Paulo M Hoff

Summary

Publications

  1. pmc Should extragonadal germ cell tumors be included in studies of families with testicular germ cell tumors?
    Rodrigo Santa Cruz Guindalini
    Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Av, Dr, Arnaldo 251, São Paulo ZIP 01246 000, Brazil
    Hered Cancer Clin Pract 11:1. 2013
  2. doi request reprint Role of angiogenesis in the pathogenesis of cancer
    Paulo M Hoff
    Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Cancer Treat Rev 38:825-33. 2012
  3. doi request reprint Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II)
    Paulo M Hoff
    FACP, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo 251, Sao Paulo, Brazil
    J Clin Oncol 30:3596-603. 2012
  4. doi request reprint A multicenter, multinational analysis of mitomycin C in refractory metastatic colorectal cancer
    Renata Ferrarotto
    Hospital Sirio Libanes, Clinical Oncology Department, Rua D Adma Jafet 91, Sao Paulo, SP 01308 050, Brazil
    Eur J Cancer 48:820-6. 2012
  5. doi request reprint Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone
    Renata Ferrarotto
    Hospital Sirio Libanes, Sao Paulo, Brazil
    Clin Colorectal Cancer 10:178-82. 2011
  6. doi request reprint Integration of anti-vascular endothelial growth factor therapies with cytotoxic chemotherapy in the treatment of colorectal cancer
    Suilane Coelho Ribeiro Oliveira
    Oncology Center, Hospital Sirio Libanes, Sao Paulo, Brazil
    Cancer J 16:220-5. 2010
  7. doi request reprint The effects of palliative chemotherapy in metastatic colorectal cancer patients with an ECOG performance status of 3 and 4
    Marcela Crosara Teixeira
    Disciplina de Radiologia e Oncologia, Faculdade de Medicina da Universidade de Sao Paulo, Instituto do Câncer do Estado de São Paulo, Sao Paulo, Brazil Centro de Oncologia, Hospital Sirio Libanes, Sao Paulo, Brazil Electronic address
    Clin Colorectal Cancer 14:52-7. 2015
  8. doi request reprint Percutaneous transhepatic biliary drainage in patients with advanced solid malignancies: prognostic factors and clinical outcomes
    Marcela Crosara Teixeira
    Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    J Gastrointest Cancer 44:398-403. 2013
  9. ncbi request reprint Bevacizumab in older patients and patients with poorer performance status
    Paulo M Hoff
    Centro de Oncologia, Hospital Sirio Libanes, Sao Paulo, Brazil
    Semin Oncol 33:S19-25. 2006
  10. doi request reprint Cediranib: a VEGF receptor tyrosine kinase inhibitor
    Marina Sahade
    Discipline of Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo and Hospital Sírio Libanês, Avenida Dr Arnaldo, 251, CEP 01246 000, Sao Paulo, Brazil
    Future Oncol 8:775-81. 2012

Collaborators

  • Rachel P Riechelmann
  • Renata Ferrarotto
  • Ulysses Ribeiro
  • Scott Kopetz
  • Airton Mota Moreira
  • Eduardo Akaishi
  • Ana O Hoff
  • Monika K Krzyzanowska
  • Marina Sahade
  • Ying Cheng
  • Everardo D Saad
  • Jin Li
  • Suilane Oliveira
  • Jane D Robertson
  • Ricardo Caponero
  • Michael J Overman
  • Aimery de Gramont
  • Silvano Wendel
  • Tae Won Kim
  • Christophe Tournigand
  • Marcela Crosara Teixeira
  • Jorge Sabbaga
  • Maria Ignez Braghiroli
  • Daniela Freitas
  • Gustavo Dos Santos Fernandes
  • Sergio Carlos Nahas
  • Luís Felipe Campesato
  • Guilherme H Garcia
  • Ivan Cecconello
  • Vanessa da Costa Miranda
  • Daniel Fernandes Marques
  • Maristela P Freire
  • Giovanni M Bariani
  • Rodrigo Santa Cruz Guindalini
  • Edson Abdala
  • Ligia C Pierrotti
  • João L Miraglia
  • Rita Fontão-Wendel
  • Fernanda Cunha Capareli
  • Guilherme Cutait Cotti
  • Carlos Frederico Sparapan Marques
  • Andre Tsin Chih Chen
  • Caio Sergio Rizkallah Nahas
  • Antonio Rocco Imperiale
  • Pedro Alexandre F Galante
  • Alexandra Khichfy Alex
  • Anezka Celis Ferrari
  • Anamaria A Camargo
  • Romualdo Barroso-Sousa
  • Bruna R Correa
  • Michel Fabiano Silva Alves
  • Leandro Jimenez
  • Luiz F L Reis
  • Luiza Dib Batista Bugiato Faria
  • Sheila Aparecida Coelho Siqueira
  • Maria P E Diz
  • Fernanda Capareli
  • Karim Y Ibrahim
  • Juliana Pereira
  • Pedro H X N Araújo
  • Bernardo Garicochea
  • Antonio E Zerati
  • Laiane P G Duarte
  • Francisco Cesar Carnevale
  • J M Motta-Leal-Filho
  • Edite Paulo de Oliveira
  • Antonia A L Souza
  • Anezka C R de Celis Ferrari
  • Marina Cavalcanto Moroja Silvino
  • Milena Perez Mak
  • Jorge Kalil
  • José da S Guedes
  • Ana T R Viso
  • Maria Regina A Cardoso
  • Carla G S Saad
  • Alexander R Precioso
  • Ieda M M Laurindo
  • André M Luiz
  • Angela Tayra
  • Nadia E Aikawa
  • Maria do Carmo S T Timenetsky
  • Expedito Luna
  • Danise S Oliveira
  • Isaias Raw
  • Luiz S Azevedo
  • Lúcia Maria A Campos
  • Adriana Balthazar
  • Márcia Pierroti
  • Maristela Tsujita
  • Arlette Lazar

Detail Information

Publications27

  1. pmc Should extragonadal germ cell tumors be included in studies of families with testicular germ cell tumors?
    Rodrigo Santa Cruz Guindalini
    Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Av, Dr, Arnaldo 251, São Paulo ZIP 01246 000, Brazil
    Hered Cancer Clin Pract 11:1. 2013
    ..In twins of men with TGCT the relative risk of testicular cancer is 37.5 (12.3-115.6). Nevertheless, information about the occurrence of TGCT in relatives of patients with extragonadal germ cell tumor is limited...
  2. doi request reprint Role of angiogenesis in the pathogenesis of cancer
    Paulo M Hoff
    Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Cancer Treat Rev 38:825-33. 2012
    ..The diversity of pathways and molecules involved in the regulation of angiogenesis in both normal development and cancer will likely offer many more prospects for successful therapeutic intervention...
  3. doi request reprint Cediranib plus FOLFOX/CAPOX versus placebo plus FOLFOX/CAPOX in patients with previously untreated metastatic colorectal cancer: a randomized, double-blind, phase III study (HORIZON II)
    Paulo M Hoff
    FACP, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo 251, Sao Paulo, Brazil
    J Clin Oncol 30:3596-603. 2012
    ....
  4. doi request reprint A multicenter, multinational analysis of mitomycin C in refractory metastatic colorectal cancer
    Renata Ferrarotto
    Hospital Sirio Libanes, Clinical Oncology Department, Rua D Adma Jafet 91, Sao Paulo, SP 01308 050, Brazil
    Eur J Cancer 48:820-6. 2012
    ..Mitomycin C (MMC) has been widely used in this context, and despite good tolerability, there are doubts regarding its true benefit...
  5. doi request reprint Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone
    Renata Ferrarotto
    Hospital Sirio Libanes, Sao Paulo, Brazil
    Clin Colorectal Cancer 10:178-82. 2011
    ..Despite the recognition of the potential for long-term survival after surgical resection of metastatic disease, long-term survival data to determine the potential curative role of chemotherapy alone is lacking...
  6. doi request reprint Integration of anti-vascular endothelial growth factor therapies with cytotoxic chemotherapy in the treatment of colorectal cancer
    Suilane Coelho Ribeiro Oliveira
    Oncology Center, Hospital Sirio Libanes, Sao Paulo, Brazil
    Cancer J 16:220-5. 2010
    ....
  7. doi request reprint The effects of palliative chemotherapy in metastatic colorectal cancer patients with an ECOG performance status of 3 and 4
    Marcela Crosara Teixeira
    Disciplina de Radiologia e Oncologia, Faculdade de Medicina da Universidade de Sao Paulo, Instituto do Câncer do Estado de São Paulo, Sao Paulo, Brazil Centro de Oncologia, Hospital Sirio Libanes, Sao Paulo, Brazil Electronic address
    Clin Colorectal Cancer 14:52-7. 2015
    ..Our objectives were to compare the survival and safety of ECOG PS 3/4 patients who were administered chemotherapy with those who received BSC only...
  8. doi request reprint Percutaneous transhepatic biliary drainage in patients with advanced solid malignancies: prognostic factors and clinical outcomes
    Marcela Crosara Teixeira
    Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    J Gastrointest Cancer 44:398-403. 2013
    ..Obstructive jaundice (OJ) is a cumbersome complication in late-stage malignancies, and percutaneous transhepatic biliary drainage (PTBD) is often used to relieve symptoms and allow chemotherapy (CT)...
  9. ncbi request reprint Bevacizumab in older patients and patients with poorer performance status
    Paulo M Hoff
    Centro de Oncologia, Hospital Sirio Libanes, Sao Paulo, Brazil
    Semin Oncol 33:S19-25. 2006
    ..Clinicians should weigh the potential survival benefits against the risk of adverse events when choosing therapy for older patients with metastatic colorectal cancer and for those with poorer performance status...
  10. doi request reprint Cediranib: a VEGF receptor tyrosine kinase inhibitor
    Marina Sahade
    Discipline of Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo and Hospital Sírio Libanês, Avenida Dr Arnaldo, 251, CEP 01246 000, Sao Paulo, Brazil
    Future Oncol 8:775-81. 2012
    ..Clinical trials are still evaluating the role of cediranib in combination chemotherapy with cytotoxic agents...
  11. pmc Primary prevention of colorectal cancer: myth or reality?
    Marcela Crosara Teixeira
    Marcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff, Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital Sirio Libanes, Sao Paulo, SP CEP 01246 000, Brazil
    World J Gastroenterol 20:15060-9. 2014
    ..Ultimately, primary prevention strategies focusing on modifying environmental, lifestyle risk factors, and chemopreventive drugs are options that have already been tested, and may impact on colon cancer incidence. ..
  12. doi request reprint ERCC1 in advanced biliary tract cancer patients treated with chemotherapy: prognostic and predictive roles
    Vanessa da Costa Miranda
    Disciplina de Radiologia e Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Avenida Dr Arnaldo 251, 12o andar, Sao Paulo, SP, 01246 000, Brazil
    J Gastrointest Cancer 45:80-6. 2014
    ..Definitive prognostic and predictive factors in advanced biliary cancer remain unknown...
  13. doi request reprint Medical management of pancreatic adenocarcinoma
    Daniela Freitas
    Oncology Center, Hospital Sirio Libanes, Sao Paulo, Brazil
    Pancreatology 9:223-32. 2009
    ....
  14. doi request reprint Antiangiogenic drugs for colorectal cancer: exploring new possibilities
    Renata Ferrarotto
    Oncology Department, Hospital Sirio Libanes, Faculdade de Medicina da Universisade de Sao Paulo, Sao Paulo, Brazil
    Clin Colorectal Cancer 12:1-7. 2013
    ..The need to identify surrogate biomarkers towards a more personalized approach in oncology is emphasized as this is becoming increasingly important in drug development...
  15. doi request reprint Literature review and practical aspects on the management of oxaliplatin-associated toxicity
    Paulo M Hoff
    Hospital Sirio Libanes, Sao Paulo, Brazil
    Clin Colorectal Cancer 11:93-100. 2012
    ..Other adverse events, such as gastrointestinal and liver toxicity, thrombocytopenia, and hypersensitivity reactions, are also reviewed in this article, and suggestions are made for their management...
  16. doi request reprint Immune-mediated pancytopenia induced by oxaliplatin: a case report
    Rita Fontão-Wendel
    Blood Bank and Oncology Center, Hospital Sirio Libanes, Sao Paulo, SP, Brazil
    Transfusion 50:1453-9. 2010
    ..Drug-induced immune pancytopenia is considered an uncommon disorder...
  17. ncbi request reprint Perioperative treatment of gastrointestinal stromal tumors
    Gustavo Dos Santos Fernandes
    Centro de Oncologia Hospital Sírio Libanês, Sao Paulo, Brazil
    Oncology (Williston Park) 23:54-61. 2009
    ..Neoadjuvant treatment often decreases the tumor size, allowing a less morbid surgery, appears to be safe and beneficial for some patients, and therefore deserves further study...
  18. doi request reprint Bevacizumab: overview of the literature
    Maria Ignez Braghiroli
    Department of Radiology and Medical Oncology, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Expert Rev Anticancer Ther 12:567-80. 2012
    ..In this paper we review the basic science behind this molecule's development, as well the major clinical trials in which bevacizumab was involved in oncology...
  19. doi request reprint Pathologic Complete Response in Rectal Cancer: Can We Detect It? Lessons Learned From a Proposed Randomized Trial of Watch-and-Wait Treatment of Rectal Cancer
    Sergio Carlos Nahas
    Hospital das Clinicas da Faculdade de Medicina, Instituto do Câncer do Estado de São Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil
    Dis Colon Rectum 59:255-63. 2016
    ..A watch-and-wait tactic has been proposed for patients with clinical complete response...
  20. pmc Immunogenicity and reactogenicity of 2009 influenza A (H1N1) inactivated monovalent non-adjuvanted vaccine in elderly and immunocompromised patients
    João L Miraglia
    Butantan Institute Clinical Trials Division, Sao Paulo, Brazil
    PLoS ONE 6:e27214. 2011
    ..Immunosuppressed individuals present serious morbidity and mortality from influenza, therefore it is important to understand the safety and immunogenicity of influenza vaccination among them...
  21. doi request reprint Squamous-cell carcinoma of the anal canal: room for improvement with targeted therapy
    Suilane Oliveira
    Instituto do Câncer do Estado de São Paulo, 251 avenida Doutor Arnaldo, 01246 000 Sao Paulo, Brazil
    Clin Res Hepatol Gastroenterol 36:209-13. 2012
    ..New treatment strategies, including molecular target therapies, are warranted in order to improve disease control. Despite the rarity of this disease, it is urgent to improve its treatment by introducing targeted therapy in the arena...
  22. pmc Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice
    Luís Felipe Campesato
    Instituto Ludwig de Pesquisa sobre o Câncer, Sao Paulo, Brazil
    Oncotarget 6:34221-7. 2015
    ..In summary, our data reveals that CGPs can be used to estimate mutational load and to predict clinical benefit to PD-1 blockade, with similar accuracy to that reported using WES...
  23. pmc Adherence to colonoscopy recommendations for first-degree relatives of young patients diagnosed with colorectal cancer
    Guilherme H Garcia
    Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 70:696-9. 2015
    ..A colonoscopy is one of the most commonly recommended exams due to its specificity and the possibility to resect pre-malignant lesions. Nevertheless, the rate of physician adherence to this recommendation is unknown...
  24. doi request reprint Infection related to implantable central venous access devices in cancer patients: epidemiology and risk factors
    Maristela P Freire
    Infection Control Service, Instituto do Cancer do Estado de São Paulo da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Sao Paulo, Brazil
    Infect Control Hosp Epidemiol 34:671-7. 2013
    ..To describe the epidemiology of infections related to the use of implantable central venous access devices (CVADs) in cancer patients and to evaluate measures aimed at reducing the rates of such infections...
  25. doi request reprint Peritonectomy for peritoneal carcinomatosis: long-term outcomes from a single Brazilian institution
    Eduardo Akaishi
    Department of Surgical Oncology, São Paulo University School of Medicine LIM62 Centro de Oncologia, Hospital Sirio Libanes, Rua Dona Adma Jafet, 91, CEP 01308 050, Sao Paulo, SP, Brazil
    World J Surg 33:835-9; discussion 840. 2009
    ..The objective of this study was to evaluate the long-term outcomes of a single institution, Hospital Sírio-Libanes in São Paulo, Brazil, regarding the treatment of peritoneal carcinomatosis...
  26. ncbi request reprint Medullary thyroid carcinoma
    Ana O Hoff
    Centro de Oncologia, Hospital Sirio Libanes, Sao Paulo, Brazil
    Hematol Oncol Clin North Am 21:475-88; viii. 2007
    ..The identification of the associated molecular events has lead to the development of specific molecular targeted agents that may change the way this disease is treated in the near future...
  27. doi request reprint Self-reported conflicts of interest of authors, trial sponsorship, and the interpretation of editorials and related phase III trials in oncology
    Giovanni M Bariani
    Instituto do Câncer do Estado de São Paulo, Sao Paulo, Brazil
    J Clin Oncol 31:2289-95. 2013
    ..We aimed to test any association between authors' conclusions and self-reported COI or trial sponsorship in cancer studies...