Jeremy A Hirota

Summary

Publications

  1. doi Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury
    Jeremy A Hirota
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 49:453-62. 2013
  2. doi The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A Hirota
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 129:1116-25.e6. 2012
  3. doi Modeling asthma in mice: what have we learned about the airway epithelium?
    Jeremy A Hirota
    University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 44:431-8. 2011
  4. doi Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1)
    Matthew J Gold
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 136:725-736.e2. 2015
  5. doi Human airway epithelial cell innate immunity: relevance to asthma
    Jeremy A Hirota
    UBC James Hogg Research Centre Heart Lung Institute, St Pauls Hospital, Vancouver, BC, V6Z 1Y6, Canada
    Curr Opin Immunol 24:740-6. 2012
  6. pmc Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects
    Ali Hosseini
    Department of Medicine, Division of Respiratory Medicine, Chan Yeung Centre for Occupational and Environmental Respiratory Disease, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada
    Part Fibre Toxicol 13:2. 2016
  7. doi PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media
    Jeremy A Hirota
    James Hogg Research Centre, University of British Columbia Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Respirology 19:881-90. 2014
  8. doi The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation
    Jeremy A Hirota
    1 University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada and
    Am J Respir Cell Mol Biol 49:517-24. 2013
  9. doi Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures
    Matthew J Gold
    The Biomedical Research Centre, University of British Columbia, Vancouver
    J Allergy Clin Immunol 133:1142-8. 2014
  10. doi Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study
    Rachel Cliff
    a Department of Medicine, Division of Respiratory Medicine, Chan Yeung Centre for Occupational and Environmental Respiratory Disease, University of British Columbia, Vancouver, BC, Canada
    Inhal Toxicol 28:145-53. 2016

Collaborators

Detail Information

Publications11

  1. doi Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury
    Jeremy A Hirota
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Respir Cell Mol Biol 49:453-62. 2013
    ..Our data demonstrate that GzmB deficiency results in the exacerbation of lymphocytic inflammation during bleomycin-induced acute lung injury, which is associated with pathology, morbidity, and mortality. ..
  2. doi The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
    Jeremy A Hirota
    St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 129:1116-25.e6. 2012
    ..The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses...
  3. doi Modeling asthma in mice: what have we learned about the airway epithelium?
    Jeremy A Hirota
    University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 44:431-8. 2011
    ....
  4. doi Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase Src homology 2 domain-containing inositol 5-phosphatase (SHIP-1)
    Matthew J Gold
    The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 136:725-736.e2. 2015
    ..Inpp5d (Src homology 2 domain-containing inositol-5-phosphatase [Ship1])-deficient mice experience spontaneous airway inflammation and have enhanced sensitivity to allergen-induced airway inflammation...
  5. doi Human airway epithelial cell innate immunity: relevance to asthma
    Jeremy A Hirota
    UBC James Hogg Research Centre Heart Lung Institute, St Pauls Hospital, Vancouver, BC, V6Z 1Y6, Canada
    Curr Opin Immunol 24:740-6. 2012
    ..In this review, we discuss the recent evidence supporting these statements, focusing primarily on data generated from using human samples...
  6. pmc Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects
    Ali Hosseini
    Department of Medicine, Division of Respiratory Medicine, Chan Yeung Centre for Occupational and Environmental Respiratory Disease, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada
    Part Fibre Toxicol 13:2. 2016
    ..We aimed to clarify whether DE increases allergen-induced inflammation and cellular immune response in the airways of atopic human subjects...
  7. doi PM10-stimulated airway epithelial cells activate primary human dendritic cells independent of uric acid: application of an in vitro model system exposing dendritic cells to airway epithelial cell-conditioned media
    Jeremy A Hirota
    James Hogg Research Centre, University of British Columbia Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Respirology 19:881-90. 2014
    ..After establishing the model, we explored how soluble mediators released from airway epithelial cells in response to air pollution influenced the phenotype of dendritic cells...
  8. doi The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation
    Jeremy A Hirota
    1 University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada and
    Am J Respir Cell Mol Biol 49:517-24. 2013
    ..Activation of the NLRP3 inflammasome by invading pathogens may prove cell type-specific in exacerbations of airway inflammation in asthma...
  9. doi Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures
    Matthew J Gold
    The Biomedical Research Centre, University of British Columbia, Vancouver
    J Allergy Clin Immunol 133:1142-8. 2014
    ....
  10. doi Effect of diesel exhaust inhalation on blood markers of inflammation and neurotoxicity: a controlled, blinded crossover study
    Rachel Cliff
    a Department of Medicine, Division of Respiratory Medicine, Chan Yeung Centre for Occupational and Environmental Respiratory Disease, University of British Columbia, Vancouver, BC, Canada
    Inhal Toxicol 28:145-53. 2016
    ..Controlled human exposure studies of the effect of air pollution on the brain have potential to enhance our understanding of this relationship and to inform potential biological mechanisms...
  11. doi Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases
    Thomas Abraham
    The James Hogg Research Centre, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Pulm Pharmacol Ther 24:487-96. 2011
    ....