Katherine A Hoadley

Summary

Publications

  1. pmc EGFR associated expression profiles vary with breast tumor subtype
    Katherine A Hoadley
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genomics 8:258. 2007
  2. pmc Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell lines
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 112:1607-13. 2004
  3. pmc Integrated RNA and DNA sequencing improves mutation detection in low purity tumors
    Matthew D Wilkerson
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 42:e107. 2014
  4. pmc Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
    Jeffrey S Damrauer
    Department of Genetics, Department of Medicine, Division of Hematology Oncology, Department of Surgery, Department of Pathology and Laboratory Medicine, and Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
    Proc Natl Acad Sci U S A 111:3110-5. 2014
  5. pmc Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
    Heather Ann Brauer
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 19:571-85. 2013
  6. pmc Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes
    Vonn Walter
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e56823. 2013
  7. ncbi request reprint RNA expression analysis of formalin-fixed paraffin-embedded tumors
    Shannon K Penland
    Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Lab Invest 87:383-91. 2007
  8. pmc TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
    Lisa A Carey
    Hematology Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, 170 Manning Dr, Chapel Hill, NC 27599 7305, USA
    J Clin Oncol 30:2615-23. 2012
  9. ncbi request reprint Cell-type-specific responses to chemotherapeutics in breast cancer
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cancer Res 64:4218-26. 2004
  10. pmc Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer
    Aaron R Thorner
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e13073. 2010

Collaborators

Detail Information

Publications16

  1. pmc EGFR associated expression profiles vary with breast tumor subtype
    Katherine A Hoadley
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genomics 8:258. 2007
    ..An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors...
  2. pmc Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell lines
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Environ Health Perspect 112:1607-13. 2004
    ..These analyses also showed that toxicant-specific gene expression patterns, similar to general stress responses, vary according to cell type...
  3. pmc Integrated RNA and DNA sequencing improves mutation detection in low purity tumors
    Matthew D Wilkerson
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 42:e107. 2014
    ..g. PIK3CA, ERBB2 and FGFR2). In summary, integrating RNA-seq with DNA-WES increases mutation detection performance, especially for low purity tumors. ..
  4. pmc Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology
    Jeffrey S Damrauer
    Department of Genetics, Department of Medicine, Division of Hematology Oncology, Department of Surgery, Department of Pathology and Laboratory Medicine, and Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
    Proc Natl Acad Sci U S A 111:3110-5. 2014
    ..Future studies exploring the predictive value of the BASE47 subtypes for standard of care bladder cancer therapies, as well as novel subtype-specific therapies, will be of interest. ..
  5. pmc Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer
    Heather Ann Brauer
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Cancer Res 19:571-85. 2013
    ..This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabolism...
  6. pmc Molecular subtypes in head and neck cancer exhibit distinct patterns of chromosomal gain and loss of canonical cancer genes
    Vonn Walter
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e56823. 2013
    ..Model systems representative of each of the four subtypes are also presented...
  7. ncbi request reprint RNA expression analysis of formalin-fixed paraffin-embedded tumors
    Shannon K Penland
    Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7295, USA
    Lab Invest 87:383-91. 2007
    ..Although only a minority of FFPE blocks could be analyzed, we show that informative RNA expression analysis can be derived from selected FFPE samples...
  8. pmc TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
    Lisa A Carey
    Hematology Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, 170 Manning Dr, Chapel Hill, NC 27599 7305, USA
    J Clin Oncol 30:2615-23. 2012
    ..Epidermal growth factor receptor (EGFR) is a targetable receptor frequently overexpressed in basal-like breast cancer, which comprises most triple-negative breast cancers (TNBCs), the only subtype without established targeted therapy...
  9. ncbi request reprint Cell-type-specific responses to chemotherapeutics in breast cancer
    Melissa A Troester
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cancer Res 64:4218-26. 2004
    ..Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics...
  10. pmc Potential tumor suppressor role for the c-Myb oncogene in luminal breast cancer
    Aaron R Thorner
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e13073. 2010
    ..However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly understood, despite its high expression in the majority of breast cancer cases (60-80%)...
  11. pmc Genomic Analysis of Immune Cell Infiltrates Across 11 Tumor Types
    Michael D Iglesia
    Lineberger Comprehensive Cancer Center MDI, JSP, KAH, JSS, CMP, BGV, Curriculum in Genetics and Molecular Biology MDI, JSP, Department of Medicine JSS, BGV, Department of Genetics KAH, CMP, Department of Microbiology and Immunology JSS, and Department of Pathology and Laboratory Medicine CMP, University of North Carolina, Chapel Hill, Chapel Hill, NC
    J Natl Cancer Inst 108:. 2016
    ..The precise makeup and prognostic relevance of immune infiltrates across a broad spectrum of tumors remain unclear...
  12. pmc Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases
    Katherine A Hoadley
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Med 13:e1002174. 2016
    ....
  13. pmc Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents
    Pu Wang
    Molecular and Cell Biology Lab of Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College, College of Life Science, Fudan University, Shanghai 200032, China Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Rep 13:2353-61. 2015
    ..Our results suggest that impairment of DNA repair may contribute to tumorigenesis driven by IDH mutations and that alkylating agents may merit exploration for treating IDH-mutated cancer patients. ..
  14. pmc Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status
    Rupninder Sandhu
    UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
    Carcinogenesis 35:2567-75. 2014
    ..These findings suggest that targeting miR-146a expression may have value for altering the aggressiveness of p53 mutant basal-like tumors. ..
  15. doi request reprint Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis
    Jian Jiang
    Curriculum in Applied and Materials Sciences, UNC CH, Chapel Hill, NC, USA
    Proteomics Clin Appl 1:1651-9. 2007
    ..The addition of stable-labeled versions of the target peptide (synthesized from stable-isotope coded amino acids) as internal standards allows absolute quantitation of the target protein...
  16. pmc Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types
    Matthew D Wilkerson
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Clin Cancer Res 16:4864-75. 2010
    ..We sought to determine if SCC mRNA expression subtypes exist, are reproducible across multiple patient cohorts, and are clinically relevant...