Tohru Hasegawa

Summary

Publications

  1. doi Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer's disease patients
    Tohru Hasegawa
    Saga Woman Junior College, Saga, Japan
    J Alzheimers Dis 31:59-64. 2012
  2. ncbi Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid
    Tohru Hasegawa
    Saga Woman Junior College, Saga 840 8550, Japan
    Med Hypotheses 69:1135-9. 2007
  3. pmc Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice
    Tohru Hasegawa
    Saga Women s Junior College, Saga City, Saga, Japan
    PLoS ONE 5:e8593. 2010
  4. ncbi Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease
    Tohru Hasegawa
    Saga Women s Junior College, Honjyou Town, Japan
    J Neurosci Res 80:869-76. 2005
  5. pmc Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer's disease patients
    Tohru Hasegawa
    Saga Woman Junior College, Saga 840 8550, Japan
    Aging (Albany NY) 8:1838-1843. 2016

Detail Information

Publications5

  1. doi Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer's disease patients
    Tohru Hasegawa
    Saga Woman Junior College, Saga, Japan
    J Alzheimers Dis 31:59-64. 2012
    ..Since amyloid-β increases HA toxicity and HA is an agonist of N-methyl-D-aspartic acid (NMDA) receptor, we speculate that elevated blood HA affects the brain cognitive function through NMDA receptor-mediated toxicity in AD...
  2. ncbi Prolonged stress will induce Alzheimer's disease in elderly people by increased release of homocysteic acid
    Tohru Hasegawa
    Saga Woman Junior College, Saga 840 8550, Japan
    Med Hypotheses 69:1135-9. 2007
    ..Finally, the aggregated alpha-synuclein induces tau pathology, which induces cell death, leading to Alzheimer's pathology. In conclusion, we propose that HA induces Alzheimer's pathology in the elderly people because of prolonged stress...
  3. pmc Treatment of Alzheimer's disease with anti-homocysteic acid antibody in 3xTg-AD male mice
    Tohru Hasegawa
    Saga Women s Junior College, Saga City, Saga, Japan
    PLoS ONE 5:e8593. 2010
    ..We conclude that increased brain HA triggers memory impairment and that this condition deteriorates with amyloid and leads to subsequent neurodegeneration in mouse models of AD...
  4. ncbi Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease
    Tohru Hasegawa
    Saga Women s Junior College, Honjyou Town, Japan
    J Neurosci Res 80:869-76. 2005
    ....
  5. pmc Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer's disease patients
    Tohru Hasegawa
    Saga Woman Junior College, Saga 840 8550, Japan
    Aging (Albany NY) 8:1838-1843. 2016
    ..Also there are other treatments hypothesis which would be possible for the effective therapies, such as ribonucleoprotein therapy, a β-secretase inhibitor treatment and the metabolic enhancement treatment...