Katalin Monostory

Summary

Affiliation: Chemical Research Center
Country: Hungary

Publications

  1. ncbi request reprint Reduction of toxic metabolite formation of acetaminophen
    Eszter Hazai
    Chemical Research Center, Hungarian Academy of Sciences, H 1525 Budapest, Hungary
    Biochem Biophys Res Commun 291:1089-94. 2002
  2. ncbi request reprint Biochemical background of toxic interaction between tiamulin and monensin
    Gyula Szucs
    Department of Toxicology, EGIS Pharmaceuticals Ltd, Bokenyfoldi ut 116, H 1165 Budapest, Hungary
    Chem Biol Interact 147:151-61. 2004
  3. ncbi request reprint Biotransformation of deramciclane in primary hepatocytes of rat, mouse, rabbit, dog, and human
    Katalin Monostory
    Chemiacl Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 33:1708-16. 2005
  4. ncbi request reprint Steroid regulation of drug-metabolizing cytochromes P450
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Curr Drug Metab 12:154-72. 2011
  5. doi request reprint Hormonal regulation of CYP1A expression
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Rev 41:547-72. 2009
  6. ncbi request reprint Role of CYP2E1 in deramciclane metabolism
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Hungary
    Drug Metab Dispos 33:1717-22. 2005
  7. ncbi request reprint The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    FEBS Lett 579:229-35. 2005
  8. ncbi request reprint Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
    Katalin Monostory
    Department of Biochemical Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, Pusztaszeri ut 59 67, H 1025 Budapest, Hungary
    Chem Biol Interact 147:331-40. 2004
  9. doi request reprint Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 37:375-85. 2009
  10. ncbi request reprint GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer
    Viola Tamasi
    P O Box 17, Budapest, H 1525 Hungary
    Drug Metab Dispos 31:1310-4. 2003

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Reduction of toxic metabolite formation of acetaminophen
    Eszter Hazai
    Chemical Research Center, Hungarian Academy of Sciences, H 1525 Budapest, Hungary
    Biochem Biophys Res Commun 291:1089-94. 2002
    ..Although cimetidin is used in the therapy of acetaminophen overdose as an inhibitor of cytochrome P450, it is not able to reduce NAPQI formation...
  2. ncbi request reprint Biochemical background of toxic interaction between tiamulin and monensin
    Gyula Szucs
    Department of Toxicology, EGIS Pharmaceuticals Ltd, Bokenyfoldi ut 116, H 1165 Budapest, Hungary
    Chem Biol Interact 147:151-61. 2004
    ..The direct effect of tiamulin as an inhibitor might play a more important role in toxicity than its putative effect as a chemical inducer of CYP3A enzymes...
  3. ncbi request reprint Biotransformation of deramciclane in primary hepatocytes of rat, mouse, rabbit, dog, and human
    Katalin Monostory
    Chemiacl Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 33:1708-16. 2005
    ..With careful approach, the rat model may be considered to be predictive for human metabolism of deramciclane...
  4. ncbi request reprint Steroid regulation of drug-metabolizing cytochromes P450
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Curr Drug Metab 12:154-72. 2011
    ..The purpose of this review is to highlight the interplay between drug-metabolizing P450s and steroid hormones as well as the interactions of xenosensor with steroid signaling pathways...
  5. doi request reprint Hormonal regulation of CYP1A expression
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Rev 41:547-72. 2009
    ..e., glucocorticoids, estrogens, progesterone, androgens, insulin, and glucagon) and hormone receptors as well as other essential factors (e.g., vitamin D, retinoids) in the modulation of CYP1A expression...
  6. ncbi request reprint Role of CYP2E1 in deramciclane metabolism
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Hungary
    Drug Metab Dispos 33:1717-22. 2005
    ..However, during the biotransformation, one or more metabolites must have been formed which were potent inhibitors of CYP2E1...
  7. ncbi request reprint The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    FEBS Lett 579:229-35. 2005
    ..Dexamethasone potentiates the induction of CYP1A1 about 3- to 4-fold in rat cells. In human hepatocytes, it reduces CYP1A1 induction by 50-60% at enzyme protein level, while it does not have an effect on CYP1A1 mRNA amount...
  8. ncbi request reprint Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
    Katalin Monostory
    Department of Biochemical Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, Pusztaszeri ut 59 67, H 1025 Budapest, Hungary
    Chem Biol Interact 147:331-40. 2004
    ..The CNS-active drugs investigated were found to be weak inhibitors of CYP2A6, CYP2C9, CYP2C19, CYP2E1 and CYP3A4. Diclofenac efficiently inhibited CYP2C9 and to a less extent CYP3A4 enzyme...
  9. doi request reprint Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 37:375-85. 2009
    ....
  10. ncbi request reprint GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer
    Viola Tamasi
    P O Box 17, Budapest, H 1525 Hungary
    Drug Metab Dispos 31:1310-4. 2003
    ..Although the imidazole part of GYKI-47261 can explain its CYP2E1-inducing capacity, the other part of the molecule must contribute to the final inducing potency...
  11. pmc Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor
    Krisztina Kohalmy
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 35:1495-501. 2007
    ..The effect of DHEA on the activation of the xenosensors PPAR alpha, PXR, and CAR, and the consequent potential for adverse drug/toxicant interactions should be considered in humans treated with this nutriceutical agent...
  12. doi request reprint Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes
    Katalin Jemnitz
    Department of Biochemical Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    Toxicol In Vitro 22:961-7. 2008
    ..We conclude that the toxicity induced by APAP overdose highly depends on the animal model applied...
  13. ncbi request reprint In vitro induction of cytochrome P450 enzymes in hepatocytes isolated from the regenerating rat liver
    Viola Tamasi
    Department of Biochemical Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, H 1525 Budapest, Hungary
    Pol J Pharmacol 56:113-9. 2004
    ..5-fold) at each regenerating time as it was detected in the hepatocytes of sham-operated animals. In conclusion, the inducibility of the cells was retained at each regenerating time, but the degree of induction showed some differences...
  14. ncbi request reprint Limited applicability of 7-methoxy-4-trifluoromethylcoumarin as a CYP2C9-selective substrate
    Pálma Porrogi
    Department of Biochemical Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri 59 67, H 1025 Budapest, Hungary
    Pharmacol Rep 60:972-9. 2008
    ..Moreover, MFC is a more potent fluorogenic substrate for CYP2B6 and CYP2E1 than for CYP2C9 in microsomes containing cDNA-expressed P450s...
  15. pmc Personalizing initial calcineurin inhibitor dosing by adjusting to donor CYP3A-status in liver transplant patients
    Katalin Monostory
    Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok 2, H 1117, Budapest
    Br J Clin Pharmacol 80:1429-37. 2015
    ..The present study evaluated the association between CYP3A4 expression combined with CYP3A5 genotype of donor livers and recipients' CNI therapy after transplantation...
  16. ncbi request reprint A study on CYP1A inhibitory action of E-2-(4'-methoxybenzylidene)-1-benzosuberone and some related chalcones and cyclic chalcone analogues
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, H 1525, P O Box 17, Budapest, Hungary
    Toxicology 184:203-10. 2003
    ....
  17. doi request reprint Estimation of drug-metabolizing capacity by cytochrome P450 genotyping and expression
    Manna Temesvári
    Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
    J Pharmacol Exp Ther 341:294-305. 2012
    ..Patients' genetic and nongenetic variations in P450 status can guide the appropriate selection of drugs and the optimal dose, minimizing the risk of harmful side effects and ensuring a successful outcome of drug therapy...
  18. pmc Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype
    Katalin Toth
    Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Ms Tóth, Mr Sirok, Mr Kiss, Ms Háfra, Mr Déri, and Dr Monostory Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary Drs Csukly, Menus, and Bitter Toxi Coop Toxicological Research Center, Budapest, Hungary Mr Sirok University of Ljubljana, Ljubljana, Slovenia Dr Belic K T and G C contributed equally to the content of the work
    Int J Neuropsychopharmacol . 2016
    ..Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors...
  19. ncbi request reprint [The role of drug metabolizing enzymes in the effect and side-effect of the drugs]
    Laszlo Vereczkey
    Magyar Tudományos Akadémia, Kémiai Kutatóközpont, Farmakobiokémiai Osztály, Budapest
    Orv Hetil 146:947-52. 2005
    ..enzymes (glucuronyl-, sulfate-, glutathione-, acetyl-, methyltranferases), their polymorphism, inductive and inhibition properties. The possible drug-drug interactions are discussed in detail...
  20. doi request reprint Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s
    Viola Tamasi
    Department of Genetics, Cell and Immunobiology, Faculty of Medicine, Semmelweis University, PO Box 370, Budapest, 1445, Hungary
    Cell Mol Life Sci 68:1131-46. 2011
    ....
  21. doi request reprint High-resolution melting curve analysis to establish CYP2C19∗2 single nucleotide polymorphism: Comparison with hydrolysis SNP analysis
    Manna Temesvári
    Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri 59 67, H 1025 Budapest, Hungary
    Mol Cell Probes 25:130-3. 2011
    ..However, the HRM analysis was found to be more efficient, rapid, user- and cost-friendly method...
  22. doi request reprint Identification of 8-Hydroxyquinoline Derivatives Active Against Somatic V658F Mutant JAK1-Dependent Cells
    Robert Kiss
    MTA TTK NAP B Drug Discovery Research Group Neurodegenerative Diseases, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary
    Arch Pharm (Weinheim) 349:925-933. 2016
    ..The compounds did not only display favorable potencies in a JAK1V658F -driven cell-based assay but were also shown to be non-cytotoxic on rat liver cells...
  23. doi request reprint Clinical significance of CYP2C9-status guided valproic acid therapy in children
    Tamás Bűdi
    2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary
    Epilepsia 56:849-55. 2015
    ..Thus, patients' CYP2C9-status may account for the predisposition to adverse reactions, and testing CYP2C9-status may contribute to the improvement and rationalization of VPA therapy in children...
  24. pmc ABCC6 is a basolateral plasma membrane protein
    Viola Pomozi
    Institute of Enzymology, RCNS, Hungarian Academy of Sciences, Budapest, Hungary
    Circ Res 112:e148-51. 2013
    ..To elucidate the role of ABCC6 in cellular physiology and disease, it is crucial to establish the exact subcellular localization of the native ABCC6 protein...
  25. doi request reprint Experimental results and clinical impact of using autologous rectus fascia sheath for vascular replacement
    László Kóbori
    Transplantation and Surgical Department, Semmelweis University, H 1082 Budapest, Baross u 23 25, Hungary
    Acta Vet Hung 56:411-20. 2008
    ..It is easy to handle and the concept of beneficial presence of the anti-clot mesothelium until endothelialisation seems to work. The first clinical use was already reported by our group with more than 2 years survival...
  26. pmc Drug-induced liver graft toxicity caused by cytochrome P450 poor metabolism
    László Kóbori
    Transplantation and Surgical Clinic, Semmelweis University, Baross 23 25, H 1082 Budapest, Hungary
    Br J Clin Pharmacol 65:428-36. 2008
    ..Rationalization of the medication resulted in the recovery of both the grafts and the recipients within 1 week...
  27. ncbi request reprint Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice
    Viola Tamasi
    Department of Genetics, Cell and Immunobiology, Semmelweis University 1089, Nagyvarad ter 4, Budapest 1089, Hungary
    Cell Biol Int 27:1011-5. 2003
    ..The results indicate a significant elevation of CYP2E1 and CYP3A activities, however, no change in CYP1A and CYP2B activities was seen in HDC targeted mice compared to wild type controls with identical genetic backgrounds...
  28. doi request reprint [Crosstalk between cholesterol homeostasis and drug metabolism]
    Krisztina Kohalmy
    Magyar Tudományos Akadémia, Kémiai Kutatóközpont Farmakobiokémiai Osztály Budapest
    Orv Hetil 149:1283-9. 2008
    ..Better understanding of the crosstalk between cholesterol homeostasis and drug metabolism is essential for developing an adequate strategy in therapy and in novel drug development...