Robert I Henkin

Summary

Publications

  1. ncbi Functional MRI of congenital hyposmia: brain activation to odors and imagination of odors and tastes
    Robert I Henkin
    Taste and Smell Clinic, Washington, DC 20016, USA
    J Comput Assist Tomogr 26:39-61. 2002
  2. doi Improved smell function with increased nasal mucus sonic hedgehog in hyposmic patients after treatment with oral theophylline
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC 20016, United States Electronic address
    Am J Otolaryngol . 2016
  3. doi On the mechanism of smell loss in patients with Type II congenital hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC Electronic address
    Am J Otolaryngol 37:436-41. 2016
  4. doi Initiation of smell function in patients with congenital hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC Electronic address
    Am J Otolaryngol 37:175-81. 2016
  5. pmc Olfactory Hallucinations without Clinical Motor Activity: A Comparison of Unirhinal with Birhinal Phantosmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, Suite 20, Washington, DC 20016, USA
    Brain Sci 3:1483-553. 2013
  6. doi Effects of smell loss (hyposmia) on salt usage
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, District of Columbia, USA Electronic address
    Nutrition 30:690-5. 2014
  7. doi Interleukin 6 in hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    JAMA Otolaryngol Head Neck Surg 139:728-34. 2013
  8. doi Taste and smell function in chronic disease: a review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Am J Otolaryngol 34:477-89. 2013
  9. doi Etiological relationships of parotid saliva cyclic nucleotides in patients with taste and smell dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, Washington, DC 20016, USA
    Arch Oral Biol 57:670-7. 2012
  10. doi Aetiological relationships of nasal mucus cyclic nucleotides in patients with taste and smell dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    J Clin Pathol 65:447-51. 2012

Collaborators

  • William A Stateman
  • Alexandra B Knoppel
  • Willy A Flegel
  • Lucien M Levy
  • Andrew J Degnan
  • Ila Sethi

Detail Information

Publications25

  1. ncbi Functional MRI of congenital hyposmia: brain activation to odors and imagination of odors and tastes
    Robert I Henkin
    Taste and Smell Clinic, Washington, DC 20016, USA
    J Comput Assist Tomogr 26:39-61. 2002
    ..Our goal was to use functional MRI (fMRI) to define brain activation in response to odors and imagination ("memory") of odors and tastes in patients who never recognized odors (congenital hyposmia)...
  2. doi Improved smell function with increased nasal mucus sonic hedgehog in hyposmic patients after treatment with oral theophylline
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC 20016, United States Electronic address
    Am J Otolaryngol . 2016
    ..Since treatment with oral theophylline has been previously associated with improvement in smell function we wished to study if such treatment increased nasal mucus Shh as well as improved smell function in patients with hyposmia...
  3. doi On the mechanism of smell loss in patients with Type II congenital hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC Electronic address
    Am J Otolaryngol 37:436-41. 2016
    ..The mechanism(s) responsible for initiation of smell function in these patients, not immediately apparent, may depend upon understanding interactions among these moieties...
  4. doi Initiation of smell function in patients with congenital hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC Electronic address
    Am J Otolaryngol 37:175-81. 2016
    ..Type II patients have neither a family history of smell loss nor any somatic abnormalities. No systematic attempts to initiate smell function in Type II patients have been reported...
  5. pmc Olfactory Hallucinations without Clinical Motor Activity: A Comparison of Unirhinal with Birhinal Phantosmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, Suite 20, Washington, DC 20016, USA
    Brain Sci 3:1483-553. 2013
    ..Mechanisms responsible for phantosmia in each group were related to decreased gamma-aminobutyric acid (GABA) activity in specific brain regions. Treatment which activated brain GABA inhibited phantosmia in both groups. ..
  6. doi Effects of smell loss (hyposmia) on salt usage
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, District of Columbia, USA Electronic address
    Nutrition 30:690-5. 2014
    ..To compensate for flavor loss, some patients with hyposmia appear to increase salt usage. The purpose of this study was to compare self-reported salt usage in patients with hyposmia with that in normal volunteers...
  7. doi Interleukin 6 in hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    JAMA Otolaryngol Head Neck Surg 139:728-34. 2013
    ..Elevated plasma levels of interleukin 6 (IL-6) have been found in patients with several acute and chronic diseases but have not been reported in patients with smell loss (hyposmia)...
  8. doi Taste and smell function in chronic disease: a review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Am J Otolaryngol 34:477-89. 2013
    ..To describe systematic methods developed over 40 years among over 5000 patients at The Taste and Smell Clinic in Washington, DC to evaluate taste and smell dysfunction...
  9. doi Etiological relationships of parotid saliva cyclic nucleotides in patients with taste and smell dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, Washington, DC 20016, USA
    Arch Oral Biol 57:670-7. 2012
    ..To learn more about these relationships we studied parotid saliva cAMP and cGMP with respect to aetiology of sensory loss in these patients...
  10. doi Aetiological relationships of nasal mucus cyclic nucleotides in patients with taste and smell dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    J Clin Pathol 65:447-51. 2012
    ..To learn more about these differences this study related levels of nasal mucus cAMP and cGMP in patients with smell and taste dysfunction to the aetiology of their sensory loss and compared these results with those in normal individuals...
  11. doi Comparative monitoring of oral theophylline treatment in blood serum, saliva, and nasal mucus
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, District of Columbia 20016, USA
    Ther Drug Monit 34:217-21. 2012
    ..No prior report of theophylline in nasal mucus has been made and no comparison of levels in nasal mucus, blood serum, or saliva has been previously reported...
  12. doi Distinguishing patients with glossopyrosis from those with oropyrosis based upon clinical differences and differences in saliva and erythrocyte magnesium
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, United States
    Arch Oral Biol 57:205-10. 2012
    ..Biochemical differences between these two groups could assist in distinguishing them...
  13. ncbi cAMP and cGMP in human parotid saliva: relationships to taste and smell dysfunction, gender, and age
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Am J Med Sci 334:431-40. 2007
    ..There was a complex pattern of change for both cAMP and cGMP with age with concentrations increasing to about age 50, then decreasing, then increasing again at age >70 years...
  14. ncbi cAMP and cGMP in nasal mucus: relationships to taste and smell dysfunction, gender and age
    R I Henkin
    Center for Molecular Nutritional and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Clin Invest Med 31:E71-7. 2008
    ..To evaluate the presence and concentration of cAMP and cGMP in human nasal mucus in normal volunteers, to relate these findings to age and gender, and to compare normal levels with those in patients with taste and smell dysfunction...
  15. ncbi cAMP and cGMP in nasal mucus related to severity of smell loss in patients with smell dysfunction
    R I Henkin
    Center for Molecular Nutritional and SensoryDisorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Clin Invest Med 31:E78-84. 2008
    ..To evaluate nasal mucus levels of cAMP and cGMP in patients with taste and smell dysfunction with respect to severity of their smell loss...
  16. doi An open-label controlled trial of theophylline for treatment of patients with hyposmia
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC, USA
    Am J Med Sci 337:396-406. 2009
    ..To test the hypothesis that theophylline is effective in correcting smell loss in patients with hyposmia...
  17. doi Decreased parotid salivary cyclic nucleotides related to smell loss severity in patients with taste and smell dysfunction
    Robert Irwin Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    Metabolism 58:1717-23. 2009
    ..These results reflect a biochemical method to identify and classify patients with smell loss in some respects similar to initial typing of serum lipid levels to assist in risk classification of patients with cardiovascular disease...
  18. doi Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation
    Robert I Henkin
    The Taste and Smell Clinic, Washington, DC, USA
    Am J Otolaryngol 32:38-46. 2011
    ..Although treatment of these symptoms has been elusive, repetitive transcranial magnetic stimulation (rTMS) has been suggested as an effective corrective therapy...
  19. pmc Carbonic anhydrase I, II, and VI, blood plasma, erythrocyte and saliva zinc and copper increase after repetitive transcranial magnetic stimulation
    Robert I Henkin
    Taste and Smell Clinic, Washington, District of Columbia 20016, USA
    Am J Med Sci 339:249-57. 2010
    ..To obtain more information about these changes after rTMS, we measured changes in several CA enzymes, proteins, and trace metals in their blood plasma, erythrocytes, and saliva...
  20. doi Differences between and within human parotid saliva and nasal mucus cAMP and cGMP in normal subjects and in patients with taste and smell dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, Washington, DC 20016, USA
    J Oral Pathol Med 40:504-9. 2011
    ..However, comparison of levels of these latter moieties in saliva and nasal mucus has not been performed and meaning of differences found has not been discussed...
  21. doi Relative resistance to oral theophylline treatment in patients with hyposmia manifested by decreased secretion of nasal mucus cyclic nucleotides
    Robert I Henkin
    Taste and Smell Clinic, Center for Molecular Nutrition and Sensory Disorders, Washington, DC 20016, USA
    Am J Med Sci 341:17-22. 2011
    ....
  22. doi Sonic hedgehog is present in parotid saliva and is decreased in patients with taste dysfunction
    Robert I Henkin
    Center for Molecular Nutrition and Sensory Disorders The Taste and Smell Clinic 5125 MacArthur Blvd, NW, 20 Washington, DC 20016
    J Oral Pathol Med . 2016
    ..To demonstrate that sonic hedgehog (Shh) is present in human parotid saliva and is decreased in human taste dysfunction...
  23. pmc A genetic marker of the ACKR1 gene is present in patients with Type II congenital smell loss who have type I hyposmia and hypogeusia
    William A Stateman
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC, United States Electronic address
    Am J Otolaryngol 37:484-489. 2016
    ..The present study correlates this genetic feature with subgroups of patients defined by specific smell and taste functions...
  24. pmc Erythrocyte membrane antigen frequencies in patients with Type II congenital smell loss
    William A Stateman
    Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, 20, Washington, DC, United States Electronic address
    Am J Otolaryngol 36:146-52. 2015
    ..The objective of this study was to determine whether there are genetic factors associated with Type II congenital smell loss...
  25. doi Anatomic olfactory structural abnormalities in congenital smell loss: magnetic resonance imaging evaluation of olfactory bulb, groove, sulcal, and hippocampal morphology
    Lucien M Levy
    From the Department of Radiology, George Washington University Medical Center, Washington, DC University of Pittsburgh Medical Center, Pittsburgh, PA and The Taste and Smell Clinic, Washington, DC
    J Comput Assist Tomogr 37:650-7. 2013
    ..The purpose of this study was to evaluate patients with congenital smell loss, primarily among group 2 patients, comparing brain magnetic resonance imaging (MRI) results in patients with types of hyposmia...