eotvos u 6, Hungary
    Curr Med Chem 16:4828-42. 2009
    ..The syntheses and transformations of 4-hydroxyquinoline-2-carboxylic acid, kynurenic acid, are reviewed, and special attention is paid to the pharmacological activities and pharmaceutical applications of its derivatives...
  40. ncbi request reprint Spatial contrast sensitivity of migraine patients without aura
    K Benedek
    Department of Neurology, University of Szeged, Hungary
    Cephalalgia 22:142-5. 2002
    ..These findings suggest that the mechanisms responsible for vision at low spatial frequencies are impaired in migraine patients. This might indicate impaired function of the magnocellular pathways in this condition...
  41. ncbi request reprint The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients
    C Rajda
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    Mult Scler 12:265-70. 2006
    ..Further studies are necessary to elucidate the immune reactions affected by the catecholamines in MS and to evaluate the roles of these potential immunotransmitters...
  42. doi request reprint Lesion probability mapping to explain clinical deficits and cognitive performance in multiple sclerosis
    Z T Kincses
    Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Hungary
    Mult Scler 17:681-9. 2011
    ..The correlation between magnetic resonance imaging (MRI) lesion load and disability is only modest, however. Strategic lesion location might at least partially account for this 'clinico-radiologic paradox'...
  43. doi request reprint Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid
    V Hornok
    Supramolecular and Nanostructured Materials Research Group of the Hungarian Academy of Sciences, Faculty of Medicine, Institute of Medical Chemistry, and Nanomedicine Program, University of Szeged, Aradi v t 1, Szeged, 6720, Hungary
    J Neural Transm (Vienna) 119:115-21. 2012
    ..The in vivo experiments showed that the encapsulated kynurenic acid is able to display effects within the central nervous system, even after its peripheral administration...
  44. pmc Kynurenic acid modulates experimentally induced inflammation in the trigeminal ganglion
    A Csati
    Department of Neurology, University of Szeged, Semmelweis 6, H 6725, Szeged, Hungary
    J Headache Pain 16:99. 2015
    ..Kynurenic acid (KYNA) is an endogenous excitatory amino acid receptor blocker, which may have an anti-inflammatory effect. We hypothesize that KYNA may reduce CFA-induced activation within the TG...
  45. ncbi request reprint Familial multiple sclerosis: case study of three affected siblings
    K Bencsik
    Department of Neurology and MTA SZTE Neurology Research Group, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 106:392-5. 2002
    ..In this case, environmental factors seem to play the crucial role. Although the anamnesis as concerns MS proved negative in the other family members examined here, further genetic examination of the sisters is needed...
  46. doi request reprint Synthesis and biological effects of some kynurenic acid analogs
    K Nagy
    Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, H 6726 Szeged, Hungary
    Bioorg Med Chem 19:7590-6. 2011
    ..Behavioral studies with these KYNA amides demonstrated that they do not exert significant nonspecific general side-effects. KYNA-1 may therefore be considered a promising candidate for clinical studies...
  47. pmc alpha-Tocopherol/lipid ratio in blood is decreased in patients with Leber's hereditary optic neuropathy and asymptomatic carriers of the 11778 mtDNA mutation
    P Klivenyi
    Department of Neurology, University of Szeged, Szeged, Semmelweis u 6, H 6725 Hungary
    J Neurol Neurosurg Psychiatry 70:359-62. 2001
    ..Furthermore, it suggests that alpha-tocopherol may be the primary scavenger molecule against the free radicals induced by complex I deficiency...
  48. ncbi request reprint Medical treatment of Parkinson's disease: today and the future
    G Gardian
    Department of Neurology, University of Szeged, Szeged, Hungary
    Int J Clin Pharmacol Ther 48:633-42. 2010
    ..Focus is placed on recent and evolving studies evaluating symptomatic and neuroprotective effects of such medication, and on how such studies may impact the future management of Parkinson's disease...
  49. doi request reprint Prevalence of multiple sclerosis in Csongrád County, Hungary
    V Zsiros
    Department of Neurology, Faculty of General Medicine, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 130:277-82. 2014
    ..There have been no previous data from Hungary, which were assessed with the more up-to-date McDonald criteria and which give comparable standardized data from the region...
  50. ncbi request reprint Huntington's disease: pathomechanism and therapeutic perspectives
    G Gardian
    Department of Neurology, University of Szeged, Szeged, Hungary
    J Neural Transm 111:1485-94. 2004
    ..In the absence of disease-modifying treatment, the other avenue is the neural transplantation.However, recent advances in understanding have furnished new hope that a therapeutic strategy may one day be possible...
  51. ncbi request reprint Polyneuropathy with endoneurial immune complex deposition as the first manifestation of systemic lupus erythematosus
    I Bodi
    Department of Histopathology, Albert Szent Györgi Medical University, Szeged, Hungary
    Acta Neuropathol 96:297-300. 1998
    ..Moreover, the polyneuropathy is an unusual initial symptom of SLE. Immune complex deposition in Schwann cell basement membrane probably plays an important role in the pathomechanism of sensorimotor polyneuropathy in SLE...
  52. doi request reprint Investigation of vitamin D receptor polymorphisms in amyotrophic lateral sclerosis
    N Torok
    Department of Neurology, Faculty of Medicine, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 133:302-8. 2016
    ....
  53. ncbi request reprint Concentration- and time-dependent effect of aminooxyacetic acid on cortical epileptogenicity
    Barbara Barna
    Department of Comparative Physiology, Szeged, Hungary
    Acta Biol Hung 53:245-56. 2002
    ..The gradual GABA accumulation - up to a certain level - at the synapses could also explain the time-dependency of the anticonvulsive effect of AOAA...
  54. doi request reprint Determination of binding capacity and adsorption enthalpy between Human Glutamate Receptor (GluR1) peptide fragments and kynurenic acid by surface plasmon resonance experiments
    E Csapo
    MTA SZTE Supramolecular and Nanostructured Materials Research Group, University of Szeged, H 6720 Dóm tér 8, Szeged, Hungary
    Colloids Surf B Biointerfaces 123:924-9. 2014
    ..In order to determine the binding enthalpy the experiments were carried out between +10°C and +40°C. The heat of adsorption was calculated by using adsorption isotherms at different surface loading of KYNA on the SPR chip...
  55. ncbi request reprint Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs
    J Kaszaki
    Institute of Surgical Research, Szent Györgyi Albert Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    Neurogastroenterol Motil 20:53-62. 2008
    ..In conclusion, KynA antagonizes the obstruction-induced motility responses and XOR activation in the colon. Inhibition of enteric NMDA receptors may provide an option to influence intestinal hypermotility and inflammatory changes...
  56. ncbi request reprint Evidence-based pharmacological treatment of neuropathic pain syndromes
    S Beniczky
    Department of Neurology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    J Neural Transm 112:735-49. 2005
    ..Consideration is given to the mechanisms of action, numbers needed to treat (NNT), the recommended doses and the most frequent side-effects of the drugs for which consistent support has been found for treatment of these pain conditions...
  57. ncbi request reprint Kynurenine metabolism in multiple sclerosis
    Z Hartai
    Department of Neurology, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 112:93-6. 2005
    ..Our data demonstrate the involvement of the kynurenine system in the pathogenesis of MS, which may predict a novel therapeutic intervention...
  58. ncbi request reprint Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model
    E Knyihar-Csillik
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    J Neural Transm (Vienna) 114:417-21. 2007
    ..Systemic kynurenine + probenecid treatment significantly diminishes nitroglycerin-induced increase of c-fos immunoreactivity in the brainstem...
  59. ncbi request reprint Optical platelet aggregometry does not appear useful as a means of assessing the risk of recurrent vascular events in aspirin-treated patients
    L K Sztriha
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    Acta Neurol Scand 117:250-4. 2008
    ..To investigate whether the results of optical platelet aggregometry indicate the risk of recurrent ischemic events...
  60. doi request reprint Cross-cultural adaptation and validation of the 'Multiple Sclerosis Quality of Life Instrument' in Hungarian
    J Füvesi
    Department of Neurology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged
    Mult Scler 14:391-8. 2008
    ..The instrument was able to distinguish between known clinical group differences. The Hungarian version of the MSQOL-54 instrument shows good psychometric properties similar to the original questionnaire...
  61. ncbi request reprint P300 component of visual event-related potentials distinguishes patients with idiopathic parkinson's disease from patients with essential tremor
    A Antal
    Department of Physiology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    J Neural Transm (Vienna) 107:787-97. 2000
    ..The primary visual evoked potential (P100) did not distinguish among the IPD, ET, and control subjects. These results suggest that visual ERPs might provide a useful diagnostic method for differentiating IPD from ET...
  62. ncbi request reprint Platelet arachidonate cascade of migraineurs in the interictal phase
    Z Mezei
    Department of Pathophysiology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Platelets 11:222-5. 2000
    ..These results suggest that the platelet eicosanoids of migraineurs in the headache-free period might promote the development of cellular, vascular and neurological events inducing headache...
  63. doi request reprint Relevance of the genetic polymorphism of NOD1 in Chlamydia pneumoniae seropositive stroke patients
    Z Tiszlavicz
    Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
    Eur J Neurol 16:1224-9. 2009
    ..NOD1 is a potent cytosolic receptor for C. pneumoniae. The aim of this study was to investigate the genetic polymorphism of NOD1 from the aspect of the development of stroke...
  64. ncbi request reprint Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats
    L Vecsei
    Department of Neurology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    J Neural Transm (Vienna) 108:273-8. 2001
    ..Reduced glutathione levels were not altered. The observations suggest an important role for alpha-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals...