Mihaly Boros

Summary

Affiliation: University of Szeged
Country: Hungary

Publications

  1. ncbi request reprint Endothelin-1 induces mucosal mast cell degranulation and tissue injury via ETA receptors
    Mihaly Boros
    University of Szeged, Institute of Surgical Research, P O Box 464, H 6701 Szeged, Hungary
    Clin Sci (Lond) 103:31S-34S. 2002
  2. doi request reprint Limb ischemia-reperfusion differentially affects the periosteal and synovial microcirculation
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    J Surg Res 178:216-22. 2012
  3. doi request reprint N-methyl-D-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats
    Dániel Erces
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, Hungary
    Eur J Pharmacol 691:225-34. 2012
  4. doi request reprint Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion
    Dénes Garab
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    Life Sci 105:14-21. 2014
  5. ncbi request reprint Dynamic in vivo observation of villus microcirculation during small bowel autotransplantation: effects of endothelin-A receptor inhibition
    Antal Wolfárd
    Institute of Surgical Research and Department of Surgery, University of Szeged, Szent Gyorgyi Albert Medical Center, H 6720 Szeged, Hungary
    Transplantation 73:1511-3. 2002
  6. doi request reprint Dietary phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis
    Tamas Kovacs
    Department of Paediatrics, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Shock 38:177-85. 2012
  7. doi request reprint Anti-inflammatory effects of limb ischaemic preconditioning are mediated by sensory nerve activation in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Pécsi utca 6, 6720, Szeged, Hungary
    Naunyn Schmiedebergs Arch Pharmacol 383:179-89. 2011
  8. doi request reprint L-α-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    J Surg Res 189:32-40. 2014
  9. doi request reprint The anti-inflammatory effects of methane
    Mihaly Boros
    Institute of Surgical Research, Department of Biochemistry, University of Szeged, Szeged, Hungary
    Crit Care Med 40:1269-78. 2012
  10. doi request reprint Methane biogenesis during sodium azide-induced chemical hypoxia in rats
    Eszter Tuboly
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Am J Physiol Cell Physiol 304:C207-14. 2013

Collaborators

  • Andrea Szabo
  • Gabor Eros
  • Zsolt Razga
  • Hidechika Okada
  • Gyorgy Lazar
  • Gyongyi Horvath
  • Ricardo Bernhardt
  • Imre Ocsovszki
  • Zsolt Molnar
  • Anton Amann
  • Gabor Szabo
  • Ferenc Fulop
  • Katalin Eder
  • Kornél Vajda
  • Laszlo Vecsei
  • Bela Suki
  • Michael D Menger
  • Tamas Cserni
  • Jozsef Kaszaki
  • Gabriella Varga
  • Petra Hartmann
  • Dániel Erces
  • Miklós Ghyczy
  • Dénes Garab
  • Tünde Tokés
  • Eszter Tuboly
  • Renata Varga
  • Gerda Strifler
  • Agnes Janovszky
  • Istvan Nemeth
  • Noriko Okada
  • Antal Wolfárd
  • Tamas Kovacs
  • András Petri
  • Laszlo Tiszlavicz
  • Miklos Czobel
  • András Mészáros
  • Chun Cao
  • Raimondo M Cervellione
  • Péter Palágyi
  • Hans Peter Wiesmann
  • József Piffkó
  • Masaki Imai
  • Miklós Nógrády
  • Rene H Tolba
  • Imola Plangar
  • Ngwi Fet
  • Ferenc Greksa
  • Adam Balogh
  • Szabolcs Abrahám
  • Sandor Nagy
  • Zsolt Palásthy
  • Edit Szél
  • Szilard Szucs
  • Enikő Kaszonyi
  • Gabor Toth
  • Mitsuru Futakuchi
  • Masumi Suzui
  • Melinda Ugocsai
  • András Tamás Mészáros
  • Alan Okada
  • Norbert Lajkó
  • Aniko Gorbe
  • Daniella Pécz
  • Tamás Fischer-Szatmári
  • George Rakoczy
  • Alan P Dickson
  • Márton Németh
  • Rachel Harwood
  • Tamás Zombori
  • Daniel Hajnal
  • Erzsébet László Kókai
  • Andrea Rostás
  • Csilla Mester
  • Rainer Kubiak
  • Gábor Kocsis Savanya
  • József Hohn
  • Peter Balazs
  • Nikolett Beretka
  • László Major
  • Emília Rita Szabó
  • Kitti Brinyiczki
  • Pramod Kadaba Srinivasan
  • Laszlo Szalay
  • Gabor Fekete
  • Dóra Bodnár
  • Katalin Hideghety
  • Imola Mán
  • János Aurél Simonka
  • Zsolt Balogh

Detail Information

Publications45

  1. ncbi request reprint Endothelin-1 induces mucosal mast cell degranulation and tissue injury via ETA receptors
    Mihaly Boros
    University of Szeged, Institute of Surgical Research, P O Box 464, H 6701 Szeged, Hungary
    Clin Sci (Lond) 103:31S-34S. 2002
    ..We conclude that a cross-talk exists between endothelial cell-derived humoral mediators and the intestinal mast cell system...
  2. doi request reprint Limb ischemia-reperfusion differentially affects the periosteal and synovial microcirculation
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    J Surg Res 178:216-22. 2012
    ..We hypothesized that the functional characteristics of the microvasculature would contribute to the differential defensive potential of the synovial membrane...
  3. doi request reprint N-methyl-D-aspartate receptor antagonist therapy suppresses colon motility and inflammatory activation six days after the onset of experimental colitis in rats
    Dániel Erces
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, Hungary
    Eur J Pharmacol 691:225-34. 2012
    ....
  4. doi request reprint Remote ischemic preconditioning differentially affects NADPH oxidase isoforms during hepatic ischemia-reperfusion
    Dénes Garab
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    Life Sci 105:14-21. 2014
    ....
  5. ncbi request reprint Dynamic in vivo observation of villus microcirculation during small bowel autotransplantation: effects of endothelin-A receptor inhibition
    Antal Wolfárd
    Institute of Surgical Research and Department of Surgery, University of Szeged, Szent Gyorgyi Albert Medical Center, H 6720 Szeged, Hungary
    Transplantation 73:1511-3. 2002
    ....
  6. doi request reprint Dietary phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis
    Tamas Kovacs
    Department of Paediatrics, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Shock 38:177-85. 2012
    ..Dietary PC efficiently decreases the cytokine-mediated progression of inflammatory events and preserves the microvascular structure in the large intestine...
  7. doi request reprint Anti-inflammatory effects of limb ischaemic preconditioning are mediated by sensory nerve activation in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Pécsi utca 6, 6720, Szeged, Hungary
    Naunyn Schmiedebergs Arch Pharmacol 383:179-89. 2011
    ....
  8. doi request reprint L-α-glycerylphosphorylcholine reduces the microcirculatory dysfunction and nicotinamide adenine dinucleotide phosphate-oxidase type 4 induction after partial hepatic ischemia in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    J Surg Res 189:32-40. 2014
    ....
  9. doi request reprint The anti-inflammatory effects of methane
    Mihaly Boros
    Institute of Surgical Research, Department of Biochemistry, University of Szeged, Szeged, Hungary
    Crit Care Med 40:1269-78. 2012
    ..We set out to characterize the effects of exogenous methane administration on the process of inflammatory events arising after reoxygenation in a large animal model of ischemia-reperfusion...
  10. doi request reprint Methane biogenesis during sodium azide-induced chemical hypoxia in rats
    Eszter Tuboly
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Am J Physiol Cell Physiol 304:C207-14. 2013
    ..GPC is protective against the inflammatory consequences of a hypoxic reaction that might involve cellular or mitochondrial methane generation...
  11. doi request reprint Effects of colloid solutions on ischemia-reperfusion-induced periosteal microcirculatory and inflammatory reactions: comparison of dextran, gelatin, and hydroxyethyl starch
    Renata Varga
    Institute of Surgical Research, University of Szeged, Hungary
    Crit Care Med 36:2828-37. 2008
    ..To compare the microhemodynamics and possible anti-inflammatory reactions of colloid resuscitation with 4% gelatin, 6% dextran, or 6% hydroxyethyl starch 130/0.4 solutions...
  12. doi request reprint Ischemic limb preconditioning downregulates systemic inflammatory activation
    Andrea Szabo
    Institute of Surgical Research, University of Szeged, H 6720 Szeged, Pécsi u 6, Hungary
    J Orthop Res 27:897-902. 2009
    ..The results show that limb IPC exerts not only local, but distant antiinflammatory effects through significant modulation of neutrophil recruitment...
  13. ncbi request reprint Intestinal nitric oxide synthase activity changes during experimental colon obstruction
    Zsolt Palásthy
    Department of Surgery, Szent Györgyi Albert Medical and Pharmaceutical Centre, University of Szeged, Hungary
    Scand J Gastroenterol 41:910-8. 2006
    ..The experiments in this study were designed to follow the time course of nitric oxide (NO) synthesis in the large bowel during acute mechanical ileus...
  14. doi request reprint Periosteal microcirculatory action of chronic estrogen supplementation in osteoporotic rats challenged with tourniquet ischemia
    Andrea Szabo
    Institute of Surgical Research, University of Szeged, Hungary
    Life Sci 88:156-62. 2011
    ..Furthermore, the effects of chronic estrogen supplementation on the postischemic local and systemic inflammatory reactions were assessed...
  15. ncbi request reprint Thoracic epidural anesthesia improves the gastric microcirculation during experimental gastric tube formation
    Gyorgy Lazar
    Department of Surgery, and the Institute of Surgical Research, Szent Gyorgyi Albert Medical Center, University of Szeged, PO Box 464, H 6701 Szeged, Hungary
    Surgery 134:799-805. 2003
    ..Our aims were to study the microcirculatory consequences of experimental gastric tube formation and characterize the effects of thoracic epidural anesthesia (TEA) during this condition...
  16. doi request reprint Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat
    Tünde Tokés
    Institute of Surgical Research, Department of Dermatology Allergology, University of Szeged, Szeged, Hungary
    Shock 36:458-65. 2011
    ..Phosphatidylcholine supplementation did not reduce the overall extent of peripheral inflammatory activation, but efficiently counteracted the disturbed hippocampal neurogenesis by lowering circulating TNF-α concentrations...
  17. doi request reprint Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats
    Petra Hartmann
    Institute of Surgical Research, University of Szeged, Szeged, Pécsi u 6, Hungary
    Eur J Pharmacol 622:58-64. 2009
    ..The present study demonstrated the anti-inflammatory effects of PC in experimental arthritis. The therapeutic potential may be linked to the reduction of neutrophil leukocyte-mediated microcirculatory inflammatory reactions...
  18. doi request reprint Oral phosphatidylcholine pretreatment decreases ischemia-reperfusion-induced methane generation and the inflammatory response in the small intestine
    Miklós Ghyczy
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    Shock 30:596-602. 2008
    ..Exhaled methane is linked to abnormal ROS generation; a decreased methane production is associated with significantly reduced inflammatory activation during I/R...
  19. doi request reprint Complement C5A antagonist treatment improves the acute circulatory and inflammatory consequences of experimental cardiac tamponade
    Dániel Erces
    1Institute of Surgical Research, University of Szeged, Szeged, Hungary 2Second Department of Medicine, University of Szeged, Szeged, Hungary 3Department of Traumatology, University of Szeged, Szeged, Hungary 4Department of Immunology, Nagoya City University School of Medicine, Nagoya, Japan 5Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan
    Crit Care Med 41:e344-51. 2013
    ..Our aim was to investigate the consequences of complement C5a antagonist treatment on the early circulatory and inflammatory changes in a clinically relevant large animal model of cardiac tamponade...
  20. doi request reprint Periosteal microvascular reorganization after tibial reaming and intramedullary nailing in rats
    Ferenc Greksa
    Department of Orthopedics, University of Szeged, Szeged, Hungary
    J Orthop Sci 17:477-83. 2012
    ..In these studies, nailing was performed with materials that affect regeneration of the endosteum differently, and the effects on the tibial periosteal microvasculatory organization were examined...
  21. pmc C5a inhibitor protects against ischemia/reperfusion injury in rat small intestine
    Eszter Tuboly
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, 6 Szőkefalvi Nagy Béla Street, Szeged, 6720, Hungary
    Microbiol Immunol 60:35-46. 2016
    ..AcPepA, a C5a inhibitory peptide, blocks the deleterious effects of C5a, indicating it has a therapeutic effect on the inflammatory consequences of experimental AMI. ..
  22. doi request reprint Complement C5a inhibition improves late hemodynamic and inflammatory changes in a rat model of nonocclusive mesenteric ischemia
    Dániel Erces
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    Surgery 159:960-71. 2016
    ....
  23. ncbi request reprint Dalteparin sodium treatment during resuscitation inhibits hemorrhagic shock-induced leukocyte rolling and adhesion in the mesenteric microcirculation
    Zsolt Balogh
    Department of Traumatology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary
    J Trauma 52:1062-9; discussion 1070. 2002
    ..Our aim was to investigate the effects of dalteparin sodium on leukocyte-endothelial cell interactions when LMWH treatment was initiated before HS or during resuscitation...
  24. doi request reprint Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats
    Agnes Janovszky
    Department of Oral and Maxillofacial Surgery, University of Szeged, Szeged, Hungary
    Clin Oral Investig 19:1279-88. 2015
    ....
  25. doi request reprint Protective effects of L-alpha-glycerylphosphorylcholine on ischaemia-reperfusion-induced inflammatory reactions
    Tünde Tokés
    Institute of Surgical Research, University of Szeged, Pécsi u 6, Szeged, 6720, Hungary
    Eur J Nutr 54:109-18. 2015
    ..We investigated the effects of L-alpha-glycerylphosphorylcholine (GPC), a deacylated PC derivative, in a rodent model of small intestinal ischaemia-reperfusion (IR) injury...
  26. doi request reprint Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane. Synthesis and biological evaluation of a new anti-inflammatory compound
    Gabriella Varga
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, H 6720, Szeged, Szőkefalvi Nagy Béla u 6, Hungary Electronic address
    Eur J Pharmacol 781:181-9. 2016
    ..ASA-Tris conjugation is an effective approach through which the GI side-effects of ASA are controlled by decreasing the cytokine-mediated progression of pro-inflammatory events. ..
  27. pmc Inhaled Methane Limits the Mitochondrial Electron Transport Chain Dysfunction during Experimental Liver Ischemia-Reperfusion Injury
    Gerda Strifler
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    PLoS ONE 11:e0146363. 2016
    ..Methane also has a demonstrated anti-inflammatory potential. We hypothesized that enriched methane inhalation can influence the respiratory activity of the liver mitochondria after an ischemia-reperfusion (IR) challenge...
  28. doi request reprint A novel method for in vivo visualization of the microcirculation of the mandibular periosteum in rats
    Renata Varga
    Department of Oral and Maxillofacial Surgery, University of Szeged, Szeged, Hungary
    Microcirculation 21:524-31. 2014
    ..This study was conducted to develop a microsurgical procedure which provides access to the mandibular periosteum in rats...
  29. doi request reprint Nonspecific inhibition of nitric oxide synthesis evokes endothelin-dependent increases in myocardial contractility
    Miklos Czobel
    Institute of Surgical Research, University of Szeged, Hungary
    Nitric Oxide 21:201-9. 2009
    ..These results demonstrate that a diminished NO synthesis leads to a preponderant ET-1 effect, which increases myocardial contractility through an ET-A receptor-dependent mechanism...
  30. pmc Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux
    Gabor Eros
    Institute of Surgical Research, University of Szeged, P O Box 427, H 6701 Szeged, Hungary
    World J Gastroenterol 12:271-9. 2006
    ..To characterize the consequences of short-term exposure to luminal bile on mucosal mast cell reactions in a canine model, and to determine the effects of systemic phosphatidylcholine pretreatment in this condition...
  31. doi request reprint Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice
    Szabolcs Abrahám
    Department of Surgery, University of Szeged, Szeged, Hungary
    Shock 30:69-74. 2008
    ..Therapeutic strategies aimed at KC blockade can potentially reduce the risk of inflammatory complications in cholestasis...
  32. ncbi request reprint Flow motion in the intestinal villi during hemorrhagic shock: a new method to characterize the microcirculatory changes
    Andrea Szabo
    Institute of Surgical Research, University of Szeged, H 6720 Szeged, Hungary
    Shock 21:320-8. 2004
    ..The probabilistic estimation of A-RBCV provides a quantitative basis for comparison of the effectiveness of different resuscitation or vasoactive strategies...
  33. ncbi request reprint Experience with different methods of treatment of nonparasitic liver cysts
    András Petri
    Department of Surgery, Faculty of Medicine, University of Szeged, Pécsi u 4, 6720 Szeged, Hungary
    Langenbecks Arch Surg 387:229-33. 2002
    ..In a search for the optimal management of nonparasitic liver cysts, a study was made of the effectiveness of different methods...
  34. pmc Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis
    Gabor Eros
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    Arthritis Res Ther 11:R43. 2009
    ..We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis)...
  35. ncbi request reprint [Surgery of benign liver tumors: indications for treatment. Personal experience and review of the literature]
    András Petri
    Sebészeti Klinika, Szegedi Egyetem, Általános Orvostudományi Kar, Szeged 6720, Hungary
    Magy Onkol 47:391-5. 2003
    ..Our aim is to give an audit of our experience over the past two decades in the form of a retrospective study...
  36. ncbi request reprint [Effects of phosphatidylcholine pretreatment during acute experimental biliary reflux]
    Gabor Eros
    Szegedi Tudomanyegyetem, Sebészeti Mutéttani Intézet igazgat6 Prof Dr Boros Mihaly
    Magy Seb 58:406-14. 2005
    ..In contrast, PC pretreatment reversed the bile-induced ATP depletion, the inducible nitric oxide synthase and myeloperoxidase activity increases, and the mast cell degranulation...
  37. pmc Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine
    Gerda Strifler
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    PLoS ONE 11:e0166682. 2016
    ..We hypothesized that L-alpha-glycerylphosphorylcholine (GPC), a deacylatedphosphatidylcholine derivative, can influence the mitochondrial respiratory activity and in this way, may exert tissue protective effects...
  38. doi request reprint Radio-neuroprotective effect of L-alpha-glycerylphosphorylcholine (GPC) in an experimental rat model
    Imola Plangar
    Department of Neurology, Albert Szent Gyorgyi Clinical Center, University of Szeged, Semmelweis str 6, Szeged, H 6725, Hungary
    J Neurooncol 119:253-61. 2014
    ..Our study warrants further research on the protective or mitigating effects of GPC on radiation injuries...
  39. doi request reprint Kynurenines and intestinal neurotransmission: the role of N-methyl-D-aspartate receptors
    Jozsef Kaszaki
    Institute of Surgical Research, Albert Szent Györgyi Medical and Pharmaceutical Centre, University of Szeged, P O Box 464, Szeged, 6701, Hungary
    J Neural Transm (Vienna) 119:211-23. 2012
    ..Inhibition of the enteric NMDA receptors by kynurenic acid or its analogues may provide a novel option via which to influence intestinal hypermotility and inflammatory processes simultaneously...
  40. doi request reprint The periosteal microcirculation in health and disease: An update on clinical significance
    Andrea Szabo
    Institute of Surgical Research, University of Szeged, Szeged, Hungary Electronic address
    Microvasc Res 110:5-13. 2016
    ....
  41. doi request reprint New alternative Mitrofanoff channel based on spiral intestinal lengthening and tailoring
    Raimondo M Cervellione
    Department of Paediatric Urology, Royal Manchester Children s Hospital, UK Institute for Surgical Research, University of Szeged, Hungary
    J Pediatr Urol 11:131.e1-5. 2015
    ..We tested the concept of spiral intestinal lengthening and tailoring (SILT), we developed originally for short bowel syndrome, to create a long and straight alternative Mitrofanoff channel (Figure)...
  42. pmc Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock
    Péter Palágyi
    Department of Anesthesiology and Intensive Therapy, University of Szeged, 6 Semmelweis Street, Szeged 6725, Hungary
    Biomed Res Int 2015:847152. 2015
    ..50, p < 0.0001), and central venous-to-arterial PCO2 difference (r = 0.62, p < 0.0001). This new sublingual tonometer may be an appropriate tool for the indirect evaluation of circulatory changes in shock...
  43. ncbi request reprint Microvascular and epithelial permeability measurements in laboratory animals
    Andrea Szabo
    Institute of Surgical Research, University of Szeged, Szeged, Hungary
    Microsurgery 26:50-3. 2006
    ..Techniques that determine the inward and outward direction of mucosal permeability changes (including radioenzymatic, fluorimetric, and intravital microscopy methods) are also discussed...
  44. doi request reprint The role of methane in mammalian physiology-is it a gasotransmitter?
    Mihaly Boros
    Institute of Surgical Research, Faculty of Medicine, University of Szeged, Szőkefalvi Nagy B u 6, H 6720 Szeged, Hungary
    J Breath Res 9:014001. 2015
    ..In this respect, the available information suggests that hypoxia-induced methane generation may be a necessary phenomenon of aerobic life, and perhaps a surviving evolutionary trait in the eukaryote cell. ..
  45. ncbi request reprint Endothelin-a receptor antagonist treatment improves the periosteal microcirculation after hindlimb ischemia and reperfusion in the rat
    Antal Wolfárd
    Department of Surgery, University of Szeged, Szent Györgyi Albert Medical and Pharmeceutical Center, Szeged, Hungary
    Microcirculation 9:471-6. 2002
    ....