Timothy Hla

Summary

Publications

  1. pmc Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells
    Cheryl Habrukowich
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA
    J Biol Chem 285:26825-31. 2010
  2. ncbi request reprint Signaling and biological actions of sphingosine 1-phosphate
    Timothy Hla
    Department of Physiology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Pharmacol Res 47:401-7. 2003
  3. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
  4. ncbi request reprint Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    Arterioscler Thromb Vasc Biol 27:1312-8. 2007
  5. pmc Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
    Myat Lin Oo
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 121:2290-300. 2011
  6. pmc S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cancer Lett 276:171-9. 2009
  7. pmc Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    Masataka Kohno
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Biol 26:7211-23. 2006
  8. pmc Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
    Shobha Thangada
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    J Exp Med 207:1475-83. 2010
  9. ncbi request reprint Inhibition of gene expression in vivo using multiplex siRNA
    Sung Suk Chae
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, USA
    Methods Mol Biol 309:197-203. 2005
  10. pmc Essential role of the RNA-binding protein HuR in progenitor cell survival in mice
    Mallika Ghosh
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 119:3530-43. 2009

Collaborators

Detail Information

Publications76

  1. pmc Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells
    Cheryl Habrukowich
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, Center for Vascular Biology, New York, New York 10065, USA
    J Biol Chem 285:26825-31. 2010
    ..Knockdown of ANP32A expression further induced p38 SAPK and COX-2. These data identify ANP32A as a novel molecular target of sphingoid bases that regulates cellular signaling events and inflammatory gene expression...
  2. ncbi request reprint Signaling and biological actions of sphingosine 1-phosphate
    Timothy Hla
    Department of Physiology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Pharmacol Res 47:401-7. 2003
    ..Since S1P is a fundamental multifunctional mediator, better understanding of the biology of S1P holds great promise to develop novel tools to control various diseases...
  3. pmc Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Circ Res 102:669-76. 2008
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P...
  4. ncbi request reprint Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    Arterioscler Thromb Vasc Biol 27:1312-8. 2007
    ..However, cellular consequences of S1P2R signaling in the vascular cells are not well understood...
  5. pmc Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
    Myat Lin Oo
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Clin Invest 121:2290-300. 2011
    ....
  6. pmc S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cancer Lett 276:171-9. 2009
    ..In addition, S1P stimulated WiT49 cell invasion through S1P(1)/Gi signaling pathway. We consider that targeting S1P(1) may be a point of therapeutic intervention in Wilms tumor...
  7. pmc Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation
    Masataka Kohno
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mol Cell Biol 26:7211-23. 2006
    ..Our findings suggest that Sphk1 plays a critical role in intestinal tumor cell proliferation and that inhibitors of Sphk1 may be useful in the control of intestinal cancer...
  8. pmc Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
    Shobha Thangada
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    J Exp Med 207:1475-83. 2010
    ..Thus, cell-surface residency of S1P(1) on T cells is a primary determinant of lymphocyte egress kinetics in vivo...
  9. ncbi request reprint Inhibition of gene expression in vivo using multiplex siRNA
    Sung Suk Chae
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, USA
    Methods Mol Biol 309:197-203. 2005
  10. pmc Essential role of the RNA-binding protein HuR in progenitor cell survival in mice
    Mallika Ghosh
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 119:3530-43. 2009
    ..This regulation of cell stress response by HuR in progenitor cells, which we believe to be novel, could potentially be exploited in cytotoxic anticancer therapies as well as stem cell transplant therapy...
  11. pmc Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient
    Krishnan Venkataraman
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Biochem J 397:461-71. 2006
    ..These results suggest that export of Sphk-1a occurs under physiological conditions and may contribute to the establishment of the vascular S1P gradient...
  12. pmc Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
    Athanasia Skoura
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Clin Invest 117:2506-16. 2007
    ..We propose that antagonism of the S1P2R may be a novel therapeutic approach for the prevention and/or treatment of pathologic ocular neovascularization...
  13. pmc PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer
    Mallika Ghosh
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, United States
    Prostaglandins Other Lipid Mediat 88:97-100. 2009
    ..We postulate that activation of the nuclear receptor PPARdelta by COX-2-derived prostanoids may be involved in the proliferation of mammary epithelial cells and therefore contribute to mammary cancer development...
  14. pmc Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    Mol Cancer Res 6:1649-56. 2008
    ..In addition, overexpression of CTGF resulted in significant inhibition of WiT49 cell growth. Taken together, these data suggest that CTGF protein induced by S1P2 might act as a growth inhibitor in Wilms' tumor...
  15. ncbi request reprint Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
    Myat Lin Oo
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    J Biol Chem 282:9082-9. 2007
    ..We propose that the ability of FTY720-P to target the S1P1 receptor to the ubiquitinylation and proteasomal degradation pathway may at least in part underlie its immunosuppressive and anti-angiogenic properties...
  16. pmc Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
    Ji Hye Paik
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    Genes Dev 18:2392-403. 2004
    ..S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases...
  17. pmc Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
    Sung Suk Chae
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    J Clin Invest 114:1082-9. 2004
    ..These data suggest that S1P(1) is a critical component of the tumor angiogenic response and argue for the utility of siRNA technology in antiangiogenic therapeutics...
  18. pmc Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis
    Sung Hee Chang
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10065, USA
    J Biol Chem 288:4908-21. 2013
    ..Together, these studies reveal an evolutionarily conserved post-transcriptional mechanism involving competitive interactions between HuR and miR-200b that controls angiogenesis...
  19. pmc Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation
    Jason Michaud
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 184:1475-83. 2010
    ..Our results suggest that S1P serves as a negative regulator of macrophage recruitment by inhibiting migration in these cells and identify an additional facet to the regulation of leukocyte trafficking by S1P...
  20. ncbi request reprint Constitutive expression of the S1P1 receptor in adult tissues
    Sung Suk Chae
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Prostaglandins Other Lipid Mediat 73:141-50. 2004
    ..We show that S1P1 is widely expressed in various cell types of adult mouse tissues, suggesting a regulatory role of this receptor in numerous physiological processes in both vascular and non-vascular tissues...
  21. doi request reprint Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction
    Shobha Thangada
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut Department of Urology, Connecticut Children s Medical Center, Hartford, Connecticut
    J Urol 191:1508-16. 2014
    ..We examined the therapeutic role of FTY720 for renal injury secondary to unilateral ureteral obstruction...
  22. pmc FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway
    Mei Hong Li
    University of Connecticut Health Center, Center for Vascular Biology, Farmington, Connecticut, USA
    Pediatr Blood Cancer 60:1418-23. 2013
    ..To date, its effect in NB has not been explored. Herein we describe our preclinical experience with FTY720, alone or in combination with topotecan, and its putative mechanism of action in NB...
  23. pmc Sphingosine 1-phosphate in coagulation and inflammation
    Hideru Obinata
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Semin Immunopathol 34:73-91. 2012
    ..This review highlights the importance of S1P signaling in these inflammatory processes as well as the contribution of each receptor subtype, which exhibits both cooperative and redundant functions...
  24. ncbi request reprint Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells
    Michael J Kluk
    Center for Vascular Biology, Department of Physiology, MC3501, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 3501, USA
    FEBS Lett 533:25-8. 2003
    ..These data question the generality of the concept that S1P1 GPCR is a critical downstream component of PDGF-induced chemotaxis...
  25. pmc Sphingolipid modulation of angiogenic factor expression in neuroblastoma
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA
    Cancer Prev Res (Phila) 4:1325-32. 2011
    ..Modulation of sphingolipid signaling by inhibiting S1P(2) may constitute a novel strategy to control NB...
  26. ncbi request reprint Sphingosine-1-phosphate signaling in endothelial activation
    Harunobu Ozaki
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Atheroscler Thromb 10:125-31. 2003
    ..This review will focus on S1P/ EDG-1 signaling in endothelial activation, in particular in the S1P-mediated adherens junctions assembly and chemotaxis in endothelial cells...
  27. doi request reprint Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Cornell University, New York, NY 10065, USA
    Neurology 76:S3-8. 2011
    ..This review highlights the normal physiologic processes modulated by S1P and S1PRs, and the therapeutic effects of S1PR modulation in the immune, central nervous, and cardiovascular systems...
  28. ncbi request reprint COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice
    Kirsi Narko
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, 06030 350, USA
    Prostaglandins Other Lipid Mediat 76:86-94. 2005
    ....
  29. ncbi request reprint Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor
    Sung Hee Chang
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, 06030 3501, USA
    Prostaglandins Other Lipid Mediat 76:48-58. 2005
    ..These results suggest that EP2 receptor is a critical element for PGE(2) mediated VEGF induction in mouse mammary tumor cells...
  30. pmc S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Urol 181:1347-52. 2009
    ..Cyclooxygenase-2 has been reported to be ubiquitously expressed in Wilms tumor, the most common malignant renal tumor in children. However, to our knowledge the regulation mechanism of cyclooxygenase-2 expression remains unexplored...
  31. pmc PTEN as an effector in the signaling of antimigratory G protein-coupled receptor
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 102:4312-7. 2005
    ..GPCR regulation of PTEN maybe a general mechanism in signaling events of cell migration and invasion...
  32. pmc A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC)
    Yong Moon Lee
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3505, USA
    Prostaglandins Other Lipid Mediat 84:154-62. 2007
    ..IMAC-based affinity-enrichment coupled with a HPLC-based separation and detection system is a rapid and sensitive method to accurately quantify S1P...
  33. pmc Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning
    Karen Mendelson
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York 10021, USA
    J Biol Chem 288:2143-56. 2013
    ..Similarly, the S1P transporter, spns2, also cooperated with s1pr1. We propose that extracellular S1P acts through vascular S1P receptors to regulate vascular development...
  34. pmc Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development
    Bongnam Jung
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Dev Cell 23:600-10. 2012
    ..These data demonstrate that blood flow and circulating S1P activate endothelial S1P1 to stabilize blood vessels in development and homeostasis...
  35. pmc The vascular S1P gradient-cellular sources and biological significance
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06001, USA
    Biochim Biophys Acta 1781:477-82. 2008
    ..From an evolutionary perspective, S1P receptors may have co-evolved with the advent of a closed vascular system and the trafficking paradigms for hematopoietic cells to navigate in and out of the vascular system...
  36. pmc Regulation of vascular physiology and pathology by the S1P2 receptor subtype
    Athanasia Skoura
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Cardiovasc Res 82:221-8. 2009
    ..These studies suggest that selective modulation of S1P2 receptor function by pharmacological tools may be useful in a variety of pathological conditions...
  37. ncbi request reprint Immunology. Dietary factors and immunological consequences
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 309:1682-3. 2005
  38. pmc HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation
    Sylvain Galvani
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Sci Signal 8:ra79. 2015
    ..We propose that the ability of ApoM(+)HDL to act as a biased agonist on S1P1 inhibits vascular inflammation, which may partially explain the cardiovascular protective functions of HDL. ..
  39. pmc Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, Connecticut M H L, L H S, F F Arroyo Biosciences, LLC, Princeton, New Jersey R S Department of Urology and Surgery, Connecticut Children s Medical Center, Hartford, Connecticut M H, F F TCG Life Sciences Limited, Hinjewadi, Pune, India S J Chem Master International Inc, Stony Brook, New York E S and Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Medical College of Cornell University, New York, New York T H
    J Pharmacol Exp Ther 354:261-8. 2015
    ..Overall, the modification of JTE-013 to produce the AB1 compound improved potency, intravenous pharmacokinetics, cellular activity, and antitumor activity in NB and may have enhanced clinical and experimental applicability. ..
  40. pmc ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages
    Yi Chien Lu
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Cell Rep 9:2330-43. 2014
    ..This study provides a resource for systems-level interrogation of posttranscriptional gene regulation in macrophages, a key cell type in inflammation, angiogenesis, and tissue homeostasis. ..
  41. pmc S1P and the birth of platelets
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    J Exp Med 209:2137-40. 2012
    ..This work reveals a novel physiological action of the S1P/S1P(1) duet that could potentially be harnessed for clinical translation...
  42. pmc Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation
    Hideru Obinata
    Laboratory Medicine, Department of Pathology, Center for Vascular Biology, Weill Cornell Medical College, Cornell University, New York, NY, USA
    Methods Mol Biol 874:69-76. 2012
    ..Here, we describe bioassays for rapidly assessing S1P activity in biological fluids based on ligand-induced receptor internalization in transfected HEK293 cells and consequent adherens junction formation of vascular endothelial cells...
  43. ncbi request reprint Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
    Jason Michaud
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3501, USA
    FEBS Lett 580:4607-12. 2006
    ..Our findings show that sphingosine kinase 1 is dispensable for inflammatory responses and support the need for more extensive studies of sphingosine kinases in inflammation...
  44. ncbi request reprint Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    Teresa Sanchez
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3501, USA
    J Biol Chem 278:47281-90. 2003
    ....
  45. ncbi request reprint Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis
    Sung Suk Chae
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Dev Biol 268:441-7. 2004
    ..Indeed, similar limb defects were observed in endothelium-specific S1P(1) null mice in vivo. These data suggest that the function of S1P(1) in the developing vasculature is essential for proper limb development...
  46. pmc COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation
    Mallika Ghosh
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Exp Med 204:2053-61. 2007
    ..Furthermore, PPARdelta agonists may be used therapeutically to suppress coxib-induced cardiovascular side effects...
  47. pmc S1P control of endothelial integrity
    Yuquan Xiong
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY, 10165, USA
    Curr Top Microbiol Immunol 378:85-105. 2014
    ..In particular, we discuss the recent discovery of the endothelium-protective functions of HDL-bound S1P which is chaperoned by apolipoprotein M. ..
  48. pmc Sphingolipid signaling in metabolic disorders
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Cell Metab 16:420-34. 2012
    ..Progress in this area may contribute to new understanding and therapeutic options in complex diseases such as atherosclerosis, diabetes, metabolic syndromes, and cancer...
  49. ncbi request reprint Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors
    Michael J Kluk
    Center for Vascular Biology, Department of Physiology, School of Medicine, University of Connecticut Health Center, 263 Farmington Ave Farmington, CT 06030, USA
    Biochim Biophys Acta 1582:72-80. 2002
    ..Further investigation in this field will likely improve our understanding of cardiovascular development as well as vascular diseases and may lead to novel therapeutic approaches...
  50. pmc Gene regulation by RNA binding proteins and microRNAs in angiogenesis
    Sung Hee Chang
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Trends Mol Med 17:650-8. 2011
    ..This review focuses on the miRNAs and RBPs which often cooperate to achieve precise spatial and temporal control of angiogenic regulatory genes...
  51. pmc Lysophospholipid receptors in vertebrate development, physiology, and pathology
    Athanasia Skoura
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Lipid Res 50:S293-8. 2009
    ..Further basic research on LP signaling is anticipated to lead to novel therapeutic tools to combat various human diseases...
  52. ncbi request reprint Genomic insights into mediator lipidomics
    Timothy Hla
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Prostaglandins Other Lipid Mediat 77:197-209. 2005
    ....
  53. pmc Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure
    Anna Cantalupo
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, New York, USA
    Nat Med 21:1028-37. 2015
    ..Our study identifies Nogo-B as a key inhibitor of local sphingolipid synthesis and shows that autocrine sphingolipid signaling within the endothelium is critical for vascular function and blood pressure homeostasis. ..
  54. pmc Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma
    Mei Hong Li
    Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 Electronic address
    J Pediatr Surg 49:1286-91. 2014
    ..In the present study, we investigated the mechanism of S1P-induced CCL2 expression in NB...
  55. ncbi request reprint The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia
    Sung Hee Chang
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    Cancer Res 65:4496-9. 2005
    ..Inhibition of the EP2 pathway in the mammary gland may be a novel approach in the prevention and/or treatment of mammary cancer...
  56. ncbi request reprint Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation
    Nicolas Ancellin
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    J Biol Chem 277:6667-75. 2002
    ..These findings suggest that S1P is made in the extracellular milieu and that extracellular export of SK contributes to the action of S1P in the vascular system...
  57. ncbi request reprint The RNA-binding protein HuR regulates the expression of cyclooxygenase-2
    Sibani Sengupta
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, 263 Farmington Avenue, 06030 3501, USA
    J Biol Chem 278:25227-33. 2003
    ..6- and 2.8-kb isoforms) and protein levels. These data suggest that HuR binding to COX-2 is critical for its post-transcriptional mRNA stabilization...
  58. ncbi request reprint Structural and functional characteristics of S1P receptors
    Teresa Sanchez
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmngton, Connecticut 06030 3501, USA
    J Cell Biochem 92:913-22. 2004
    ..Understanding the physiological role of these receptors and the basics of the ligand-receptor interaction will potentially provide new therapies to control a variety of diseases...
  59. ncbi request reprint Physiological and pathological actions of sphingosine 1-phosphate
    Timothy Hla
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Semin Cell Dev Biol 15:513-20. 2004
    ....
  60. pmc Ramping up RANTES in the acute response to arterial injury
    Timothy Hla
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    J Clin Invest 120:90-2. 2010
    ..Upon activation, these factors turn on transcription of a potent T cell chemokine, RANTES, which selectively recruits T cells into the vessel wall as part of the vascular wound-healing response...
  61. doi request reprint Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis
    Sung Hee Chang
    Department of Pathology and Laboratory Medicine, Center for Vascular Biology, Weill Cornell Medical College, Cornell University, New York, New York, USA
    Curr Opin Hematol 21:235-40. 2014
    ..Specifically, we focus on gene regulation by HuR, an RNA-binding protein (RBP), and microRNAs (miRNAs) and their interplay, which ultimately influences cellular phenotypes of cells involved in angiogenesis...
  62. pmc Fine-Tuning S1P Therapeutics
    Hideru Obinata
    Center for Vascular Biology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA
    Chem Biol 19:1080-2. 2012
    ..in this issue of Chemistry & Biology), suggests that fine-tuning of S1P(1) modulators may lead to novel immune modulators with better efficacy to adverse events ratio...
  63. pmc A festschrift for J. Martyn Bailey, a biochemist extraordinaire
    Timothy Hla
    Center for Vascular Biology, University of Connecticut School of Medicine, Farmington, CT, USA
    Prostaglandins Other Lipid Mediat 83:154-7. 2007
    ..He made important contributions in the areas of essential fatty acids, prostaglandins, thromboxanes and lipoxygenase metabolites...
  64. pmc Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression
    Sung Hee Chang
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Proc Natl Acad Sci U S A 101:591-6. 2004
    ..These results define COX-2-derived PGE(2) as a potent inducer of angiogenic switch during mammary cancer progression...
  65. ncbi request reprint Point-counterpoint of sphingosine 1-phosphate metabolism
    Julie D Saba
    Children s Hospital of Oakland Research Institute, Oakland, Calif, USA
    Circ Res 94:724-34. 2004
    ....
  66. ncbi request reprint Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity
    Jen Fu Lee
    Gheens Center on Aging, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
    J Biol Chem 281:29190-200. 2006
    ..The concerted operation of these two ZO-1 complexes may coordinate two important S1P-mediated functions, i.e. migration and barrier integrity, in vascular endothelial cells...
  67. ncbi request reprint Deafness and stria vascularis defects in S1P2 receptor-null mice
    Mari Kono
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1821, USA
    J Biol Chem 282:10690-6. 2007
    ..Vascular disturbance within the stria vascularis is a potential mechanism that leads to deafness in the S1P(2) receptor-null mice...
  68. ncbi request reprint Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells
    Jen Fu Lee
    Gheens Center on Aging, Department of Microbiology and Immunology, University of Louisville Health Science Center, 580 S Preston St, Louisville, KY 40202, USA
    Histochem Cell Biol 126:297-304. 2006
    ....
  69. ncbi request reprint Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression
    Masayasu Kitano
    Hyogo College of Medicine, Nishinomiya City, Hyogo, Japan
    Arthritis Rheum 54:742-53. 2006
    ..This study was undertaken to examine the role of S1P/S1P1 signaling in the pathogenesis of rheumatoid arthritis (RA)...
  70. ncbi request reprint International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    ..Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed...
  71. ncbi request reprint Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome
    Masahiro Sekiguchi
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    J Immunol 180:1921-8. 2008
    ..These effects of S1P were inhibited by pretreatment of pertussis toxin. Our data reveal that S1P(1) signaling may modulate the autoimmune phenotype of primary SS by the action of immune as well as epithelial cells...
  72. ncbi request reprint Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization
    Kenneth LaMontagne
    Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA
    Cancer Res 66:221-31. 2006
    ..These data show that functional antagonism of vascular S1P receptors by FTY720 potently inhibits angiogenesis; therefore, this may provide a novel therapeutic approach for pathologic conditions with dysregulated angiogenesis...
  73. ncbi request reprint Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics
    Pedro J Gonzalez-Cabrera
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:7254-64. 2007
    ..These data suggest that the hierarchy of ubiquitin recruitment to S1P(1) (AFD-R > S1P > SEW2871) correlates with the efficiency of lysosomal receptor degradation and reflects intrinsic differences between agonists...
  74. ncbi request reprint S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate
    Euijung Jo
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 118, La Jolla, CA 92037, USA
    Chem Biol 12:703-15. 2005
    ....
  75. ncbi request reprint FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function
    Volker Brinkmann
    Transplantation and Immunology, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Am J Transplant 4:1019-25. 2004
    ..The available data establish S1P(1) as a key target for FTY720, and further point to therapeutically relevant effects of the drug on lymphocytes and vascular endothelium...
  76. ncbi request reprint TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity
    Patrick J Donohue
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Arterioscler Thromb Vasc Biol 23:594-600. 2003
    ..We also determined whether a soluble Fn14-Fc fusion protein could inhibit TWEAK biologic activity on ECs and investigated TWEAK signal transduction in ECs...